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Fluralaner/Moxidectin Spot-On

Detailed information about Fluralaner/Moxidectin Spot-On

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

Your vet decides this. Here's what owners typically ask/watch for.

What to watch for:

  • wobbly/unsteady walking (1 reports)
  • very low energy (1 reports)
  • Ocular discharge (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • wobbly/unsteady walking
  • very low energy
  • Ocular discharge

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Tiredness (lethargy) (1 reports)
  • Ocular discharge (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 16, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Mar 10, 2026, 10:06 AM UTC
Image coming soon
Fluralaner/Moxidectin Spot-On

Fluralaner/Moxidectin Spot-On

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
19
Species represented
2
Grouped by Body System
Digestive (5) · Vomiting, Nausea, Loss of appetite Skin & allergy (4) · Nose swelling, Itching, Hair loss at application site Neurologic (2) · Unsteady walking (ataxia), Tiredness (lethargy) Effectiveness (1) · Lack of efficacy (ectoparasite) - flea Other (20) · Ocular discharge, Not eating, Not drinking
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Dog 1
Neurologic 1 Dog 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Skin & allergy 1 Cat 1
Digestive 1 Cat 1
Digestive 1 Cat 1

Species coverage: Cat (25) Dog (7)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Non-serious - 1
Neurologic Dog Serious - 1
Neurologic Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Skin & allergy Cat Serious - 1
Digestive Cat Serious - 1
Digestive Cat Serious - 1
Other Cat Serious - 1
Effectiveness Cat Non-serious - 1
Skin & allergy Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Skin & allergy Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Digestive Dog Non-serious - 1
Digestive Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Skin & allergy Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 16, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Mar 10, 2026, 10:06 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 8 • Cat 22 • View
Case summaries: 16 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Unsteady walking (ataxia) (1) Tiredness (lethargy) (1) Ocular discharge (1) Not eating (1) Not drinking (1) Nose swelling (1) Nausea (1) Loss of appetite (1)

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 1 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Emesis (multiple), Ataxia, Diarrhoea, Disorientation, Hiding, Hyperactivity. (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Nausea (1) • Cat Loss of appetite (1) • Cat Diarrhea (1) • Dog Blood in vomit (1) • Cat

Showing top 5 for Digestive.

Skin & allergy
Nose swelling (1) • Cat Itching (1) • Cat Hair loss at application site (1) • Cat Application site hair loss (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Dog Tiredness (1) • Dog

Showing top 5 for Neurologic.

Effectiveness
Lack of efficacy (ectoparasite) - flea (1) • Cat

Showing top 5 for Effectiveness.

Other
Ocular discharge (1) • Cat Not eating (1) • Cat Not drinking (1) • Cat Licking at application site (1) • Cat INEFFECTIVE, PARASITE(S) NOS (1) • Cat
Show more (15)
Increased heart rate (1) • Cat Hypersensitivity reaction (1) • Cat Hyperactivity (1) • Dog Hiding (1) • Dog Grooming disorder (1) • Cat Fever (1) • Cat Excessive chewing, licking and/or grooming (1) • Cat Elevated temperature (1) • Cat Drug administered at inappropriate site (1) • Cat Distress (1) • Cat Disorientation (1) • Dog Application site scab (1) • Cat Application site reddening (1) • Cat Application site burn (1) • Cat Application site blister (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Mediumhair, Female, 9 month, 3.992 kilogram • Drug: MSK, Solution, Topical, Dose: 250 Milligram per animal • Reactions: Scratching, Itching, Grooming disorder, Excessive chewing, licking and/or grooming • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-056033
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 9.00 Month
  • Weight: 3.992 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 250 Milligram per animal
Reactions Reported:
Scratching Itching Grooming disorder Excessive chewing, licking and/or grooming
Outcomes: Ongoing

Cat, Domestic Shorthair, Female, 4 year, 4.763 kilogram • Drug: MSK, Solution, Topical, Dose: 1 syringe per animal • Reactions: Distress, Nausea, Vomiting, Increased heart rate, Application site hair loss… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-056034
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 4.00 Year
  • Weight: 4.763 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 syringe per animal
Reactions Reported:
Distress Nausea Vomiting Increased heart rate Application site hair loss Elevated temperature Not eating Not drinking Tiredness (lethargy) Fever Blood in vomit Quiet
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 2 year, 7.257 kilogram • Drug: MSK, Solution, Topical, Dose: 500 Milligram per animal, Frequency: 6 per month • Reactions: Lack of efficacy (ectoparasite) - flea • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-056041
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 2.00 Year
  • Weight: 7.257 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 500 Milligram per animal
  • Frequency: 6 per month
Reactions Reported:
Lack of efficacy (ectoparasite) - flea
Outcomes: Ongoing

Cat, Cat (unknown), Unknown • Drug: MSK, Solution, Topical • Reactions: INEFFECTIVE, PARASITE(S) NOS • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-056036
  • Serious AE: No
  • Treated For AE: No
  • Sex: Unknown
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
Reactions Reported:
INEFFECTIVE, PARASITE(S) NOS
Outcomes: Ongoing

Cat, Cat (unknown), Unknown, 7.257 kilogram • Drug: MSK, Solution, Topical, Dose: 500 Milligram per animal, Frequency: 12 per week • Reactions: Lack of efficacy (ectoparasite) - flea • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-056037
  • Serious AE: No
  • Treated For AE: No
  • Sex: Unknown
  • Weight: 7.257 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 500 Milligram per animal
  • Frequency: 12 per week
Reactions Reported:
Lack of efficacy (ectoparasite) - flea
Outcomes: Ongoing

Cat, Cat (unknown), Unknown, 4.763 kilogram • Drug: MSK, Solution, Topical, Dose: 250 Milligram per animal, Frequency: 12 per week • Reactions: Lack of efficacy (ectoparasite) - flea • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-056039
  • Serious AE: No
  • Treated For AE: No
  • Sex: Unknown
  • Weight: 4.763 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 250 Milligram per animal
  • Frequency: 12 per week
Reactions Reported:
Lack of efficacy (ectoparasite) - flea
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 3 year, 4.99 kilogram • Drug: MSK, Solution, Topical, Dose: 1 Vial per animal • Reactions: Swelling around eye, Nose swelling, Sneezing, Ocular discharge, Open mouth breathing… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055671
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 3.00 Year
  • Weight: 4.990 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 Vial per animal
Reactions Reported:
Swelling around eye Nose swelling Sneezing Ocular discharge Open mouth breathing Loss of appetite Fever Hypersensitivity reaction
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 3 year, 6.169 kilogram • Drug: MSK, Solution, Topical, Dose: 250 Milligram per animal • Reactions: Hair loss at application site, Application site scab, Licking at application site, Application site reddening, Drug administered at inappropriate site • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-056032
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 3.00 Year
  • Weight: 6.169 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 250 Milligram per animal
Reactions Reported:
Hair loss at application site Application site scab Licking at application site Application site reddening Drug administered at inappropriate site
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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