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Polymyxin B

Detailed information about Polymyxin B

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

Terramycin® is indicated for the prophylaxis and local treatment of superficial ocular infections due to oxytetracycline and polymyxin-sensitive organisms, including infections due to streptococci, rickettsiae, E. coli ,...

What to watch for:

  • For use in dogs only
  • Shake drug thoroughly and clean lesion before using
  • If redness, irritation, or swelling persists or increases, discontinue use and reevaluate diagnosis
  • For otic use in dogs only
  • Do not administer orally
  • Do not use in dogs with known perforated tympanum
  • Do not use with drugs known to induce ototoxicity
  • Tremors (1 reports)
  • Mewing (1 reports)
  • Loss of hearing (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • For use in dogs only
  • Shake drug thoroughly and clean lesion before using
  • If redness, irritation, or swelling persists or increases, discontinue use and reevaluate diagnosis
  • For otic use in dogs only
  • Do not administer orally

Most reported reactions:

  • Tremors (1 reports)
  • Mewing (1 reports)
  • Loss of hearing (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:04 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Image coming soon
Polymyxin B

Polymyxin B

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Zoetis Inc.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Zoetis Inc.
Form: Liquid, Liquid (Solution), Liquid (Suspension), Ointment
Identifiers:
ANADA: 200553 NADA: 141298 NADA: 38801 NADA: 40123 NADA: 49725 NADA: 49726 NADA: 65015 NADA: 65016 NADA: 65114 NADA: 65119 NADA: 65476 NADA: 65485 NADA: 8763 NDC Package: 54771-1096-1 NDC Package: 58198-0813-1 NDC Package: 58198-0813-2 NDC Package: 63732-2043-4 NDC Product: 54771 NDC Product: 58198 NDC Product: 63732
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. For use in dogs only. Shake drug thoroughly and clean lesion before using. If redness, irritation, or swelling persists or increases, discontinue use and reevaluate diagnosis. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For otic use in dogs only. Do not administer orally. Do not use in dogs with known perforated tympanum. Do not use with drugs known to induce ototoxicity. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. For use in dogs only. Shake drug thoroughly and clean lesion before using. If redness, irritation, or swelling persists or increases, discontinue use and reevaluate diagnosis. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For otic use in dogs only. Do not administer orally. Do not use in dogs with known perforated tympanum. Do not use with drugs known to induce ototoxicity. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
23
Reported cases
23
Serious reports
5
Species represented
2
Grouped by Body System
Digestive (2) · Vomiting, Loss of appetite Skin & allergy (2) · Itching, Alopecia NOS Neurologic (3) · Unsteady walking (ataxia), Tremors, Head tremor Behavior (1) · Behavioral disorder (unspecified) Other (15) · Weight loss, Walking difficulty, Vocalisation
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Dog 1
Other 1 Cat 1
Other 1 Cat 1
Neurologic 1 Dog 1
Other 1 Dog 1
Other 1 Cat 0
Other 1 Cat 0
Digestive 1 Dog 0

Species coverage: Cat (15) Dog (8)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Digestive Dog Non-serious - 1
Other Cat Non-serious - 1
Neurologic Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Neurologic Dog Serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Digestive Dog Non-serious - 1
Skin & allergy Cat Non-serious - 1
Neurologic Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Behavior Cat Non-serious - 1
Skin & allergy Cat Non-serious - 1
Source metadata:

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)
  • No owner handouts linked yet.
Official label / PI (0)
  • No official label or package insert links yet.
SPL (15)
FOI (2)
  • UCM457307.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1236
  • UCM202424.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/862
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Anaprime® Ophthalmic Solution Anaprime® Opthakote Ophthalmic Bac-Neo-Poly Ophthalmic Ointment Vetropolycin Ophthalmic Ointment Cortisporin Veterinary Ophthalmic Ointment Forte Topical® Ointment Mycitracin® Sterile Ophthalmic Ointment Neomycin and Polymyxin B Sulfates, and Bacitracin Zinc Ophthalmic Ointment Neosporin Ophthalmic Ointment Optiprime® Opthakote Ophthalmic Solution Surolan® Terramycin® Toptic Ointment (15 g) Vetropolycin HC Ophthalmic Ointment Bacitracin-Neomycin-Polymyxin with Hydrocortisone Acetate Ophthalmic Ointment
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat, Dog, Horse, No Use Class Stated Or Implied, Sheep
Rx/OTC: OTC, RX
Form/route: Liquid, Liquid (Solution), Liquid (Suspension), Ointment • Ophthalmic, Otic, Topical
Applications: NADA 8763 • ANADA 200-553 • NADA 38801 • NADA 49725 • NADA 65016 • NADA 65476 • NADA 65119 • NADA 65114 • NADA 65485 • NADA 49726 • NADA 141-298 • NADA 40123 • NADA 65015
Documents: 2 (FOI: 2) • SPL: 15 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 16 • Cat 8 • View
Case summaries: 10 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: H60.90 ICD10_CM: L20.9
Otitis externa, unspecified ear

