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Dexmedetomidine

Detailed information about Dexmedetomidine

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures.

What to watch for:

  • Do not use DEXDOMITOR in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue
  • Federal law (USA) restricts this drug to use by or on the order of a licensed veterinarian
  • trouble breathing (1 reports)
  • Loss of appetite (1 reports)
  • Hypochloraemia (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Do not use DEXDOMITOR in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue
  • Federal law (USA) restricts this drug to use by or on the order of a licensed veterinarian
  • trouble breathing
  • Loss of appetite
  • Hypochloraemia

Most reported reactions:

  • Trouble breathing (dyspnea) (1 reports)
  • Loss of appetite (1 reports)
  • Hypochloraemia (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:03 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:03 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Mar 3, 2026, 11:06 AM UTC
Image coming soon
Dexmedetomidine

Dexmedetomidine

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available
Form: Injectable Solution, Liquid (Solution), Oromucosal Gel, Sterile Injectable Solution, Sterile Solution
Identifiers:
ANADA: 200573 ANADA: 200699 ANADA: 200735 ANADA: 200752 ANADA: 200824 NADA: 141267 NADA: 141456 NDC Package: 11695-6967-1 NDC Package: 17033-005-10 NDC Package: 46066-088-13 NDC Package: 54771-1050-1 NDC Package: 54771-2805-1 NDC Package: 54771-2806-1 NDC Package: 64189-8502-0 NDC Package: 64189-8502-1 NDC Package: 68504-006-10 NDC Package: 69043-038-10 NDC Package: 86101-061-41 NDC Package: 86136-105-31 NDC Product: 11695
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use DEXDOMITOR in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue. Federal law (USA) restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use DEXDOMITOR in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue. Federal law (USA) restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
25
Species represented
2
Grouped by Body System
Digestive (3) · Vomiting, Loss of appetite, Drooling Neurologic (1) · Unsteady walking (ataxia) Other (28) · Trouble breathing (dyspnea), Hypochloraemia, Hyperthermia
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Dog 1
Digestive 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (27) Cat (5)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Non-serious - 1
Neurologic Dog Non-serious - 1
Other Dog Serious - 1
Digestive Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Source metadata:

