Meds A-Z

Methylprednisolone Acetate

Detailed information about Methylprednisolone Acetate

Official label facts Owner quick guide first Marketing clearly labeled

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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

FDA application profile · official_label
FDA application profile · official_label
Medication usage source · fda_animal_drugs
openFDA case USA-USFDACVM-2025-US-055801 · adverse_reaction
SPL · document

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

Treatment of inflammation and related disorders in dogs; treatment of allergic and dermatologic disorders in dogs; and as supportive therapy to antibacterial treatment of severe infections in dogs.

What to watch for:

Not for human use
Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis
Systemic therapy with methylprednisolone acetate, as with other corticoids, is contraindicated in animals with arrested tuberculosis, peptic ulcer, and Cushing's syndrome
The presence of active tuberculosis, diabetes mellitus, osteoporosis, renal insufficiency, predisposition to thrombophlebitis, hypertension, or congestive heart failure necessitates carefully controlled use of corticosteroids
Intrasynovial, intratendinous or other injections of corticosteroids for local effect are contraindicated in the presence of acute infectious conditions
Exacerbation of pain, further loss of joint motion, with fever and malaise following injection may indicate that the condition has become septic
Appropriate antibacterial therapy should be instituted immediately
Not for use in horses intended for food
Systemic therapy with methylprednisolone acetate, as with other corticoids, is contraindicated in animals with arrested tuberculosis,
Non-regenerative anaemia (1 reports)
Mucous stool (1 reports)
Medication error NOS (1 reports)

When to call the vet:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Trouble breathing.
Facial swelling or hives.
Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to ask your vet today:

Is this medicine the right fit for my pet’s current symptoms?
Which warning signs mean I should call back right away?
How should I handle missed doses or refusal to take the medicine?

Safety & side effects

What to watch:

Not for human use
Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis
Systemic therapy with methylprednisolone acetate, as with other corticoids, is contraindicated in animals with arrested tuberculosis, peptic ulcer, and Cushing's syndrome
The presence of active tuberculosis, diabetes mellitus, osteoporosis, renal insufficiency, predisposition to thrombophlebitis, hypertension, or congestive heart failure necessitates carefully controlled use of corticosteroids
Intrasynovial, intratendinous or other injections of corticosteroids for local effect are contraindicated in the presence of acute infectious conditions

Most reported reactions:

Non-regenerative anaemia (1 reports)
Mucous stool (1 reports)
Medication error NOS (1 reports)

When to call your vet:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Trouble breathing.

Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness

Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
openFDA reaction terms: Source FDA openFDA | Refreshed Mar 17, 2026, 10:04 AM UTC
openFDA case summaries: Source FDA openFDA | Refreshed Feb 24, 2026, 11:06 AM UTC

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Methylprednisolone Acetate

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both

Manufacturer: Not available

Form: Liquid (Suspension)

Identifiers:

NADA: 12204 NADA: 136212 NDC Package: 54771-1613-1 NDC Package: 54771-1614-1 NDC Product: 54771

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/12204 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/136212 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source

Warnings / Contraindications

Not for human use. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis. Systemic therapy with methylprednisolone acetate, as with other corticoids, is contraindicated in animals with arrested tuberculosis, peptic ulcer, and Cushing's syndrome. The presence of active tuberculosis, diabetes mellitus, osteoporosis, renal insufficiency, predisposition to thrombophlebitis, hypertension, or congestive heart failure necessitates carefully controlled use of corticosteroids. Intrasynovial, intratendinous or other injections of corticosteroids for local effect are contraindicated in the presence of acute infectious conditions. Exacerbation of pain, further loss of joint motion, with fever and malaise following injection may indicate that the condition has become septic. Appropriate antibacterial therapy should be instituted immediately. Not for human use. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Systemic therapy with methylprednisolone acetate, as with other corticoids, is contraindicated in animals with arrested tuberculosis, peptic ulcer, and Cushing's syndrome. The presence of active tuberculosis, diabetes mellitus, osteoporosis, renal insufficiency, predisposition to thrombophlebitis hypertension, or congestive heart failure necessitates carefully controlled use of corticosteroids. Intrasynovial, intratendinous or other injections of corticosteroids for local effect are contraindicated in the presence of acute infectious conditions. Exacerbation of pain, further loss of joint motion, with fever and malaise following injection may indicate that the condition has become septic. Appropriate antibacterial therapy should be instituted immediately. Not for use in horses intended for food. Not for human use. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Systemic therapy with methylprednisolone acetate, as with other corticoids, is contraindicated in animals with arrested tuberculosis,

