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Toceranib Phosphate

Detailed information about Toceranib Phosphate

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

For the treatment of Patnaik grade II or III, recurrent, cutaneous mast cell tumors with or without regional lymph node involvement in dogs.

What to watch for:

  • For oral use in dogs only
  • Do not use in dogs used for breeding, or for pregnant or lactating bitches
  • Do not split tablets
  • Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian
  • Loss of appetite (1 reports)
  • Intentional misuse (1 reports)
  • Injection site skin discolouration (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • For oral use in dogs only
  • Do not use in dogs used for breeding, or for pregnant or lactating bitches
  • Do not split tablets
  • Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian
  • Loss of appetite

Most reported reactions:

  • Loss of appetite (1 reports)
  • Intentional misuse (1 reports)
  • Injection site skin discolouration (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 17, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC
Image coming soon
Toceranib Phosphate

Toceranib Phosphate

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available
Form: Tablet
Identifiers:
NADA: 141295 NDC Package: 54771-1690-1 NDC Package: 54771-1691-1 NDC Package: 54771-1692-1 NDC Package: 71052-210-10 NDC Package: 71052-210-25 NDC Package: 72969-072-10 NDC Package: 73309-089-01 NDC Package: 73309-089-02 NDC Package: 73309-089-03 NDC Package: 73377-156-01 NDC Package: 73377-156-02 NDC Package: 82774-003-01 NDC Package: 82774-003-02 NDC Package: 86032-034-01 NDC Package: 86197-007-01 NDC Product: 54771 NDC Product: 71052 NDC Product: 72969 NDC Product: 73309
Source metadata:

Warnings / Contraindications

For oral use in dogs only. Do not use in dogs used for breeding, or for pregnant or lactating bitches. Do not split tablets. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: For oral use in dogs only. Do not use in dogs used for breeding, or for pregnant or lactating bitches. Do not split tablets. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
28
Species represented
2
Grouped by Body System
Digestive (4) · Vomiting, Loss of appetite, Diarrhea Neurologic (1) · Convulsion Effectiveness (1) · Lack of efficacy - NOS Other (26) · Intentional misuse, Injection site skin discolouration, Injection site serosanguinous discharge
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Digestive 1 Cat 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (19) Cat (13)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Non-serious - 1
Digestive Cat Serious - 1
Effectiveness Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Neurologic Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Digestive Cat Non-serious - 1
Other Cat Non-serious - 1
Source metadata:

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)
  • No owner handouts linked yet.
Official label / PI (2)
  • PALLADIA N141295C0016.pdf · Labeling
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadLabeling/887
  • PALLADIA N141295C0016.pdf · Labeling
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadLabeling/888
SPL (1)
  • Palladia® · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2033/Palladia%C2%AE
FOI (1)
  • UCM164091.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/860
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 17, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Palladia®
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Tablet • Oral
Applications: NADA 141-295
Documents: 3 (FOI: 1) • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 16 • Cat 8 • View
Case summaries: 10 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Mast Cell Tumor (MCT)
Linked using: Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: C96.A
Mast cell neoplasm

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • For oral use in dogs only. Do not use in dogs used for breeding, or for pregnant or lactating bitches. Do not split tablets. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Loss of appetite (1) Intentional misuse (1) Injection site skin discolouration (1) Injection site serosanguinous discharge (1) Injection site reaction NOS (1) Injection site discharge NOS (1) Increased respiratory rate (1) Increased heart rate (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141295 NDC Package: 54771-1690-1 NDC Package: 54771-1691-1 NDC Package: 54771-1692-1 NDC Package: 71052-210-10 NDC Package: 71052-210-25 NDC Package: 72969-072-10 NDC Package: 73309-089-01 NDC Package: 73309-089-02 NDC Package: 73309-089-03 NDC Package: 73377-156-01 NDC Package: 73377-156-02 NDC Package: 82774-003-01 NDC Package: 82774-003-02 NDC Package: 86032-034-01 NDC Package: 86197-007-01 NDC Product: 54771 NDC Product: 71052 NDC Product: 72969 NDC Product: 73309 NDC Product: 73377 NDC Product: 82774 NDC Product: 86032 NDC Product: 86197
Package NDC Product NDC Form / Route Status
54771-1690-1 54771 -
54771-1691-1 54771 -
54771-1692-1 54771 -
71052-210-10 71052 -
71052-210-25 71052 -
72969-072-10 72969 -
73309-089-01 73309 -
73309-089-02 73309 -
73309-089-03 73309 -
73377-156-01 73377 -
73377-156-02 73377 -
82774-003-01 82774 -
82774-003-02 82774 -
86032-034-01 86032 -
86197-007-01 86197 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • PALLADIA N141295C0016.pdf • Official label • Official • May 17, 2021
    FDA official labeling for application 141295
  • PALLADIA N141295C0016.pdf • Official label • Official • May 17, 2021
    FDA official labeling for application 141295
  • UCM164091.pdf • FOI summary • Official • May 17, 2021
    FDA FOI summary for application 141295

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 6 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: For oral use in dogs only. Do not use in dogs used for breeding, or for pregnant or lactating bitches. Do not split tablets. Federal (USA) law restricts this d… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Diarrhoea, Vomiting, Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Neutropenia, Leucopen… (Official, 2026-02-12)
  • usage: For the treatment of Patnaik grade II or III, recurrent, cutaneous mast cell tumors with or without regional lymph node involvement in dogs. (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Palladia®
RX
Toceranib Phosphate
Tablet • Oral
Label highlights
Official documents
Zoetis Inc. NADA 141-295 Approved May 17, 2021

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each tablet contains 10, 15, or 50 mg toceranib as toceranib phosphate.
Dogs
Indication
For the treatment of Patnaik grade II or III, recurrent, cutaneous mast cell tumors with or without regional lymph node involvement in dogs.
Dosage
Administer an initial dosage of 3.25 mg/kg (1.48 mg/lb) body weight, orally every other day.
Limitations
For oral use in dogs only. Do not use in dogs used for breeding, or for pregnant or lactating bitches. Do not split tablets. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

For the treatment of Patnaik grade II or III, recurrent, cutaneous mast cell tumors with or without regional lymph node involvement in dogs.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

For oral use in dogs only. Do not use in dogs used for breeding, or for pregnant or lactating bitches. Do not split tablets. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Loss of appetite (1) • Cat Diarrhea (1) • Dog Appetite loss (1) • Cat

Showing top 5 for Digestive.

