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Milbemycin Oxime + Lufenuron

Detailed information about Milbemycin Oxime + Lufenuron

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

Your vet decides this. Here's what owners typically ask/watch for.

What to watch for:

  • Death (1 reports)
  • Cutaneous haemangiosarcoma (1 reports)
  • Vomiting (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Death
  • Cutaneous haemangiosarcoma
  • Vomiting

Most reported reactions:

  • Death (1 reports)
  • Cutaneous haemangiosarcoma (1 reports)
  • Vomiting (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:04 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Image coming soon
Milbemycin Oxime + Lufenuron

Milbemycin Oxime + Lufenuron

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
18
Reported cases
14
Serious reports
2
Species represented
1
Grouped by Body System
Digestive (2) · Vomiting, Diarrhea Skin & allergy (3) · Rash, Itching, Hair loss NOS Neurologic (2) · Seizure NOS, Lethargy (see also Central nervous system depression in 'Neurological') Behavior (1) · Head shake - behavioural disorder Effectiveness (1) · Lack of efficacy (endoparasite) - heartworm Other (9) · Skin disorders NOS, Scratching, Other abnormal test result NOS
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Dog 1
Other 1 Dog 1
Digestive 1 Dog 0
Other 1 Dog 0
Other 1 Dog 0
Skin & allergy 1 Dog 0
Other 1 Dog 0
Effectiveness 1 Dog 0

Species coverage: Dog (18)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Skin & allergy Dog Non-serious - 1
Other Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Skin & allergy Dog Non-serious - 1
Behavior Dog Non-serious - 1
Skin & allergy Dog Non-serious - 1
Other Dog Non-serious - 1
Digestive Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Neurologic Dog Unknown - -
Other Dog Unknown - -
Neurologic Dog Unknown - -
Other Dog Unknown - -
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 10 • Cat 0 • View
Case summaries: 5 (showing 5) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Death (1) Cutaneous haemangiosarcoma (1) Vomiting (1) Skin disorders NOS (1) Scratching (1) Rash (1) Other abnormal test result NOS (1) Lack of efficacy (endoparasite) - heartworm (1)

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 1 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Vomiting, Diarrhoea, Lethargy (see also Central nervous system depression in 'Ne… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Diarrhea (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Rash (1) • Dog Itching (1) • Dog Hair loss NOS (1) • Dog

Showing top 5 for Skin & allergy.

Neurologic
Tiredness (lethargy) • Dog Seizure NOS • Dog

Showing top 5 for Neurologic.

Behavior
Head shake - behavioural disorder (1) • Dog

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy (endoparasite) - heartworm (1) • Dog

Showing top 5 for Effectiveness.

Other
Skin disorders NOS (1) • Dog Scratching (1) • Dog Other abnormal test result NOS (1) • Dog Eye inflamed (1) • Dog Defect Unknown/Not Specified (1) • Dog
Show more (4)
Death (1) • Dog Cutaneous haemangiosarcoma (1) • Dog Not eating • Dog INEFFECTIVE, HEARTWORM LARVAE • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, ['Beagle', 'Dog (unknown)'], Female, 1.5 year, 6.4 kilogram • Drug: MSK, Oral, Frequency: 1 per month • Reactions: Other abnormal test result NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055808
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 1.50 Year
  • Weight: 6.400 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Frequency: 1 per month
Reactions Reported:
Other abnormal test result NOS
Outcomes: Outcome Unknown

Dog, Bulldog - French, Male, 5 year, 12.7 kilogram • Drug: MSK, Unknown • Reactions: Rash, Eye inflamed • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-051885
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 5.00 Year
  • Weight: 12.700 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Rash Eye inflamed
Outcomes: Ongoing

Dog, Shepherd Dog - German, Female, 9 year, 37.285 kilogram • Drug: MSK, Unknown • Reactions: Cutaneous haemangiosarcoma, Death • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-045280
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 9.00 Year
  • Weight: 37.285 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Cutaneous haemangiosarcoma Death
Outcomes: Died

Dog, Maltese, Female, 3 year, 4.08 kilogram • Drug: MSK, Unknown • Reactions: Diarrhea, Itching, Hair loss NOS, Vomiting, Scratching… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-045182
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 3.00 Year
  • Weight: 4.080 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Diarrhea Itching Hair loss NOS Vomiting Scratching Head shake - behavioural disorder Skin disorders NOS Defect Unknown/Not Specified
Outcomes: Ongoing

Dog, Shepherd Dog - Belgian Malinois, Male, 8 year, 21.773 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-042291
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 8.00 Year
  • Weight: 21.773 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Lack of efficacy (endoparasite) - heartworm
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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