Meds A-Z

Butorphanol Tartrate

Detailed information about Butorphanol Tartrate

Official label facts Owner quick guide first Marketing clearly labeled

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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

FDA application profile · official_label
FDA application profile · official_label
Medication usage source · fda_animal_drugs
Torphadine® · official_label
openFDA case USA-USFDACVM-2025-US-055350 · adverse_reaction

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures

What to watch for:

Repeat at intervals of 6 to 12 hours as required
If necessary, increase dose to maximum of 0.05 milligram per pound of body weight
Treatment should not normally be required for longer than 7 days
For oral use in dogs only
If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight
Dose may be repeated within 3 to 4 hours
Treatment should not exceed 48 hours
Not for use in horses intended for food
Vomiting (1 reports)
wobbly/unsteady walking (1 reports)
very low energy (1 reports)

When to call the vet:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Trouble breathing.
Facial swelling or hives.
Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to ask your vet today:

Is this medicine the right fit for my pet’s current symptoms?
Which warning signs mean I should call back right away?
How should I handle missed doses or refusal to take the medicine?

Safety & side effects

What to watch:

Repeat at intervals of 6 to 12 hours as required
If necessary, increase dose to maximum of 0.05 milligram per pound of body weight
Treatment should not normally be required for longer than 7 days
For oral use in dogs only
If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight

Most reported reactions:

Vomiting (1 reports)
Unsteady walking (ataxia) (1 reports)
Tiredness (lethargy) (1 reports)

When to call your vet:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Trouble breathing.

Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:03 a.m.

Data freshness

Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:03 AM UTC
openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC

Image coming soon

Butorphanol Tartrate

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Zoetis Inc.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both

Manufacturer: Zoetis Inc.

Form: Liquid (Solution), Tablet

Identifiers:

ANADA: 200239 ANADA: 200322 ANADA: 200332 ANADA: 200408 ANADA: 200446 NADA: 102990 NADA: 103390 NADA: 135780 NADA: 141047 NDC Package: 11695-7044-1 NDC Package: 11695-7044-2 NDC Package: 17033-097-01 NDC Package: 17033-097-05 NDC Package: 54771-2033-1 NDC Package: 54771-2033-2 NDC Package: 57926-722-66 NDC Package: 69043-064-02 NDC Package: 69043-064-05 NDC Package: 73377-107-01 NDC Package: 86136-137-31

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200408 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200332 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source

Warnings / Contraindications

Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

High: Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Source metadata:

https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals

Reported cases

Serious reports

Species represented

Grouped by Body System

Digestive (2) · Vomiting, Decreased appetite Neurologic (2) · Unsteady walking (ataxia), Tiredness (lethargy) Behavior (1) · Biting -aggression Effectiveness (1) · Lack of efficacy - NOS Other (26) · Sedation, Regurgitation, Pain NOS

Most Reported Reactions

Body system	Cases	Species	Serious cases
Digestive	1	Dog	1
Neurologic	1	Dog	1
Neurologic	1	Dog	1
Other	1	Dog	1
Other	1	Cat	1
Other	1	Cat	1
Other	1	Cat	1
Other	1	Dog	1

Species coverage: Dog (21) Cat (11)

View detailed reaction table

Body system	Species	Seriousness	Frequency	Reports
Digestive	Dog	Serious	-	1
Neurologic	Dog	Serious	-	1
Neurologic	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Effectiveness	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Digestive	Dog	Serious	-	1
Other	Dog	Serious	-	1
Behavior	Dog	Serious	-	1
Other	Cat	Serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1

Source metadata:

https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-055350

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)

No owner handouts linked yet.

Official label / PI (0)

No official label or package insert links yet.

