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Grapiprant

Detailed information about Grapiprant

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

For the control of pain and inflammation associated with osteoarthritis in dogs.

What to watch for:

  • For oral use in dogs only
  • very low energy (1 reports)
  • Other abnormal test result NOS (1 reports)
  • Not sleeping (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • For oral use in dogs only
  • very low energy
  • Other abnormal test result NOS
  • Not sleeping

Most reported reactions:

  • Tiredness (lethargy) (1 reports)
  • Other abnormal test result NOS (1 reports)
  • Not sleeping (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:02 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC
Image coming soon
Grapiprant

Grapiprant

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available
Form: Tablet
Identifiers:
NADA: 141455 NDC Package: 58198-5810-1 NDC Package: 58198-5810-2 NDC Package: 58198-5810-3 NDC Package: 58198-5811-1 NDC Package: 58198-5811-2 NDC Package: 58198-5811-3 NDC Package: 58198-5812-1 NDC Package: 58198-5812-2 NDC Package: 58198-5812-3 NDC Product: 58198
Source metadata:

Warnings / Contraindications

For oral use in dogs only.

  • High: For oral use in dogs only.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
24
Species represented
2
Grouped by Body System
Neurologic (1) · Tiredness (lethargy) Behavior (1) · Behavioral disorder (unspecified) Effectiveness (1) · Lack of efficacy - NOS Other (29) · Other abnormal test result NOS, Not sleeping, Not himself/herself
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1

Species coverage: Cat (25) Dog (7)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Effectiveness Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Behavior Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Source metadata:

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)
  • No owner handouts linked yet.
Official label / PI (2)
SPL (1)
  • Galliprant™ · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2568/Galliprant%E2%84%A2
FOI (1)
  • UCM494127.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/941
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Galliprant™
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Tablet • Oral
Applications: NADA 141-455
Documents: 3 (FOI: 1) • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 26 • Cat 9 • View
Case summaries: 10 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: M19.90
Unspecified osteoarthritis, unspecified site

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • For oral use in dogs only. (Contraindication, High)
Top reaction signals
Tiredness (lethargy) (1) Other abnormal test result NOS (1) Not sleeping (1) Not himself/herself (1) Not eating (1) Neutrophilia (1) Monocytosis (1) Lymphocytosis (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141455 NDC Package: 58198-5810-1 NDC Package: 58198-5810-2 NDC Package: 58198-5810-3 NDC Package: 58198-5811-1 NDC Package: 58198-5811-2 NDC Package: 58198-5811-3 NDC Package: 58198-5812-1 NDC Package: 58198-5812-2 NDC Package: 58198-5812-3 NDC Product: 58198
Package NDC Product NDC Form / Route Status
58198-5810-1 58198 -
58198-5810-2 58198 -
58198-5810-3 58198 -
58198-5811-1 58198 -
58198-5811-2 58198 -
58198-5811-3 58198 -
58198-5812-1 58198 -
58198-5812-2 58198 -
58198-5812-3 58198 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • N-141455-C-0055-CS-AA_PI.pdf • Official label • Official • July 15, 2025
    FDA official labeling for application 141455
  • N-141455-C-0045-NL-AA_CIS.pdf • Official label • Official • July 15, 2025
    FDA official labeling for application 141455
  • UCM494127.pdf • FOI summary • Official • July 15, 2025
    FDA FOI summary for application 141455

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 6 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: For oral use in dogs only. (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Vomiting, Diarrhoea, Lack of efficacy - NOS, Lethargy (see also Central nervous system depression in 'Neurological'), Elevate… (Official, 2026-02-12)
  • usage: For the control of pain and inflammation associated with osteoarthritis in dogs. (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Galliprant™
RX
Grapiprant
Tablet • Oral
Label highlights
Official documents
Elanco US Inc. NADA 141-455 Approved Jul 15, 2025

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
20 mg, 60 mg, or 100 mg
Dogs
Indication
For the control of pain and inflammation associated with osteoarthritis in dogs.
Dosage
0.9 mg/lb (2 mg/kg) once daily.
Limitations
For oral use in dogs only.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

For the control of pain and inflammation associated with osteoarthritis in dogs.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

For oral use in dogs only.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Neurologic
Tiredness (1) • Cat

Showing top 5 for Neurologic.

Behavior
Behavioral disorder (1) • Cat

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy - NOS (1) • Cat

Showing top 5 for Effectiveness.