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handout (Client Information Sheet)
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadLabeling/909
Owner handouts (1)
Official label / PI (1)
  • PI SILEO N141456G0022.pdf · Labeling
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadLabeling/910
SPL (7)
  • DEXVETRA™ · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/10614/DEXVETRA%E2%84%A2
  • Dexmedetomidine Hydrochloride · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/17786/Dexmedetomidine%20Hydrochloride
  • DexmedVet™ · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/14472/DexmedVet%E2%84%A2
  • Dexmedetomidine Hydrochloride · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/13531/Dexmedetomidine%20Hydrochloride
  • Dexmedesed® · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2332/Dexmedesed%C2%AE
  • SILEO® · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2337/SILEO%C2%AE
  • Dexdomitor® · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/168/Dexdomitor%C2%AE
FOI (9)
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:03 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Mar 3, 2026, 11:06 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: DEXVETRA™ Dexdomitor® DexmedVet™ Dexmedesed® Dexmedetomidine Hydrochloride SILEO®
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat, Dog
Rx/OTC: RX
Form/route: Injectable Solution, Liquid (Solution), Oromucosal Gel, Sterile Injectable Solution, Sterile Solution • Intramuscular, Intravenous, Oromucosal
Applications: ANADA 200-699 • ANADA 200-824 • ANADA 200-752 • ANADA 200-735 • ANADA 200-573 • NADA 141-456 • NADA 141-267
NDC: Packages 11695-6967-1 64189-8502-0 64189-8502-1 68504-006-10 • Products 11695 64189 64189 68504
Documents: 11 (FOI: 9) • SPL: 7 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 26 • Cat 23 • View
Case summaries: 12 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use DEXDOMITOR in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue. Federal law (USA) restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Trouble breathing (dyspnea) (1) Loss of appetite (1) Hypochloraemia (1) Hyperphosphataemia (1) General pain (1) Eosinophilia (1) Eosinopenia (1) Enamel disorder (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200573 ANADA: 200699 ANADA: 200735 ANADA: 200752 ANADA: 200824 NADA: 141267 NADA: 141456 NDC Package: 11695-6967-1 NDC Package: 17033-005-10 NDC Package: 46066-088-13 NDC Package: 54771-1050-1 NDC Package: 54771-2805-1 NDC Package: 54771-2806-1 NDC Package: 64189-8502-0 NDC Package: 64189-8502-1 NDC Package: 68504-006-10 NDC Package: 69043-038-10 NDC Package: 86101-061-41 NDC Package: 86136-105-31 NDC Product: 11695 NDC Product: 17033 NDC Product: 46066 NDC Product: 54771 NDC Product: 64189
Package NDC Product NDC Form / Route Status
11695-6967-1 11695 -
17033-005-10 17033 -
46066-088-13 46066 -
54771-1050-1 54771 -
54771-2805-1 54771 -
54771-2806-1 54771 -
64189-8502-0 64189 -
64189-8502-1 64189 -
68504-006-10 68504 -
69043-038-10 69043 -
86101-061-41 86101 -
86136-105-31 86136 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 14 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use DEXDOMITOR in dogs or cats with cardiovascular disease, respir… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Lack of efficacy - NOS, Vomiting, Injection site swelling, Death, Bradycardia, Diarrhoea. (Official, 2026-02-12)
  • usage: For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. For use a… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
DEXVETRA™
RX
Dexmedetomidine hydrochloride
Injectable Solution • Intravenous, Intramuscular
Label highlights
Official documents
Parnell Technologies Pty. Ltd. ANADA 200-699 Approved Jan 8, 2026
Dexmedetomidine Hydrochloride
RX
Dexmedetomidine hydrochloride
Sterile Injectable Solution • Intravenous, Intramuscular
Label highlights
Official documents
Felix Pharmaceuticals Pvt. Ltd. ANADA 200-824 Approved Oct 1, 2025
DexmedVet™
RX
Dexmedetomidine hydrochloride
Sterile Injectable Solution • Intramuscular, Intravenous
Label highlights
Official documents
Cronus Pharma Specialities India Private Ltd. ANADA 200-752 Approved Aug 1, 2023
Dexmedetomidine Hydrochloride
RX
Dexmedetomidine hydrochloride
Injectable Solution • Intravenous, Intramuscular
Label highlights
Official documents
ZYVET AH, Inc. ANADA 200-735 Approved Feb 1, 2023
Dexmedesed®
RX
Dexmedetomidine hydrochloride
Sterile Solution • Intramuscular, Intravenous
Label highlights
Official documents
Dechra Veterinary Products LLC ANADA 200-573 Approved Dec 16, 2021
SILEO®
RX
Dexmedetomidine
Oromucosal Gel • Oromucosal
Label highlights
Official documents
Orion Corp. NADA 141-456 Approved May 17, 2021
Dexdomitor®
RX
Dexmedetomidine hydrochloride
Liquid (Solution) • Intravenous, Intramuscular
Label highlights
Official documents
Orion Corp. NADA 141-267 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
0.5 mg/mL
Dogs
Indication

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures.

Dosage

Administer 375 micrograms (mcg) per square meter (/m2) of body surface area by intravenous injection or 500 mcg/m2 of body surface area by intramuscular injection.

Limitations
Indication

For use as a preanesthetic to general anesthesia.

Dosage

Administer 125 mcg/m2 of body surface area or 375 mcg/m2 of body surface area by intramuscular injection.

Limitations
Cats
Indication

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures; and as a preanesthetic to general anesthesia.

Dosage

40 mcg/kg by intramuscular injection

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications
0.5 mg/mL
Dogs
Indication

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures.

Dosage

Administer 375 micrograms (µg) per square meter (/m2) of body surface area by intravenous injection or 500 µg/m2 of body surface area by intramuscular injection.

Limitations
Indication

For use as a preanesthetic to general anesthesia.

Dosage

Administer 125 µg/m2 of body surface area or 375 µg/m2 of body surface area by intramuscular injection.

Limitations
Cats
Indication

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures; and as a preanesthetic to general anesthesia.

Dosage

40 µg/killogram by intramuscular injection.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
0.5 mg/mL
Dogs
Indication

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. It is also indicated for use as a preanesthetic to general anesthesia.

Dosage

Sedation and Analgesia: 500 mcg/m2 intramuscularly (IM) or 375 mcg/m2 intravenously (IV). Preanesthesia: 125 or 375 mcg/m2 IM.

