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Afoxolaner 136 Mg Chewable Tablets

Detailed information about Afoxolaner 136 Mg Chewable Tablets

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

Your vet decides this. Here's what owners typically ask/watch for.

What to watch for:

  • Weakness (1 reports)
  • Urinary incontinence (1 reports)
  • wobbly/unsteady walking (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Weakness
  • Urinary incontinence
  • wobbly/unsteady walking

Most reported reactions:

  • Weakness (1 reports)
  • Urinary incontinence (1 reports)
  • Unsteady walking (ataxia) (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:04 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC
Image coming soon
Afoxolaner 136 Mg Chewable Tablets

Afoxolaner 136 Mg Chewable Tablets

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
17
Reported cases
16
Serious reports
0
Species represented
2
Grouped by Body System
Digestive (1) · Diarrhea Skin & allergy (1) · Itching Neurologic (2) · Unsteady walking (ataxia), Tiredness (lethargy) Effectiveness (5) · Lack of efficacy (endoparasite) - Trichostrongylus, Lack of efficacy (endoparasite) - heartworm, Lack of efficacy (ectoparasite) - tick NOS Other (8) · Weakness, Urinary incontinence, Underdose
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Dog 0
Other 1 Dog 0
Neurologic 1 Dog 0
Other 1 Dog 0
Neurologic 1 Dog 0
Other 1 Dog 0
Other 1 Dog 0
Other 1 Dog 0

Species coverage: Dog (15) Cat (2)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Neurologic Dog Non-serious - 1
Other Dog Non-serious - 1
Neurologic Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Other Cat Non-serious - 1
Skin & allergy Cat Non-serious - 1
Other Dog Non-serious - 1
Digestive Dog Unknown - -
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 16 • Cat 2 • View
Case summaries: 7 (showing 7) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Weakness (1) Urinary incontinence (1) Unsteady walking (ataxia) (1) Underdose (1) Tiredness (lethargy) (1) Stumbling gait (1) Reluctant to move (1) Not eating (1)

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 1 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Vomiting, Skin disorders NOS, Lack of efficacy (tick), Diarrhoea, Lack of efficacy (flea), Lethargy (see also Central nervous… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Diarrhea • Dog

Showing top 5 for Digestive.

Skin & allergy
Itching (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Dog Tiredness (1) • Dog

Showing top 5 for Neurologic.

Effectiveness
Lack of efficacy (endoparasite) - Trichostrongylus (1) • Dog Lack of efficacy (endoparasite) - heartworm (1) • Dog Lack of efficacy (ectoparasite) - tick NOS (1) • Dog Lack of efficacy (ectoparasite) - flea (1) • Dog Lack of efficacy (bacteria) - Borrelia (1) • Dog

Showing top 5 for Effectiveness.

Other
Weakness (1) • Dog Urinary incontinence (1) • Dog Underdose (1) • Dog Stumbling gait (1) • Dog Reluctant to move (1) • Dog
Show more (3)
Not eating (1) • Dog Laboured breathing (1) • Cat Inappropriate urination (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Retriever - Golden, Female, 9 year, 33.112 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per animal • Reactions: Unsteady walking (ataxia), Tiredness (lethargy), Stumbling gait, Weakness, Not eating… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055816
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 9.00 Year
  • Weight: 33.112 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per animal
Reactions Reported:
Unsteady walking (ataxia) Tiredness (lethargy) Stumbling gait Weakness Not eating Urinary incontinence Inappropriate urination Reluctant to move
Outcomes: Outcome Unknown

Dog, Dog (other), Female, 4 year, 40.55 kilogram • Drug: MSK, Tablet, Unknown • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-053007
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 4.00 Year
  • Weight: 40.550 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Tablet
Reactions Reported:
Lack of efficacy (endoparasite) - heartworm
Outcomes: Outcome Unknown

Dog, Retriever - Labrador, Male, 7 year, 55.338 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 dose per animal • Reactions: Lack of efficacy (ectoparasite) - flea, Underdose • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-053412
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 7.00 Year
  • Weight: 55.338 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 dose per animal
Reactions Reported:
Lack of efficacy (ectoparasite) - flea Underdose
Outcomes: Outcome Unknown

Dog, Deutsche Dogge, Great Dane, Female, 1.5 year, 51.256 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per animal, Frequency: 1 per month • Reactions: Lack of efficacy (ectoparasite) - tick NOS, Lack of efficacy (bacteria) - Borrelia • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055245
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 1.50 Year
  • Weight: 51.256 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (ectoparasite) - tick NOS Lack of efficacy (bacteria) - Borrelia
Outcomes: Ongoing

Dog, ['Retriever - Labrador', 'Dog (unknown)'], Male, 2 year, 36.38 kilogram • Drug: MSK, Tablet, Unknown • Reactions: Lack of efficacy (endoparasite) - Trichostrongylus • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-025707
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 2.00 Year
  • Weight: 36.380 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Tablet
Reactions Reported:
Lack of efficacy (endoparasite) - Trichostrongylus
Outcomes: Outcome Unknown

Cat, Mixed (Cat), Female, 8 month, 3.6 kilogram • Drug: MSK, Tablet, chewable, Oral • Reactions: Itching, Laboured breathing • Outcome: Ongoing

  • Report ID: BRA-USFDACVM-2017-BR-000373
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 8.00 Month
  • Weight: 3.600 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
Reactions Reported:
Itching Laboured breathing
Outcomes: Ongoing

Cat, Mixed (Cat), Female, 3 month, 1.9 kilogram • Drug: MSK, Tablet, chewable, Oral • Reactions: Itching, Laboured breathing • Outcome: Ongoing

  • Report ID: BRA-USFDACVM-2017-BR-000376
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 3.00 Month
  • Weight: 1.900 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
Reactions Reported:
Itching Laboured breathing
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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