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Afoxolaner 28.3 Mg Chewable Tablets

Detailed information about Afoxolaner 28.3 Mg Chewable Tablets

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

Your vet decides this. Here's what owners typically ask/watch for.

What to watch for:

  • Vomiting (1 reports)
  • wobbly/unsteady walking (1 reports)
  • Underdose (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Vomiting
  • wobbly/unsteady walking
  • Underdose

Most reported reactions:

  • Vomiting (1 reports)
  • Unsteady walking (ataxia) (1 reports)
  • Underdose (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 23, 2026, 11:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC
Image coming soon
Afoxolaner 28.3 Mg Chewable Tablets

Afoxolaner 28.3 Mg Chewable Tablets

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
17
Reported cases
12
Serious reports
0
Species represented
2
Grouped by Body System
Digestive (2) · Vomiting, Diarrhea Skin & allergy (1) · Itching Neurologic (3) · Unsteady walking (ataxia), Tiredness (lethargy), Lethargy (see also Central nervous system depression in 'Neurological') Effectiveness (4) · Lack of efficacy (ectoparasite) - flea, Lack of efficacy (bacteria) - Anaplasma, Lack of efficacy (flea) Other (7) · Underdose, Other abnormal test result NOS, Not eating
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Digestive 1 Dog 0
Neurologic 1 Cat 0
Other 1 Dog 0
Neurologic 1 Cat 0
Other 1 Cat 0
Other 1 Cat 0
Effectiveness 1 Dog 0
Effectiveness 1 Dog 0

Species coverage: Dog (12) Cat (5)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Non-serious - 1
Neurologic Cat Non-serious - 1
Other Dog Non-serious - 1
Neurologic Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Digestive Dog Non-serious - 1
Other Cat Non-serious - 1
Other Dog Unknown - -
Neurologic Dog Unknown - -
Effectiveness Dog Unknown - -
Effectiveness Dog Unknown - -
Skin & allergy Dog Unknown - -
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 23, 2026, 11:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 9 • Cat 5 • View
Case summaries: 6 (showing 6) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Vomiting (1) Unsteady walking (ataxia) (1) Underdose (1) Tiredness (lethargy) (1) Other abnormal test result NOS (1) Not eating (1) Lack of efficacy (ectoparasite) - flea (1) Lack of efficacy (bacteria) - Anaplasma (1)

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 1 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Skin disorders NOS, Lack of efficacy (tick), Vomiting, Lack of efficacy (flea), Diarrhoea, Lethargy (see also Central nervous… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Diarrhea (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Itching • Dog

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Cat Tiredness (1) • Cat Tiredness (lethargy) • Dog

Showing top 5 for Neurologic.

Effectiveness
Lack of efficacy (ectoparasite) - flea (1) • Dog Lack of efficacy (bacteria) - Anaplasma (1) • Dog Lack of efficacy (ectoparasite) - NOS • Dog Lack of efficacy • Dog

Showing top 5 for Effectiveness.

Other
Underdose (1) • Dog Other abnormal test result NOS (1) • Cat Not eating (1) • Cat Impaired consciousness (1) • Dog Glazed eye (1) • Dog
Show more (2)
Anaemia NOS (1) • Cat Skin disorders NOS • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, ['Poodle - Miniature', 'Dog (unknown)'], Female, 9.5 year, 4.763 kilogram • Drug: MSK, Oral, Dose: 1 tablet per animal • Reactions: Glazed eye, Impaired consciousness • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-053121
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 9.50 Year
  • Weight: 4.763 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Dose: 1 tablet per animal
Reactions Reported:
Glazed eye Impaired consciousness
Outcomes: Recovered/Normal

Dog, Schnauzer (unspecified), Male, 9 year, 6.5 kilogram • Drug: MSK, Oral, Dose: 1 tablet per animal, Frequency: 1 per month • Reactions: Diarrhea, Underdose • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-048775
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 9.00 Year
  • Weight: 6.500 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Dose: 1 tablet per animal
  • Frequency: 1 per month
Reactions Reported:
Diarrhea Underdose
Outcomes: Outcome Unknown

Dog, Dog (other), Male, 4 year, 5.715 kilogram • Drug: MSK, Oral, Dose: 1 tablet per animal, Frequency: 1 per month • Reactions: Lack of efficacy (bacteria) - Anaplasma • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-042455
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 4.00 Year
  • Weight: 5.715 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Dose: 1 tablet per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (bacteria) - Anaplasma
Outcomes: Ongoing

Dog, Terrier - Jack Russell, Female, 19 month, 6.713 kilogram • Drug: MSK, Unknown, Dose: 1 tablet per animal • Reactions: Vomiting • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-035411
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 19.00 Month
  • Weight: 6.713 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Dose: 1 tablet per animal
Reactions Reported:
Vomiting
Outcomes: Outcome Unknown

Dog, Shih Tzu, Male, 10 year, 9.525 kilogram • Drug: MSK, Oral, Dose: 1 tablet per animal, Frequency: 1 per month • Reactions: Lack of efficacy (ectoparasite) - flea • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-036213
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 10.00 Year
  • Weight: 9.525 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Dose: 1 tablet per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (ectoparasite) - flea
Outcomes: Outcome Unknown

Cat, Maine Coon, Female, 15 year, 4.264 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 dose per animal, Frequency: 1 per day • Reactions: Tiredness (lethargy), Unsteady walking (ataxia), Not eating, Anaemia NOS, Other abnormal test result NOS • Outcome: Outcome Unknown

  • Report ID: CAN-USFDACVM-2017-CA-000517
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 15.00 Year
  • Weight: 4.264 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 dose per animal
  • Frequency: 1 per day
Reactions Reported:
Tiredness (lethargy) Unsteady walking (ataxia) Not eating Anaemia NOS Other abnormal test result NOS
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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