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Amoxicillin-Clavulanate

Detailed information about Amoxicillin-Clavulanate

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 7:40 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

Antibiotic combination used for susceptible bacterial infections (often skin, soft tissue, dental, urinary).

What to watch for:

  • Avoid in pets with known penicillin allergy
  • Use caution with severe kidney disease
  • Vomiting (1 reports)
  • trouble breathing (1 reports)
  • Loss of appetite (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Avoid in pets with known penicillin allergy
  • Use caution with severe kidney disease
  • Vomiting
  • trouble breathing
  • Loss of appetite

Most reported reactions:

  • Vomiting (1 reports)
  • Trouble breathing (dyspnea) (1 reports)
  • Loss of appetite (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
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Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 7:40 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 7, 2026, 11:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:19 AM UTC
Image for Amoxicillin-Clavulanate

Amoxicillin-Clavulanate

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Species: Both

Manufacturer: Zoetis

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Zoetis

Warnings / Contraindications

Avoid in pets with known penicillin allergy. Use caution with severe kidney disease.

  • High: Avoid in pets with known penicillin allergy. Use caution with severe kidney disease.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
32
Species represented
1
Grouped by Body System
Digestive (4) · Vomiting, Loss of appetite, Drooling Skin & allergy (1) · Hair loss NOS Other (27) · Trouble breathing (dyspnea), Foaming at the mouth, Fever
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Digestive 1 Dog 1
Other 1 Dog 1
Digestive 1 Dog 1
Skin & allergy 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (32)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Serious - 1
Other Dog Serious - 1
Digestive Dog Serious - 1
Skin & allergy Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Digestive Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Digestive Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Source metadata:

Storage & Handling

Store at room temperature; follow label directions for liquid suspensions.

Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 7:40 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 7, 2026, 11:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:19 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 14 • Cat 0 • View
Case summaries: 5 (showing 5) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Avoid in pets with known penicillin allergy. Use caution with severe kidney disease. (Contraindication, High)
Top reaction signals
Vomiting (1) Trouble breathing (dyspnea) (1) Loss of appetite (1) Hair loss NOS (1) Foaming at the mouth (1) Fever (1) Elevated total bilirubin (1) Elevated temperature (1)

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 1 Clinical 4 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Avoid in pets with known penicillin allergy. Use caution with severe kidney disease. (Clinical, 2026-02-12)
  • overdose_info: Mild overdose may cause more pronounced GI symptoms; extreme overdose could lead to kidney damage or neurologic effects. Supportive care is recommended. (Clinical, 2026-02-12)
  • storage_handling: Store at room temperature; follow label directions for liquid suspensions. (Clinical, 2026-02-12)
  • usage: Antibiotic combination used for susceptible bacterial infections (often skin, soft tissue, dental, urinary). (Clinical, 2026-02-12)
  • side_effects: GI upset (vomiting/diarrhea), decreased appetite. Rare: allergic reaction. (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields

Usage

Antibiotic combination used for susceptible bacterial infections (often skin, soft tissue, dental, urinary).

Contraindications

Avoid in pets with known penicillin allergy. Use caution with severe kidney disease.

Side Effects

GI upset (vomiting/diarrhea), decreased appetite. Rare: allergic reaction.

Source: FDA openFDA • Reference

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Loss of appetite (1) • Dog Drooling (1) • Dog Decreased appetite (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Hair loss NOS (1) • Dog

Showing top 5 for Skin & allergy.

Other
Trouble breathing (1) • Dog Foaming at the mouth (1) • Dog Fever (1) • Dog Elevated total bilirubin (1) • Dog Elevated temperature (1) • Dog
Show more (22)
Elevated symmetrical dimethylarginine (1) • Dog Elevated serum alkaline phosphatase (1) • Dog Elevated globulins (1) • Dog Elevated amylase (1) • Dog Elevated alanine aminotransferase (1) • Dog Dysphagia (1) • Dog Dullness (1) • Dog Disoriented state (1) • Dog Disorientation (1) • Dog Discoloured urine (1) • Dog Decreased activity (1) • Dog Death by euthanasia (1) • Dog Death (1) • Dog Cyanotic mucous membranes (1) • Dog Cardiac disorder NOS (1) • Dog Basophilia (1) • Dog Anaphylaxis (1) • Dog Agitation (1) • Dog Abnormal ultrasound finding (1) • Dog Abnormal radiograph finding (1) • Dog Abnormal pupil light reflex (1) • Dog Abnormal cytology (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Weimaraner, Female, 16 month, 28.1 kilogram • Drug: MSK, Oral, Dose: 375 Milligram per animal, Frequency: 12 per hour • Reactions: Injection site swelling, Hyperactivity, Abnormal cytology, Injection site skin change NOS, Local swelling… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-054707
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 16.00 Month
  • Weight: 28.100 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Dose: 375 Milligram per animal
  • Frequency: 12 per hour
Reactions Reported:
Injection site swelling Hyperactivity Abnormal cytology Injection site skin change NOS Local swelling Injection site inflammation Injection site granuloma
Outcomes: Outcome Unknown

