Skip to main content
Start triage

Start triage first, then route to emergency care.

Start symptom intake Emergency vets near you

Need urgent help? Start triage first, then route to emergency care.

Start symptom intake Emergency vets near you

Meds A-Z

Doxycycline

Detailed information about Doxycycline

Official label facts Owner quick guide first Marketing clearly labeled
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Veterinary professional?

Showing simplified owner view. Switch to Vet View for full technical detail.

Add to My Pet's Meds

Choose a pet, confirm current or past, and optionally add reminder notes.

Sign in to save this medication to your pet profile.

Sign in to continue

Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 7:40 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

DOXIROBE Gel is indicated for the treatment and control of periodontal disease in dogs.

What to watch for:

  • Use caution in young animals and in pregnancy
  • In cats, dry pilling can cause esophageal injury
  • Melaena (1 reports)
  • Injection site swelling (1 reports)
  • Injection site pain (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Use caution in young animals and in pregnancy
  • In cats, dry pilling can cause esophageal injury
  • Melaena
  • Injection site swelling
  • Injection site pain

Most reported reactions:

  • Melaena (1 reports)
  • Injection site swelling (1 reports)
  • Injection site pain (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 7:40 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 17, 2026, 10:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:19 AM UTC
Image coming soon
Doxycycline

Doxycycline

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available
Form: Liquid
Identifiers:
NADA: 141082 NDC Package: 17163-017-16 NDC Package: 43457-541-25 NDC Package: 46144-604-01 NDC Package: 54771-5193-1 NDC Package: 58645-005-01 NDC Package: 62157-482-01 NDC Package: 62157-538-01 NDC Package: 62157-816-01 NDC Package: 73377-033-01 NDC Package: 73377-033-02 NDC Package: 73377-033-03 NDC Product: 17163 NDC Product: 43457 NDC Product: 46144 NDC Product: 54771 NDC Product: 58645 NDC Product: 62157 NDC Product: 73377
Source metadata:

Warnings / Contraindications

Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.

  • High: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
18
Species represented
2
Grouped by Body System
Digestive (2) · Decreased appetite, Blood in vomit Skin & allergy (2) · Injection site swelling, Hair loss NOS Neurologic (2) · Unsteady walking (ataxia), Tiredness (lethargy) Effectiveness (1) · Lack of efficacy - NOS Other (25) · Melaena, Low thyroxine, Localised oedema
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Cat 1
Skin & allergy 1 Dog 1
Other 1 Dog 1
Skin & allergy 1 Cat 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (17) Cat (15)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Cat Non-serious - 1
Neurologic Dog Non-serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Other Cat Non-serious - 1
Skin & allergy Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Skin & allergy Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Digestive Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Digestive Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Source metadata:

Storage & Handling

Store at room temperature; protect from moisture.

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)
  • No owner handouts linked yet.
Official label / PI (0)
  • No official label or package insert links yet.
SPL (1)
  • Doxirobe™ Gel · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1851/Doxirobe%E2%84%A2%20Gel
FOI (1)
  • UCM437264.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/616
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 7:40 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 17, 2026, 10:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:19 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Doxirobe™ Gel
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Liquid • Subgingival
Applications: NADA 141-082
Documents: 1 (FOI: 1) • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 33 • Cat 10 • View
Case summaries: 10 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: K05.6
Periodontal disease, unspecified

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Contraindication, High)
Top reaction signals
Melaena (1) Injection site swelling (1) Injection site pain (1) Hair loss NOS (1) General illness (1) Gagging (1) Facial paralysis (1) Facial palsy (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141082 NDC Package: 17163-017-16 NDC Package: 43457-541-25 NDC Package: 46144-604-01 NDC Package: 54771-5193-1 NDC Package: 58645-005-01 NDC Package: 62157-482-01 NDC Package: 62157-538-01 NDC Package: 62157-816-01 NDC Package: 73377-033-01 NDC Package: 73377-033-02 NDC Package: 73377-033-03 NDC Product: 17163 NDC Product: 43457 NDC Product: 46144 NDC Product: 54771 NDC Product: 58645 NDC Product: 62157 NDC Product: 73377
Package NDC Product NDC Form / Route Status
17163-017-16 17163 -
43457-541-25 43457 -
46144-604-01 46144 -
54771-5193-1 54771 -
58645-005-01 58645 -
62157-482-01 62157 -
62157-538-01 62157 -
62157-816-01 62157 -
73377-033-01 73377 -
73377-033-02 73377 -
73377-033-03 73377 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • UCM437264.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 141082

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 4 Clinical 1 Manufacturer 0 Marketing 0
Current Field Facts
  • storage_handling: Store at room temperature; protect from moisture. (Clinical, 2026-02-12)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Official, 2026-02-12)
  • side_effects: GI upset; photosensitivity. (Official, 2026-02-12)
  • usage: Tetracycline antibiotic used for a variety of infections (often tick-borne diseases in dogs). (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Doxirobe™ Gel
RX
Doxycycline Hyclate
Liquid • Subgingival
Label highlights
Official documents
Zoetis Inc. NADA 141-082 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, Restricted During Pregnancy • Dog, Excluding Under 12 Months
Composition / specifications
Doxycycline hyclate solution contains 8.5 percent doxycycline activity. A syringe of N-methyl-2-pyrrolidone and poly (DL-lactide) mixed with a syringe of doxycycline produces 0.5 milliliter of solution.
Dogs (Over 1 Year)
Indication
DOXIROBE Gel is indicated for the treatment and control of periodontal disease in dogs.
Dosage
Apply subgingivally to periodontal pocket(s) of affected teeth.
Limitations
Do not use in dogs less than 1-year old. Use of tetracyclines during tooth development has been associated with permanent discoloration of teeth. Do not use in pregnant bitches. Use in breeding dogs has not been evaluated. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
  • Summary
    The Heska Periodontal Disease Therapeutic is indicated for the treatment and control of periodontal disease in dogs.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

Tetracycline antibiotic used for a variety of infections (often tick-borne diseases in dogs).

