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Pergolide Mesylate

Detailed information about Pergolide Mesylate

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease) in horses.

What to watch for:

  • For oral use in horses only
  • The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated
  • The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known
  • however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation
  • Vomiting bile (1 reports)
  • Vomiting (1 reports)
  • very low energy (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • For oral use in horses only
  • The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated
  • The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known
  • however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation
  • Vomiting bile

Most reported reactions:

  • Vomiting bile (1 reports)
  • Vomiting (1 reports)
  • Tiredness (lethargy) (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 9, 2026, 3:14 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC
Image coming soon
Pergolide Mesylate

Pergolide Mesylate

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available
Form: Tablet
Identifiers:
ANADA: 200823 NADA: 141331 NDC Package: 58597-8072-1 NDC Package: 58597-8072-2 NDC Package: 58597-8072-4 NDC Package: 58597-8072-6 NDC Package: 62991-2528-1 NDC Package: 62991-2528-2 NDC Package: 62991-2528-3 NDC Package: 62991-2528-5 NDC Package: 62991-2528-6 NDC Package: 62991-2528-7 NDC Package: 62991-2528-8 NDC Package: 73377-297-01 NDC Package: 73377-297-02 NDC Package: 73377-297-03 NDC Package: 73377-297-04 NDC Package: 83251-004-00 NDC Product: 58597 NDC Product: 62991
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
19
Reported cases
16
Serious reports
0
Species represented
2
Grouped by Body System
Digestive (4) · Vomiting bile, Vomiting, Nausea Neurologic (2) · Tiredness (lethargy), Lethargy (see also Central nervous system depression in 'Neurological') Behavior (1) · Anxiety Other (12) · Third eyelid protrusion, Tachypnoea, Syncope
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Digestive 1 Dog 0
Digestive 1 Dog 0
Neurologic 1 Dog 0
Other 1 Cat 0
Other 1 Dog 0
Other 1 Dog 0
Other 1 Dog 0
Digestive 1 Dog 0

Species coverage: Dog (13) Cat (6)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Non-serious - 1
Digestive Dog Non-serious - 1
Neurologic Dog Non-serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Digestive Dog Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Behavior Cat Non-serious - 1
Other Dog Non-serious - 1
Neurologic Dog Unknown - -
Other Dog Unknown - -
Digestive Dog Unknown - -
Source metadata:

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)
  • No owner handouts linked yet.
Official label / PI (0)
  • No official label or package insert links yet.
SPL (2)
  • Zygolide® · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/18159/Zygolide%C2%AE
  • Prascend® · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2215/Prascend%C2%AE
FOI (2)
  • A-200823-Q-0001-OT-AA_foi.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/17829
  • UCM280354.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/890
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 9, 2026, 3:14 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Prascend® Zygolide®
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: No Use Class Stated Or Implied
Rx/OTC: RX
Form/route: Tablet • Oral
Applications: ANADA 200-823 • NADA 141-331
Documents: 2 (FOI: 2) • SPL: 2 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 6 • Cat 6 • View
Case summaries: 8 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: E24.9
Cushing syndrome, unspecified

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation. (Contraindication, High)
Top reaction signals
Vomiting bile (1) Vomiting (1) Tiredness (lethargy) (1) Third eyelid protrusion (1) Tachypnoea (1) Syncope (1) Shaking (1) Nausea (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200823 NADA: 141331 NDC Package: 58597-8072-1 NDC Package: 58597-8072-2 NDC Package: 58597-8072-4 NDC Package: 58597-8072-6 NDC Package: 62991-2528-1 NDC Package: 62991-2528-2 NDC Package: 62991-2528-3 NDC Package: 62991-2528-5 NDC Package: 62991-2528-6 NDC Package: 62991-2528-7 NDC Package: 62991-2528-8 NDC Package: 73377-297-01 NDC Package: 73377-297-02 NDC Package: 73377-297-03 NDC Package: 73377-297-04 NDC Package: 83251-004-00 NDC Product: 58597 NDC Product: 62991 NDC Product: 73377 NDC Product: 83251
Package NDC Product NDC Form / Route Status
58597-8072-1 58597 -
58597-8072-2 58597 -
58597-8072-4 58597 -
58597-8072-6 58597 -
62991-2528-1 62991 -
62991-2528-2 62991 -
62991-2528-3 62991 -
62991-2528-5 62991 -
62991-2528-6 62991 -
62991-2528-7 62991 -
62991-2528-8 62991 -
73377-297-01 73377 -
73377-297-02 73377 -
73377-297-03 73377 -
73377-297-04 73377 -
83251-004-00 83251 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • A-200823-Q-0001-OT-AA_foi.pdf • FOI summary • Official • Jan. 8, 2026
    FDA FOI summary for application 200823
  • UCM280354.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 141331

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 5 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, o… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Emesis, Vomiting, Emesis (multiple), Lethargy (see also Central nervous system depression in 'Neurologic… (Official, 2026-02-12)
  • usage: For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing's Disease) in horses. For the control of clinical signs… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Zygolide®
RX
Pergolide mesylate
Tablet • Oral
Label highlights
Official documents
Dechra Veterinary Products LLC ANADA 200-823 Approved Jan 8, 2026
Prascend®
RX
Pergolide mesylate
Tablet • Oral
Label highlights
Official documents
Boehringer lngelheim Animal Health USA, Inc. NADA 141-331 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Composition / specifications
1 mg of pergolide (as pergolide mesylate) per tablet
Horses
Indication

For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease) in horses.

