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Milbemycin Oxime, Praziquantel

Detailed information about Milbemycin Oxime, Praziquantel

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

Your vet decides this. Here's what owners typically ask/watch for.

What to watch for:

  • Palpebral disorder NOS (1 reports)
  • Not himself/herself (1 reports)
  • Lack of efficacy - heartworm (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Palpebral disorder NOS
  • Not himself/herself
  • Lack of efficacy - heartworm

Most reported reactions:

  • Palpebral disorder NOS (1 reports)
  • Not himself/herself (1 reports)
  • Lack of efficacy (endoparasite) - heartworm (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 1, 2026, 11:05 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Image coming soon
Milbemycin Oxime, Praziquantel

Milbemycin Oxime, Praziquantel

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
23
Reported cases
16
Serious reports
8
Species represented
2
Grouped by Body System
Digestive (2) · Drooling, Diarrhea Skin & allergy (3) · Swelling around eye, Facial swelling (possible allergy), Facial swelling (see also Skin) Neurologic (4) · Tiredness (lethargy), Head tilt - neurological disorder, Lethargy (see also Central nervous system depression in Neurological) Effectiveness (3) · Lack of efficacy (endoparasite) - heartworm, Lack of efficacy (endoparasite) - tapeworm, Lack of efficacy (endoparasite) - hookworm Other (11) · Skin lump, Reddening of the skin, Panting
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Dog 1
Other 1 Dog 1
Effectiveness 1 Dog 1
Other 1 Dog 1
Neurologic 1 Dog 1
Other 1 Dog 1
Digestive 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (21) Cat (2)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Cat Non-serious - 1
Skin & allergy Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Effectiveness Dog Serious - 1
Other Dog Serious - 1
Neurologic Dog Serious - 1
Skin & allergy Dog Non-serious - 1
Other Dog Serious - 1
Digestive Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Unknown - -
Neurologic Cat Unknown - -
Effectiveness Dog Unknown - -
Effectiveness Dog Unknown - -
Neurologic Dog Unknown - -
Skin & allergy Dog Unknown - -
Digestive Dog Unknown - -
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 1, 2026, 11:05 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 19 • Cat 1 • View
Case summaries: 6 (showing 6) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Palpebral disorder NOS (1) Not himself/herself (1) Lack of efficacy (endoparasite) - heartworm (1) Horizontal nystagmus (1) Head tilt - neurological disorder (1) Facial paralysis (1) Drooling (1) Abnormal menace reflex test (1)

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 1 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Vomiting, Diarrhoea, Lethargy (see also Central nervous system depression in Neu… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Drooling (1) • Dog Diarrhea • Dog

Showing top 5 for Digestive.

Skin & allergy
Swelling around eye (1) • Dog Facial swelling (possible allergy) (1) • Dog

Showing top 5 for Skin & allergy.

Neurologic
Tiredness (1) • Cat Head tilt - neurological disorder (1) • Dog Tiredness (lethargy) • Cat

Showing top 5 for Neurologic.

Effectiveness
Lack of efficacy (endoparasite) - heartworm (1) • Dog Lack of efficacy (endoparasite) - tapeworm • Dog Lack of efficacy (endoparasite) - hookworm • Dog

Showing top 5 for Effectiveness.

Other
Skin lump (1) • Dog Reddening of the skin (1) • Dog Panting (1) • Dog Palpebral disorder NOS (1) • Dog Not himself/herself (1) • Dog
Show more (6)
Horizontal nystagmus (1) • Dog Facial paralysis (1) • Dog Cough, hacking (1) • Dog Cough (1) • Dog Abnormal menace reflex test (1) • Dog Other abnormal test result NOS • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Schnauzer - Miniature, Female, 3 year, 7.484 kilogram • Drug: MSK, Tablet, chewable, Oral • Reactions: Panting, Facial swelling (possible allergy), Swelling around eye, Reddening of the skin • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-051409
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 3.00 Year
  • Weight: 7.484 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
Reactions Reported:
Panting Facial swelling (possible allergy) Swelling around eye Reddening of the skin
Outcomes: Recovered/Normal

Dog, Terrier - Bull - American Pit, Female, 8 year, 29.211 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Facial paralysis, Drooling, Not himself/herself, Horizontal nystagmus, Abnormal menace reflex test… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-050499
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 8.00 Year
  • Weight: 29.211 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Facial paralysis Drooling Not himself/herself Horizontal nystagmus Abnormal menace reflex test Palpebral disorder NOS Head tilt - neurological disorder
Outcomes: Ongoing

Dog, Dachshund (unspecified), Female, 11 year, 8.4 kilogram • Drug: MSK, Tablet, chewable, Oral • Reactions: Skin lump • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-042953
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 11.00 Year
  • Weight: 8.400 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
Reactions Reported:
Skin lump
Outcomes: Outcome Unknown

Dog, Shepherd Dog - Belgian Malinois, Female, 2 year, 29.484 kilogram • Drug: MSK, Tablet, chewable, Oral, Frequency: 1 per month • Reactions: Cough, hacking, Cough • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-040843
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 2.00 Year
  • Weight: 29.484 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Frequency: 1 per month
Reactions Reported:
Cough, hacking Cough
Outcomes: Ongoing

Dog, Crossbred Canine/dog, Male, 2 year, 12.519 kilogram • Drug: MSK, Tablet, chewable, Oral • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-036391
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 2.00 Year
  • Weight: 12.519 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
Reactions Reported:
Lack of efficacy (endoparasite) - heartworm
Outcomes: Ongoing

Cat, Domestic Shorthair, Female, 2 year, 3.1 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 Other per animal • Reactions: Tiredness (lethargy) • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2024-US-079781
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 2.00 Year
  • Weight: 3.100 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 Other per animal
Reactions Reported:
Tiredness (lethargy)
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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