Neurologic
Convulsion (1) • Dog

Showing top 5 for Neurologic.

Effectiveness
Lack of efficacy - NOS (1) • Cat

Showing top 5 for Effectiveness.

Other
Intentional misuse (1) • Dog Injection site skin discolouration (1) • Dog Injection site serosanguinous discharge (1) • Dog Injection site reaction NOS (1) • Dog Injection site discharge NOS (1) • Dog
Show more (21)
Increased respiratory rate (1) • Dog Increased heart rate (1) • Dog Gut pain (1) • Cat Fixed pupil (1) • Dog Eye neoplasm NOS (1) • Cat Elevated temperature (1) • Dog Elevated renal parameters (1) • Cat Dilated pupils (1) • Dog Digestive tract neoplasm NOS (1) • Cat Digestive tract disorder NOS (1) • Cat Decreased red blood cell count (1) • Cat Death by euthanasia (1) • Cat Death (1) • Cat Cyanotic mucous membranes (1) • Dog Coma (1) • Dog Chronic renal failure (1) • Cat Cellulitis (1) • Dog Cardiorespiratory arrest (1) • Dog Bloody stool (1) • Dog Asystole (1) • Dog Abdominal mass (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Boxer (German Boxer), Female, 2.3 year, 28.7 kilogram • Drug: MSK, Tablet, Oral, Dose: 15 Milligram per dose, Frequency: 48 per hour • Reactions: Death, Injection site discharge NOS, Swollen limb, Pain NOS, Not eating… • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-055852
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 2.30 Year
  • Weight: 28.700 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 15 Milligram per dose
  • Frequency: 48 per hour
Reactions Reported:
Death Injection site discharge NOS Swollen limb Pain NOS Not eating Not drinking Uncomfortable Elevated temperature Increased heart rate Increased respiratory rate Pitting oedema Injection site skin discolouration Injection site serosanguinous discharge Injection site reaction NOS Wound Cellulitis Local skin slough Convulsion Cardiorespiratory arrest Panting Fixed pupil Dilated pupils Cyanotic mucous membranes Coma Neurological signs NOS Premature ventricular contractions Ventricular fibrillation Asystole
Outcomes: Died

Dog, Terrier - Scottish, Female, 9.5 year, 10.28 kilogram • Drug: MSK, Unknown • Reactions: Mammary gland neoplasm NOS, Low platelet count, Nausea, Leucopenia NOS, Neutropenia… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-049474
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 9.50 Year
  • Weight: 10.280 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Mammary gland neoplasm NOS Low platelet count Nausea Leucopenia NOS Neutropenia Lung nodule NOS
Outcomes: Outcome Unknown

Dog, Bulldog - English, Male, 7 year, 27.216 kilogram • Drug: MSK, Tablet, Oral • Reactions: Tremors, Diarrhea • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-043938
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 7.00 Year
  • Weight: 27.216 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
Reactions Reported:
Tremors Diarrhea
Outcomes: Ongoing

Dog, Bulldog - French, Male, 12 year, 11.34 kilogram • Drug: MSK, Tablet, Oral, Dose: 25 Milligram per animal • Reactions: Bloody stool, Intentional misuse • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-043858
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 12.00 Year
  • Weight: 11.340 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 25 Milligram per animal
Reactions Reported:
Bloody stool Intentional misuse
Outcomes: Ongoing

Dog, Pug, Female, 4 year, 9.072 kilogram • Drug: MSK, Tablet, Unknown, Dose: 25 Milligram per animal • Reactions: Vomiting • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-041014
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 4.00 Year
  • Weight: 9.072 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Tablet
  • Dose: 25 Milligram per animal
Reactions Reported:
Vomiting
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 20 year, 3.4 kilogram • Drug: MSK, Unknown • Reactions: Digestive tract neoplasm NOS, Eye neoplasm NOS, Not eating, Not drinking, Death by euthanasia… • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2025-US-036809
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 20.00 Year
  • Weight: 3.400 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Digestive tract neoplasm NOS Eye neoplasm NOS Not eating Not drinking Death by euthanasia Swollen lymph node Metastatic neoplasia Elevated renal parameters
Outcomes: Euthanized

Cat, Cat (other), Male • Drug: MSK, Tablet, Oral • Reactions: Decreased red blood cell count, Gut pain, Weakness, Loss of appetite, Vocalisation… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-022668
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
Reactions Reported:
Decreased red blood cell count Gut pain Weakness Loss of appetite Vocalisation Digestive tract disorder NOS Intentional misuse
Outcomes: Outcome Unknown

Cat, Mixed (Cat), Mixed, 6 year • Drug: MSK, Tablet, Oral • Reactions: Tiredness (lethargy), Loss of appetite, Neutropenia, Vomiting, Diarrhea… • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-021212
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Mixed
  • Age: 6.00 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
Reactions Reported:
Tiredness (lethargy) Loss of appetite Neutropenia Vomiting Diarrhea Chronic renal failure Pulmonary metastases Death
Outcomes: Died

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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