Dosage

Administer orally at a starting dose of 2 mcg/kg once daily. Dosage may be adjusted to effect, not to exceed 4 mcg/kg daily.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: No Use Class Stated Or Implied
Composition / specifications
Each tablet contains 1 milligram (mg) pergolide, as pergolide mesylate.
Horses
Indication
For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing's Disease) in horses.
Dosage
Administer orally at a starting dose of 2 mcg/kg once daily. Dosage may be adjusted to effect, not to exceed 4 mcg/kg daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
  • Summary

    For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing's Disease) in horses.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease) in horses.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing's Disease) in horses. For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease) in horses.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting bile (1) • Dog Vomiting (1) • Dog Nausea (1) • Dog Diarrhea • Dog

Showing top 5 for Digestive.

Neurologic
Tiredness (1) • Dog Tiredness (lethargy) • Dog

Showing top 5 for Neurologic.

Behavior
Anxiety (1) • Cat

Showing top 5 for Behavior.

Other
Third eyelid protrusion (1) • Cat Tachypnoea (1) • Dog Syncope (1) • Dog Shaking (1) • Dog Hyperthermia (1) • Cat
Show more (6)
Hyperexcitation (1) • Cat Hallucination (1) • Cat Dry heaving (1) • Dog Dilated pupils (1) • Cat Chattering of teeth (1) • Dog Accidental exposure (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Dog (unknown), Unknown, 22.68 kilogram • Drug: MSK, Tablet, Oral, Dose: 0.50 Milligram per animal • Reactions: Vomiting, Shaking, Accidental exposure • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-020401
  • Serious AE: No
  • Treated For AE: No
  • Sex: Unknown
  • Weight: 22.680 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 0.50 Milligram per animal
Reactions Reported:
Vomiting Shaking Accidental exposure
Outcomes: Outcome Unknown

Dog, Shepherd Dog - Australian, Male, 5 year, 22.68 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per animal • Reactions: Vomiting bile, Tiredness (lethargy), Nausea, Tachypnoea • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-020364
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 5.00 Year
  • Weight: 22.680 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per animal
Reactions Reported:
Vomiting bile Tiredness (lethargy) Nausea Tachypnoea
Outcomes: Outcome Unknown

Dog, Rottweiler, Female, 7.5 month, 27.216 kilogram • Drug: MSK, Tablet, Oral • Reactions: Vomiting • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-011484
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 7.50 Month
  • Weight: 27.216 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
Reactions Reported:
Vomiting
Outcomes: Recovered/Normal

Dog, Dog (unknown), Unknown • Drug: MSK, Tablet, Oral, Dose: 0.50 tablet per animal • Reactions: Dry heaving, Chattering of teeth • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2024-US-077604
  • Serious AE: No
  • Treated For AE: No
  • Sex: Unknown
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 0.50 tablet per animal
Reactions Reported:
Dry heaving Chattering of teeth
Outcomes: Recovered/Normal

Dog, Dog (unknown), Unknown • Drug: MSK, Tablet, Oral • Reactions: Syncope • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2024-US-068793
  • Serious AE: No
  • Treated For AE: No
  • Sex: Unknown
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
Reactions Reported:
Syncope
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Female, 4.082 kilogram • Drug: MSK, Tablet, Oral, Dose: 0.50 tablet per animal • Reactions: Third eyelid protrusion, Hyperthermia • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2024-US-030123
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Weight: 4.082 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 0.50 tablet per animal
Reactions Reported:
Third eyelid protrusion Hyperthermia
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Male, 2 year, 6.804 kilogram • Drug: MSK, Tablet, Oral, Dose: 0.07 Milligram per kilogram, Frequency: 1 per day • Reactions: Hallucination, Hyperexcitation, Anxiety, Dilated pupils • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2024-US-002644
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 2.00 Year
  • Weight: 6.804 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 0.07 Milligram per kilogram
  • Frequency: 1 per day
Reactions Reported:
Hallucination Hyperexcitation Anxiety Dilated pupils
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 1 year, 4.99 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 Milligram per animal • Reactions: Third eyelid protrusion • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2018-US-047691
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 1.00 Year
  • Weight: 4.990 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 Milligram per animal
Reactions Reported:
Third eyelid protrusion
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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