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Mirtazapine

Detailed information about Mirtazapine

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

For body weight gain in cats with a history of weight loss.

What to watch for:

  • Lack of efficacy - NOS (1 reports)
  • Joint pain (1 reports)
  • Inappropriate urination (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Lack of efficacy - NOS
  • Joint pain
  • Inappropriate urination

Most reported reactions:

  • Lack of efficacy - NOS (1 reports)
  • Joint pain (1 reports)
  • Inappropriate urination (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:03 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:03 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 12, 2026, 10:43 PM UTC
Image coming soon
Mirtazapine

Mirtazapine

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available
Form: Transdermal ointment
Identifiers:
NADA: 141481 NDC Package: 17033-060-05 NDC Package: 62157-466-01 NDC Package: 62157-506-01 NDC Package: 73377-003-01 NDC Package: 73377-090-01 NDC Package: 73377-090-02 NDC Package: 73377-090-04 NDC Package: 86032-071-01 NDC Product: 17033 NDC Product: 62157 NDC Product: 73377 NDC Product: 86032
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
16
Species represented
2
Grouped by Body System
Digestive (4) · Vomiting, Loss of appetite, Diarrhea Neurologic (2) · Unsteady walking (ataxia), Tiredness (lethargy) Behavior (2) · Circling - behavioural disorder, Behavioral disorder (unspecified) Effectiveness (1) · Lack of efficacy - NOS Other (23) · Malaise, Lymphopenia, Joint pain
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Effectiveness 1 Cat 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (19) Cat (13)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Cat Non-serious - 1
Neurologic Cat Non-serious - 1
Neurologic Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Digestive Dog Non-serious - 1
Effectiveness Cat Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Digestive Dog Non-serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Digestive Dog Non-serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Behavior Dog Non-serious - 1
Behavior Dog Serious - 1
Other Cat Non-serious - 1
Source metadata:

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)
  • No owner handouts linked yet.
Official label / PI (0)
  • No official label or package insert links yet.
SPL (1)
  • Mirataz® · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/3129/Mirataz%C2%AE
FOI (1)
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:03 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 12, 2026, 10:43 PM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Mirataz®
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat
Rx/OTC: RX
Form/route: Transdermal ointment • Topical (transdermal)
Applications: NADA 141-481
Documents: 1 (FOI: 1) • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 21 • Cat 23 • View
Case summaries: 11 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Pica Weight loss
Linked using: Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Lack of efficacy - NOS (1) Joint pain (1) Inappropriate urination (1) Immune mediated thrombocytopenia (1) Immune mediated haemolytic anaemia (1) Hiding (1) Haemoglobinuria (1) Glomerulonephritis (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141481 NDC Package: 17033-060-05 NDC Package: 62157-466-01 NDC Package: 62157-506-01 NDC Package: 73377-003-01 NDC Package: 73377-090-01 NDC Package: 73377-090-02 NDC Package: 73377-090-04 NDC Package: 86032-071-01 NDC Product: 17033 NDC Product: 62157 NDC Product: 73377 NDC Product: 86032
Package NDC Product NDC Form / Route Status
17033-060-05 17033 -
62157-466-01 62157 -
62157-506-01 62157 -
73377-003-01 73377 -
73377-090-01 73377 -
73377-090-02 73377 -
73377-090-04 73377 -
86032-071-01 86032 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 3 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Death by euthanasia, Vomiting, Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Decreased a… (Official, 2026-02-12)
  • usage: For body weight gain in cats with a history of weight loss. (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Mirataz®
RX
Mirtazapine
Transdermal ointment • Topical (transdermal)
Label highlights
Official documents
Dechra, Ltd. NADA 141-481 Approved Jan 4, 2023

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
Each 1 g of Mirataz™ contains 20 mg of mirtazapine (2%).
Cats
Indication

For body weight gain in cats with a history of weight loss.

Dosage

Administer topically by applying a 1.5-inch ribbon of ointment (approximately 2 mg/cat) on the inner pinna of the cat’s ear once daily for 14 days.

Limitations

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

For body weight gain in cats with a history of weight loss.

Source: FDA Animal Drugs @ FDA • Reference

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Cat Loss of appetite (1) • Dog Diarrhea (1) • Dog Decreased appetite (1) • Dog

Showing top 5 for Digestive.

Neurologic
Unsteady walking (1) • Cat Tiredness (1) • Cat

Showing top 5 for Neurologic.