SPL (9)

Butorphanol Tartrate Injection · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/204/Butorphanol%20Tartrate%20Injection
Butorphic™ Injection · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/170/Butorphic%E2%84%A2%20Injection
Torphadine® · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/90/Torphadine%C2%AE
Butorphine™ · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2027/Butorphine%E2%84%A2
Dolorex® · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/153/Dolorex%C2%AE
Torbugesic® · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1757/Torbugesic%C2%AE
Torbugesic-SA® · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1219/Torbugesic-SA%C2%AE
Torbutrol® Injection · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/572/Torbutrol%C2%AE%20Injection
Torbutrol® Tablets · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2532/Torbutrol%C2%AE%20Tablets

FOI (6)

ucm061350.pdf · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1145
ucm061797.pdf · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1080
ucm061785.pdf · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1073
UCM214392.pdf · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1168
UCM061667.pdf · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1010
UCM490962.pdf · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/582

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1145 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/204/Butorphanol%20Tartrate%20Injection · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1080 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/170/Butorphic%E2%84%A2%20Injection · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1073 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/90/Torphadine%C2%AE · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1168 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2027/Butorphine%E2%84%A2 · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1010 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/153/Dolorex%C2%AE · document · SPL

Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness

Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:03 AM UTC
openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC

Official (FDA)

Identity: Generic ingredient • FDA branded products available

Official FDA brands: Butorphanol Tartrate Injection Butorphic™ Injection Butorphine™ Dolorex® Torbugesic-SA® Torbugesic® Torbutrol® Injection Torbutrol® Tablets Torphadine®

Case-reported brands (openFDA): MSK

Catalog species: Both • FDA-labeled species: Cat, Dog, Horse, No Use Class Stated Or Implied

Rx/OTC: RX

Form/route: Liquid (Solution), Tablet • Intravenous, Oral, Subcutaneous

Applications: ANADA 200-408 • ANADA 200-332 • ANADA 200-322 • ANADA 200-446 • ANADA 200-239 • NADA 135-780 • NADA 141-047 • NADA 102-990 • NADA 103-390

Documents: 6 (FOI: 6) • SPL: 9 • Label highlights • Official documents

Safety (openFDA)

Top reactions: Dog 20 • Cat 11 • View

Case summaries: 10 (showing 8) • View

openFDA reports are unverified and do not prove causation.

Explore

Related conditions: Cough (acute/chronic) Pain (acute, chronic) Tracheitis (non-kennel cough) Trauma (HBC, falls, bite wounds)

Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)

Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points

Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)

Top reaction signals

Vomiting (1) Unsteady walking (ataxia) (1) Tiredness (lethargy) (1) Sedation (1) Pain NOS (1) Not eating (1) Limb amputation (1) Lateral recumbency (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers

Package NDC	Product NDC	Status
11695-7044-1	11695	-
11695-7044-2	11695	-
17033-097-01	17033	-
17033-097-05	17033	-
54771-2033-1	54771	-
54771-2033-2	54771	-
57926-722-66	57926	-
69043-064-02	69043	-
69043-064-05	69043	-
73377-107-01	73377	-
86136-137-31	86136	-
86136-137-69	86136	-

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

ucm061350.pdf • FOI summary • Official • Feb. 27, 2026
FDA FOI summary for application 200408
ucm061797.pdf • FOI summary • Official • June 13, 2024
FDA FOI summary for application 200332
ucm061785.pdf • FOI summary • Official • Oct. 7, 2022
FDA FOI summary for application 200322
UCM214392.pdf • FOI summary • Official • April 26, 2022
FDA FOI summary for application 200446
UCM061667.pdf • FOI summary • Official • June 1, 2016
FDA FOI summary for application 200239
UCM490962.pdf • FOI summary • Official • June 1, 2016
FDA FOI summary for application 141047

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 9 Clinical 0 Manufacturer 0 Marketing 0

Current Field Facts

contraindications: Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not norma… (Official, 2026-02-12)
side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy - NOS, Death, Diarrhoea, Bradycardia, Injection site swelling. (Official, 2026-02-12)
usage: For the relief of chronic nonproductive cough associated with tracheo-bronchitis, tracheitis tonsillitis, laryngitis, and pharyngitis associated with inflammat… (Official, 2026-02-12)