High: Not for human use. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis. Systemic therapy with methylprednisolone acetate, as with other corticoids, is contraindicated in animals with arrested tuberculosis, peptic ulcer, and Cushing's syndrome. The presence of active tuberculosis, diabetes mellitus, osteoporosis, renal insufficiency, predisposition to thrombophlebitis, hypertension, or congestive heart failure necessitates carefully controlled use of corticosteroids. Intrasynovial, intratendinous or other injections of corticosteroids for local effect are contraindicated in the presence of acute infectious conditions. Exacerbation of pain, further loss of joint motion, with fever and malaise following injection may indicate that the condition has become septic. Appropriate antibacterial therapy should be instituted immediately. Not for human use. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Systemic therapy with methylprednisolone acetate, as with other corticoids, is contraindicated in animals with arrested tuberculosis, peptic ulcer, and Cushing's syndrome. The presence of active tuberculosis, diabetes mellitus, osteoporosis, renal insufficiency, predisposition to thrombophlebitis hypertension, or congestive heart failure necessitates carefully controlled use of corticosteroids. Intrasynovial, intratendinous or other injections of corticosteroids for local effect are contraindicated in the presence of acute infectious conditions. Exacerbation of pain, further loss of joint motion, with fever and malaise following injection may indicate that the condition has become septic. Appropriate antibacterial therapy should be instituted immediately. Not for use in horses intended for food. Not for human use. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Systemic therapy with methylprednisolone acetate, as with other corticoids, is contraindicated in animals with arrested tuberculosis,

Source metadata:

https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals

Reported cases

Serious reports

Species represented

Grouped by Body System

Digestive (4) · Diarrhea, Decreased appetite, Bloody diarrhoea Skin & allergy (1) · Hives Neurologic (3) · Unsteady walking (ataxia), Tiredness (lethargy), Head tilt - neurological disorder Effectiveness (3) · Lack of efficacy - NOS, Lack of efficacy (endoparasite) - roundworm NOS, Lack of efficacy (ectoparasite) - flea Other (21) · Not eating, Not drinking, Non-regenerative anaemia

Most Reported Reactions

Body system	Cases	Species	Serious cases
Other	1	Dog	1
Other	1	Dog	1
Other	1	Dog	1
Effectiveness	1	Dog	1
Effectiveness	1	Dog	1
Effectiveness	1	Dog	1
Other	1	Dog	1
Other	1	Dog	1

Species coverage: Dog (19) Cat (13)

View detailed reaction table

Body system	Species	Seriousness	Frequency	Reports
Neurologic	Cat	Non-serious	-	1
Neurologic	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Non-serious	-	1
Effectiveness	Dog	Serious	-	1
Effectiveness	Dog	Serious	-	1
Effectiveness	Dog	Serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Skin & allergy	Dog	Serious	-	1
Other	Cat	Non-serious	-	1
Neurologic	Cat	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Digestive	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Serious	-	1
Other	Dog	Serious	-	1
Digestive	Cat	Non-serious	-	1
Digestive	Dog	Serious	-	1
Digestive	Dog	Serious	-	1
Other	Cat	Non-serious	-	1

Source metadata:

https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-055801

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)

No owner handouts linked yet.

Official label / PI (0)

No official label or package insert links yet.

SPL (2)

Depo-Medrol® · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/703/Depo-Medrol%C2%AE
Methylprednisolone Acetate Inj. · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/522/Methylprednisolone%20Acetate%20Inj.

FOI (0)

No FOI links yet.

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/703/Depo-Medrol%C2%AE · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/522/Methylprednisolone%20Acetate%20Inj. · document · SPL

Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness

Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
openFDA reaction terms: Source FDA openFDA | Refreshed Mar 17, 2026, 10:04 AM UTC
openFDA case summaries: Source FDA openFDA | Refreshed Feb 24, 2026, 11:06 AM UTC

Official (FDA)

Identity: Generic ingredient • FDA branded products available

Official FDA brands: Depo-Medrol® Methylprednisolone Acetate Inj.

Case-reported brands (openFDA): MSK

Catalog species: Both • FDA-labeled species: Cat, Dog, Horse, Restricted During Pregnancy

Rx/OTC: RX

Form/route: Liquid (Suspension) • Intramuscular, Intrasynovial

Applications: NADA 12204 • NADA 136-212

Documents: • SPL: 2 • Label highlights • Official documents

Safety (openFDA)

Top reactions: Dog 16 • Cat 26 • View

Case summaries: 11 (showing 8) • View

openFDA reports are unverified and do not prove causation.