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. For use in dogs only. Shake drug thoroughly and clean lesion before using. If redness, irritation, or swelling persists or increases, discontinue use and reevaluate diagnosis. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For otic use in dogs only. Do not administer orally. Do not use in dogs with known perforated tympanum. Do not use with drugs known to induce ototoxicity. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Tremors (1) Mewing (1) Loss of hearing (1) Head tremor (1) Deafness (1) Weight loss (1) Walking difficulty (1) Vomiting (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200553 NADA: 141298 NADA: 38801 NADA: 40123 NADA: 49725 NADA: 49726 NADA: 65015 NADA: 65016 NADA: 65114 NADA: 65119 NADA: 65476 NADA: 65485 NADA: 8763 NDC Package: 54771-1096-1 NDC Package: 58198-0813-1 NDC Package: 58198-0813-2 NDC Package: 63732-2043-4 NDC Product: 54771 NDC Product: 58198 NDC Product: 63732
Package NDC Product NDC Form / Route Status
54771-1096-1 54771 -
58198-0813-1 58198 -
58198-0813-2 58198 -
63732-2043-4 63732 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • UCM457307.pdf • FOI summary • Official • Oct. 25, 2023
    FDA FOI summary for application 200553
  • UCM202424.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 141298

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 5 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. For use in dogs only. Shake drug thoroughly and clean lesion before using… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Loss of hearing, Deafness, Lack of efficacy - NOS, Impaired hearing, Hearing decreased, Behavioural disorder NOS. (Official, 2026-02-12)
  • usage: Terramycin® is indicated for the prophylaxis and local treatment of superficial ocular infections due to oxytetracycline and polymyxin-sensitive organisms, inc… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Terramycin®
RX
Oxytetracycline Hydrochloride Polymyxin B Sulfate
Ointment • Ophthalmic
Label highlights
Official documents
Zoetis Inc. NADA 8763 Approved Jul 1, 2024
Neomycin and Polymyxin B Sulfates, and Bacitracin Zinc Ophthalmic Ointment
RX
Bacitracin Zinc Neomycin Sulfate Polymyxin B Sulfate
Ointment • Ophthalmic
Label highlights
Official documents
Domes Pharma S.A. ANADA 200-553 Approved Oct 25, 2023
Anaprime® Ophthalmic Solution
RX
Flumethasone Neomycin Sulfate Polymyxin B Sulfate
Liquid • Ophthalmic
Label highlights
Official documents
Zoetis Inc. NADA 38801 Approved Jun 1, 2016
Anaprime® Opthakote Ophthalmic
RX
Flumethasone Neomycin Sulfate Polymyxin B Sulfate
Liquid • Ophthalmic
Label highlights
Official documents
Zoetis Inc. NADA 49725 Approved Jun 1, 2016
Bac-Neo-Poly Ophthalmic Ointment Vetropolycin Ophthalmic Ointment
RX
Bacitracin Zinc Neomycin Sulfate Polymyxin B Sulfate
Ointment • Ophthalmic
Label highlights
Official documents
Dechra, Ltd. NADA 65016 Approved Jun 1, 2016
Cortisporin Veterinary Ophthalmic Ointment
RX
Bacitracin Zinc Hydrocortisone Neomycin Sulfate Polymyxin B Sulfate
Ointment • Ophthalmic
Label highlights
Official documents
Intervet, Inc. NADA 65476 Approved Jun 1, 2016
Forte Topical® Ointment
RX
Hydrocortisone Acetate Neomycin Sulfate Penicillin G Procaine Polymyxin B Sulfate
Ointment • Topical
Label highlights
Official documents
Zoetis Inc. NADA 65119 Approved Jun 1, 2016
Mycitracin® Sterile Ophthalmic Ointment
OTC
Bacitracin Zinc Neomycin Sulfate Polymyxin B Sulfate
Ointment • Ophthalmic
Label highlights
Official documents
Zoetis Inc. NADA 65114 Approved Jun 1, 2016
Neosporin Ophthalmic Ointment
RX
Bacitracin Zinc Neomycin Sulfate Polymyxin B Sulfate
Ointment • Ophthalmic
Label highlights
Official documents
Intervet, Inc. NADA 65485 Approved Jun 1, 2016
Optiprime® Opthakote Ophthalmic Solution
RX
Neomycin Sulfate Polymyxin B Sulfate
Liquid (Solution) • Ophthalmic
Label highlights
Official documents
Zoetis Inc. NADA 49726 Approved Jun 1, 2016
Surolan®
RX
Miconazole Nitrate Polymyxin B Sulfate Prednisolone Acetate
Liquid (Suspension) • Otic
Label highlights
Official documents
Elanco US Inc. NADA 141-298 Approved Jun 1, 2016
Toptic Ointment (15 g)
RX
Cephalonium Flumethasone Iodochlorhydroxyquin Piperocaine Hydrochloride Polymyxin B Sulfate
Official documents
Elanco Animal Health, A Division of Eli Lilly & Co. NADA 40123 W Jun 1, 2016
Vetropolycin HC Ophthalmic Ointment Bacitracin-Neomycin-Polymyxin with Hydrocortisone Acetate Ophthalmic Ointment
RX
Bacitracin Zinc Hydrocortisone Acetate Neomycin Sulfate Polymyxin B Sulfate
Ointment • Ophthalmic
Label highlights
Official documents
Dechra, Ltd. NADA 65015 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, No Use Class Stated Or Implied • Horse, No Use Class Stated Or Implied • No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied • Sheep, No Use Class Stated Or Implied
Composition / specifications
Each gram of
ointment contains oxytetracycline HCl equivalent to 5 mg of
oxytetracycline and 10,000 units of polymyxin B as the sulfate.
Cattle
Indication

