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Roxee Meds Catalog

Esafoxolaner

Medication catalog facts with explicit FDA-approval, off-label, source-limited, and safety context.

Both Source review pending Regulatory linkage incomplete Owner quick guide first
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Data freshness

Storefront facts
Source review pending
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Roxee is still reviewing source support for this medication profile.

FDA applications
Regulatory match pending
No refresh timestamp yet

Roxee has safety or ingredient evidence for this medication, but a regulatory product/application match is still pending.

Safety reports
No safety reports linked
No refresh timestamp yet

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Storefront facts: Source Roxee | Refreshed May 2, 2026, 10:05 AM UTC
    The storefront fact projection used for browse cards and quick facts.

Evidence

Reviewed / Updated / Sources

Reviewed by: Not available

Last reviewed: May 2, 2026

Updated: May 2, 2026, 10:05 AM UTC

Sources:
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Esafoxolaner

Esafoxolaner

Drug type: Generic ingredient • Generic profile • Regulatory linkage incomplete

Both 73% storefront ready

Species: Both

Approval status: Official document linked, regulatory match incomplete. An official source document is available, but Roxee has not linked this row to a confirmed FDA animal-drug application or product record yet.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Esafoxolaner

For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in cats and kittens. Species commonly shown: Both.

Generic name
Esafoxolaner
Species
Both
Completeness
73%
Validation
Incomplete

Indications / Uses

For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in cats and kittens.

Side Effects

Top reported reactions (openFDA): Accidental exposure, Vomiting, Behavioural disorder NOS, Incorrect route of drug administration, Anorexia, Ataxia.

FAQ

Both

Related Conditions

Myiasis (fly strike)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in cats and kittens.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Death (1 reports)
  • Vomiting (1 reports)
  • Urinary tract infection (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Major cautions & emergency warning signs

Side effects to monitor:

  • Death
  • Vomiting
  • Urinary tract infection

Most reported reactions:

  • Death (1 reports)
  • Vomiting (1 reports)
  • Urinary tract infection (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Manufacturer not confirmed
Identifiers:
NADA: 6686 NDC Package: 0010-4120-01 NDC Package: 0010-4120-02 NDC Package: 0010-4120-03 NDC Package: 0010-4121-01 NDC Package: 0010-4121-02 NDC Package: 0010-4121-03 NDC Product: 0010

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
1
Species represented
2
Grouped by Body System
Digestive (4) · Vomiting, Loss of appetite, Diarrhea Skin & allergy (2) · Itching, Application site itching Neurologic (4) · Unsteady walking (ataxia), Tremors, Tiredness (lethargy) Effectiveness (2) · Lack of efficacy (endoparasite) - roundworm NOS, Lack of efficacy (endoparasite) - hookworm Other (20) · Urinary tract infection, Scaly condition NOS, Peeling skin
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Cat 1
Digestive 1 Dog 0
Other 1 Dog 0
Neurologic 1 Dog 0
Neurologic 1 Dog 0
Neurologic 1 Cat 0
Other 1 Cat 0
Other 1 Cat 0

Species coverage: Cat (18) Dog (14)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Non-serious - 1
Other Dog Non-serious - 1
Neurologic Dog Non-serious - 1
Neurologic Dog Non-serious - 1
Neurologic Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Neurologic Dog Non-serious - 1
Digestive Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Effectiveness Cat Non-serious - 1
Effectiveness Cat Non-serious - 1
Skin & allergy Dog Non-serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Digestive Dog Non-serious - 1
Other Cat Serious - 1
Digestive Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Skin & allergy Cat Non-serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Source metadata:

Documents

Owner handouts and official technical documents open on-page first, with the original source still one click away.

