Meds A-Z

Hyaluronate Sodium

Detailed information about Hyaluronate Sodium

Official label facts Owner quick guide first Marketing clearly labeled

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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

FDA application profile · official_label
FDA application profile · official_label
Medication usage source · fda_animal_drugs
Hyvisc® · official_label
openFDA adverse-event data · openfda

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

Treatment of carpal or fetlock joint dysfunction due to acute or chronic noninfectious synovitis associated with equine osteoarthritis.

What to watch for:

For intra-articular injection in horses only
Treatment may be repeated at weekly intervals for a total of three treatments
Do not use in horse intended for human consumption
must not be administered intravascularly
Do not use in horses intended for human consumption
For intraarticular injection in horses only
Treatment may be repeated at weekly intervals for a total of four treatments
Not for use in horses intended for food

When to call the vet:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Trouble breathing.
Facial swelling or hives.
Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to ask your vet today:

Is this medicine the right fit for my pet’s current symptoms?
Which warning signs mean I should call back right away?
How should I handle missed doses or refusal to take the medicine?

Safety & side effects

What to watch:

For intra-articular injection in horses only
Treatment may be repeated at weekly intervals for a total of three treatments
Do not use in horse intended for human consumption
must not be administered intravascularly
Do not use in horses intended for human consumption

When to call your vet:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Trouble breathing.

Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness

Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).

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Hyaluronate Sodium

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Zoetis Inc.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both

Manufacturer: Zoetis Inc.

Form: Injectable Solution, Liquid (Solution)

Identifiers:

ANADA: 200432 NADA: 112048 NADA: 122578 NADA: 139913 NADA: 140474 NADA: 140806 NADA: 140883 NDC Package: 0010-3140-01 NDC Package: 0010-3141-01 NDC Package: 0010-3142-01 NDC Package: 0010-4130-01 NDC Package: 0010-4705-01 NDC Package: 0010-4705-02 NDC Package: 17030-098-01 NDC Package: 17030-098-12 NDC Package: 17033-045-10 NDC Product: 0010 NDC Product: 17030 NDC Product: 17033

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/140806 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/140883 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source

Warnings / Contraindications

For intra-articular injection in horses only. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horse intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intra-articular injection in horses only; must not be administered intravascularly. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intraarticular injection in horses only. Treatment may be repeated at weekly intervals for a total of four treatments. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

High: For intra-articular injection in horses only. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horse intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intra-articular injection in horses only; must not be administered intravascularly. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intraarticular injection in horses only. Treatment may be repeated at weekly intervals for a total of four treatments. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Source metadata:

https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)

No owner handouts linked yet.

Official label / PI (0)

No official label or package insert links yet.

SPL (9)

Hyalovet® · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1442/Hyalovet%C2%AE
Legend® Multi Dose · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1853/Legend%C2%AE%20Multi%20Dose
Legend® Injectable Solution · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1852/Legend%C2%AE%20Injectable%20Solution
Hyvisc® · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1725/Hyvisc%C2%AE
Equron® · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2464/Equron%C2%AE
Hylartin® V Injection · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1501/Hylartin%C2%AE%20V%20Injection
Hylartin® V · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1500/Hylartin%C2%AE%20V
NexHA™ · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2342/NexHA%E2%84%A2
Synacid™ · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1784/Synacid%E2%84%A2

FOI (7)

N140806_Org_5_31_88.pdf · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/3655
ucm054829.pdf · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/515
N140883_Orig_9_12_1991.pdf · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/3577
N122578_Supp_09_30_1998.pdf · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1623
UCM478007.pdf · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/466
UCM381702.pdf · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1158
UCM478013.pdf · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/487

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/3655 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1442/Hyalovet%C2%AE · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/515 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/3577 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1853/Legend%C2%AE%20Multi%20Dose · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1852/Legend%C2%AE%20Injectable%20Solution · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1623 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1725/Hyvisc%C2%AE · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/466 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2464/Equron%C2%AE · document · SPL

Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness

Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).

Official (FDA)

Identity: Generic ingredient • FDA branded products available

Official FDA brands: Equron® Hyalovet® Hylartin® V Injection Hylartin® V Hyvisc® Legend® Multi Dose Legend® Injectable Solution NexHA™ Synacid™

Catalog species: Both • FDA-labeled species: Horse, No Use Class Stated Or Implied

Rx/OTC: RX

Form/route: Injectable Solution, Liquid (Solution) • Intra-Articular, Intravenous

Applications: NADA 140-806 • NADA 140-883 • NADA 122-578 • NADA 139-913 • NADA 112-048 • ANADA 200-432 • NADA 140-474

Documents: 7 (FOI: 7) • SPL: 9 • Label highlights • Official documents

Safety (openFDA)

Top reactions: Dog 0 • Cat 0

Case summaries: 0

openFDA reports are unverified and do not prove causation.