Terramycin® is indicated for the prophylaxis and local treatment of superficial ocular infections due to oxytetracycline and polymyxin-sensitive organisms, including infections due to streptococci, rickettsiae, E. coli, and A.aerogenes, such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis in dogs, cats, cattle, sheep, and horses; ocular infections due to secondary bacterial complications of distemper in dogs, and bacterial inflammatory conditions whichmay occur secondary to other infectious diseases in the above species.

Dosage
Administered topically to the eye 2-4 times daily.
Limitations
Sheep
Indication
Terramycin Ophthalmic Ointment with Polymyxin B Sulfate is indicated for the prophylaxis and local treatment of superficial ocular infections due to oxytetracycline and polymyxin-sensitive organisms, including infections due to streptococci, rickettsiae, E. coli, and A. aerogenes, such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis in dogs, cats, cattle, sheep, and horses; ocular infections due to secondary bacterial complications of distemper in dogs, and bacterial inflammatory conditions which may occur secondary to other infectious diseases in the above species.
Dosage
Administered topically to the eye 2-4 times daily.
Limitations
Horses
Indication
Terramycin Ophthalmic Ointment with Polymyxin B Sulfate is indicated for the prophylaxis and local treatment of superficial ocular infections due to oxytetracycline and polymyxin-sensitive organisms, including infections due to streptococci, rickettsiae, E. coli, and A. aerogenes, such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis in dogs, cats, cattle, sheep, and horses; ocular infections due to secondary bacterial complications of distemper in dogs, and bacterial inflammatory conditions which may occur secondary to other infectious diseases in the above species.
Dosage
Administered topically to the eye 2-4 times daily.
Limitations
Dogs
Indication
Terramycin Ophthalmic Ointment with Polymyxin B Sulfate is indicated for the prophylaxis and local treatment of superficial ocular infections due to oxytetracycline and polymyxin-sensitive organisms, including infections due to streptococci, rickettsiae, E. coli, and A. aerogenes, such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis in dogs, cats, cattle, sheep, and horses; ocular infections due to secondary bacterial complications of distemper in dogs, and bacterial inflammatory conditions which may occur secondary to other infectious diseases in the above species.
Dosage
Administered topically to the eye 2-4 times daily.
Limitations
Cats
Indication
Terramycin Ophthalmic Ointment with Polymyxin B Sulfate is indicated for the prophylaxis and local treatment of superficial ocular infections due to oxytetracycline and polymyxin-sensitive organisms, including infections due to streptococci, rickettsiae, E. coli, and A. aerogenes, such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis in dogs, cats, cattle, sheep, and horses; ocular infections due to secondary bacterial complications of distemper in dogs, and bacterial inflammatory conditions which may occur secondary to other infectious diseases in the above species.
Dosage
Administered topically to the eye 2-4 times daily.
Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each gram of ointment contains: polymyxin B sulfate 10,000 units, bacitracin zinc 400 units, and neomycin sulfate 5 mg (equivalent to 3.5 mg neomycin base).
Label highlights
Indication
For the treatment of superficial bacterial infections of the eyelid and conjunctiva of dogs and cats when due to organisms susceptible to one or more of the antibiotics contained in the ointment
Dosage
Apply a thin film over the cornea 3 or 4 times daily
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of ophthalmic preparation contains 0.10 milligram flumethasone, 5.0 milligrams neomycin sulfate (3.5 milligrams neomycin base), and 10,000 units of polymyxin B sulfate, without hydroxypropyl methylcellulose.
Dogs
Indication
Treatment of the inflammation, edema, and secondary bacterial infections associated with topical ophthalmological conditions of the eye such as corneal injuries, incipient pannus, superficial keratitis, conjunctivitis, acute nongranulomatous anterior uveitis, kerato- conjunctivitis, and blepharitis.
Dosage
Apply 2 to 3 drops per eye, every 4 hours.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cats
Indication
Treatment of the inflammation, edema, and secondary bacterial infections associated with topical ophthalmological conditions of the eye such as corneal injuries, incipient pannus, superficial keratitis, conjunctivitis, acute nongranulomatous anterior uveitis, kerato- conjunctivitis, and blepharitis.
Dosage
Apply 2 to 3 drops per eye, every 4 hours.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of ophthalmic preparation contains 5.0 milligrams neomycin sulfate (3.5 milligrams neomycin base), 0.10 milligram flumethasone, and 10,000 Units of polymyxin B sulfate.
Dogs
Indication
For the treatment of bacterial infections associated with topical ophthalmological conditions such as corneal injuries, superficial keratitis, conjunctivitis, keratoconjunctivitis, and blepharitis.
Dosage
Instill 1 to 2 drops per eye every 6 hours.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each gram contains 400 units of bacitracin zinc, 3.5 milligrams of neomycin, and 10,000 units of polymyxin B.
