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Roxee Medication Guide

Amoxicillin

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Source review pending Regulatory linkage incomplete Owner quick guide first
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Data freshness

Reference facts
Source review pending
No refresh timestamp yet

Roxee is still reviewing source support for this medication profile.

FDA applications
Regulatory match pending
No refresh timestamp yet

Roxee has safety or ingredient evidence for this medication, but a regulatory product/application match is still pending.

Safety reports
Safety data refreshed
Aug 6, 2026, 7:49 p.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Jul 22, 2026, 7:08 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Illustration placeholder
Amoxicillin

Amoxicillin

Drug type: Generic ingredient • Generic profile • Regulatory linkage incomplete

Both 83% reference complete

Species: Both

Approval status: Official document linked, regulatory match incomplete. An official source document is available, but Roxee has not linked this row to a confirmed FDA animal-drug application or product record yet.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Amoxicillin

For the treatment of susceptible strains of the organisms causing the following infections: Respiratory tract infections (tonsillitis, tracheobronchitis) due to Staphylococcus aureus, Streptococcus spp., Escherichia coli, and Proteus mirabilis . Genitourinary tract infections (cystitis) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Proteus mirabilis . Gastrointestinal tract infections (bacterial gastroenteritis) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Proteus mirabilis . Bacterial dermatitis due to Staphylococcus aureus, Streptococcus spp., and Proteus mirabilis . Soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Proteus mirabilis . For the treatment of susceptible strains of the organisms causing the following infections: Upper respiratory tract infections due to Staphylococcus aureus, Streptococcus spp., and E. coli . Genitourinary tract infections (cystitis) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Proteus mirabilis . Gastrointestinal tract infections due to E. coli . Skin and soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Pasteurella multocida . For the treatment of baby pigs under 10 pounds for porcine colibacillosis caused by Escherichia coli susceptible to amoxicillin. Species commonly shown: Both.

Generic name
Amoxicillin
Species
Both
Completeness
83%
Validation
Incomplete

Indications / Uses

For the treatment of susceptible strains of the organisms causing the following infections: Respiratory tract infections (tonsillitis, tracheobronchitis) due to Staphylococcus aureus , Streptococcus spp., Escherichia coli , and Proteus mirabilis . Genitourinary tract infections (cystitis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Gastrointestinal tract infections (bacterial gastroenteritis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Bacterial dermatitis due to Staphylococcus aureus , Streptococcus spp., and Proteus mirabilis . Soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . For the treatment of susceptible strains of the organisms causing the following infections: Upper respiratory tract infections due to Staphylococcus aureus , Streptococcus spp., and E. coli . Genitourinary tract infections (cystitis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Gastrointestinal tract infections due to E. coli . Skin and soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Pasteurella multocida . For the treatment of baby pigs under 10 pounds for porcine colibacillosis caused by Escherichia coli susceptible to amoxicillin.

Warnings / Contraindications

Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter animals during treatment or for 20 days after the latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment. Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter animals during treatment or for 20 days after the latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment. Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Side Effects

Top reported reactions (openFDA): Vomiting, Lethargy (see also Central nervous system depression in 'Neurological'), Elevated alanine aminotransferase (ALT), Diarrhoea, Anorexia, Death by euthanasia.

FAQ

Both

Related Conditions

Abscesses (cat bite abscess) Gastroenteritis (nonspecific) Gastrointestinal (additional) Urinary tract infection (cystitis)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the treatment of susceptible strains of the organisms causing the following infections: Respiratory tract infections (tonsillitis, tracheobronchitis) due to Staphylococcus aureus , Streptococcus spp., Escherichia col...

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Do not slaughter during treatment or for 15 days after latest treatment
  • Do not slaughter animals during treatment or for 20 days after the latest treatment
  • Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment
  • Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment
  • Loss of appetite (1 reports)
  • Dehydration (1 reports)
  • Decreased red blood cell count (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Amoxicillin; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2025-US-048791
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 30 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2025-US-048791
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2025-US-048791
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Loss of appetite (1 reports), Dehydration (1 reports), Decreased red blood cell count (1 reports), Decreased percentage of reticulocytes (1 reports), Decreased packed cell volume (1 reports)

Body systems represented Signal grouping

Digestive (4), Behavior (2), Other (26)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Dog (22 reports), Cat (10 reports)

Breed metadata in reports Metadata only

Domestic Shorthair (2), Deutsche Dogge, Great Dane (1), Retriever - Labrador (1), Crossbred Canine/dog (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Amoxicillin fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Do not slaughter during treatment or for 15 days after latest treatment, Do not slaughter animals during treatment or for 20 days after the latest treatment, Treated animals must not be slaughtered for food during treatment and for 25 days after the last tre, Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 mi, Loss of appetite

