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Roxee Meds Catalog

Ivermectin 68Mcg Pyrantel 57Mg

Medication catalog facts with explicit FDA-approval, off-label, source-limited, and safety context.

Both Source review pending Regulatory linkage incomplete Owner quick guide first
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Data freshness

Storefront facts
Source review pending
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Roxee is still reviewing source support for this medication profile.

FDA applications
Regulatory match pending
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Roxee has safety or ingredient evidence for this medication, but a regulatory product/application match is still pending.

Safety reports
Safety data refreshed
May 5, 2026, 10:01 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:05 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC

Evidence

Reviewed / Updated / Sources

Reviewed by: Not available

Last reviewed: April 11, 2026

Updated: April 11, 2026, 10:04 AM UTC

Sources:
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Ivermectin 68Mcg Pyrantel 57Mg

Ivermectin 68Mcg Pyrantel 57Mg

Drug type: Generic ingredient • Generic profile • Regulatory linkage incomplete

Both 77% storefront ready

Species: Both

Approval status: Official document linked, regulatory match incomplete. An official source document is available, but Roxee has not linked this row to a confirmed FDA animal-drug application or product record yet.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Ivermectin 68Mcg Pyrantel 57Mg

To prevent canine heartworm diseases by eliminating the tissue stage of heartworm larvae ( Dirofilaria immitis ) for a month (30 days) after infection. For the treatment and control of ascarids ( Toxocara canis , Toxascaris leonine ), and hookworms ( Ancylostoma caninum , A braziliense , and Uncinaria stenocephala ). Ivermectin: to prevent canine heartworm diseases by eliminating the tissue larval stage of Dirofilaria immitis for a month (30 days) after infection. Pyrantel pamoate: for the treatment and control of adult Toxocara canis, Toxascaris leonina, Ancylostoma caninum, A braziliense, and Uncinaria stenocephala. Species commonly shown: Both.

Generic name
Ivermectin 68Mcg Pyrantel 57Mg
Species
Both
Completeness
77%
Validation
Incomplete

Indications / Uses

To prevent canine heartworm diseases by eliminating the tissue stage of heartworm larvae ( Dirofilaria immitis ) for a month (30 days) after infection. For the treatment and control of ascarids ( Toxocara canis , Toxascaris leonine ), and hookworms ( Ancylostoma caninum , A braziliense , and Uncinaria stenocephala ). Ivermectin: to prevent canine heartworm diseases by eliminating the tissue larval stage of Dirofilaria immitis for a month (30 days) after infection. Pyrantel pamoate: for the treatment and control of adult Toxocara canis, Toxascaris leonina, Ancylostoma caninum, A braziliense, and Uncinaria stenocephala.

Warnings / Contraindications

Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D. immitis . Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus. Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian.

  • Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D. immitis . Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus. Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian.

Side Effects

Top reported reactions (openFDA): Vomiting, Diarrhoea, INEFFECTIVE, HEARTWORM LARVAE, Lethargy (see also Central nervous system depression in 'Neurological'), Lack of efficacy (endoparasite) - hookworm, Underdose.

FAQ

Both

Related Conditions

Heartworm Disease

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

To prevent canine heartworm diseases by eliminating the tissue stage of heartworm larvae ( Dirofilaria immitis ) for a month (30 days) after infection. For the treatment and control of ascarids ( Toxocara canis , Toxasca...

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Use monthly
  • Recommended for dogs 6 weeks of age or older
  • All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D
  • immitis
  • Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus
  • Lack of efficacy - heartworm (1 reports)
  • Vomiting (1 reports)
  • Loss of appetite (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Major cautions & emergency warning signs

Side effects to monitor:

  • Use monthly
  • Recommended for dogs 6 weeks of age or older
  • All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D
  • immitis
  • Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus

Most reported reactions:

  • Lack of efficacy (endoparasite) - heartworm (1 reports)
  • Vomiting (1 reports)
  • Loss of appetite (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
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Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Manufacturer not confirmed
Identifiers:
ANADA: 200338 NADA: 140971

Warnings / Contraindications

Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D. immitis . Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus. Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian.

  • High: Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D. immitis . Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus. Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
10
Reported cases
6
Serious reports
1
Species represented
1
Grouped by Body System
Digestive (3) · Vomiting, Loss of appetite, Diarrhea Neurologic (1) · Lethargy (see also Central nervous system depression in 'Neurological') Behavior (1) · Behavioral disorder (unspecified) Effectiveness (3) · Lack of efficacy (endoparasite) - heartworm, Lack of efficacy, Lack of efficacy (endoparasite) - hookworm Other (2) · INEFFECTIVE, HEARTWORM LARVAE, Underdose
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Effectiveness 1 Dog 1
Digestive 1 Dog 0
Digestive 1 Dog 0
Effectiveness 1 Dog 0
Other 1 Dog 0
Digestive 1 Dog 0
Other 0 Dog 0
Neurologic 0 Dog 0

Species coverage: Dog (10)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Non-serious - 1
Digestive Dog Non-serious - 1
Effectiveness Dog Serious - 1
Effectiveness Dog Non-serious - 1
Other Dog Non-serious - 1
Digestive Dog Non-serious - 1
Other Dog Unknown - -
Neurologic Dog Unknown - -
Effectiveness Dog Unknown - -
Behavior Dog Unknown - -
Source metadata:

Documents

Owner handouts and official technical documents open on-page first, with the original source still one click away.