Dogs
Indication
Treatment of superficial bacterial infections of the eyelid and conjunctiva of dogs and cats when due to susceptible organisms.
Dosage
Apply a thin film over the cornea 3 or 4 times daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Indication
Treatment of superficial bacterial infections of the eyelid and conjunctiva of dogs and cats when due to susceptible organisms.
Dosage
Apply a thin film over the cornea 3 or 4 times daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each gram of ointment contains 400 units of bacitracin zinc, 10,000 units of polymyxin B sulfate, 5 milligrams of neomycin sulfate (equivalent to 3.5 milligrams of neomycin base), and 10 milligrams of hydrocortisone.
Cats
Indication
Treating acute or chronic conjunctivitis caused by susceptible organisms.
Dosage
Apply a thin film over the cornea three or four times daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
Treating acute or chronic conjunctivitis caused by susceptible organisms.
Dosage
Apply a thin film over the cornea three or four times daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of suspension contains 25 milligrams of neomycin sulfate equivalent to 17.5 milligrams of neomycin, 10,000 international units of penicillin G procaine, 5,000 international units of polymyxin B sulfate, 2 milligrams of hydrocortisone acetate, and 1.25 milligrams of hydrocortisone sodium succinate.
Dogs
Indication
Treatment of summer eczema, atopic dermatitis, interdigital eczema and otitis externa caused by bacteria susceptible to neomycin, penicillin, and polymyxin B.
Dosage
Rub a small amount into the involved area 1 to 3 times a day. After definite improvement, it may be applied once a day or every other day.
Limitations
For use in dogs only. Shake drug thoroughly and clean lesion before using. If redness, irritation, or swelling persists or increases, discontinue use and reevaluate diagnosis. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each gram contains 500 units of bacitracin, 3.5 milligrams of neomycin, and 10,000 units of polymyxin B.
Cats
Indication
Treatment of superficial bacterial infections of the eyelid and conjunctiva of cats when due to susceptible organisms.
Dosage
Apply a thin film over the cornea 3 or 4 times daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
Treatment of superficial bacterial infections of the eyelid and conjunctiva of dogs when due to susceptible organisms.
Dosage
Apply a thin film over the cornea 3 or 4 times daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each gram contains 400 units of bacitracin zinc, 3.5 milligrams of neomycin, and 10,000 units of polymyxin B.
Cats
Indication
Treatment of superficial bacterial infections of the eyelid and conjunctiva of cats when due to susceptible organisms.
Dosage
Apply a thin film over the cornea three or four times daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
Treatment of superficial bacterial infections of the eyelid and conjunctiva of dogs when due to susceptible organisms.
Dosage
Apply a thin film over the cornea three or four times daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of the ophthalmic preparation contains 5.0 milligrams neomycin sulfate (3.5 milligrams neomycin base), and 10,000 Units of polymyxin B sulfate.
Dogs
Indication
For the treatment of bacterial infections associated with topical ophthalmological conditions such as corneal injuries, superficial keratitis, conjunctivitis, keratoconjunctivitis, and blepharitis.
Dosage
Instill 1 to 2 drops per eye every 6 hours.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
23 mg/mL miconazole nitrate, 0.5293 mg/mL polymyxin B sulfate, 5 mg/mL prednisolone acetate
Dogs
Indication
For the treatment of canine otitis externa associated with susceptible strains of yeast (Malassezia pachydermatis) and bacteria (Staphylococcus pseudintermedius).
Dosage
Instill 5 drops in the ear canal twice daily and massage the ear. Therapy should continue for 7 consecutive days.
Limitations
For otic use in dogs only. Do not administer orally. Do not use in dogs with known perforated tympanum. Do not use with drugs known to induce ototoxicity. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each gram of ointment contains 400 units of bacitracin zinc, 10,000 units of polymyxin B sulfate, 5 milligrams of neomycin sulfate (equivalent to 3.5 milligrams of neomycin base), and 10 milligrams of hydrocortisone acetate.
Cats
Indication
Treating acute or chronic conjunctivitis caused by susceptible organisms.
Dosage
Apply a thin film over the cornea three or four times daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
Treating acute or chronic conjunctivitis caused by susceptible organisms.
Dosage
Apply a thin film over the cornea three or four times daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For the treatment of superficial bacterial infections of the eyelid and conjunctiva of dogs and cats when due to organisms susceptible to one or more of the antibiotics contained in the ointment.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For the treatment of canine otitis externa associated with susceptible strains of yeast ( Malassezia pachydermatis) and bacteria ( Staphylococcus pseudintermedius)
SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