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Amoxicillin brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2025-US-048791 · adverse_reaction · adverse reactions
  2. Medication contraindications · safety_warning · warnings contraindications
  3. FOI summary · document · documents
  4. FOI summary · document · documents
  5. FOI summary · document · documents
  6. FOI summary · document · documents
  7. FOI summary · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: April 15, 2026, 10:04 AM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Do not slaughter during treatment or for 15 days after latest treatment
  • Do not slaughter animals during treatment or for 20 days after the latest treatment
  • Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment
  • Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment
  • Loss of appetite

Most reported reactions:

  • Loss of appetite (1 reports)
  • Dehydration (1 reports)
  • Decreased red blood cell count (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Not linked yet
Indication / use
For the treatment of susceptible strains of the organisms causing the following infections: Respiratory tract infections (tonsillitis, tracheobronchitis) due to Staphylococcus aur…
Form / route / dose
Confirm product label and patient-specific plan.
Warnings
  • High: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or o…
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Manufacturer not confirmed
Identifiers:
ANADA: 200592 ANADA: 200604 ANADA: 200702 ANADA: 200709 NADA: 141004 NADA: 141005 NADA: 55078 NADA: 55080 NADA: 55081 NADA: 55085 NADA: 55087 NADA: 55088 NADA: 55089 NADA: 55091 NADA: 55100 NADA: 55101 NADA: 65492 NADA: 65495 NDC Package: 0061-8128-01 NDC Package: 11695-6991-1

Warnings / Contraindications

Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter animals during treatment or for 20 days after the latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment. Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter animals during treatment or for 20 days after the latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment. Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
15
Matching reports
1
Active filters
2
Selected filters
Reaction: Elevated serum alkaline phosphatase (ALP) Clear Body system: Effectiveness Clear
Reset
Drill into common report signals
Diarrhoea (4) Vomiting (4) Death (3) Elevated serum alkaline phosphatase (ALP) (3) Other (14) Digestive (6) Effectiveness (4) Neurologic (4)
Showing up to 50 matching reports.

USA-USFDACVM-2026-US-008597

Received 2026-02-16 · MSK · MSK

Serious
Species
Dog
Breed
Crossbred Canine/dog
Age
Under 1 year (9 Week)
Sex
Male Intact
Region
USA
Reactions
Death by euthanasiaLack of efficacy (bacteria) - BordetellaSkin lumpDecreased haemoglobinHypokalaemiaDecreased haematocritOther abnormal test result NOSLow amylaseHyperproteinaemiaDecreased packed cell volume (PCV)Reduced globulinsEosinopeniaHyperphosphataemiaLow platelet countElevated creatine-kinase (CK)HypoproteinaemiaElevated creatinineElevated triglycerideHyperglycaemiaNeutrophiliaDecreased percentage of reticulocytesIncreased band neutrophiliaMonocytosisElevated serum alkaline phosphatase (ALP)Leukocytosis NOSElevated symmetrical dimethylarginine (SDMA)HypoalbuminaemiaElevated aspartate aminotransferase (AST)Elevated total bilirubinDecreased red blood cell countNeutropeniaLymphopeniaHypernatraemiaElevated C-reactive proteinElevated alanine aminotransferase (ALT)Elevated cholesterol (total)HyperchloraemiaElevated blood urea nitrogen (BUN)HypochloraemiaElevated lipaseDistension of abdomenLeukopenia NOS
Body systems
OtherEffectiveness
Outcomes
Euthanized

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
30
Species represented
2
Grouped by Body System
Digestive (4) · Loss of appetite, Decreased appetite, Bloody diarrhoea Behavior (2) · Behavioral disorder (unspecified), Anxiety Other (26) · Dehydration, Decreased red blood cell count, Decreased percentage of reticulocytes
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Digestive 1 Cat 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Digestive 1 Cat 1

Species coverage: Dog (22) Cat (10)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Digestive Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Digestive Dog Non-serious - 1
Other Dog Serious - 1
Behavior Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Digestive Dog Serious - 1
Behavior Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Source metadata:

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Only technical FDA review documents are linked right now. Owner handouts, official label / PI, and SPL documents are not linked yet.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

FOI Summary oA 200-709 Approved August 18, 2021.pdf FOI · FOI summary FOI Summary oA 200-702 Approved April 23, 2021.pdf FOI · FOI summary N055101_Supp_12_23_1997.pdf FOI · FOI summary

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

0
No SPL links yet.

FOI

5

FOI Summary oA 200-709 Approved August 18, 2021.pdf

FOI · FOI summary

Open original

FOI Summary oA 200-702 Approved April 23, 2021.pdf

FOI · FOI summary

Open original

N055101_Supp_12_23_1997.pdf

FOI · FOI summary

Open original

FOI Summary oA 200-604 Approved October 20, 2021.pdf

FOI · FOI summary

Open original

UCM524262.pdf

FOI · FOI summary

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Jul 22, 2026, 7:08 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 96 • Cat 22 • View
Case summaries: 15 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Usage_Inferred (0.78), Usage_Inferred (0.78), Usage_Inferred (0.78)
Diagnosis Codes
ICD10_CM: K05.6
Periodontal disease, unspecified

