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Hydroxyzine

Detailed information about Hydroxyzine

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

Your vet decides this. Here's what owners typically ask/watch for.

What to watch for:

  • Skin scab (1 reports)
  • Scratching (1 reports)
  • Pinnal irritation (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Skin scab
  • Scratching
  • Pinnal irritation

Most reported reactions:

  • Skin scab (1 reports)
  • Scratching (1 reports)
  • Pinnal irritation (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 11, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Image coming soon
Hydroxyzine

Hydroxyzine

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
17
Species represented
2
Grouped by Body System
Digestive (2) · Diarrhea, Decreased appetite Skin & allergy (1) · Itching Neurologic (2) · Tiredness (lethargy), Head tremor Behavior (1) · Biting -aggression Effectiveness (3) · Partial lack of efficacy, Lack of efficacy - NOS, Lack of efficacy (endoparasite) - hookworm Other (23) · Tarry or black stool, Skin scab, Skin disorders NOS
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Effectiveness 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Dog 1
Skin & allergy 1 Cat 1

Species coverage: Dog (18) Cat (14)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Dog Non-serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Effectiveness Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Skin & allergy Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Neurologic Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Digestive Dog Serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Behavior Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 11, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 17 • Cat 8 • View
Case summaries: 10 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Skin scab (1) Scratching (1) Pinnal irritation (1) Partial lack of efficacy (1) Neutropenia (1) Neoplasia NOS (1) Low thyroxine (1) Itching (1)

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 1 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Vomiting, Lethargy (see also Central nervous system depression in 'Neurological'), Diarrhoea, Lack of efficacy - NOS, INEFFEC… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Diarrhea (1) • Dog Decreased appetite (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Itching (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Tiredness (1) • Dog Head tremor (1) • Cat

Showing top 5 for Neurologic.

Behavior
Biting -aggression (1) • Cat

Showing top 5 for Behavior.

Effectiveness
Partial lack of efficacy (1) • Cat Lack of efficacy - NOS (1) • Dog Lack of efficacy (endoparasite) - hookworm (1) • Dog

Showing top 5 for Effectiveness.

Other
Tarry or black stool (1) • Dog Skin scab (1) • Cat Skin disorders NOS (1) • Dog Scratching (1) • Cat Pinnal irritation (1) • Cat
Show more (18)
Ocular discharge (1) • Dog Neutropenia (1) • Cat Neoplasia NOS (1) • Cat Low thyroxine (1) • Dog Impaired consciousness (1) • Dog Hyperphosphataemia (1) • Dog Hiding (1) • Cat Flatulence (1) • Dog Entropion (1) • Dog Elevated cholesterol (1) • Dog Ear infection NOS (1) • Cat Ear canal inflammation (1) • Cat Death (1) • Cat Deafness NOS (1) • Cat Corneal ulcer (1) • Dog Bone and joint disorder NOS (1) • Dog Atopic allergy NOS (1) • Dog Allergic dermatitis (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, ['Hound - Basset', 'Dog (unknown)'], Female, 8.9 year, 16.33 kilogram • Drug: MSK, Tablet, Oral, Dose: 35 Milligram per animal, Frequency: 12 per hour • Reactions: Diarrhea, Vomiting, Decreased appetite, Low thyroxine • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055287
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 8.90 Year
  • Weight: 16.330 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 35 Milligram per animal
  • Frequency: 12 per hour
Reactions Reported:
Diarrhea Vomiting Decreased appetite Low thyroxine
Outcomes: Outcome Unknown

Dog, Retriever - Labrador, Female, 42.6 kilogram • Drug: MSK, Unknown • Reactions: Flatulence, Itching, Corneal ulcer, Ocular discharge, Atopic allergy NOS… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-054647
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Weight: 42.600 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Flatulence Itching Corneal ulcer Ocular discharge Atopic allergy NOS Allergic dermatitis Bone and joint disorder NOS Entropion
Outcomes: Outcome Unknown

Dog, ['Retriever - Golden', 'Dog (unknown)'], Male, 8 year, 34.47 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy - NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-052516
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 8.00 Year
  • Weight: 34.470 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Lack of efficacy - NOS
Outcomes: Outcome Unknown

Dog, Spaniel - Cocker English, Female, 7.6 month, 10.34 kilogram • Drug: MSK, Unknown • Reactions: Hyperphosphataemia, Elevated cholesterol, Tiredness (lethargy), Diarrhea, Impaired consciousness • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-052484
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 7.60 Month
  • Weight: 10.340 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Hyperphosphataemia Elevated cholesterol Tiredness (lethargy) Diarrhea Impaired consciousness
Outcomes: Outcome Unknown

Dog, Bulldog - French, Male, 9 month, 9.52 kilogram • Drug: MSK, Unknown • Reactions: Skin disorders NOS, Vomiting, Tarry or black stool, Diarrhea, Lack of efficacy (endoparasite) - hookworm • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-043502
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 9.00 Month
  • Weight: 9.520 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Skin disorders NOS Vomiting Tarry or black stool Diarrhea Lack of efficacy (endoparasite) - hookworm
Outcomes: Ongoing

Cat, Cat (other), Male, 7 year, 5.67 kilogram • Drug: MSK, Unknown • Reactions: Itching, Wound, Skin scab, Hiding, Deafness NOS… • Outcome: Died

  • Report ID: USA-USFDACVM-2024-US-026153
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 7.00 Year
  • Weight: 5.670 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Itching Wound Skin scab Hiding Deafness NOS Biting -aggression Ear infection NOS Partial lack of efficacy Death Neoplasia NOS
Outcomes: Died

Cat, Cat (other), Male, 7 year, 5.67 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Itching, Wound, Skin scab, Hiding, Biting -aggression… • Outcome: Died

  • Report ID: USA-USFDACVM-2024-US-011130
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 7.00 Year
  • Weight: 5.670 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Itching Wound Skin scab Hiding Biting -aggression Deafness NOS Ear infection NOS Partial lack of efficacy Death Neoplasia NOS
Outcomes: Died

Cat, Cat (other), Male, 6.9 year, 4.672 kilogram • Drug: MSK, Tablet, Oral, Dose: 0.50 dose per animal, Frequency: 12 per hour • Reactions: Neutropenia, Pinnal irritation • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2023-US-053548
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 6.90 Year
  • Weight: 4.672 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 0.50 dose per animal
  • Frequency: 12 per hour
Reactions Reported:
Neutropenia Pinnal irritation
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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