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Buprenorphine

Detailed information about Buprenorphine

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

For the control of postoperative pain associated with surgical procedures in cats.

What to watch for:

  • wobbly/unsteady walking (1 reports)
  • very low energy (1 reports)
  • Loss of appetite (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • wobbly/unsteady walking
  • very low energy
  • Loss of appetite

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Tiredness (lethargy) (1 reports)
  • Loss of appetite (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:02 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Mar 10, 2026, 10:05 AM UTC
Image coming soon
Buprenorphine

Buprenorphine

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available
Form: Injectable Solution, Transdermal Solution
Identifiers:
NADA: 141434 NADA: 141547 NDC Package: 54771-4131-1 NDC Package: 58198-0078-1 NDC Package: 58198-0078-2 NDC Package: 86084-100-30 NDC Product: 54771 NDC Product: 58198 NDC Product: 86084
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
24
Species represented
2
Grouped by Body System
Digestive (3) · Loss of appetite, Drooling, Bloody diarrhoea Neurologic (2) · Unsteady walking (ataxia), Tiredness (lethargy) Behavior (1) · Behavioral disorder (unspecified) Other (26) · Leucocytosis NOS, Intervertebral disc disease, Injection site pain
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Dog 1
Neurologic 1 Dog 1
Digestive 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (25) Cat (7)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Dog Serious - 1
Neurologic Dog Serious - 1
Digestive Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Digestive Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Digestive Dog Serious - 1
Behavior Cat Non-serious - 1
Other Cat Non-serious - 1
Source metadata:

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)
  • No owner handouts linked yet.
Official label / PI (0)
  • No official label or package insert links yet.
SPL (2)
  • Simbadol® · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2294/Simbadol%C2%AE
  • Zorbium™ · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/11955/Zorbium%E2%84%A2
FOI (2)
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Mar 10, 2026, 10:05 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Simbadol® Zorbium™
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat
Rx/OTC: RX
Form/route: Injectable Solution, Transdermal Solution • Subcutaneous, Topical
Applications: NADA 141-434 • NADA 141-547
Documents: 2 (FOI: 2) • SPL: 2 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 27 • Cat 23 • View
Case summaries: 12 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Pain (acute, chronic) Pica
Linked using: Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Unsteady walking (ataxia) (1) Tiredness (lethargy) (1) Loss of appetite (1) Leucocytosis NOS (1) Intervertebral disc disease (1) Injection site pain (1) Injection site oedema (1) Increased lung sounds (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141434 NADA: 141547 NDC Package: 54771-4131-1 NDC Package: 58198-0078-1 NDC Package: 58198-0078-2 NDC Package: 86084-100-30 NDC Product: 54771 NDC Product: 58198 NDC Product: 86084
Package NDC Product NDC Form / Route Status
54771-4131-1 54771 -
58198-0078-1 58198 -
58198-0078-2 58198 -
86084-100-30 86084 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 5 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lethargy (see also Central nervous system depression in 'Neurological'), Diarrhoea, Death, Death by euthanasia, Ano… (Official, 2026-02-12)
  • usage: For the control of postoperative pain associated with surgical procedures in cats. (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Simbadol®
RX
Buprenorphine
Injectable Solution • Subcutaneous
Label highlights
Official documents
Zoetis Inc. NADA 141-434 Approved Feb 8, 2023
Zorbium™
RX
Buprenorphine
Transdermal Solution • Topical
Label highlights
Official documents
Elanco US Inc. NADA 141-547 Approved Feb 1, 2022

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of solution contains 1.8 milligrams buprenorphine.
Cats
Indication
For the control of postoperative pain associated with surgical procedures in cats.
Dosage
Administer 0.24 mg/kg (0.11 mg/lb) by subcutaneous injection once daily for up to 3 days. Administer the first dose approximately 1 hour prior to surgery.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
20mg/mL
Cats
Indication

For the control of postoperative pain associated with surgical procedures in cats.

Dosage

Administer topically to the dorsal cervical area at the base of the skull a single dose of 1.2 to 3.1 mg/lb (2.7 to 6.7 mg/kg) approximately 1 to 2 hours before surgery.

Limitations

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
  • Summary
    For the control of postoperative pain associated with surgical procedures in cats.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

For the control of postoperative pain associated with surgical procedures in cats.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Dog Drooling (1) • Dog Bloody diarrhoea (1) • Dog

Showing top 5 for Digestive.

Neurologic
Unsteady walking (1) • Dog Tiredness (1) • Dog

Showing top 5 for Neurologic.