Explore

Related conditions: Osteoarthritis (Degenerative Joint Disease) Osteoarthritis (Degenerative Joint Disease) Trauma (HBC, falls, bite wounds)

Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)

Diagnosis Codes

ICD10_CM: M19.90

Unspecified osteoarthritis, unspecified site

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points

For intra-articular injection in horses only. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horse intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intra-articular injection in horses only; must not be administered intravascularly. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intraarticular injection in horses only. Treatment may be repeated at weekly intervals for a total of four treatments. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers

Package NDC	Product NDC	Status
0010-3140-01	0010	-
0010-3141-01	0010	-
0010-3142-01	0010	-
0010-4130-01	0010	-
0010-4705-01	0010	-
0010-4705-02	0010	-
17030-098-01	17030	-
17030-098-12	17030	-
17033-045-10	17033	-

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

N140806_Org_5_31_88.pdf • FOI summary • Official • May 15, 2020
FDA FOI summary for application 140806
N140883_Orig_9_12_1991.pdf • FOI summary • Official • Dec. 11, 2019
FDA FOI summary for application 140883
ucm054829.pdf • FOI summary • Official • Dec. 11, 2019
FDA FOI summary for application 140883
N122578_Supp_09_30_1998.pdf • FOI summary • Official • July 10, 2017
FDA FOI summary for application 122578
UCM381702.pdf • FOI summary • Official • June 1, 2016
FDA FOI summary for application 200432
UCM478013.pdf • FOI summary • Official • June 1, 2016
FDA FOI summary for application 140474
UCM478007.pdf • FOI summary • Official • June 1, 2016
FDA FOI summary for application 139913

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 9 Clinical 0 Manufacturer 0 Marketing 0

Current Field Facts

contraindications: For intra-articular injection in horses only. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horse intended for h… (Official, 2026-02-12)
usage: Treatment of joint dysfunction in horses due to noninfectious synovitis associated with equine osteoarthritis. Treatment of joint dysfunction in horses due to … (Official, 2026-02-12)

Recent Revisions

contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product	Sponsor	Application	Status	Published
Hyalovet® RX Hyaluronate Sodium Liquid (Solution) • Intra-Articular Label highlights Official documents	Boehringer lngelheim Animal Health USA, Inc.	NADA 140-806	Approved	May 15, 2020
Legend® Multi Dose Legend® Injectable Solution RX Hyaluronate Sodium Liquid (Solution) • Intra-Articular, Intravenous Label highlights Official documents	Boehringer lngelheim Animal Health USA, Inc.	NADA 140-883	Approved	Dec 11, 2019
Hyvisc® RX Hyaluronate Sodium Liquid (Solution) • Intra-Articular Label highlights Official documents	Anika Therapeutics	NADA 122-578	Approved	Jul 10, 2017
Equron® RX Hyaluronate Sodium Liquid (Solution) • Intra-Articular Label highlights Official documents	Zoetis Inc.	NADA 139-913	Approved	Jun 1, 2016
Hylartin® V Injection Hylartin® V RX Hyaluronate Sodium Liquid (Solution) • Intra-Articular Label highlights Official documents	Zoetis Inc.	NADA 112-048	Approved	Jun 1, 2016
NexHA™ RX Hyaluronate Sodium Injectable Solution • Intra-Articular, Intravenous Label highlights Official documents	Vetoquinol USA, Inc.	ANADA 200-432	Approved	Jun 1, 2016
Synacid™ RX Hyaluronate Sodium Liquid (Solution) • Intra-Articular Label highlights Official documents	Intervet, Inc.	NADA 140-474	Approved	Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Horse, Not For Meat Production

Composition / specifications

Each milliliter of sterile aqueous solution contains 10 milligrams of hyaluronate sodium.

Horses

Indication

Treatment of carpal or fetlock joint dysfunction due to acute or chronic noninfectious synovitis associated with equine osteoarthritis.

Dosage

Small and medium-sized joints (carpal, fetlock)-20 milligrams. Treatment may be repeated after 1 or more weeks but not to exceed 2 injections per week for a total of 4 weeks.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production

Composition / specifications

Each milliliter of sterile aqueous solution contains 10 milligrams of hyaluronate sodium.

Horses

Indication

Treatment of carpal or fetlock joint dysfunction in horses due to noninfectious synovitis associated with equine osteoarthritis.

Dosage

4 mL (40 milligrams) by slow intravenous injection into the jugular vein. Intra-articular- 2 mL (20 mg) in the carpus or fetlock. Treatment may be repeated at weekly intervals for a total of three treatments.

