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Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate

Detailed information about Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

Your vet decides this. Here's what owners typically ask/watch for.

What to watch for:

  • Urination (1 reports)
  • Unresponsive to stimuli (1 reports)
  • Proteinuria (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Urination
  • Unresponsive to stimuli
  • Proteinuria

Most reported reactions:

  • Urination (1 reports)
  • Unresponsive to stimuli (1 reports)
  • Proteinuria (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:04 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Mar 19, 2026, 10:08 AM UTC
Image coming soon
Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate

Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
18
Species represented
2
Grouped by Body System
Digestive (3) · Vomiting, Loss of appetite, Diarrhea Skin & allergy (1) · Itching Neurologic (1) · Tiredness (lethargy) Behavior (1) · Behavioral disorder (unspecified) Effectiveness (4) · Lack of efficacy - NOS, Lack of efficacy (endoparasite) - roundworm NOS, Lack of efficacy (endoparasite) - heartworm Other (22) · Urination, Unresponsive to stimuli, Reduced food intake
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Dog 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Cat 1

Species coverage: Dog (21) Cat (11)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Neurologic Dog Non-serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Digestive Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Cat Serious - 1
Skin & allergy Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Digestive Dog Non-serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Behavior Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Mar 19, 2026, 10:08 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 20 • Cat 8 • View
Case summaries: 13 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Urination (1) Unresponsive to stimuli (1) Proteinuria (1) Prescribing error (1) Polydipsia (1) Pale mucous membrane (1) Neutrophilia (1) Low serum alkaline phosphatase (1)

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 1 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Vomiting, Diarrhoea, Lethargy (see also Central nervous system depression in Neurological), Behavioural disorder NOS, Emesis … (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Loss of appetite (1) • Cat Diarrhea (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Itching (1) • Dog

Showing top 5 for Skin & allergy.

Neurologic
Tiredness (1) • Dog

Showing top 5 for Neurologic.

Behavior
Behavioral disorder (1) • Dog

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy - NOS (1) • Dog Lack of efficacy (endoparasite) - roundworm NOS (1) • Dog Lack of efficacy (endoparasite) - heartworm (1) • Dog Lack of efficacy (ectoparasite) - flea (1) • Cat

Showing top 5 for Effectiveness.

Other
Urination (1) • Dog Unresponsive to stimuli (1) • Dog Reduced food intake (1) • Dog Proteinuria (1) • Cat Prescribing error (1) • Cat
Show more (17)
Polydipsia (1) • Cat Pale mucous membrane (1) • Dog Overdose (1) • Dog Not drinking (1) • Dog Neutrophilia (1) • Cat Low serum alkaline phosphatase (1) • Cat Low blood pressure (1) • Dog Loose stool (1) • Dog Limping (1) • Dog Leucocytosis NOS (1) • Cat Hypokalaemia (1) • Cat Elevated mean corpuscular haemoglobin concentration (1) • Cat Collapse NOS (1) • Dog Blood in urine (1) • Cat Anaphylaxis (1) • Dog Accidental exposure (1) • Dog Abdominal pain (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Boxer (German Boxer), Female, 4 month, 10.433 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal, Frequency: 1 per month • Reactions: Lack of efficacy - NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055862
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 4.00 Month
  • Weight: 10.433 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy - NOS
Outcomes: Outcome Unknown

Dog, ['Retriever - Golden', 'Poodle (unspecified)'], Female, 5.07 month, 19.05 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal, Frequency: 1 per month • Reactions: Loose stool, Lack of efficacy (endoparasite) - roundworm NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055783
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 5.07 Month
  • Weight: 19.050 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
  • Frequency: 1 per month
Reactions Reported:
Loose stool Lack of efficacy (endoparasite) - roundworm NOS
Outcomes: Outcome Unknown

Dog, Shih Tzu, Male, 3.5 year, 5.89 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal • Reactions: Vomiting, Overdose • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055861
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 3.50 Year
  • Weight: 5.890 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
Reactions Reported:
Vomiting Overdose
Outcomes: Recovered/Normal

Dog, Chihuahua, Female, 2 year, 1.67 kilogram • Drug: MSK, Tablet, chewable, Oral • Reactions: Limping, Collapse NOS, Urination, Unresponsive to stimuli, Pale mucous membrane… • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055640
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 2.00 Year
  • Weight: 1.670 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
Reactions Reported:
Limping Collapse NOS Urination Unresponsive to stimuli Pale mucous membrane Anaphylaxis Vomiting bile Low blood pressure
Outcomes: Recovered/Normal

Dog, Retriever - Labrador, Male, 2.75 year, 33.11 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal, Frequency: 1 per month • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055687
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 2.75 Year
  • Weight: 33.110 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (endoparasite) - heartworm
Outcomes: Outcome Unknown

Dog, ['Collie (unspecified)', 'Dog (unknown)'], Female, 4 year, 24.9 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal, Frequency: 1 per day • Reactions: Vomiting, Diarrhea • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055774
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 4.00 Year
  • Weight: 24.900 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
  • Frequency: 1 per day
Reactions Reported:
Vomiting Diarrhea
Outcomes: Ongoing

Dog, Retriever - Golden, Male, 5 year, 36 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal, Frequency: 1 per day • Reactions: Vomiting • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-056005
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 5.00 Year
  • Weight: 36.000 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
  • Frequency: 1 per day
Reactions Reported:
Vomiting
Outcomes: Recovered/Normal

Dog, Chihuahua, Female, 4 year, 3.45 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal • Reactions: Tiredness (lethargy), Vocalisation, Abdominal pain, Not drinking, Reduced food intake… • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-056009
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 4.00 Year
  • Weight: 3.450 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
Reactions Reported:
Tiredness (lethargy) Vocalisation Abdominal pain Not drinking Reduced food intake Behavioral disorder (unspecified)
Outcomes: Recovered/Normal

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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