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Amitraz

Detailed information about Amitraz

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

For the treatment of generalized demodicosis (Demodex canis).

What to watch for:

  • Continue treatment until no viable mites are found in skin scrapings at 2 successive treatments, or until 6 treatments have been applied
  • Do not use for treatment of localized demodicosis or scabies
  • wobbly/unsteady walking (1 reports)
  • Syncope (1 reports)
  • Stomach upset (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Continue treatment until no viable mites are found in skin scrapings at 2 successive treatments, or until 6 treatments have been applied
  • Do not use for treatment of localized demodicosis or scabies
  • wobbly/unsteady walking
  • Syncope
  • Stomach upset

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Syncope (1 reports)
  • Stomach upset (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 9, 2026, 3:15 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Image coming soon
Amitraz

Amitraz

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available
Form: Liquid
Identifiers:
NADA: 120299
Source metadata:

Warnings / Contraindications

Continue treatment until no viable mites are found in skin scrapings at 2 successive treatments, or until 6 treatments have been applied. Do not use for treatment of localized demodicosis or scabies. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Continue treatment until no viable mites are found in skin scrapings at 2 successive treatments, or until 6 treatments have been applied. Do not use for treatment of localized demodicosis or scabies. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
27
Reported cases
22
Serious reports
13
Species represented
1
Grouped by Body System
Digestive (2) · Loss of appetite, Vomiting Skin & allergy (2) · Itching, Alopecia general Neurologic (3) · Unsteady walking (ataxia), Tiredness (lethargy), Lethargy (see also Central nervous system depression in 'Neurological') Behavior (2) · Biting -aggression, Behavioral disorder (unspecified) Effectiveness (3) · Lack of efficacy (endoparasite) - NOS, Lack of efficacy (ectoparasite) - tick NOS, Lack of efficacy (ectoparasite) - flea Other (15) · Weight gain, Syncope, Stomach upset
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Effectiveness 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (27)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Other Dog Non-serious - 1
Neurologic Dog Serious - 1
Neurologic Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Digestive Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Behavior Dog Serious - 1
Behavior Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Digestive Dog Unknown - -
Neurologic Dog Unknown - -
Effectiveness Dog Unknown - -
Skin & allergy Dog Unknown - -
Skin & allergy Dog Unknown - -
Source metadata:

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)
  • No owner handouts linked yet.
Official label / PI (0)
  • No official label or package insert links yet.
SPL (1)
  • Mitaban® Liquid Concentrate · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1751/Mitaban%C2%AE%20Liquid%20Concentrate
FOI (0)
  • No FOI links yet.
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 9, 2026, 3:15 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Mitaban® Liquid Concentrate
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Liquid • Topical
Applications: NADA 120-299
Documents: • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 8 • Cat 0 • View
Case summaries: 5 (showing 5) • View
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Demodicosis
Linked using: Fda_Label (0.95)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Continue treatment until no viable mites are found in skin scrapings at 2 successive treatments, or until 6 treatments have been applied. Do not use for treatment of localized demodicosis or scabies. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Unsteady walking (ataxia) (1) Syncope (1) Stomach upset (1) Polyneuritis (1) Lack of efficacy (ectoparasite) - tick NOS (1) Drug administration error (1) Dilated pupils (1) Death by euthanasia (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 120299

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 3 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Continue treatment until no viable mites are found in skin scrapings at 2 successive treatments, or until 6 treatments have been applied. Do not use for treatm… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Pruritus, Vomiting, Drug administration error, Alope… (Official, 2026-02-12)
  • usage: For the treatment of generalized demodicosis (Demodex canis). (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Mitaban® Liquid Concentrate
RX
Amitraz
Liquid • Topical
Label highlights
Official documents
Zoetis Inc. NADA 120-299 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Amitraz liquid contains 19.9 percent amitraz in an organic solvent.
Dogs
Indication
For the treatment of generalized demodicosis (Demodex canis).
Dosage
One 10.6 milliliter bottle per 2 gallons of warm water (250 parts per million) for each treatment, for a total of 3 to 6 treatments, 14 days apart.
Limitations
Continue treatment until no viable mites are found in skin scrapings at 2 successive treatments, or until 6 treatments have been applied. Do not use for treatment of localized demodicosis or scabies. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Usage

For the treatment of generalized demodicosis (Demodex canis).