Explore

Related conditions: Congestive heart failure Diabetes Mellitus Diabetes Mellitus Diabetes Mellitus (Canine) Dystocia Metritis Pain (acute, chronic)

Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)

Diagnosis Codes

ICD10_CM: E11.9

Type 2 diabetes mellitus without complications

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points

Not for human use. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis. Systemic therapy with methylprednisolone acetate, as with other corticoids, is contraindicated in animals with arrested tuberculosis, peptic ulcer, and Cushing's syndrome. The presence of active tuberculosis, diabetes mellitus, osteoporosis, renal insufficiency, predisposition to thrombophlebitis, hypertension, or congestive heart failure necessitates carefully controlled use of corticosteroids. Intrasynovial, intratendinous or other injections of corticosteroids for local effect are contraindicated in the presence of acute infectious conditions. Exacerbation of pain, further loss of joint motion, with fever and malaise following injection may indicate that the condition has become septic. Appropriate antibacterial therapy should be instituted immediately. Not for human use. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Systemic therapy with methylprednisolone acetate, as with other corticoids, is contraindicated in animals with arrested tuberculosis, peptic ulcer, and Cushing's syndrome. The presence of active tuberculosis, diabetes mellitus, osteoporosis, renal insufficiency, predisposition to thrombophlebitis hypertension, or congestive heart failure necessitates carefully controlled use of corticosteroids. Intrasynovial, intratendinous or other injections of corticosteroids for local effect are contraindicated in the presence of acute infectious conditions. Exacerbation of pain, further loss of joint motion, with fever and malaise following injection may indicate that the condition has become septic. Appropriate antibacterial therapy should be instituted immediately. Not for use in horses intended for food. Not for human use. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Systemic therapy with methylprednisolone acetate, as with other corticoids, is contraindicated in animals with arrested tuberculosis, (Contraindication, High)

Top reaction signals

Non-regenerative anaemia (1) Mucous stool (1) Medication error NOS (1) Lack of efficacy - NOS (1) Lack of efficacy (endoparasite) - roundworm NOS (1) Lack of efficacy (ectoparasite) - flea (1) Hypoalbuminaemia (1) Hyperglycaemia (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers

NADA: 12204 NADA: 136212 NDC Package: 54771-1613-1 NDC Package: 54771-1614-1 NDC Product: 54771

Package NDC	Product NDC	Form / Route	Status
54771-1613-1	54771		-
54771-1614-1	54771		-

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 3 Clinical 0 Manufacturer 0 Marketing 0

Current Field Facts

contraindications: Not for human use. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that … (Official, 2026-02-12)
side_effects: Top reported reactions (openFDA): Lack of efficacy - NOS, Vomiting, Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Weight l… (Official, 2026-02-12)
usage: Treatment of inflammation and related disorders in dogs; treatment of allergic and dermatologic disorders in dogs; and as supportive therapy to antibacterial t… (Official, 2026-02-12)

Recent Revisions

side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product	Sponsor	Application	Status	Published
Depo-Medrol® RX Methylprednisolone Acetate Liquid (Suspension) • Intramuscular, Intrasynovial Label highlights Official documents	Zoetis Inc.	NADA 12204	Approved	Dec 7, 2021
Methylprednisolone Acetate Inj. RX Methylprednisolone Acetate Liquid (Suspension) • Intramuscular, Intrasynovial Label highlights Official documents	Cronus Pharma Specialities India Private Ltd.	NADA 136-212	Approved	Feb 1, 2018

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, Restricted During Pregnancy • Restricted During Pregnancy • Cat, Restricted During Pregnancy

Composition / specifications

Each milliliter of aqueous suspension contains 20 or 40 milligrams of methylprednisolone acetate.

Dogs

Indication

Treatment of inflammation and related disorders in dogs; treatment of allergic and dermatologic disorders in dogs; and as supportive therapy to antibacterial treatment of severe infections in dogs.

Dosage

2 to 40 milligrams (up to 120 milligrams in extremely large breeds or dogs with severe involvement) intramuscularly. Dosage may be repeated when necessary. Up to 20 milligrams intrasynovially. Dosage may be repeated when necessary.

