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Sevoflurane

Detailed information about Sevoflurane

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

For induction and maintenance of general anesthesia in dogs.

What to watch for:

  • trouble breathing (1 reports)
  • Loss of appetite (1 reports)
  • Injection site granuloma (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • trouble breathing
  • Loss of appetite
  • Injection site granuloma

Most reported reactions:

  • Trouble breathing (dyspnea) (1 reports)
  • Loss of appetite (1 reports)
  • Injection site granuloma (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 17, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 24, 2026, 11:06 AM UTC
Image coming soon
Sevoflurane

Sevoflurane

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available
Form: Liquid, Liquid (Solution)
Identifiers:
ANADA: 200438 ANADA: 200467 ANADA: 200830 NADA: 141103 NDC Package: 11695-0505-2 NDC Package: 13985-711-25 NDC Package: 17033-092-25 NDC Package: 46066-116-04 NDC Package: 54771-5458-2 NDC Package: 66794-018-10 NDC Package: 66794-018-25 NDC Package: 68504-011-01 NDC Product: 11695 NDC Product: 13985 NDC Product: 17033 NDC Product: 46066 NDC Product: 54771 NDC Product: 66794 NDC Product: 68504
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
17
Species represented
2
Grouped by Body System
Digestive (3) · Loss of appetite, Drooling, Diarrhea Other (29) · Trouble breathing (dyspnea), Injection site granuloma, Increased red blood cell count
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Dog 1
Digestive 1 Dog 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (17) Cat (15)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Other Dog Serious - 1
Digestive Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Digestive Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Digestive Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Source metadata:

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)
  • No owner handouts linked yet.
Official label / PI (0)
  • No official label or package insert links yet.
SPL (4)
  • Sevoflurane · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/18331/Sevoflurane
  • Petrem® · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/174/Petrem%C2%AE
  • Sevospire™ · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2577/Sevospire%E2%84%A2
  • SevoFlo® · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1386/SevoFlo%C2%AE
FOI (4)
  • FOI Summary oA 200-830 Approved January 30, 2026.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/17972
  • ucm061373.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1164
  • UCM202417.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1181
  • ucm117135.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/635
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 17, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 24, 2026, 11:06 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Petrem® SevoFlo® Sevoflurane Sevospire™
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Liquid, Liquid (Solution) • Inhalation
Applications: ANADA 200-830 • ANADA 200-438 • ANADA 200-467 • NADA 141-103
NDC: Packages 11695-0505-2 46066-116-04 68504-011-01 • Products 11695 46066 68504
Documents: 4 (FOI: 4) • SPL: 4 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 26 • Cat 8 • View
Case summaries: 12 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Trouble breathing (dyspnea) (1) Loss of appetite (1) Injection site granuloma (1) Hypotension (1) Hyperthermia (1) Hyperglycaemia (1) Hyperactivity (1) General pain (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200438 ANADA: 200467 ANADA: 200830 NADA: 141103 NDC Package: 11695-0505-2 NDC Package: 13985-711-25 NDC Package: 17033-092-25 NDC Package: 46066-116-04 NDC Package: 54771-5458-2 NDC Package: 66794-018-10 NDC Package: 66794-018-25 NDC Package: 68504-011-01 NDC Product: 11695 NDC Product: 13985 NDC Product: 17033 NDC Product: 46066 NDC Product: 54771 NDC Product: 66794 NDC Product: 68504
Package NDC Product NDC Form / Route Status
11695-0505-2 11695 -
13985-711-25 13985 -
17033-092-25 17033 -
46066-116-04 46066 -
54771-5458-2 54771 -
66794-018-10 66794 -
66794-018-25 66794 -
68504-011-01 68504 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 7 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and fac… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Vomiting, Death, Lethargy (see also Central nervous system depression in 'Neurological'), Bradycardia, Diarrhoea, Lack of eff… (Official, 2026-02-12)
  • usage: SevoFlo is indicated for induction and maintenance of general anesthesia in dogs. For induction and maintenance of general anesthesia in dogs. (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Sevoflurane
RX
Sevoflurane
Liquid • Inhalation
Label highlights
Official documents
Parnell Technologies Pty. Ltd. ANADA 200-830 Approved Feb 2, 2026
Petrem®
RX
Sevoflurane
Liquid (Solution) • Inhalation
Label highlights
Official documents
Piramal Pharma Ltd. ANADA 200-438 Approved Mar 14, 2024
Sevospire™
RX
Sevoflurane
Liquid • Inhalation
Label highlights
Official documents
Dechra Veterinary Products LLC ANADA 200-467 Approved Oct 14, 2022
SevoFlo®
RX
Sevoflurane
Liquid • Inhalation
Label highlights
Official documents
Zoetis Inc. NADA 141-103 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Composition / specifications
250 mL sevoflurane
Dogs
Indication