Only technical FDA review documents are linked right now. Owner handouts, official label / PI, and SPL documents are not linked yet.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

0
No SPL links yet.

FOI

3

ucm061802.pdf

FOI · FOI summary

Open original

UCM487710.pdf

FOI · FOI summary

Open original

UCM487711.pdf

FOI · FOI summary

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:05 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 1 • Cat 0 • View
Case summaries: 1 (showing 1) • View
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Heartworm Disease
Linked using: Usage_Inferred (0.78)
Diagnosis Codes
ICD10_CM: B74.8
Other filariases

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D. immitis . Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus. Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. (Contraindication, High)
Top reaction signals
Lack of efficacy (endoparasite) - heartworm (1) Vomiting (1) Loss of appetite (1) Lack of efficacy (1) INEFFECTIVE, HEARTWORM LARVAE (1) Diarrhea (1) Underdose (0) Lethargy (see also Central nervous system depression in 'Neurological') (0)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200338 NADA: 140971

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • ucm061802.pdf • FOI summary • Official • Feb. 8, 2024
    FDA FOI summary for application 200338
  • UCM487710.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 140971
  • UCM487711.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 140971

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 18 Clinical 19 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be test… (Clinical, 2026-05-05)
  • contraindications: Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be test… (Clinical, 2026-05-03)
  • contraindications: Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be test… (Clinical, 2026-04-30)
  • contraindications: Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be test… (Clinical, 2026-04-29)
  • contraindications: Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be test… (Clinical, 2026-04-28)
  • contraindications: Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be test… (Clinical, 2026-04-27)
  • contraindications: Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be test… (Clinical, 2026-04-26)
  • contraindications: Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be test… (Clinical, 2026-04-25)
  • contraindications: Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be test… (Clinical, 2026-04-22)
  • side_effects: Top reported reactions (openFDA): Vomiting, Diarrhoea, INEFFECTIVE, HEARTWORM LARVAE, Lethargy (see also Central nervous system depression in 'Neurological'), … (Clinical, 2026-04-11)
  • usage: To prevent canine heartworm diseases by eliminating the tissue stage of heartworm larvae ( Dirofilaria immitis ) for a month (30 days) after infection. For the… (Clinical, 2026-05-05)
  • usage: To prevent canine heartworm diseases by eliminating the tissue stage of heartworm larvae ( Dirofilaria immitis ) for a month (30 days) after infection. For the… (Clinical, 2026-05-03)
  • usage: To prevent canine heartworm diseases by eliminating the tissue stage of heartworm larvae ( Dirofilaria immitis ) for a month (30 days) after infection. For the… (Clinical, 2026-04-30)
  • usage: To prevent canine heartworm diseases by eliminating the tissue stage of heartworm larvae ( Dirofilaria immitis ) for a month (30 days) after infection. For the… (Clinical, 2026-04-29)
  • usage: To prevent canine heartworm diseases by eliminating the tissue stage of heartworm larvae ( Dirofilaria immitis ) for a month (30 days) after infection. For the… (Clinical, 2026-04-28)
  • usage: To prevent canine heartworm diseases by eliminating the tissue stage of heartworm larvae ( Dirofilaria immitis ) for a month (30 days) after infection. For the… (Clinical, 2026-04-27)
  • usage: To prevent canine heartworm diseases by eliminating the tissue stage of heartworm larvae ( Dirofilaria immitis ) for a month (30 days) after infection. For the… (Clinical, 2026-04-26)
  • usage: To prevent canine heartworm diseases by eliminating the tissue stage of heartworm larvae ( Dirofilaria immitis ) for a month (30 days) after infection. For the… (Clinical, 2026-04-25)
  • usage: To prevent canine heartworm diseases by eliminating the tissue stage of heartworm larvae ( Dirofilaria immitis ) for a month (30 days) after infection. For the… (Clinical, 2026-04-22)
  • contraindications: Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be test… (Official, 2026-04-12)
Recent Revisions
  • side_effects updated 2026-05-05 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-05-05 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-05-05 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-05-03 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-05-03 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-05-03 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-30 10:09 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-30 10:09 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-30 10:09 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-29 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-29 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-29 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-28 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-28 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-28 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-27 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-27 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-27 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-26 10:06 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-26 10:06 by etl_backfill • Backfilled from existing medication fields

Usage

To prevent canine heartworm diseases by eliminating the tissue stage of heartworm larvae ( Dirofilaria immitis ) for a month (30 days) after infection. For the treatment and control of ascarids ( Toxocara canis , Toxascaris leonine ), and hookworms ( Ancylostoma caninum , A braziliense , and Uncinaria stenocephala ). Ivermectin: to prevent canine heartworm diseases by eliminating the tissue larval stage of Dirofilaria immitis for a month (30 days) after infection. Pyrantel pamoate: for the treatment and control of adult Toxocara canis, Toxascaris leonina, Ancylostoma caninum, A braziliense, and Uncinaria stenocephala.

Contraindications

Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D. immitis . Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus. Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Loss of appetite (1) • Dog Diarrhea (1) • Dog

Showing top 5 for Digestive.

Neurologic
Tiredness (lethargy) • Dog

Showing top 5 for Neurologic.

Behavior
Behavioral disorder • Dog

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy (endoparasite) - heartworm (1) • Dog Lack of efficacy (1) • Dog Lack of efficacy (endoparasite) - hookworm • Dog

Showing top 5 for Effectiveness.

Other
INEFFECTIVE, HEARTWORM LARVAE (1) • Dog Underdose • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, ['Sheepdog (unspecified)', 'Dog (unknown)'], Male, 2 year, 16.692 kilogram • Drug: MSK, Tablet, chewable, Oral • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-075429
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 2.00 Year
  • Weight: 16.692 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
Reactions Reported:
Lack of efficacy (endoparasite) - heartworm
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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