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Enalapril

Detailed information about Enalapril

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

Treatment of mild, moderate, and severe (modified New York Heart Association Class II, III, IV) heart failure in dogs.

What to watch for:

  • Use 0.5 milligram per kilogram once daily
  • In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of 1.0 milligram per kilogram)
  • Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatment of dilated cardiomyopathy and furosemide with or without digoxin in the treatment of chronic valvular disease
  • The safety of enalapril for use in breeding dogs has not been established
  • Use in pregnant bitches is not recommended
  • wobbly/unsteady walking (1 reports)
  • trouble breathing (1 reports)
  • very low energy (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Use 0.5 milligram per kilogram once daily
  • In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of 1.0 milligram per kilogram)
  • Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatment of dilated cardiomyopathy and furosemide with or without digoxin in the treatment of chronic valvular disease
  • The safety of enalapril for use in breeding dogs has not been established
  • Use in pregnant bitches is not recommended

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Trouble breathing (dyspnea) (1 reports)
  • Tiredness (lethargy) (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 15, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC
Image coming soon
Enalapril

Enalapril

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available
Form: Tablet
Identifiers:
NADA: 141015 NDC Package: 73377-124-02 NDC Package: 73377-124-03 NDC Product: 73377
Source metadata:

Warnings / Contraindications

Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of 1.0 milligram per kilogram). Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatment of dilated cardiomyopathy and furosemide with or without digoxin in the treatment of chronic valvular disease. The safety of enalapril for use in breeding dogs has not been established. Use in pregnant bitches is not recommended. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of 1.0 milligram per kilogram). Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatment of dilated cardiomyopathy and furosemide with or without digoxin in the treatment of chronic valvular disease. The safety of enalapril for use in breeding dogs has not been established. Use in pregnant bitches is not recommended. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
25
Species represented
2
Grouped by Body System
Digestive (3) · Diarrhea, Decreased appetite, Appetite disorder NOS Neurologic (3) · Unsteady walking (ataxia), Tiredness (lethargy), Head tremor Behavior (1) · Behavioral disorder (unspecified) Other (25) · Trouble breathing (dyspnea), Laboured breathing, Irregular breathing
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Cat 1
Other 1 Cat 1
Neurologic 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Cat 1

Species coverage: Cat (19) Dog (13)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Cat Serious - 1
Other Cat Serious - 1
Neurologic Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Neurologic Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Digestive Cat Serious - 1
Other Cat Serious - 1
Digestive Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Behavior Dog Serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Source metadata:

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)
  • No owner handouts linked yet.
Official label / PI (0)
  • No official label or package insert links yet.
SPL (1)
  • Enacard® Tablets For Dogs · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1819/Enacard%C2%AE%20Tablets%20For%20Dogs
FOI (0)
  • No FOI links yet.
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 15, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Enacard® Tablets For Dogs
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Tablet • Oral
Applications: NADA 141-015
Documents: • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 20 • Cat 12 • View
Case summaries: 10 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Dilated cardiomyopathy (dogs)
Linked using: Fda_Label (0.95)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of 1.0 milligram per kilogram). Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatment of dilated cardiomyopathy and furosemide with or without digoxin in the treatment of chronic valvular disease. The safety of enalapril for use in breeding dogs has not been established. Use in pregnant bitches is not recommended. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Unsteady walking (ataxia) (1) Trouble breathing (dyspnea) (1) Tiredness (lethargy) (1) Laboured breathing (1) Irregular breathing (1) Inappropriate urination (1) Impaired vision (1) Hypokalaemia (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141015 NDC Package: 73377-124-02 NDC Package: 73377-124-03 NDC Product: 73377
Package NDC Product NDC Form / Route Status
73377-124-02 73377 -
73377-124-03 73377 -

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 3 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Diarrhoea, Vomiting, Lethargy (see also Central nervous system depression in 'Neurological'), Death by euthanasia, Seizure NO… (Official, 2026-02-12)
  • usage: Treatment of mild, moderate, and severe (modified New York Heart Association Class II, III, IV) heart failure in dogs. (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Enacard® Tablets For Dogs
RX
Enalapril Maleate
Tablet • Oral
Label highlights
Official documents
Boehringer lngelheim Animal Health USA Inc. NADA 141-015 W May 15, 2024

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each tablet contains either 1.0, 2.5, 5.0, 10.0, or 20.0 milligrams of enalapril maleate.
Dogs
Indication
Treatment of mild, moderate, and severe (modified New York Heart Association Class II, III, IV) heart failure in dogs.
Dosage
0.5 to 1.0 milligram of enalapril maleate per kilogram of body weight per day.
Limitations
Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of 1.0 milligram per kilogram). Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatment of dilated cardiomyopathy and furosemide with or without digoxin in the treatment of chronic valvular disease. The safety of enalapril for use in breeding dogs has not been established. Use in pregnant bitches is not recommended. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Usage

Treatment of mild, moderate, and severe (modified New York Heart Association Class II, III, IV) heart failure in dogs.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of 1.0 milligram per kilogram). Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatment of dilated cardiomyopathy and furosemide with or without digoxin in the treatment of chronic valvular disease. The safety of enalapril for use in breeding dogs has not been established. Use in pregnant bitches is not recommended. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Diarrhea (1) • Cat Decreased appetite (1) • Cat Appetite disorder NOS (1) • Dog

Showing top 5 for Digestive.