Recent Revisions

side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product	Sponsor	Application	Status	Published
Butorphanol Tartrate Injection RX Butorphanol Tartrate Liquid (Solution) • Subcutaneous Label highlights Official documents	Dechra Veterinary Products LLC	ANADA 200-408	W	Feb 27, 2026
Butorphic™ Injection RX Butorphanol Tartrate Liquid (Solution) • Intravenous Label highlights Official documents	Cronus Pharma Specialities India Private Ltd.	ANADA 200-332	Approved	Jun 13, 2024
Torphadine® RX Butorphanol Tartrate Liquid (Solution) • Intravenous Label highlights Official documents	Dechra Veterinary Products LLC	ANADA 200-322	Approved	Oct 7, 2022
Butorphine™ RX Butorphanol Tartrate Liquid (Solution) • Subcutaneous Label highlights Official documents	Modern Veterinary Therapeutics, LLC	ANADA 200-446	W	Apr 26, 2022
Dolorex® RX Butorphanol Tartrate Liquid (Solution) • Intravenous Label highlights Official documents	Intervet, Inc.	ANADA 200-239	Approved	Jun 1, 2016
Torbugesic® RX Butorphanol Tartrate Liquid (Solution) • Intravenous Label highlights Official documents	Zoetis Inc.	NADA 135-780	Approved	Jun 1, 2016
Torbugesic-SA® RX Butorphanol Tartrate Liquid (Solution) • Subcutaneous Label highlights Official documents	Zoetis Inc.	NADA 141-047	Approved	Jun 1, 2016
Torbutrol® Injection RX Butorphanol Tartrate Liquid (Solution) • Subcutaneous Label highlights Official documents	Zoetis Inc.	NADA 102-990	Approved	Jun 1, 2016
Torbutrol® Tablets RX Butorphanol Tartrate Tablet • Oral Label highlights Official documents	Zoetis Inc.	NADA 103-390	Approved	Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Cat, No Use Class Stated Or Implied

Composition / specifications

Each milliliter of aqueous solution contains 2 milligrams of butorphanol (as butorphanol tartrate).

Cats

Indication

For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures

Dosage

0.2 milligram of butorphanol base activity per pound of body weight (0.4 milligrams per kilogram), using 2 milligrams per milliliter solution. For subcutaneous injection.

Limitations

Dose may be repeated up to 4 times per day. Do not treat for more than 2 days. Safety for use in pregnant female cats, breeding male cats of kittens less than 4 months of age has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian

FDA page: Open in Animal Drugs @ FDA

Species: No Use Class Stated Or Implied

Composition / specifications

Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).

Horses

Indication

For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.

Dosage

0.05 milligram of butorphanol per pound of body weight (0.1 milligram per kilogram of body weight). Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours.

Limitations

Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, No Use Class Stated Or Implied

Composition / specifications

Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).

Horses

Indication

For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.

Dosage

0.05 milligram of butorphanol base activity per pound of body weight (0.1 milligram/kilogram) using 10 milligrams per milliliter solution. For intravenous use.

Limitations

Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied

Composition / specifications

Each mL contains 2 mg butorphanol base (as butorphanol tartrate, USP).

Cats

Indication

For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.

Dosage

Administer 0.4 mg of butorphanol per kilogram body weight (0.2 mg/lb). This is equivalent to 1.0 mL solution per 10 lbs body weight.

Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production

Composition / specifications

Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).

Horses

Indication

For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.

Dosage

0.05 milligram of butorphanol base activity per pound of body weight (0.1 milligram/kilogram) using 10 milligrams per milliliter solution. For intravenous use.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production

Composition / specifications

Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).

Horses

Indication

For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.

Dosage

0.05 milligram of butorphanol base activity per pound of body weight (0.1 milligram/kilogram) using 10 milligrams per milliliter solution. For intravenous use.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied

Composition / specifications

Each milliliter of aqueous solution contains 2 milligrams of butorphanol (as butorphanol tartrate).

Cats

Indication

For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.

Dosage

0.2 milligram of butorphanol base activity per pound of body weight (0.4 milligrams per kilogram)

Limitations

For subcutaneous injection. Dose may be repeated up to 4 times per day. Do not treat for more than 2 days. Safety for use in pregnant female cats, breeding male cats of kittens less than 4 months of age has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied

Composition / specifications

Each milliliter of aqueous solution contains either 0.5 of butorphanol (as butorphanol tartrate).