Behavior
Circling - behavioural disorder (1) • Dog Behavioral disorder (1) • Dog

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy - NOS (1) • Cat

Showing top 5 for Effectiveness.

Other
Malaise (1) • Cat Lymphopenia (1) • Dog Joint pain (1) • Cat Intentional misuse (1) • Cat Increased percentage reticulocytes (1) • Dog
Show more (18)
Inappropriate urination (1) • Dog Immune mediated thrombocytopenia (1) • Dog Immune mediated haemolytic anaemia (1) • Dog Hypothermia (1) • Cat Hiding (1) • Cat Haemoglobinuria (1) • Dog Glomerulonephritis (1) • Dog General illness (1) • Cat Elevated total bilirubin (1) • Dog Elevated symmetrical dimethylarginine (1) • Dog Elevated lipase (1) • Dog Elevated creatinine (1) • Dog Elevated blood urea nitrogen (1) • Dog Decreased mean corpuscular volume (1) • Dog Decreased haematocrit (1) • Cat Death by euthanasia (1) • Dog Death (1) • Cat Abnormal radiograph finding (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Shar Pei, Female, 5 year, 16.23 kilogram • Drug: MSK, Unknown • Reactions: Neuromuscular disorder NOS, Unsteady gait, Nystagmus, Circling - behavioural disorder, Not himself/herself • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055976
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 5.00 Year
  • Weight: 16.230 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Neuromuscular disorder NOS Unsteady gait Nystagmus Circling - behavioural disorder Not himself/herself
Outcomes: Recovered/Normal

Cat, Cat (unknown), Female, 20.5 year • Drug: MSK, Unknown • Reactions: General illness, Hiding, Joint pain, Elevated creatinine, Elevated symmetrical dimethylarginine… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055646
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 20.50 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
General illness Hiding Joint pain Elevated creatinine Elevated symmetrical dimethylarginine Decreased haematocrit Urinary tract infection
Outcomes: Outcome Unknown

Cat, Crossbred Feline/cat, Female, 17.83 year, 2.767 kilogram • Drug: MSK, Unknown • Reactions: Vomiting • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-054249
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 17.83 Year
  • Weight: 2.767 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Vomiting
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Female, 18 year, 2.87 kilogram • Drug: MSK, Unknown • Reactions: Vomiting • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-054398
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 18.00 Year
  • Weight: 2.870 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Vomiting
Outcomes: Recovered/Normal

Cat, Domestic Mediumhair, Female, 13 year, 2.858 kilogram • Drug: MSK, Auricular (Otic) • Reactions: Tiredness (lethargy), Unresponsive to stimuli, Not eating, Not drinking, Hiding… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055801
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 13.00 Year
  • Weight: 2.858 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Auricular (Otic)
Reactions Reported:
Tiredness (lethargy) Unresponsive to stimuli Not eating Not drinking Hiding Unsteady walking (ataxia) Abnormal radiograph finding Hypothermia Tympanic opacity Weight loss Malaise Muscle weakness NOS Intentional misuse Lack of efficacy - NOS
Outcomes: Ongoing

Cat, Cat (unknown), Male, 18 year, 5.1 kilogram • Drug: MSK, Ointment, Transdermal, Dose: 1.50 Other per animal, Frequency: 24 per hour • Reactions: Lack of efficacy - NOS, Death • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-055952
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 18.00 Year
  • Weight: 5.100 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Transdermal
  • Form: Ointment
  • Dose: 1.50 Other per animal
  • Frequency: 24 per hour
Reactions Reported:
Lack of efficacy - NOS Death
Outcomes: Died

Cat, Domestic Mediumhair, Female, 5 year, 4 kilogram • Drug: MSK, Ointment, Auricular (Otic), Frequency: 1 per day • Reactions: Unsteady walking (ataxia) • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055804
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 5.00 Year
  • Weight: 4.000 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Auricular (Otic)
  • Form: Ointment
  • Frequency: 1 per day
Reactions Reported:
Unsteady walking (ataxia)
Outcomes: Outcome Unknown

Dog, ['Corgi (unspecified)', 'Terrier - Jack Russell'], Female, 15 year, 17.69 kilogram • Drug: MSK, Unknown • Reactions: Loss of appetite, Tiredness (lethargy) • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-052158
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 15.00 Year
  • Weight: 17.690 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Loss of appetite Tiredness (lethargy)
Outcomes: Recovered/Normal

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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