Neurologic
Unsteady walking (1) • Cat Tiredness (1) • Cat Head tremor (1) • Dog

Showing top 5 for Neurologic.

Behavior
Behavioral disorder (1) • Dog

Showing top 5 for Behavior.

Other
Trouble breathing (1) • Cat Laboured breathing (1) • Cat Irregular breathing (1) • Cat Intentional misuse (1) • Dog Inappropriate urination (1) • Cat
Show more (20)
Impaired vision (1) • Dog Hypokalaemia (1) • Cat Hypermetria (1) • Dog Hyperkalaemia (1) • Dog Heart murmur (1) • Cat Harsh lung sounds (1) • Cat Gastroenteritis (1) • Cat Elevated symmetrical dimethylarginine (1) • Dog Elevated serum alkaline phosphatase (1) • Dog Elevated blood urea nitrogen (1) • Dog Disorientation (1) • Cat Decreased haematocrit (1) • Cat Death by euthanasia (1) • Cat Cough (1) • Dog Congestive heart failure (1) • Cat Cognitive disorder NOS (1) • Dog Bronchitis (1) • Dog Administration error NOS (1) • Cat Abnormal posture NOS (1) • Cat Abnormal echocardiogram (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, ['Beagle', 'Terrier (unspecified)'], Female, 11 year, 21.772 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Head tremor, Hypermetria, Underdose • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-054757
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 11.00 Year
  • Weight: 21.772 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Head tremor Hypermetria Underdose
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Male, 15 year, 5.806 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Tiredness (lethargy), Pain NOS, Gastroenteritis, Recumbency • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055363
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 15.00 Year
  • Weight: 5.806 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Tiredness (lethargy) Pain NOS Gastroenteritis Recumbency
Outcomes: Ongoing

Dog, Beagle, Male, 15 year, 12.61 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Cognitive disorder NOS, Pacing, Partial deafness, Impaired vision, Behavioral disorder (unspecified)… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054448
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 15.00 Year
  • Weight: 12.610 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Cognitive disorder NOS Pacing Partial deafness Impaired vision Behavioral disorder (unspecified) Cough Appetite disorder NOS Tiredness (lethargy)
Outcomes: Ongoing

Dog, ['Terrier (unspecified)', 'Dog (unknown)'], Male, 12 year, 12.13 kilogram • Drug: MSK, Oral • Reactions: Bronchitis, Musculoskeletal disorder NOS, Cough, Not eating, Tarry or black stool… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055491
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 12.00 Year
  • Weight: 12.130 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
Reactions Reported:
Bronchitis Musculoskeletal disorder NOS Cough Not eating Tarry or black stool Diarrhea Hyperkalaemia Low sodium-potassium ratio
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 11 year • Drug: MSK, Oral, Dose: 0.35 Milligram per kilogram, Frequency: 24 per hour • Reactions: Decreased appetite, Tiredness (lethargy), Death by euthanasia • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2025-US-052789
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 11.00 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Dose: 0.35 Milligram per kilogram
  • Frequency: 24 per hour
Reactions Reported:
Decreased appetite Tiredness (lethargy) Death by euthanasia
Outcomes: Euthanized

Dog, ['Beagle', 'Crossbred Canine/dog'], Female, 15 year, 12.474 kilogram • Drug: MSK, Oral • Reactions: Urinary tract infection, Elevated serum alkaline phosphatase, Proteinuria, Pyuria, Elevated symmetrical dimethylarginine… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054660
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 15.00 Year
  • Weight: 12.474 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
Reactions Reported:
Urinary tract infection Elevated serum alkaline phosphatase Proteinuria Pyuria Elevated symmetrical dimethylarginine Elevated blood urea nitrogen Neurological signs NOS Intentional misuse Overdose
Outcomes: Ongoing

Dog, Chihuahua, Female, 11 year, 9.798 kilogram • Drug: MSK • Reactions: Syncope • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-052324
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 11.00 Year
  • Weight: 9.798 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
Reactions Reported:
Syncope
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 9 year, 4.536 kilogram • Drug: MSK, Oral, Dose: 2.50 Milligram per dose, Frequency: 12 per hour • Reactions: Not eating, Diarrhea, Not drinking, Irregular breathing, Laboured breathing… • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2025-US-046743
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 9.00 Year
  • Weight: 4.536 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Dose: 2.50 Milligram per dose
  • Frequency: 12 per hour
Reactions Reported:
Not eating Diarrhea Not drinking Irregular breathing Laboured breathing Trouble breathing (dyspnea) Congestive heart failure Pleural effusion Pulmonary oedema Decreased haematocrit Hypokalaemia Harsh lung sounds Death by euthanasia Administration error NOS
Outcomes: Euthanized

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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