Terramycin® is indicated for the prophylaxis and local treatment of superficial ocular infections due to oxytetracycline and polymyxin-sensitive organisms, including infections due to streptococci, rickettsiae, E. coli , and A.aerogenes , such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis in dogs, cats, cattle, sheep, and horses; ocular infections due to secondary bacterial complications of distemper in dogs, and bacterial inflammatory conditions whichmay occur secondary to other infectious diseases in the above species. Terramycin Ophthalmic Ointment with Polymyxin B Sulfate is indicated for the prophylaxis and local treatment of superficial ocular infections due to oxytetracycline and polymyxin-sensitive organisms, including infections due to streptococci, rickettsiae, E. coli , and A. aerogenes , such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis in dogs, cats, cattle, sheep, and horses; ocular infections due to secondary bacterial complications of distemper in dogs, and bacterial inflammatory conditions which may occur secondary to other infectious diseases in the above species. Treatment of the inflammation, edema, and secondary bacterial infections associated with topical ophthalmological conditions of the eye such as corneal injuries, incipient pannus, superficial keratitis, conjunctivitis, acute nongranulomatous anterior uveitis, kerato- conjunctivitis, and blepharitis.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. For use in dogs only. Shake drug thoroughly and clean lesion before using. If redness, irritation, or swelling persists or increases, discontinue use and reevaluate diagnosis. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For otic use in dogs only. Do not administer orally. Do not use in dogs with known perforated tympanum. Do not use with drugs known to induce ototoxicity. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Loss of appetite (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Itching (1) • Cat Alopecia NOS (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Cat Tremors (1) • Dog Head tremor (1) • Dog

Showing top 5 for Neurologic.