Limitations

Cats

Indication

Treatment of inflammation and related disorders in cats; treatment of allergic and dermatologic disorders in cats; and as supportive therapy to antibacterial treatment of severe infections in cats.

Dosage

10 to 20 milligrams intramuscularly. Dosage may be repeated when necessary.

Limitations

Horses

Indication

Treatment of inflammation and related disorders in horses.

Dosage

200 milligrams intramuscularly. Dosage may be repeated when necessary. 40 to 240 milligrams intrasynovially. Dosage may be repeated when necessary.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, Restricted During Pregnancy • Horse, Restricted During Pregnancy • Horse, Not For Meat Production • Cat, Restricted During Pregnancy

Composition / specifications

Each milliliter of aqueous suspension contains 20 or 40 milligrams of methylprednisolone acetate.

Dogs

Indication

Treatment of inflammation and related disorders; treatment of allergic and dermatologic disorders; and as supportive therapy to antibacterial treatment of severe infections.

Dosage

2 to 40 milligrams (up to 120 milligrams in extremely large breeds or dogs with severe involvement) intramuscularly. Dosage may be repeated when necessary. Or up to 20 milligrams intrasynovially. Dosage may be repeated when necessary.

Limitations

Cats

Indication

Treatment of inflammation and related disorders; treatment of allergic and dermatologic disorders; and as supportive therapy to antibacterial treatment of severe infections.

Dosage

10 to 20 milligrams intramuscularly. Dosage may be repeated when necessary.

Limitations

Horses

Indication

Treatment of inflammation and related disorders.

Dosage

200 milligrams intramuscularly. Dosage may be repeated when necessary. Or 40 to 240 milligrams intrasynovially. Dosage may be repeated when necessary.

Limitations

Not for use in horses intended for food. Not for human use. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Systemic therapy with methylprednisolone acetate, as with other corticoids, is contraindicated in animals with arrested tuberculosis, peptic ulcer, and Cushing's syndrome. The presence of active tuberculosis, diabetes mellitus, osteoporosis, renal insufficiency, predisposition to thrombophlebitis hypertension, or congestive heart failure necessitates carefully controlled use of corticosteroids. Intrasynovial, intratendinous or other injections of corticosteroids for local effect are contraindicated in the presence of acute infectious conditions. Exacerbation of pain, further loss of joint motion, with fever and malaise following injection may indicate that the condition has become septic. Appropriate antibacterial therapy should be instituted immediately.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

SPL Packages

Depo-Medrol® (ZIP)

FDA page: Open in Animal Drugs @ FDA

SPL Packages

Methylprednisolone Acetate Inj. (ZIP)

FDA page: Open in Animal Drugs @ FDA

Usage

Treatment of inflammation and related disorders in dogs; treatment of allergic and dermatologic disorders in dogs; and as supportive therapy to antibacterial treatment of severe infections in dogs. Treatment of inflammation and related disorders in cats; treatment of allergic and dermatologic disorders in cats; and as supportive therapy to antibacterial treatment of severe infections in cats. Treatment of inflammation and related disorders in horses.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive

Diarrhea (1) • Dog Decreased appetite (1) • Cat Bloody diarrhoea (1) • Dog Blood in vomit (1) • Dog

Showing top 5 for Digestive.

Skin & allergy

Hives (1) • Dog

Showing top 5 for Skin & allergy.

Neurologic

Unsteady walking (1) • Cat Tiredness (1) • Cat Head tilt - neurological disorder (1) • Cat

Showing top 5 for Neurologic.

Effectiveness

Lack of efficacy - NOS (1) • Dog Lack of efficacy (endoparasite) - roundworm NOS (1) • Dog Lack of efficacy (ectoparasite) - flea (1) • Dog

Showing top 5 for Effectiveness.

Other

Not eating (1) • Cat Not drinking (1) • Cat Non-regenerative anaemia (1) • Dog Muscle weakness NOS (1) • Cat Mucous stool (1) • Dog

Show more (16)

Medication error NOS (1) • Dog Malaise (1) • Cat Intentional misuse (1) • Cat Hypothermia (1) • Cat Hypoalbuminaemia (1) • Dog Hyperglycaemia (1) • Dog Hiding (1) • Cat Gut sounds increased (1) • Dog Glucosuria (1) • Dog Gastroenteritis (1) • Dog Gastritis (1) • Dog Digestive tract hypomotility (1) • Dog Diabetes (1) • Dog Dermatitis (1) • Cat Dental calculus (1) • Dog Abnormal radiograph finding (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Shorthair, Male, 2 year, 4.35 kilogram • Drug: MSK, Suspension, Unknown • Reactions: Partial lack of efficacy, Medication error NOS • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-054729
Serious AE: Yes
Treated For AE: Yes
Sex: Male
Age: 2.00 Year
Weight: 4.350 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown
Form: Suspension