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter animals during treatment or for 20 days after the latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment. Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Loss of appetite (1) Dehydration (1) Decreased red blood cell count (1) Decreased percentage of reticulocytes (1) Decreased packed cell volume (1) Decreased haemoglobin (1) Decreased haematocrit (1) Decreased appetite (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200592 ANADA: 200604 ANADA: 200702 ANADA: 200709 NADA: 141004 NADA: 141005 NADA: 55078 NADA: 55080 NADA: 55081 NADA: 55085 NADA: 55087 NADA: 55088 NADA: 55089 NADA: 55091 NADA: 55100 NADA: 55101 NADA: 65492 NADA: 65495 NDC Package: 0061-8128-01 NDC Package: 11695-6991-1 NDC Package: 11695-6992-1 NDC Package: 11695-6993-1 NDC Package: 11695-6994-1 NDC Package: 11695-7007-1
Package NDC Product NDC Form / Route Status
0061-8128-01 0061 -
11695-6991-1 11695 -
11695-6992-1 11695 -
11695-6993-1 11695 -
11695-6994-1 11695 -
11695-7007-1 11695 -
13744-540-01 13744 -
13744-541-01 13744 -
13744-542-01 13744 -
13744-543-01 13744 -
17033-440-07 17033 -
17033-440-21 17033 -
17033-441-07 17033 -
17033-441-21 17033 -
17033-442-07 17033 -
17033-442-21 17033 -
17033-443-07 17033 -
17033-443-21 17033 -
17033-451-15 17033 -
32903-122-25 32903 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 5 Clinical 120 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-22)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-22)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-22)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-20)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-19)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-16)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-16)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-13)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-12)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-11)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-11)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-11)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-10)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-07)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-06)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-06)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-03)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-03)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-02)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-07-01)
Recent Revisions
  • side_effects updated 2026-07-22 19:08 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-22 19:08 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-22 19:08 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-22 18:40 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-22 18:40 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-22 18:40 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-22 08:29 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-22 08:29 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-22 08:29 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-20 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-20 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-20 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-19 13:48 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-19 13:48 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-19 13:48 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-16 16:34 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-16 16:34 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-16 16:34 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-16 15:43 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-16 15:43 by etl_backfill • Backfilled from existing medication fields

Usage

For the treatment of susceptible strains of the organisms causing the following infections: Respiratory tract infections (tonsillitis, tracheobronchitis) due to Staphylococcus aureus , Streptococcus spp., Escherichia coli , and Proteus mirabilis . Genitourinary tract infections (cystitis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Gastrointestinal tract infections (bacterial gastroenteritis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Bacterial dermatitis due to Staphylococcus aureus , Streptococcus spp., and Proteus mirabilis . Soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . For the treatment of susceptible strains of the organisms causing the following infections: Upper respiratory tract infections due to Staphylococcus aureus , Streptococcus spp., and E. coli . Genitourinary tract infections (cystitis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Gastrointestinal tract infections due to E. coli . Skin and soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Pasteurella multocida . For the treatment of baby pigs under 10 pounds for porcine colibacillosis caused by Escherichia coli susceptible to amoxicillin.

Contraindications

Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter animals during treatment or for 20 days after the latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment. Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Cat Decreased appetite (1) • Cat Bloody diarrhoea (1) • Dog Appetite loss (1) • Dog

Showing top 5 for Digestive.

Behavior
Behavioral disorder (1) • Cat Anxiety (1) • Cat

Showing top 5 for Behavior.

Other
Dehydration (1) • Cat Decreased red blood cell count (1) • Dog Decreased percentage of reticulocytes (1) • Dog Decreased packed cell volume (1) • Dog Decreased haemoglobin (1) • Dog
Show more (21)
Decreased haematocrit (1) • Dog Death by euthanasia (1) • Dog Death (1) • Dog Cough (1) • Dog Corneal ulcer (1) • Dog Constipation (1) • Dog Conjunctival oedema (1) • Dog Cholangitis (1) • Cat Blood in urine (1) • Dog Barking (1) • Dog Aspiration pneumonia (1) • Dog Arched back (1) • Cat Anal and rectal disorder NOS (1) • Dog Anaemia NOS (1) • Dog Abnormal ultrasound finding (1) • Cat Abnormal radiograph finding (1) • Dog Abnormal posture NOS (1) • Dog Abnormal posture (1) • Cat Abnormal cytology (1) • Dog Abdominal pain (1) • Dog Abdominal mass (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Deutsche Dogge, Great Dane, Female, 10 year, 47.174 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Vomiting, Appetite loss, Tiredness (lethargy), Heavy breathing, Death • Outcome: Died