Behavior
Behavioral disorder (1) • Cat

Showing top 5 for Behavior.

Other
Leucocytosis NOS (1) • Dog Intervertebral disc disease (1) • Dog Injection site pain (1) • Dog Injection site oedema (1) • Dog Increased lung sounds (1) • Dog
Show more (21)
Increased band neutrophilia (1) • Dog Inappropriate urination (1) • Cat Hypothermia (1) • Dog Hypochloraemia (1) • Dog Hyperthermia (1) • Cat Hyperactivity (1) • Cat Hiding (1) • Cat Groaning (1) • Dog Fever (1) • Dog Excessive chewing, licking and/or grooming (1) • Dog Eosinophilia (1) • Dog Enamel disorder (1) • Dog Elevated symmetrical dimethylarginine (1) • Dog Elevated gamma-glutamyl transferase (1) • Dog Elevated blood urea nitrogen (1) • Dog Dysphoria (1) • Cat Dehydration (1) • Dog Decreased blood urea nitrogen (BUN) or creatinine (1) • Dog Decreased activity (1) • Dog Burn (1) • Dog Agitation (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Longhair, Male, 6 month, 2.631 kilogram • Drug: MSK, Injection, solution, Subcutaneous, Dose: 0.36 mL per animal • Reactions: Hyperthermia, Underdose • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-056102
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 6.00 Month
  • Weight: 2.631 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Injection, solution
  • Dose: 0.36 mL per animal
Reactions Reported:
Hyperthermia Underdose
Outcomes: Ongoing

Cat, Cat (unknown), Unknown • Drug: MSK, Solution, Unknown • Reactions: Dysphoria, Agitation, Behavioral disorder (unspecified) • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-056125
  • Serious AE: No
  • Treated For AE: No
  • Sex: Unknown
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Solution
Reactions Reported:
Dysphoria Agitation Behavioral disorder (unspecified)
Outcomes: Recovered/Normal

Cat, Siamese, Female, 6 year, 3.44 kilogram • Drug: MSK, Solution, Transdermal, Dose: 1 tube per animal • Reactions: Inappropriate urination, Not drinking, Reluctant to move, Not eating, Hiding… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055785
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 6.00 Year
  • Weight: 3.440 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Transdermal
  • Form: Solution
  • Dose: 1 tube per animal
Reactions Reported:
Inappropriate urination Not drinking Reluctant to move Not eating Hiding Sedation Behavioral disorder (unspecified)
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 5 year, 8.61 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal • Reactions: Hyperthermia, Hyperactivity • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055972
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 5.00 Year
  • Weight: 8.610 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
Reactions Reported:
Hyperthermia Hyperactivity
Outcomes: Ongoing

Cat, Domestic Shorthair, Female, 18 year, 2.51 kilogram • Drug: MSK, Solution, Topical, Dose: 0.20 mL per animal • Reactions: Not sleeping, Dysphoria • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-056122
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 18.00 Year
  • Weight: 2.510 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 0.20 mL per animal
Reactions Reported:
Not sleeping Dysphoria
Outcomes: Outcome Unknown

Dog, ['Collie (unspecified)', 'Dog (unknown)'], Female, 11 year, 18.234 kilogram • Drug: MSK, Unknown • Reactions: Decreased activity, Otitis NOS, Mucous stool, Bloody diarrhoea, Loss of hearing • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055634
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 11.00 Year
  • Weight: 18.234 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Decreased activity Otitis NOS Mucous stool Bloody diarrhoea Loss of hearing
Outcomes: Ongoing

Dog, ['Shepherd Dog - German', 'Dog (unknown)'], Female, 2.5 year • Drug: MSK, Intramuscular, Dose: 0.48 mL per animal • Reactions: Neutropenia, Eosinophilia, Lymphocytosis, Enamel disorder, Tooth disorder • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055809
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 2.50 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Dose: 0.48 mL per animal
Reactions Reported:
Neutropenia Eosinophilia Lymphocytosis Enamel disorder Tooth disorder
Outcomes: Outcome Unknown

Dog, Shepherd Dog - German, Female, 3 year, 39.463 kilogram • Drug: MSK, Unassigned, Unknown, Dose: 1.30 mL per animal • Reactions: Tiredness (lethargy), Drooling, Restlessness, Groaning • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054508
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 3.00 Year
  • Weight: 39.463 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
  • Dose: 1.30 mL per animal
Reactions Reported:
Tiredness (lethargy) Drooling Restlessness Groaning
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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