Other
Other abnormal test result NOS (1) • Cat Not sleeping (1) • Cat Not himself/herself (1) • Cat Not eating (1) • Cat Neutrophilia (1) • Cat
Show more (24)
Monocytosis (1) • Cat Lymphocytosis (1) • Cat Low serum alkaline phosphatase (1) • Cat Low creatinine (1) • Cat Leucocytosis NOS (1) • Cat Intentional misuse (1) • Cat Inappropriate urination (1) • Dog Hypoalbuminaemia (1) • Cat Horner's syndrome (1) • Dog Hiding (1) • Cat Gait abnormality (1) • Dog Eosinopenia (1) • Cat Enlarged pupils (1) • Cat Elevated symmetrical dimethylarginine (1) • Cat Elevated serum alkaline phosphatase (1) • Dog Elevated creatinine (1) • Cat Elevated blood urea nitrogen (1) • Cat Elevated alanine aminotransferase (1) • Dog Dental discolouration (1) • Dog Death by euthanasia (1) • Cat Arthritis (1) • Dog Anaemia NOS (1) • Cat Agitation (1) • Cat Accidental exposure (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Dog (unknown), Unknown, 15 year, 27.66 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per animal, Frequency: 1 per day • Reactions: Arthritis, Dental discolouration, Elevated alanine aminotransferase, Elevated serum alkaline phosphatase • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055864
  • Serious AE: No
  • Treated For AE: No
  • Sex: Unknown
  • Age: 15.00 Year
  • Weight: 27.660 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per animal
  • Frequency: 1 per day
Reactions Reported:
Arthritis Dental discolouration Elevated alanine aminotransferase Elevated serum alkaline phosphatase
Outcomes: Ongoing

Dog, Retriever - Labrador, Male, 12 year, 34.292 kilogram • Drug: MSK, Tablet, Unknown • Reactions: Horner's syndrome • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055778
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 12.00 Year
  • Weight: 34.292 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Tablet
Reactions Reported:
Horner's syndrome
Outcomes: Ongoing

Dog, ['Retriever - Labrador', 'Dog (unknown)'], Male, 14 year, 15.876 kilogram • Drug: MSK, Tablet, Oral • Reactions: Seizure NOS, Inappropriate urination, Walking difficulty, Urinary incontinence, Swelling NOS… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-056004
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 14.00 Year
  • Weight: 15.876 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
Reactions Reported:
Seizure NOS Inappropriate urination Walking difficulty Urinary incontinence Swelling NOS Unable to walk
Outcomes: Ongoing

Dog, Crossbred Canine/dog, Female, 7 year, 14.061 kilogram • Drug: MSK, Tablet, Oral, Frequency: 1 per day • Reactions: Vomiting • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055518
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 14.061 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Frequency: 1 per day
Reactions Reported:
Vomiting
Outcomes: Recovered/Normal

Dog, ['Weimaraner', 'Retriever - Labrador'], Male, 14 year, 26.3 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per animal • Reactions: Gait abnormality, Walking difficulty, Unsteady gait, Product label issues • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054553
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 14.00 Year
  • Weight: 26.300 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per animal
Reactions Reported:
Gait abnormality Walking difficulty Unsteady gait Product label issues
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 4 year, 7.257 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per animal, Frequency: 1 per day • Reactions: Accidental exposure, Hiding • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-052521
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 4.00 Year
  • Weight: 7.257 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per animal
  • Frequency: 1 per day
Reactions Reported:
Accidental exposure Hiding
Outcomes: Ongoing

Cat, Cat (unknown), Male, 12 week, 0.998 kilogram • Drug: MSK, Tablet, Unknown • Reactions: Lack of efficacy - NOS, Intentional misuse, Weight loss, Anaemia NOS, Leucocytosis NOS… • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2024-US-076581
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 12.00 Week
  • Weight: 0.998 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Tablet
Reactions Reported:
Lack of efficacy - NOS Intentional misuse Weight loss Anaemia NOS Leucocytosis NOS Neutrophilia Lymphocytosis Monocytosis Eosinopenia Low creatinine Elevated blood urea nitrogen Hypoalbuminaemia Low serum alkaline phosphatase Elevated alanine aminotransferase Death by euthanasia Other abnormal test result NOS Prolonged capillary refill time Tiredness (lethargy) Not eating
Outcomes: Euthanized

Cat, Domestic Shorthair, Male, 17 year, 6.53 kilogram • Drug: MSK, Tablet, Oral, Dose: 0.50 tablet per animal • Reactions: Agitation, Not sleeping, Hiding, Not eating, Enlarged pupils… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2024-US-027068
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 17.00 Year
  • Weight: 6.530 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 0.50 tablet per animal
Reactions Reported:
Agitation Not sleeping Hiding Not eating Enlarged pupils Not himself/herself Behavioral disorder (unspecified) Elevated blood urea nitrogen Elevated creatinine Elevated symmetrical dimethylarginine
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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