For induction and maintenance of general anesthesia in dogs.

Dosage

For induction of surgical anesthesia: up to 7 percent sevoflurane. For maintenance of surgical anesthesia: 3.7 to 4percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Label highlights
Indication
For induction and maintenance of general anesthesia in dogs.
Dosage
For induction of surgical anesthesia: Up to 7 percent sevoflurane with oxygen. For maintenance of surgical anesthesia: 3.7 to 4 percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
250 mL sevoflurane
Dogs
Indication
For induction and maintenance of general anesthesia in dogs.
Dosage
Induction: For mask induction using Sevoflurane alone, inspired concentrations of up to 7% sevoflurane with oxygen are employed to induce surgical anesthesia in the healthy dog. Maintenance: Surgical levels of anesthesia in the healthy dog may be maintained with inhaled concentrations of 3.7-4.0% sevoflurane in oxygen in the absence of premedication and 3.3-3.6% in the presence of premedication.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Dogs
Indication
SevoFlo is indicated for induction and maintenance of general anesthesia in dogs.
Dosage
For induction of surgical anesthesia: Up to 7 percent sevoflurane with oxygen. For maintenance of surgical anesthesia: 3.7 to 4 percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    PETREM is indicated for induction and maintenance of general anesthesia in dogs.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For induction and maintenance of general anesthesia in dogs.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For induction and maintenance of general anesthesia.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

SevoFlo is indicated for induction and maintenance of general anesthesia in dogs. For induction and maintenance of general anesthesia in dogs.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Dog Drooling (1) • Dog Diarrhea (1) • Cat

Showing top 5 for Digestive.

Other
Trouble breathing (1) • Dog Injection site granuloma (1) • Dog Increased red blood cell count (1) • Cat Hypotension (1) • Cat Hyperthermia (1) • Dog
Show more (24)
Hypersensitivity reaction (1) • Cat Hyperglycaemia (1) • Cat Hyperactivity (1) • Dog Hiding (1) • Cat General pain (1) • Dog Fear/fearful (1) • Cat Excessive chewing, licking and/or grooming (1) • Dog Elevated serum alkaline phosphatase (1) • Dog Disorder of red blood cell NOS (1) • Cat Dilated pupils (1) • Cat Defect Unknown/Not Specified (1) • Cat Death (1) • Dog Burn (1) • Dog Bacterial skin infection NOS (1) • Dog Arthritis (1) • Dog Application site ulcer (1) • Cat Application site scratching (1) • Cat Application site scab (1) • Cat Application site lesion (1) • Cat Application site bleeding (1) • Cat Allergic oedema (1) • Dog Acid-base disorder (1) • Dog Abnormal electrocardiogram (1) • Dog Abnormal cytology (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, ['Dachshund - Standard Long-haired', 'Dog (unknown)'], Female, 12 year, 5.942 kilogram • Drug: MSK, Unassigned, Respiratory (Inhalation) • Reactions: Localised pain NOS, Intervertebral disc disease, Excessive chewing, licking and/or grooming, Skin necrosis, Reddening of the skin… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054276
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 12.00 Year
  • Weight: 5.942 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Respiratory (Inhalation)
  • Form: Unassigned
Reactions Reported:
Localised pain NOS Intervertebral disc disease Excessive chewing, licking and/or grooming Skin necrosis Reddening of the skin Burn Sedation prolonged Medication error NOS
Outcomes: Ongoing