Dog, Corgi (unspecified), Female, 5 year, 13.154 kilogram • Drug: MSK, Oral • Reactions: Decreased appetite, Myocarditis, Heart failure, Cardiac disorder NOS, Abnormal ultrasound finding… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-011542
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 5.00 Year
  • Weight: 13.154 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
Reactions Reported:
Decreased appetite Myocarditis Heart failure Cardiac disorder NOS Abnormal ultrasound finding Pulmonary oedema Abnormal radiograph finding Trouble breathing (dyspnea) Loss of appetite Tiredness (lethargy) Elevated temperature Oesophagitis Not himself/herself Dysphagia Injection site swelling Injection site pain Decreased activity Abnormal cytology
Outcomes: Outcome Unknown

Dog, Corgi (unspecified), Female, 5 year, 13.154 kilogram • Drug: MSK, Oral • Reactions: Decreased appetite, Decreased activity, Injection site pain, Injection site swelling, Dysphagia… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-008900
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 5.00 Year
  • Weight: 13.154 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
Reactions Reported:
Decreased appetite Decreased activity Injection site pain Injection site swelling Dysphagia Not himself/herself Oesophagitis Elevated temperature Tiredness (lethargy) Loss of appetite Trouble breathing (dyspnea) Abnormal radiograph finding Pulmonary oedema Abnormal ultrasound finding Cardiac disorder NOS Heart failure Myocarditis Underdose Injection site abscess Injection site necrosis Injection site lump Injection site complication NOS Abnormal cytology
Outcomes: Outcome Unknown

Dog, ['Boxer (German Boxer)', 'Mastiff (unspecified)'], Male, 6 year, 40.823 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Tiredness (lethargy), Decreased appetite, Elevated alanine aminotransferase, Lymphocytosis, Monocytosis… • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2024-US-073827
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 6.00 Year
  • Weight: 40.823 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
Reactions Reported:
Tiredness (lethargy) Decreased appetite Elevated alanine aminotransferase Lymphocytosis Monocytosis Basophilia Hypoglycaemia Death by euthanasia Not drinking Panting Shaking Vomiting bile Elevated serum alkaline phosphatase Elevated total bilirubin Leucocytosis NOS Thrombocytopenia Non-regenerative anaemia Elevated symmetrical dimethylarginine Low thyroxine Loose stool Drooling Disorientation Discoloured urine Salivary gland disorder Icterus Hair loss NOS Tense abdomen Increased band neutrophilia Hyperphosphataemia Elevated amylase Hypoalbuminaemia Elevated globulins Hyperkalaemia Hypochloraemia
Outcomes: Euthanized

Dog, Bulldog - French, Female, 5 year, 12.247 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Fever, Agitation, Vomiting, Inappropriate defecation, Uncomfortable… • Outcome: Died

  • Report ID: USA-USFDACVM-2024-US-054007
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 5.00 Year
  • Weight: 12.247 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
Reactions Reported:
Fever Agitation Vomiting Inappropriate defecation Uncomfortable Tachypnoea Heavy breathing Warm feeling to the touch Cyanotic mucous membranes Disoriented state Foaming at the mouth Abnormal pupil light reflex Tachycardia Harsh lung sounds Anaphylaxis Dullness Death Abnormal radiograph finding Tiredness (lethargy)
Outcomes: Died

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

Mild overdose may cause more pronounced GI symptoms; extreme overdose could lead to kidney damage or neurologic effects. Supportive care is recommended.

Storage & Handling

Store at room temperature; follow label directions for liquid suspensions.

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