Dogs

Indication

Dosage

0.025 milligram of butorphanol base activity per pound of body weight (equivalent to 0.5 milliliter per 10 pounds), using 0.5 milligram per milliliter solution. For subcutaneous injection.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied

Composition / specifications

Each tablet contains 1, 5, or 10 milligrams of butorphanol base activity as butorphanol tartrate.

Dogs

Indication

Dosage

0.25 milligram of butorphanol base activity per pound of body weight.

Limitations

For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents

FOI ucm061350.pdf

Summary

Indicated for the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.

SPL Packages

Butorphanol Tartrate Injection (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI ucm061797.pdf

Summary

Butorphic Injection is indicated for relief of pain associated with colic in adult horses and yearlings. Clinical studies in the horse have shown that Butorphic Injection alleviates abdominal pain associated with torsion, impaction, intussusception, and tympanic colic, and postpartum pain.

SPL Packages

Butorphic™ Injection (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI ucm061785.pdf

Summary

Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings.

SPL Packages

Torphadine® (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM214392.pdf

Summary

Indicated for the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.

SPL Packages

Butorphine™ (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM061667.pdf

Summary

For the relief of pain associated with colic in adult horses and yearlings and postpartum pain in mares.

SPL Packages

Dolorex® (ZIP)

FDA page: Open in Animal Drugs @ FDA

SPL Packages

Torbugesic® (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM490962.pdf

Summary

Torbugesic-SA (butorphanol tartrate, USP) is indicated for the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.

SPL Packages

Torbugesic-SA® (ZIP)

FDA page: Open in Animal Drugs @ FDA

SPL Packages

Torbutrol® Injection (ZIP)

FDA page: Open in Animal Drugs @ FDA

SPL Packages

Torbutrol® Tablets (ZIP)

FDA page: Open in Animal Drugs @ FDA

Usage

For the relief of chronic nonproductive cough associated with tracheo-bronchitis, tracheitis tonsillitis, laryngitis, and pharyngitis associated with inflammatory conditions of the upper respiratory tract. For the relief of pain associated with colic and postpartum pain in adult horses and yearlings. For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive

Vomiting (1) • Dog Decreased appetite (1) • Dog

Showing top 5 for Digestive.

Neurologic

Unsteady walking (1) • Dog Tiredness (1) • Dog

Showing top 5 for Neurologic.

Behavior

Biting -aggression (1) • Dog

Showing top 5 for Behavior.

Effectiveness

Lack of efficacy - NOS (1) • Dog

Showing top 5 for Effectiveness.

Other

Sedation (1) • Dog Regurgitation (1) • Cat Pain NOS (1) • Cat Not eating (1) • Cat Limb amputation (1) • Cat

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Lateral recumbency (1) • Dog Lameness (1) • Dog Intentional misuse (1) • Dog Injection site sarcoma (1) • Cat Injection site lump (1) • Cat Injected sclera (1) • Dog Hypothermia (1) • Dog Hyperthermia (1) • Cat Hyperglycaemia (1) • Cat Hyperactivity (1) • Cat Heart block NOS (1) • Dog Dysphoria (1) • Cat Dry mucous membrane (1) • Dog Drooping eyelid (1) • Dog Dilated pupils (1) • Dog Dehydration (1) • Dog Decreased heart rate (1) • Dog Cardiac arrest (1) • Dog Abnormal radiograph finding (1) • Cat Abnormal pupil light reflex (1) • Dog Abnormal menace reflex test (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Longhair, Male, 6 month, 2.631 kilogram • Drug: MSK, Unassigned, Intramuscular, Dose: 0.05 mL per animal • Reactions: Hyperthermia, Underdose • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-056102
Serious AE: No
Treated For AE: No
Sex: Male
Age: 6.00 Month
Weight: 2.631 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Intramuscular
Form: Unassigned
Dose: 0.05 mL per animal

Reactions Reported:

Hyperthermia Underdose

Outcomes: Ongoing

Cat, Cat (unknown), Female, 4.05 kilogram • Drug: MSK, Suspension, Unknown, Dose: 0.66 Milligram per kilogram • Reactions: Hyperglycaemia • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-054116
Serious AE: No
Treated For AE: No
Sex: Female
Weight: 4.050 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown
Form: Suspension
Dose: 0.66 Milligram per kilogram

Reactions Reported:

Hyperglycaemia

Outcomes: Outcome Unknown

Dog, Retriever - Labrador, Male, 6 month, 20.094 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Vomiting, Drooping eyelid, Unsteady walking (ataxia), Dehydration, Abnormal menace reflex test… • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-055350
Serious AE: Yes
Treated For AE: Yes
Sex: Male
Age: 6.00 Month
Weight: 20.094 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown
Form: Unassigned

Reactions Reported:

Vomiting Drooping eyelid Unsteady walking (ataxia) Dehydration Abnormal menace reflex test Hyperglycaemia Dilated pupils Seizure NOS Lateral recumbency Strabismus Vertical nystagmus Abnormal pupil light reflex Tremors Dry mucous membrane Injected sclera Wobbliness

Outcomes: Ongoing

Dog, American Pit Bull Terrier, Male, 4 year, 36.4 kilogram • Drug: MSK, Suspension, Intramuscular, Dose: 0.20 Milligram per kilogram • Reactions: Lack of efficacy - NOS, Sedation prolonged, Hypothermia, Dysphoria, Biting -aggression… • Outcome: Recovered/Normal

Report ID: USA-USFDACVM-2025-US-054711
Serious AE: Yes
Treated For AE: No
Sex: Male
Age: 4.00 Year
Weight: 36.400 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Intramuscular
Form: Suspension
Dose: 0.20 Milligram per kilogram

Reactions Reported:

Lack of efficacy - NOS Sedation prolonged Hypothermia Dysphoria Biting -aggression Unsteady walking (ataxia)

Outcomes: Recovered/Normal

Dog, Griffon - French Wire-haired Pointing, Female, 2 year, 26.308 kilogram • Drug: MSK, Injection, Intravenous, Dose: 0.50 mL per animal • Reactions: Tiredness (lethargy), Sedation, Decreased heart rate, Heart block NOS, Underdose… • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-052402
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 2.00 Year
Weight: 26.308 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Intravenous
Form: Injection
Dose: 0.50 mL per animal

Reactions Reported:

Tiredness (lethargy) Sedation Decreased heart rate Heart block NOS Underdose Intentional misuse

Outcomes: Ongoing

Dog, Hound - Basset, Female, 6 year, 26.127 kilogram • Drug: MSK, Injection, Intravenous • Reactions: Cardiac arrest, Seizure NOS, Sudden death • Outcome: Died

Report ID: USA-USFDACVM-2025-US-052656
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 6.00 Year
Weight: 26.127 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Intravenous
Form: Injection

Reactions Reported:

Cardiac arrest Seizure NOS Sudden death

Outcomes: Died

Cat, Domestic Shorthair, Unknown, 8.3 month, 4.7 kilogram • Drug: MSK, Unknown, Dose: 0.07 mL per animal • Reactions: Regurgitation • Outcome: Recovered/Normal

Report ID: USA-USFDACVM-2025-US-051279
Serious AE: No
Treated For AE: No
Sex: Unknown
Age: 8.30 Month
Weight: 4.700 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown
Dose: 0.07 mL per animal

Reactions Reported:

Regurgitation

Outcomes: Recovered/Normal

Dog, Retriever - Labrador, Male, 9 year, 33.112 kilogram • Drug: MSK, Injection, solution, Intravenous, Dose: 0.30 mL per dose, Frequency: 1 per day • Reactions: Swollen limb, Pain NOS, Lameness, Decreased appetite • Outcome: Recovered/Normal

Report ID: USA-USFDACVM-2025-US-049681
Serious AE: Yes
Treated For AE: No
Sex: Male
Age: 9.00 Year
Weight: 33.112 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Intravenous
Form: Injection, solution
Dose: 0.30 mL per dose
Frequency: 1 per day

Reactions Reported:

Swollen limb Pain NOS Lameness Decreased appetite

Outcomes: Recovered/Normal

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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