Dog, ['Dog (unknown)', 'Poodle (unspecified)'], Male, 8 month, 21.863 kilogram • Drug: MSK, Solution, Unknown • Reactions: Hyperthermia, Tachycardia, Abnormal electrocardiogram, Tachypnoea • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055950
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 8.00 Month
  • Weight: 21.863 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Solution
Reactions Reported:
Hyperthermia Tachycardia Abnormal electrocardiogram Tachypnoea
Outcomes: Ongoing

Dog, Dog (unknown), Male, 10 year, 32.659 kilogram • Drug: MSK, Solution, Unknown • Reactions: Mass NOS, Lymph node abscess, Lymphadenopathy, Tachycardia, Drooling… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055759
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 10.00 Year
  • Weight: 32.659 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Solution
Reactions Reported:
Mass NOS Lymph node abscess Lymphadenopathy Tachycardia Drooling Elevated serum alkaline phosphatase Monocytosis Neutrophilia Leucocytosis NOS Acid-base disorder Musculoskeletal disorder NOS Luxation/subluxation Arthritis Muscle tremor Tachypnoea Trouble breathing (dyspnea) Bacterial skin infection NOS Trauma NOS Hyperthermia Loss of appetite Oedema NOS Tiredness (lethargy) General pain
Outcomes: Outcome Unknown

Dog, Dog (unknown), Unknown • Drug: MSK, Unknown • Reactions: Regurgitation • Outcome: Outcome Unknown

  • Report ID: GBR-USFDACVM-2025-GB-000058
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Unknown
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Regurgitation
Outcomes: Outcome Unknown

Dog, Weimaraner, Female, 16 month, 28.1 kilogram • Drug: MSK, Respiratory (Inhalation), Frequency: 1 per day • Reactions: Injection site swelling, Hyperactivity, Abnormal cytology, Injection site skin change NOS, Local swelling… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-054707
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 16.00 Month
  • Weight: 28.100 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Respiratory (Inhalation)
  • Frequency: 1 per day
Reactions Reported:
Injection site swelling Hyperactivity Abnormal cytology Injection site skin change NOS Local swelling Injection site inflammation Injection site granuloma
Outcomes: Outcome Unknown

Dog, Dachshund (unspecified), Male, 7 year, 5.443 kilogram • Drug: MSK, Solution, Unknown • Reactions: Allergic oedema • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-054215
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 7.00 Year
  • Weight: 5.443 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Solution
Reactions Reported:
Allergic oedema
Outcomes: Recovered/Normal

Dog, Dog (unknown), Unknown • Drug: MSK, Unknown • Reactions: Regurgitation, Death, Trouble breathing (dyspnea) • Outcome: Died

  • Report ID: GBR-USFDACVM-2025-GB-000059
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Unknown
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Regurgitation Death Trouble breathing (dyspnea)
Outcomes: Died

Cat, Domestic Shorthair, Male, 2.83 year, 5.77 kilogram • Drug: MSK, Respiratory (Inhalation) • Reactions: Application site ulcer, Increased red blood cell count, Application site scab, Disorder of red blood cell NOS, Application site bleeding… • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-045337
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 2.83 Year
  • Weight: 5.770 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Respiratory (Inhalation)
Reactions Reported:
Application site ulcer Increased red blood cell count Application site scab Disorder of red blood cell NOS Application site bleeding Application site scratching Application site lesion Diarrhea
Outcomes: Recovered/Normal

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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