Reactions Reported:

Partial lack of efficacy Medication error NOS

Outcomes: Ongoing

Cat, Domestic Shorthair, Unknown, 13 year • Drug: MSK, Suspension, Intramuscular • Reactions: Dermatitis, Self trauma, Lack of efficacy - NOS • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-055096
Serious AE: Yes
Treated For AE: Yes
Sex: Unknown
Age: 13.00 Year

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Intramuscular
Form: Suspension

Reactions Reported:

Dermatitis Self trauma Lack of efficacy - NOS

Outcomes: Ongoing

Cat, Domestic Mediumhair, Female, 13 year, 2.858 kilogram • Drug: MSK, Intramuscular, Dose: 0.40 mL per animal • Reactions: Tiredness (lethargy), Unresponsive to stimuli, Not eating, Not drinking, Hiding… • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-055801
Serious AE: No
Treated For AE: Yes
Sex: Female
Age: 13.00 Year
Weight: 2.858 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Intramuscular
Dose: 0.40 mL per animal

Reactions Reported:

Tiredness (lethargy) Unresponsive to stimuli Not eating Not drinking Hiding Unsteady walking (ataxia) Abnormal radiograph finding Hypothermia Tympanic opacity Weight loss Malaise Muscle weakness NOS Intentional misuse Lack of efficacy - NOS

Outcomes: Ongoing

Cat, Domestic Shorthair, Female, 5 year, 3.6 kilogram • Drug: MSK, Unknown • Reactions: Head tilt - neurological disorder, Unsteady walking (ataxia), Decreased appetite • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-055932
Serious AE: No
Treated For AE: No
Sex: Female
Age: 5.00 Year
Weight: 3.600 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown

Reactions Reported:

Head tilt - neurological disorder Unsteady walking (ataxia) Decreased appetite

Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 8 year, 5.157 kilogram • Drug: MSK, Suspension, Intramuscular, Dose: 1.40 mL per animal • Reactions: Skin ulcer • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-054861
Serious AE: No
Treated For AE: No
Sex: Male
Age: 8.00 Year
Weight: 5.157 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Intramuscular
Form: Suspension
Dose: 1.40 mL per animal

Reactions Reported:

Skin ulcer

Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Female, 9 year, 5.262 kilogram • Drug: MSK, Suspension, Subcutaneous • Reactions: Skin ulcer, Lack of efficacy - NOS, Skin sore • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-054827
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 9.00 Year
Weight: 5.262 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Subcutaneous
Form: Suspension

Reactions Reported:

Skin ulcer Lack of efficacy - NOS Skin sore

Outcomes: Ongoing

Dog, Shih Tzu, Male, 13.2 year, 4.59 kilogram • Drug: MSK, Suspension, Unknown • Reactions: Lack of efficacy - NOS • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-052033
Serious AE: Yes
Treated For AE: Yes
Sex: Male
Age: 13.20 Year
Weight: 4.590 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown
Form: Suspension

Reactions Reported:

Lack of efficacy - NOS

Outcomes: Ongoing

Dog, Retriever - Labrador, Female, 8 year, 28.12 kilogram • Drug: MSK, Unknown • Reactions: Vomiting, Not eating, Tiredness (lethargy), Pancreatitis NOS, Lack of efficacy (endoparasite) - roundworm NOS… • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-055168
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 8.00 Year
Weight: 28.120 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown

Reactions Reported:

Vomiting Not eating Tiredness (lethargy) Pancreatitis NOS Lack of efficacy (endoparasite) - roundworm NOS Other abnormal test result NOS Shaking Diarrhea Hypoalbuminaemia Hives Skin scab Gastroenteritis Non-regenerative anaemia Digestive tract hypomotility Dental calculus Bloody diarrhoea Blood in vomit Tense abdomen Gastritis Mucous stool Pale mucous membrane Gut sounds increased Lack of efficacy (ectoparasite) - flea Trembling

Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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Medical Disclaimer: The medication details provided on Roxee are for informational purposes only and are not a substitute for professional veterinary advice. Always consult your veterinarian about your pet's specific needs.

Methylprednisolone Acetate

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