Limitations
Cats
Indication

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. It is also indicated for use as a preanesthetic to general anesthesia.


Dosage

Sedation, Analgesia and Preanesthesia: 40 mcg/kg IM.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
0.5 mg/mL
Dogs
Indication

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. It is also indicated for use as a preanesthetic to general anesthesia.

Dosage

Sedation and Analgesia: 500 mcg/m2 intramuscularly (IM) or 375 mcg/m2 intravenously (IV). Preanesthesia: 125 or 375 mcg/m2 IM.

Limitations
Cats
Indication

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. It is also indicated for use as a preanesthetic to general anesthesia.

Dosage

Sedation, Analgesia and Preanesthesia: 40 mcg/kg intramuscularly (IM)

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
0.5 mg/mL
<strong>Dogs</strong>
Indication
Dosage
For sedative and analgesic administer 375 mcg/m2 by intravenous (IV) injection or 500 mcg/m2 by intramuscular (IM) injection; for preanesthesia administer 125 or 375 mcg/m2 by IM injection
Limitations
<strong>Cats</strong>
Indication
For use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. Dexmedetomidine HCl is also indicated for use as a preanesthetic to general anesthesia in dogs and cats
Dosage
For sedation, analgesia, or preanesthesia administer 40 mcg/kg IM
Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each mL contains 0.09 mg dexmedetomidine (equivalent to 0.1 mg dexmedetomidine hydrochloride)
Dogs
Indication
For the treatment of noise aversion in dogs.
Dosage
Administer onto the oral mucosa between the dog’s cheek and gum at the dose of 125 micrograms per square meter.
Limitations
Federal law (USA) restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each mL contains 0.5 mg dexmedetomidine hydrochloride
Cats
Indication
For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures.
Dosage
40 mcg/kg by intramuscular (IM) injection.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use DEXDOMITOR in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue.
Indication
For use as a preanesthetic to general anesthesia.
Dosage
40 mcg/kg by intramuscular (IM) injection.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use DEXDOMITOR in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue.
Dogs
Indication
For use as a sedative and analgesic in dogs to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures.
Dosage
Administer 500 mcg/m2 intramuscularly (IM) or 375 mcg/m2 of body surface area by intravenous (IV) injection. Note that the mcg/kg dosage decreases as body weight increases.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use DEXDOMITOR in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue.
Indication
For use as a preanesthetic to general anesthesia.
Dosage
Administer 125 mcg/m2 of body surface area or 375 mcg/m2 of body surface area by intramuscular injection. Note that the mcg/kg dosage decreases as body weight increases.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use DEXDOMITOR in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
  • Summary

    For use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. It is also indicated for use as a preanesthetic to general anesthesia in dogs and cats.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    For use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. It is also indicated for use as a preanesthetic to general anesthesia in dogs and cats.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    For use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. It is also indicated for use as a preanesthetic to general anesthesia in dogs and cats.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    For use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. It is also indicated for use as a preanesthetic to general anesthesia in dogs and cats.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. Dexmedetomidine HCl is also indicated for use as a preanesthetic to general anesthesia in dogs and cats.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    This supplement provides for a new indication for use as a preanesthetic to general anesthesia in cats.
  • Summary
    The effect of the supplement is to add an indication for its use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures in cats.
  • Summary
    DEXDOMITOR is indicated for use as a sedative and analgesic in dogs to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. DEXDOMITOR is also indicated for use as a preanesthetic to general anesthesia
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. For use as a preanesthetic to general anesthesia. For use as a sedative and analgesic in dogs to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use DEXDOMITOR in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue. Federal law (USA) restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Loss of appetite (1) • Dog Drooling (1) • Dog

Showing top 5 for Digestive.

Neurologic
Unsteady walking (1) • Dog

Showing top 5 for Neurologic.

