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Pyriproxyfen

Detailed information about Pyriproxyfen

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

Your vet decides this. Here's what owners typically ask/watch for.

What to watch for:

  • very low energy (1 reports)
  • Overdose (1 reports)
  • Other abnormal test result NOS (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • very low energy
  • Overdose
  • Other abnormal test result NOS

Most reported reactions:

  • Tiredness (lethargy) (1 reports)
  • Overdose (1 reports)
  • Other abnormal test result NOS (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 7, 2026, 11:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC
Image coming soon
Pyriproxyfen

Pyriproxyfen

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
22
Species represented
2
Grouped by Body System
Digestive (4) · Drooling, Diarrhea, Bloody diarrhoea Skin & allergy (5) · Localised itching, Localised hair loss, Hives Neurologic (1) · Tiredness (lethargy) Behavior (1) · Behavioral disorder (unspecified) Effectiveness (3) · Lack of efficacy (endoparasite) - tapeworm, Lack of efficacy (endoparasite) - roundworm NOS, Lack of efficacy (ectoparasite) - flea Other (18) · Overdose, Other abnormal test result NOS, Not eating
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Cat 1
Effectiveness 1 Dog 1

Species coverage: Dog (21) Cat (11)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Skin & allergy Cat Non-serious - 1
Skin & allergy Cat Non-serious - 1
Effectiveness Cat Non-serious - 1
Effectiveness Dog Serious - 1
Effectiveness Dog Non-serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Skin & allergy Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Digestive Cat Non-serious - 1
Other Dog Serious - 1
Digestive Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Digestive Dog Serious - 1
Digestive Dog Serious - 1
Skin & allergy Dog Non-serious - 1
Behavior Cat Serious - 1
Skin & allergy Dog Non-serious - 1
Other Cat Non-serious - 1
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 7, 2026, 11:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 13 • Cat 14 • View
Case summaries: 10 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Tiredness (lethargy) (1) Overdose (1) Other abnormal test result NOS (1) Not eating (1) Non-regenerative anaemia (1) Mucous stool (1) Mixed Product (1) Lack of efficacy (endoparasite) - roundworm NOS (1)

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 1 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (ectoparasite) - flea, Pruritus, Vomiting, Lethargy (see also Central nervous system depression in 'Neurolog… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Drooling (1) • Cat Diarrhea (1) • Dog Bloody diarrhoea (1) • Dog Blood in vomit (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Localised itching (1) • Cat Localised hair loss (1) • Cat Hives (1) • Dog Biting - pruritus (1) • Dog Alopecia local (1) • Dog

Showing top 5 for Skin & allergy.

Neurologic
Tiredness (1) • Dog

Showing top 5 for Neurologic.

Behavior
Behavioral disorder (1) • Cat

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy (endoparasite) - tapeworm (1) • Cat Lack of efficacy (endoparasite) - roundworm NOS (1) • Dog Lack of efficacy (ectoparasite) - flea (1) • Dog

Showing top 5 for Effectiveness.

Other
Overdose (1) • Dog Other abnormal test result NOS (1) • Dog Not eating (1) • Dog Non-regenerative anaemia (1) • Dog Mucous stool (1) • Dog
Show more (13)
Mixed Product (1) • Cat Hypothermia (1) • Cat Hypoalbuminaemia (1) • Dog Hot spot (1) • Dog Gut sounds increased (1) • Dog Gastroenteritis (1) • Dog Gastritis (1) • Dog Digestive tract hypomotility (1) • Dog Dental calculus (1) • Dog Death (1) • Cat Cough, hacking (1) • Cat Chattering of teeth (1) • Cat Administration error NOS (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Cat (unknown), Female, 16 year • Drug: MSK, Solution, Topical, Dose: 1 tube per animal • Reactions: Localised itching, Rubbing, Skin discolouration NOS, Skin lesion NOS, Skin sore… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-053922
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 16.00 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
Reactions Reported:
Localised itching Rubbing Skin discolouration NOS Skin lesion NOS Skin sore Localised hair loss
Outcomes: Outcome Unknown

Dog, Dog (unknown), Male, 3 year, 9.525 kilogram • Drug: MSK, Unassigned, Topical, Dose: 1 dose per animal, Frequency: 1 per month • Reactions: Lack of efficacy (ectoparasite) - flea • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-047850
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 3.00 Year
  • Weight: 9.525 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Unassigned
  • Dose: 1 dose per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (ectoparasite) - flea
Outcomes: Outcome Unknown

Dog, ['Retriever - Labrador', 'Dog (unknown)'], Unknown, 4 year, 24.94 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal • Reactions: Hot spot, Skin sore, Itching, Self trauma, Alopecia local… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-048328
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Unknown
  • Age: 4.00 Year
  • Weight: 24.940 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
Reactions Reported:
Hot spot Skin sore Itching Self trauma Alopecia local Lack of efficacy (ectoparasite) - flea Biting - pruritus
Outcomes: Ongoing

Dog, Retriever - Chesapeake Bay, Female, 5.83 year, 20.77 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal • Reactions: Seizure NOS, Overdose • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-046457
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 5.83 Year
  • Weight: 20.770 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
Reactions Reported:
Seizure NOS Overdose
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Male, 8 year, 7.26 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal • Reactions: Lack of efficacy (endoparasite) - tapeworm • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-047725
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 8.00 Year
  • Weight: 7.260 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
Reactions Reported:
Lack of efficacy (endoparasite) - tapeworm
Outcomes: Outcome Unknown

Dog, Brittany, Female, 7 year, 20.41 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal, Frequency: 1 per month • Reactions: Vomiting • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-046584
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 20.410 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
  • Frequency: 1 per month
Reactions Reported:
Vomiting
Outcomes: Recovered/Normal

Dog, Retriever - Labrador, Female, 8 year, 28.12 kilogram • Drug: MSK, Solution, Topical • Reactions: Vomiting, Not eating, Tiredness (lethargy), Pancreatitis NOS, Lack of efficacy (endoparasite) - roundworm NOS… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-045276
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 8.00 Year
  • Weight: 28.120 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
Reactions Reported:
Vomiting Not eating Tiredness (lethargy) Pancreatitis NOS Lack of efficacy (endoparasite) - roundworm NOS Other abnormal test result NOS Shaking Non-regenerative anaemia Pale mucous membrane Diarrhea Gastroenteritis Bloody diarrhoea Gastritis Blood in vomit Trembling Mucous stool Hives Hypoalbuminaemia Gut sounds increased Tense abdomen Digestive tract hypomotility Skin scab Dental calculus Lack of efficacy (ectoparasite) - flea
Outcomes: Outcome Unknown

Cat, Domestic Longhair, Male, 11 year, 5.44 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal, Frequency: 1 per month • Reactions: Death • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-042915
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 11.00 Year
  • Weight: 5.440 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 dose per animal
  • Frequency: 1 per month
Reactions Reported:
Death
Outcomes: Died

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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