Only technical FDA review documents are linked right now. Owner handouts, official label / PI, and SPL documents are not linked yet.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

0
No SPL links yet.

FOI

1

FOI Summary 006-686 Granted February 18, 2026.pdf

FOI · FOI summary

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Storefront facts: Source Roxee | Refreshed May 2, 2026, 10:05 AM UTC
    The storefront fact projection used for browse cards and quick facts.
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 0 • Cat 0 • View
Case summaries: 0
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Myiasis (fly strike)
Linked using: Usage_Inferred (0.78)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Death (1) Vomiting (1) Urinary tract infection (1) Unsteady walking (ataxia) (1) Tremors (1) Tiredness (lethargy) (1) Scaly condition NOS (1) Peeling skin (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 6686 NDC Package: 0010-4120-01 NDC Package: 0010-4120-02 NDC Package: 0010-4120-03 NDC Package: 0010-4121-01 NDC Package: 0010-4121-02 NDC Package: 0010-4121-03 NDC Product: 0010
Package NDC Product NDC Form / Route Status
0010-4120-01 0010 -
0010-4120-02 0010 -
0010-4120-03 0010 -
0010-4121-01 0010 -
0010-4121-02 0010 -
0010-4121-03 0010 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 5 Clinical 7 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Vomiting, Behavioural disorder NOS, Incorrect route of drug administration, Anorexia, Ataxia. (Clinical, 2026-05-02)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Vomiting, Behavioural disorder NOS, Incorrect route of drug administration, Anorexia, Ataxia. (Clinical, 2026-04-15)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Vomiting, Behavioural disorder NOS, Incorrect route of drug administration, Anorexia, Ataxia. (Clinical, 2026-04-11)
  • usage: For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in cats and kittens. (Clinical, 2026-05-02)
  • usage: For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in cats and kittens. (Clinical, 2026-04-30)
  • usage: For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in cats and kittens. (Clinical, 2026-04-15)
  • usage: For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in cats and kittens. (Clinical, 2026-04-11)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Vomiting, Behavioural disorder NOS, Incorrect route of drug administration, Anorexia, Ataxia. (Official, 2026-04-30)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Vomiting, Behavioural disorder NOS, Incorrect route of drug administration, Anorexia, Ataxia. (Official, 2026-03-03)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Vomiting, Behavioural disorder NOS, Incorrect route of drug administration, Anorexia, Ataxia. (Official, 2026-02-12)
  • usage: For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in cats and kittens. (Official, 2026-03-03)
Recent Revisions
  • side_effects updated 2026-05-02 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-05-02 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-30 10:09 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-30 10:09 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-15 10:04 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-15 10:04 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-03-03 11:08 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-03-03 11:08 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

Usage

For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in cats and kittens.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Loss of appetite (1) • Cat Diarrhea (1) • Dog Blood in vomit (1) • Cat

Showing top 5 for Digestive.

Skin & allergy
Itching (1) • Dog Application site itching (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Dog Tremors (1) • Dog Tiredness (1) • Cat Muscle tremor (1) • Dog

Showing top 5 for Neurologic.

Effectiveness
Lack of efficacy (endoparasite) - roundworm NOS (1) • Cat Lack of efficacy (endoparasite) - hookworm (1) • Cat

Showing top 5 for Effectiveness.

Other
Urinary tract infection (1) • Dog Scaly condition NOS (1) • Cat Peeling skin (1) • Cat Pale mucous membrane (1) • Dog Neutrophilia (1) • Dog
Show more (15)
Loose stool (1) • Cat Local erythema (1) • Dog Limb weakness (1) • Dog Leucocytosis NOS (1) • Dog Incorrect route of drug administration (1) • Dog Head bobbing (1) • Cat Foaming at the mouth (1) • Cat Death (1) • Cat Blepharospasm (1) • Cat Application site scab (1) • Cat Application site reddening (1) • Cat Application site pyoderma (1) • Cat Accidental exposure (1) • Dog Abnormal posture NOS (1) • Cat Abnormal movement NOS (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

No case-level openFDA reports are linked for this medication yet.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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This medication has not been reviewed by a veterinarian yet.