Other
Trouble breathing (1) • Dog Hypochloraemia (1) • Dog Hyperthermia (1) • Cat Hyperphosphataemia (1) • Dog Hyperglycaemia (1) • Cat
Show more (23)
Hyperactivity (1) • Cat General pain (1) • Dog Eosinophilia (1) • Dog Eosinopenia (1) • Dog Enamel disorder (1) • Dog Elevated temperature (1) • Dog Elevated serum alkaline phosphatase (1) • Dog Elevated creatinine (1) • Dog Elevated alanine aminotransferase (1) • Dog Dull (1) • Dog Dry mucous membrane (1) • Dog Death by euthanasia (1) • Cat Death (1) • Dog Cardiac arrest (1) • Cat Bruising (1) • Dog Bradycardia (1) • Dog Bacterial skin infection NOS (1) • Dog Arthritis (1) • Dog Application site pain (1) • Dog Application site discharge NOS (1) • Dog Application site bleeding (1) • Dog Acid-base disorder (1) • Dog Abnormal electrocardiogram (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Shorthair, Male, 5 year, 8.61 kilogram • Drug: MSK, Unknown • Reactions: Hyperthermia, Hyperactivity • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055972
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 5.00 Year
  • Weight: 8.610 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Hyperthermia Hyperactivity
Outcomes: Ongoing

Dog, ['Shepherd Dog - German', 'Dog (unknown)'], Female, 2.5 year • Drug: MSK, Intramuscular, Dose: 0.29 mL per animal • Reactions: Neutropenia, Eosinophilia, Lymphocytosis, Enamel disorder, Tooth disorder • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055809
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 2.50 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Dose: 0.29 mL per animal
Reactions Reported:
Neutropenia Eosinophilia Lymphocytosis Enamel disorder Tooth disorder
Outcomes: Outcome Unknown

Cat, Domestic Mediumhair, Female, 19 week, 2.06 kilogram • Drug: MSK, Unknown • Reactions: Sleepiness - neurological disorder, Temporary blindness, Tiredness (lethargy), Reduced responses, Mydriasis… • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2025-US-055689
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 19.00 Week
  • Weight: 2.060 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Sleepiness - neurological disorder Temporary blindness Tiredness (lethargy) Reduced responses Mydriasis Death by euthanasia
Outcomes: Euthanized

Cat, Cat (unknown), Female, 4.05 kilogram • Drug: MSK, Injection, Unknown, Dose: 0.03 Milligram per kilogram • Reactions: Hyperglycaemia • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-054116
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Weight: 4.050 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Injection
  • Dose: 0.03 Milligram per kilogram
Reactions Reported:
Hyperglycaemia
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 13 year, 6.804 kilogram • Drug: MSK, Injection, Intramuscular, Dose: 5 Microgram per kilogram • Reactions: Nausea, Prolonged one stage prothrombin time, Prolonged activated partial thrombin time, Cardiac arrest, Death • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-055853
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 13.00 Year
  • Weight: 6.804 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Form: Injection
  • Dose: 5 Microgram per kilogram
Reactions Reported:
Nausea Prolonged one stage prothrombin time Prolonged activated partial thrombin time Cardiac arrest Death
Outcomes: Died

Dog, ['Crossbred Canine/dog', 'Retriever - Labrador', 'Poodle - Medium size'], Female, 3 year, 12.338 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy - NOS, Rubbing, Application site pain • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-056018
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 3.00 Year
  • Weight: 12.338 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Lack of efficacy - NOS Rubbing Application site pain
Outcomes: Ongoing

Dog, Dog (unknown), Male, 10 year, 32.659 kilogram • Drug: MSK, Unknown • Reactions: Mass NOS, Lymph node abscess, Lymphadenopathy, Tachycardia, Drooling… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055759
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 10.00 Year
  • Weight: 32.659 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Mass NOS Lymph node abscess Lymphadenopathy Tachycardia Drooling Elevated serum alkaline phosphatase Monocytosis Neutrophilia Leucocytosis NOS Acid-base disorder Musculoskeletal disorder NOS Luxation/subluxation Arthritis Muscle tremor Tachypnoea Trouble breathing (dyspnea) Bacterial skin infection NOS Trauma NOS Hyperthermia Loss of appetite Oedema NOS Tiredness (lethargy) General pain
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 16 year, 4.36 kilogram • Drug: MSK, Solution, Intramuscular, Dose: 0.0050 Milligram per kilogram • Reactions: Lack of efficacy - NOS • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055487
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 16.00 Year
  • Weight: 4.360 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Form: Solution
  • Dose: 0.0050 Milligram per kilogram
Reactions Reported:
Lack of efficacy - NOS
Outcomes: Recovered/Normal

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

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Storage & Handling

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