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Afoxolaner 11.3 Mg Chewable Tablets

Detailed information about Afoxolaner 11.3 Mg Chewable Tablets

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

Your vet decides this. Here's what owners typically ask/watch for.

What to watch for:

  • Panleucopenia (1 reports)
  • Other abnormal test result NOS (1 reports)
  • Not drinking (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Panleucopenia
  • Other abnormal test result NOS
  • Not drinking

Most reported reactions:

  • Panleucopenia (1 reports)
  • Other abnormal test result NOS (1 reports)
  • Not drinking (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 9, 2026, 3:15 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Image coming soon
Afoxolaner 11.3 Mg Chewable Tablets

Afoxolaner 11.3 Mg Chewable Tablets

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
22
Species represented
2
Grouped by Body System
Digestive (3) · Vomiting, Loss of appetite, Bloody diarrhoea Skin & allergy (1) · Hair loss Neurologic (1) · Tiredness (lethargy) Behavior (1) · Anxiety Effectiveness (1) · Lack of efficacy (bacteria) - Borrelia Other (25) · Panting, Panleucopenia, Other abnormal test result NOS
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (27) Cat (5)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Non-serious - 1
Neurologic Cat Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Digestive Cat Non-serious - 1
Other Dog Serious - 1
Effectiveness Dog Non-serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Skin & allergy Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Digestive Dog Serious - 1
Other Dog Serious - 1
Behavior Dog Non-serious - 1
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 9, 2026, 3:15 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 7 • Cat 7 • View
Case summaries: 7 (showing 7) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Panleucopenia (1) Other abnormal test result NOS (1) Not drinking (1) Lymphocytosis (1) Low serum alkaline phosphatase (1) Lateral recumbency (1) Increased percentage reticulocytes (1) Hypokalaemia (1)

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 1 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (tick), Skin disorders NOS, Vomiting, Lack of efficacy (flea), Lack of efficacy (ectoparasite) - NOS, Diarrh… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Loss of appetite (1) • Cat Bloody diarrhoea (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Hair loss (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Tiredness (1) • Cat

Showing top 5 for Neurologic.

Behavior
Anxiety (1) • Dog

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy (bacteria) - Borrelia (1) • Dog

Showing top 5 for Effectiveness.

Other
Panting (1) • Dog Panleucopenia (1) • Dog Other abnormal test result NOS (1) • Dog Not eating (1) • Dog Not drinking (1) • Dog
Show more (20)
Lymphocytosis (1) • Dog Low serum alkaline phosphatase (1) • Dog Lateral recumbency (1) • Dog Increased percentage reticulocytes (1) • Dog Hypothermia (1) • Cat Hypokalaemia (1) • Dog Hypoalbuminaemia (1) • Dog Haematuria (1) • Dog Fever (1) • Dog Elevated lipase (1) • Dog Elevated amylase (1) • Dog Dilated pupils (1) • Dog Dehydration (1) • Dog Decreased cholesterol (1) • Dog Death (1) • Dog Crystalluria (1) • Dog Collapse (1) • Dog Cervical ventroflexion (1) • Cat Bradycardia (1) • Dog Bilirubinuria (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Terrier - Yorkshire, Female, 7 year, 4.395 kilogram • Drug: MSK, Oral, Dose: 0.50 tablet per animal, Frequency: 1 per day • Reactions: Restlessness, Uncomfortable, Bloody diarrhoea, Tiredness (lethargy), Dehydration… • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-042117
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 4.395 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Dose: 0.50 tablet per animal
  • Frequency: 1 per day
Reactions Reported:
Restlessness Uncomfortable Bloody diarrhoea Tiredness (lethargy) Dehydration Hypoalbuminaemia Low serum alkaline phosphatase Decreased cholesterol Elevated amylase Elevated lipase Hypokalaemia Increased percentage reticulocytes Lymphocytosis Collapse Lateral recumbency Unresponsive to stimuli Bradycardia Weak pulse Dilated pupils Death
Outcomes: Died

Dog, Spitz - German Pomeranian, Female, 15 month, 3.311 kilogram • Drug: MSK, Oral, Dose: 1 tablet per animal, Frequency: 1 per month • Reactions: Lack of efficacy (bacteria) - Borrelia • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-029208
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 15.00 Month
  • Weight: 3.311 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Dose: 1 tablet per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (bacteria) - Borrelia
Outcomes: Outcome Unknown

Dog, Terrier (unspecified), Female, 5 year, 2.449 kilogram • Drug: MSK, Oral, Dose: 1 dose per animal • Reactions: Vomiting • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2024-US-079393
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 5.00 Year
  • Weight: 2.449 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Dose: 1 dose per animal
Reactions Reported:
Vomiting
Outcomes: Recovered/Normal

Dog, ['Maltese', 'Poodle - Miniature'], Male, 3.5 year, 3.221 kilogram • Drug: MSK, Oral, Dose: 1 tablet per animal • Reactions: Tiredness (lethargy), Not eating, Fever, Not drinking, Panleucopenia… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2024-US-056061
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 3.50 Year
  • Weight: 3.221 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Dose: 1 tablet per animal
Reactions Reported:
Tiredness (lethargy) Not eating Fever Not drinking Panleucopenia Bilirubinuria Haematuria Other abnormal test result NOS Proteinuria Pyuria Crystalluria
Outcomes: Ongoing

Dog, Terrier - Yorkshire, Male, 2 year, 4.173 kilogram • Drug: MSK, Oral, Dose: 1 tablet per animal, Frequency: 1 per month • Reactions: Shaking, Panting, Whining, Anxiety, Not eating • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2024-US-080684
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 2.00 Year
  • Weight: 4.173 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Dose: 1 tablet per animal
  • Frequency: 1 per month
Reactions Reported:
Shaking Panting Whining Anxiety Not eating
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Female, 13 year, 3.6 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 dose per unknown • Reactions: Skin lesion NOS, Hair loss, Scaly condition NOS • Outcome: Outcome Unknown

  • Report ID: AUS-USFDACVM-2017-AU-000194
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 13.00 Year
  • Weight: 3.600 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 dose per unknown
Reactions Reported:
Skin lesion NOS Hair loss Scaly condition NOS
Outcomes: Outcome Unknown

Cat, European, Unknown, 4 month, 1.5 kilogram • Drug: MSK, Tablet, chewable, Oral • Reactions: Loss of appetite, Hypothermia, Tiredness (lethargy), Cervical ventroflexion • Outcome: Outcome Unknown

  • Report ID: FRA-USFDACVM-2016-FR-000176
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Unknown
  • Age: 4.00 Month
  • Weight: 1.500 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
Reactions Reported:
Loss of appetite Hypothermia Tiredness (lethargy) Cervical ventroflexion
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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