Behavior
Behavioral disorder (1) • Cat

Showing top 5 for Behavior.

Other
Weight loss (1) • Cat Walking difficulty (1) • Cat Vocalisation (1) • Cat Unclassifiable adverse event (1) • Cat Ulceration NOS (1) • Cat
Show more (10)
Third eyelid extrusion (1) • Cat Squinting (1) • Dog Pinnae disorder (1) • Cat Other abnormal test result NOS (1) • Cat Mewing (1) • Cat Medication error NOS (1) • Dog Loss of hearing (1) • Cat Eye irritation (1) • Dog Deafness (1) • Dog Crust (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, ['Retriever - Golden', 'Poodle (unspecified)'], Male, 3 year, 31.75 kilogram • Drug: MSK, Suspension, Intraocular • Reactions: Squinting, Eye irritation, Medication error NOS • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055998
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 3.00 Year
  • Weight: 31.750 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intraocular
  • Form: Suspension
Reactions Reported:
Squinting Eye irritation Medication error NOS
Outcomes: Ongoing

Dog, Terrier - West Highland White, Male, 12 year, 9.52 kilogram • Drug: MSK, Suspension, Auricular (Otic), Dose: 1 dose per animal • Reactions: Deafness • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055789
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 12.00 Year
  • Weight: 9.520 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Auricular (Otic)
  • Form: Suspension
  • Dose: 1 dose per animal
Reactions Reported:
Deafness
Outcomes: Ongoing

Dog, Pekingese, Male, 9 year, 3.17 kilogram • Drug: MSK, Suspension, Topical, Dose: 5 drops per animal, Frequency: 1 per day • Reactions: Unsteady walking (ataxia), Tremors, Head tremor, Loss of hearing • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-052802
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 9.00 Year
  • Weight: 3.170 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Suspension
  • Dose: 5 drops per animal
  • Frequency: 1 per day
Reactions Reported:
Unsteady walking (ataxia) Tremors Head tremor Loss of hearing
Outcomes: Ongoing

Dog, Shepherd Dog - German, Male, 8.58 year, 46.62 kilogram • Drug: MSK, Suspension, Auricular (Otic), Dose: 5 drops per animal, Frequency: 12 per hour • Reactions: Vomiting, Loss of appetite • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-052712
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 8.58 Year
  • Weight: 46.620 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Auricular (Otic)
  • Form: Suspension
  • Dose: 5 drops per animal
  • Frequency: 12 per hour
Reactions Reported:
Vomiting Loss of appetite
Outcomes: Ongoing

Dog, Maltese, Female, 11 year, 5.35 kilogram • Drug: MSK, Suspension, Auricular (Otic), Frequency: 12 per hour • Reactions: Loss of hearing • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-052344
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 11.00 Year
  • Weight: 5.350 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Auricular (Otic)
  • Form: Suspension
  • Frequency: 12 per hour
Reactions Reported:
Loss of hearing
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 14 year, 6.58 kilogram • Drug: MSK, Suspension, Auricular (Otic) • Reactions: Unsteady walking (ataxia), Vocalisation • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-050900
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 14.00 Year
  • Weight: 6.580 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Auricular (Otic)
  • Form: Suspension
Reactions Reported:
Unsteady walking (ataxia) Vocalisation
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Female, 18 year, 3.68 kilogram • Drug: MSK, Suspension, Auricular (Otic), Dose: 5 drops per animal, Frequency: 12 per hour • Reactions: Mewing, Loss of hearing • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-031666
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 18.00 Year
  • Weight: 3.680 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Auricular (Otic)
  • Form: Suspension
  • Dose: 5 drops per animal
  • Frequency: 12 per hour
Reactions Reported:
Mewing Loss of hearing
Outcomes: Ongoing

Cat, Cat (unknown), Unknown • Drug: MSK, Suspension, Auricular (Otic), Dose: 1 dose per animal • Reactions: Unclassifiable adverse event • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2024-US-052436
  • Serious AE: No
  • Treated For AE: No
  • Sex: Unknown
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Auricular (Otic)
  • Form: Suspension
  • Dose: 1 dose per animal
Reactions Reported:
Unclassifiable adverse event
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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