  • Report ID: USA-USFDACVM-2026-US-012910
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 10.00 Year
  • Weight: 47.174 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Vomiting Appetite loss Tiredness (lethargy) Heavy breathing Death
Outcomes: Died

Dog, Retriever - Labrador, Female, 14 year, 34.927 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Urine leakage, Increased urine volume, Urinary incontinence, Haematuria, Elevated serum alkaline phosphatase… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-012700
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 14.00 Year
  • Weight: 34.927 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Urine leakage Increased urine volume Urinary incontinence Haematuria Elevated serum alkaline phosphatase Urinary tract infection Polyuria Polydipsia
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 6 month, 1.8 kilogram • Drug: MSK, Unknown • Reactions: Decreased appetite, Listless, Dehydration, Not himself/herself, Stumbling gait… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-009572
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 6.00 Month
  • Weight: 1.800 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Decreased appetite Listless Dehydration Not himself/herself Stumbling gait Arched back Abnormal posture Spinal pain NOS Knuckling Dysphoria Slow reflexes Reduced responses Dilated pupils Staring Elevated temperature Stiff gait Behavioral disorder (unspecified)
Outcomes: Ongoing

Dog, Crossbred Canine/dog, Male, 9 week • Drug: MSK, Unknown, Dose: 3 mL per animal, Frequency: 12 per hour • Reactions: Death by euthanasia, Lack of efficacy (bacteria) - Bordetella, Skin lump, Decreased haemoglobin, Hypokalaemia… • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2026-US-008597
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 9.00 Week
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Dose: 3 mL per animal
  • Frequency: 12 per hour
Reactions Reported:
Death by euthanasia Lack of efficacy (bacteria) - Bordetella Skin lump Decreased haemoglobin Hypokalaemia Decreased haematocrit Other abnormal test result NOS Low amylase Hyperproteinaemia Decreased packed cell volume Reduced globulins Eosinopenia Hyperphosphataemia Low platelet count Elevated creatine-kinase Hypoproteinaemia Elevated creatinine Elevated triglyceride Hyperglycaemia Neutrophilia Decreased percentage of reticulocytes Increased band neutrophilia Monocytosis Elevated serum alkaline phosphatase Leukocytosis NOS Elevated symmetrical dimethylarginine Hypoalbuminaemia Elevated aspartate aminotransferase Elevated total bilirubin Decreased red blood cell count Neutropenia Lymphopenia Hypernatraemia Elevated C-reactive protein Elevated alanine aminotransferase Elevated cholesterol Hyperchloraemia Elevated blood urea nitrogen Hypochloraemia Elevated lipase Distension of abdomen Leukopenia NOS
Outcomes: Euthanized

Dog, ['Chihuahua', 'Poodle (unspecified)'], Male, 16 year, 3.937 kilogram • Drug: MSK, Unassigned, Oral, Dose: 50 Milligram per animal, Frequency: 12 per hour • Reactions: Renal failure, Death by euthanasia, Leukocytosis NOS, Elevated blood urea nitrogen, Elevated serum alkaline phosphatase… • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2026-US-008052
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 16.00 Year
  • Weight: 3.937 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
  • Dose: 50 Milligram per animal
  • Frequency: 12 per hour
Reactions Reported:
Renal failure Death by euthanasia Leukocytosis NOS Elevated blood urea nitrogen Elevated serum alkaline phosphatase Not eating Not drinking Constipation Tiredness (lethargy) Hyperglycaemia Abnormal radiograph finding Corneal ulcer Walking slowly Neck pain - neurological Oral mass Toothache
Outcomes: Euthanized

Dog, ['Hound (unspecified)', 'Dog (unknown)'], Male, 8 year, 29.03 kilogram • Drug: MSK, Oral • Reactions: Diarrhea, Seizure NOS, Not eating, Vomiting • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-007126
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 8.00 Year
  • Weight: 29.030 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
Reactions Reported:
Diarrhea Seizure NOS Not eating Vomiting
Outcomes: Ongoing

Cat, Domestic Shorthair, Female, 6 year, 3.2 kilogram • Drug: MSK, Tablet, Oral, Frequency: 24 per hour • Reactions: Swollen eye, Ocular discharge, Squinting • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2026-US-001285
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 6.00 Year
  • Weight: 3.200 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Frequency: 24 per hour
Reactions Reported:
Swollen eye Ocular discharge Squinting
Outcomes: Outcome Unknown

Dog, Bulldog - French, Male, 4.96 month, 6.57 kilogram • Drug: MSK, Suspension, Unknown • Reactions: Anal and rectal disorder NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075322
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 4.96 Month
  • Weight: 6.570 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Suspension
Reactions Reported:
Anal and rectal disorder NOS
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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