Limitations

Use aseptic technique and inject slowly into the jugular vein. Horses should be given stall rest after treatment before gradually resuming normal activity. Not for intra-articular use - 4 mL (40 milligrams). Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: No Use Class Stated Or Implied

Horses

Indication

Treatment of joint dysfunction in horses due to non-infectious synovitis associated with equine osteoarthritis.

Dosage

The recommended dose is 2 mL (22 mg) given intra-articularly in small and medium-size joints (carpal, fetlock) and 4 mL (44 mg) in larger joints (hock).

Limitations

For intra-articular injection in horses only; must not be administered intravascularly. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production

Composition / specifications

Each milliliter of sterile aqueous solution contains 5 milligrams of hyaluronate sodium.

Horses

Indication

Treatment of joint dysfunction in horses due to noninfectious synovitis associated with equine osteoarthritis.

Dosage

Small and medium-size joints (carpal, fetlock)-10 milligrams; larger joint (hock)-20 milligrams.

Limitations

For intraarticular injection in horses only. Treatment may be repeated at weekly intervals for a total of four treatments. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production

Composition / specifications

Each milliliter of sterile aqueous solution contains 10 milligrams of hyaluronate sodium.

Horses

Indication

Treatment of joint dysfunction in horses due to noninfectious synovitis associated with equine osteoarthritis.

Dosage

Small and medium-size joints (carpal, fetlock)-20 milligrams; larger joint (hock)-40 milligrams.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: No Use Class Stated Or Implied

Composition / specifications

10 mg/ml

Horses

Indication

Treatment of joint dysfunction of the carpus or fetlock in horses due to non-infectious synovitis associated with equine osteoarthritis.

Dosage

Administer 2 mL (20 mg) by intra-articular injection into the carpus or fetlock or 4 mL (40 mg) by slow intravenous injection into the jugular vein. Treatment may be repeated at weekly intervals for a total of three treatments.

Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production

Composition / specifications

Each milliliter of sterile aqueous solution contains 10 milligrams of hyaluronate sodium.

Horses

Indication

For treatment of equine carpal and fetlock joint dysfunction caused by traumatic and/or degenerative joint disease of mild to moderate severity.

Dosage

50 milligrams in carpal and fetlock joints.

Limitations

For intraarticular injection in horses only. Not for use in horses intended for food. Not intended for use in breeding animals. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents

FOI N140806_Org_5_31_88.pdf

Summary

Hyalovet (hyaluronate sodium) is indicated for the intra-articular treatment of carpal or fetlock joint dysfunction in horses due to acute or chronic, non-infectious synovitis associated with equine osteoarthritis.

SPL Packages

Hyalovet® (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI ucm054829.pdf

Summary

Approval of the supplement will add a multiple dose vial containing the preservative benzyl alcohol.
FOI N140883_Orig_9_12_1991.pdf

Summary

Legend Injectable Solution is indicated in the treatment of joint dysfunction of the carpus or fetlock in horses due to non-infectious synovitis associated with equine osteoarthritis.

SPL Packages

Legend® Multi Dose (ZIP)
Legend® Injectable Solution (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI N122578_Supp_09_30_1998.pdf

Summary

To increase the concentration of hyaluronate sodium from 10 mg/mL to 11 mg/mL, and increase the dose from 20 mg to 22 mg for small joints and from 40 mg to 44 mg for large joints.

SPL Packages

Hyvisc® (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM478007.pdf

Summary

Equron is indicated for the treatment of joint dysfunction in horses due to noninfectious synovitis associated with equine osteoarthritis.

SPL Packages

Equron® (ZIP)

FDA page: Open in Animal Drugs @ FDA

SPL Packages

Hylartin® V Injection (ZIP)
Hylartin® V (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM381702.pdf

Summary

Treatment of joint dysfunction of the carpus or fetlock in horses due to non-infectious synovitis associated with equine osteoarthritis.

SPL Packages

NexHA™ (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM478013.pdf

Summary

For the treatment of equine carpal and fetlock joint dysfunction caused by traumatic and/or degenerative joint disease of mile to moderate severity.

SPL Packages

Synacid™ (ZIP)

FDA page: Open in Animal Drugs @ FDA

Usage

Treatment of joint dysfunction in horses due to noninfectious synovitis associated with equine osteoarthritis. Treatment of joint dysfunction in horses due to non-infectious synovitis associated with equine osteoarthritis. For treatment of equine carpal and fetlock joint dysfunction caused by traumatic and/or degenerative joint disease of mild to moderate severity.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

No case-level openFDA reports are linked for this medication yet.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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Medical Disclaimer: The medication details provided on Roxee are for informational purposes only and are not a substitute for professional veterinary advice. Always consult your veterinarian about your pet's specific needs.

Hyaluronate Sodium

Add to My Pet's Meds

Reviewed / Updated / Sources

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