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Meds A-Z

Ivermectin/Pyrantel

Detailed information about Ivermectin/Pyrantel

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

Your vet decides this. Here's what owners typically ask/watch for.

What to watch for:

  • Lack of efficacy - heartworm (1 reports)
  • Urinary incontinence (1 reports)
  • Polydipsia (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Lack of efficacy - heartworm
  • Urinary incontinence
  • Polydipsia

Most reported reactions:

  • Lack of efficacy (endoparasite) - heartworm (1 reports)
  • Urinary incontinence (1 reports)
  • Polydipsia (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:04 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Image coming soon
Ivermectin/Pyrantel

Ivermectin/Pyrantel

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available
Identifiers:
NDC Package: 13985-951-25 NDC Package: 13985-969-50 NDC Package: 13985-970-10 NDC Package: 51311-170-20 NDC Package: 51311-171-20 NDC Package: 51311-172-20 NDC Package: 51311-504-02 NDC Package: 51311-505-04 NDC Package: 51311-506-06 NDC Package: 51311-507-08 NDC Product: 13985 NDC Product: 51311

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
9
Reported cases
6
Serious reports
1
Species represented
1
Grouped by Body System
Digestive (2) · Diarrhea, Decreased appetite Behavior (1) · Behavioral disorder (unspecified) Effectiveness (1) · Lack of efficacy (endoparasite) - heartworm Other (5) · Urinary incontinence, Polydipsia, Elevated alanine aminotransferase
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Effectiveness 1 Dog 1
Other 1 Dog 0
Other 1 Dog 0
Other 1 Dog 0
Other 1 Dog 0
Behavior 1 Dog 0
Digestive 0 Dog 0
Digestive 0 Dog 0

Species coverage: Dog (9)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Effectiveness Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Behavior Dog Non-serious - 1
Other Dog Unknown - -
Digestive Dog Unknown - -
Digestive Dog Unknown - -
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 13 • Cat 0 • View
Case summaries: 5 (showing 5) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Lack of efficacy (endoparasite) - heartworm (1) Urinary incontinence (1) Polydipsia (1) Elevated alanine aminotransferase (1) Decreased urine concentration (1) Behavioral disorder (unspecified) (1) Diarrhea (0) Decreased appetite (0)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NDC Package: 13985-951-25 NDC Package: 13985-969-50 NDC Package: 13985-970-10 NDC Package: 51311-170-20 NDC Package: 51311-171-20 NDC Package: 51311-172-20 NDC Package: 51311-504-02 NDC Package: 51311-505-04 NDC Package: 51311-506-06 NDC Package: 51311-507-08 NDC Product: 13985 NDC Product: 51311
Package NDC Product NDC Form / Route Status
13985-951-25 13985 -
13985-969-50 13985 -
13985-970-10 13985 -
51311-170-20 51311 -
51311-171-20 51311 -
51311-172-20 51311 -
51311-504-02 51311 -
51311-505-04 51311 -
51311-506-06 51311 -
51311-507-08 51311 -

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 1 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Vomiting, INEFFECTIVE, HEARTWORM LARVAE, Lethargy (see also Central nervous syst… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Diarrhea • Dog Decreased appetite • Dog

Showing top 5 for Digestive.

Behavior
Behavioral disorder (1) • Dog

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy (endoparasite) - heartworm (1) • Dog

Showing top 5 for Effectiveness.

Other
Urinary incontinence (1) • Dog Polydipsia (1) • Dog Elevated alanine aminotransferase (1) • Dog Decreased urine concentration (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Brittany, Female, 7 year, 23.133 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 dose per animal • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054794
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 23.133 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 dose per animal
Reactions Reported:
Lack of efficacy (endoparasite) - heartworm
Outcomes: Ongoing

Dog, Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog), Male, 6 year, 14.832 kilogram • Drug: MSK, Solution/drops, Unknown • Reactions: Polydipsia, Urinary incontinence, Behavioral disorder (unspecified), Elevated alanine aminotransferase, Decreased urine concentration • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054529
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 6.00 Year
  • Weight: 14.832 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Solution/drops
Reactions Reported:
Polydipsia Urinary incontinence Behavioral disorder (unspecified) Elevated alanine aminotransferase Decreased urine concentration
Outcomes: Ongoing

Dog, Siberian Husky, Female, 2 year, 18.597 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054713
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 2.00 Year
  • Weight: 18.597 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
Reactions Reported:
Lack of efficacy (endoparasite) - heartworm
Outcomes: Ongoing

Dog, Shepherd Dog - Australian, Female, 1 year, 16.783 kilogram • Drug: MSK, Tablet, Oral • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-051760
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 1.00 Year
  • Weight: 16.783 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
Reactions Reported:
Lack of efficacy (endoparasite) - heartworm
Outcomes: Ongoing

Dog, Terrier - Bull - American Pit, Male, 2 year, 31.525 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-049172
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 2.00 Year
  • Weight: 31.525 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Lack of efficacy (endoparasite) - heartworm
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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