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.

Side Effects

GI upset; photosensitivity.

Source: FDA openFDA • Reference

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Decreased appetite (1) • Cat Blood in vomit (1) • Cat

Showing top 5 for Digestive.

Skin & allergy
Injection site swelling (1) • Dog Hair loss NOS (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Cat Tiredness (1) • Dog

Showing top 5 for Neurologic.

Effectiveness
Lack of efficacy - NOS (1) • Dog

Showing top 5 for Effectiveness.

Other
Melaena (1) • Cat Low thyroxine (1) • Dog Localised oedema (1) • Dog Lick granuloma (1) • Dog Ketosis (1) • Cat
Show more (20)
Injection site pain (1) • Dog Increased drinking (1) • Dog Hypothyroidism (1) • Dog Hyperglycaemia (1) • Cat General illness (1) • Dog Gagging (1) • Cat Facial paralysis (1) • Dog Facial palsy (1) • Dog Excessive thirst (1) • Dog Elevated temperature (1) • Cat Elevated alanine aminotransferase (1) • Cat Digestive tract disorder NOS (1) • Cat Decreased red blood cell count (1) • Dog Death by euthanasia (1) • Dog Cellulitis (1) • Dog Blood in urine (1) • Cat Barbering (1) • Cat Arthritis (1) • Dog Anaemia NOS (1) • Cat Abdominal pain (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, ['Retriever - Labrador', 'Dog (unknown)'], Male, 11 year, 29.3 kilogram • Drug: MSK, Unknown • Reactions: Excessive thirst, Increased drinking • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054420
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 11.00 Year
  • Weight: 29.300 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Excessive thirst Increased drinking
Outcomes: Ongoing

Dog, Mastiff (unspecified), Male, 5.5 year, 90.26 kilogram • Drug: MSK, Unknown • Reactions: Regenerative anaemia, Tiredness (lethargy), Localised oedema, Uncomfortable, Lack of efficacy - NOS… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054417
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 5.50 Year
  • Weight: 90.260 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Regenerative anaemia Tiredness (lethargy) Localised oedema Uncomfortable Lack of efficacy - NOS Cellulitis Low thyroxine Swelling NOS Hypothyroidism Lick granuloma
Outcomes: Ongoing

Dog, Dog (other), Female, 4 year, 33.29 kilogram • Drug: MSK, Unknown • Reactions: Facial paralysis, Facial palsy • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-056006
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 4.00 Year
  • Weight: 33.290 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Facial paralysis Facial palsy
Outcomes: Outcome Unknown

Dog, Chihuahua, Female, 2 year, 5.534 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Injection site pain, Injection site swelling • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054500
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 2.00 Year
  • Weight: 5.534 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
Reactions Reported:
Injection site pain Injection site swelling
Outcomes: Ongoing

Dog, Dachshund - Miniature, Female, 12 year, 5.443 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Arthritis, Tiredness (lethargy), Decreased red blood cell count, Death by euthanasia, Pale mucous membrane… • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2025-US-053358
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 12.00 Year
  • Weight: 5.443 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Arthritis Tiredness (lethargy) Decreased red blood cell count Death by euthanasia Pale mucous membrane Weakness General illness
Outcomes: Euthanized

Cat, Domestic Longhair, Male, 15 year, 6.8 kilogram • Drug: MSK, Solution/drops, Oral, Dose: 0.60 mL per animal, Frequency: 24 per hour • Reactions: Unsteady walking (ataxia), Stiffness NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-052743
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 15.00 Year
  • Weight: 6.800 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution/drops
  • Dose: 0.60 mL per animal
  • Frequency: 24 per hour
Reactions Reported:
Unsteady walking (ataxia) Stiffness NOS
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Female, 16 year • Drug: MSK, Unknown • Reactions: Ketosis, Hyperglycaemia • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-048331
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 16.00 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Ketosis Hyperglycaemia
Outcomes: Ongoing

Cat, Domestic Mediumhair, Male, 16.5 year, 2.948 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Digestive tract disorder NOS, Gagging, Tongue disorder NOS, Weight loss, Tiredness (lethargy)… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-047609
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 16.50 Year
  • Weight: 2.948 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Digestive tract disorder NOS Gagging Tongue disorder NOS Weight loss Tiredness (lethargy) Wobbliness General illness Blood in urine Skin lesion NOS Barbering Hair loss NOS Reddening of the skin Vasculitis
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

Store at room temperature; protect from moisture.

Share Your Thoughts

Let others know your experience or advice regarding this medication.

This medication has not been reviewed by a veterinarian yet.