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Continue treatment until no viable mites are found in skin scrapings at 2 successive treatments, or until 6 treatments have been applied. Do not use for treatment of localized demodicosis or scabies. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Dog Vomiting • Dog

Showing top 5 for Digestive.

Skin & allergy
Itching • Dog Alopecia general • Dog

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Dog Tiredness (1) • Dog Tiredness (lethargy) • Dog

Showing top 5 for Neurologic.

Behavior
Biting -aggression (1) • Dog Behavioral disorder (1) • Dog

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy (endoparasite) - NOS (1) • Dog Lack of efficacy (ectoparasite) - tick NOS (1) • Dog Lack of efficacy (ectoparasite) - flea • Dog

Showing top 5 for Effectiveness.

Other
Weight gain (1) • Dog Syncope (1) • Dog Stomach upset (1) • Dog Polyneuritis (1) • Dog Palpable mass NOS (1) • Dog
Show more (10)
Ocular discharge (1) • Dog Eyelid lump (1) • Dog Drug dose administration interval too short (1) • Dog Drug administration error (1) • Dog Dilated pupils (1) • Dog Death by euthanasia (1) • Dog Cognitive disorder NOS (1) • Dog Blindness (1) • Dog Anterior uveitis (1) • Dog Adipsia (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, ['Retriever - Labrador', 'Terrier (unspecified)'], Male, 5 year, 19.9 kilogram • Drug: MSK, Topical, Dose: 1 collar per unknown • Reactions: Syncope, Stomach upset, Lack of efficacy (ectoparasite) - tick NOS, Drug administration error, Drug dose administration interval too short • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2023-US-011531
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 5.00 Year
  • Weight: 19.900 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Dose: 1 collar per unknown
Reactions Reported:
Syncope Stomach upset Lack of efficacy (ectoparasite) - tick NOS Drug administration error Drug dose administration interval too short
Outcomes: Outcome Unknown

Dog, Dachshund (unspecified), Male, 1 year, 9.5 kilogram • Drug: MSK, Topical, Dose: 1 collar per unknown • Reactions: Syncope, Stomach upset, Lack of efficacy (ectoparasite) - tick NOS, Cognitive disorder NOS, Death by euthanasia… • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2023-US-011351
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 1.00 Year
  • Weight: 9.500 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Dose: 1 collar per unknown
Reactions Reported:
Syncope Stomach upset Lack of efficacy (ectoparasite) - tick NOS Cognitive disorder NOS Death by euthanasia Behavioral disorder (unspecified) Biting -aggression Drug administration error
Outcomes: Euthanized

Dog, Retriever - Labrador, Female, 8 year, 42.365 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy (endoparasite) - NOS, Ocular discharge, Weight gain, Eyelid lump, Palpable mass NOS • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2021-US-044720
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 8.00 Year
  • Weight: 42.365 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Lack of efficacy (endoparasite) - NOS Ocular discharge Weight gain Eyelid lump Palpable mass NOS
Outcomes: Ongoing

Dog, Bulldog - French, Male, 5 month • Drug: MSK, Solution, Topical • Reactions: Dilated pupils, Unsteady walking (ataxia), Blindness, Anterior uveitis, Polyneuritis • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2018-US-045794
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 5.00 Month
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
Reactions Reported:
Dilated pupils Unsteady walking (ataxia) Blindness Anterior uveitis Polyneuritis
Outcomes: Ongoing

Dog, Terrier - Bull, Female, 5 month, 10.433 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal • Reactions: Loss of appetite, Adipsia, Tiredness (lethargy) • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2018-US-019263
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 5.00 Month
  • Weight: 10.433 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 dose per animal
Reactions Reported:
Loss of appetite Adipsia Tiredness (lethargy)
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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