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Meds A-Z

Milbemycin Oxime, Lufenuron

Detailed information about Milbemycin Oxime, Lufenuron

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

Your vet decides this. Here's what owners typically ask/watch for.

What to watch for:

  • Vocalisation (1 reports)
  • Tachycardia (1 reports)
  • Shaking (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Vocalisation
  • Tachycardia
  • Shaking

Most reported reactions:

  • Vocalisation (1 reports)
  • Tachycardia (1 reports)
  • Shaking (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 10, 2026, 10:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC
Image coming soon
Milbemycin Oxime, Lufenuron

Milbemycin Oxime, Lufenuron

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available
Identifiers:
NDC Package: 0061-5354-01 NDC Package: 0061-5354-02 NDC Package: 0061-5355-01 NDC Package: 0061-5355-02 NDC Package: 0061-5356-01 NDC Package: 0061-5356-02 NDC Package: 0061-5357-01 NDC Package: 0061-5357-02 NDC Product: 0061

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
28
Reported cases
21
Serious reports
13
Species represented
2
Grouped by Body System
Digestive (3) · Vomiting, Drooling, Diarrhea Neurologic (2) · Tiredness (lethargy), Lethargy (see also Central nervous system depression in 'Neurological') Behavior (1) · Anxiety Effectiveness (3) · Lack of efficacy (endoparasite) - heartworm, Lack of efficacy (endoparasite) - whipworm, Lack of efficacy (endoparasite) - hookworm Other (19) · Vocalisation, Uncomfortable, Tachycardia
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Effectiveness 1 Dog 1
Other 1 Cat 1
Other 1 Cat 1

Species coverage: Cat (17) Dog (11)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Cat Non-serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Neurologic Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Effectiveness Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Digestive Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Behavior Cat Serious - 1
Other Cat Non-serious - 1
Neurologic Dog Unknown - -
Effectiveness Dog Unknown - -
Effectiveness Dog Unknown - -
Other Dog Unknown - -
Other Dog Unknown - -
Other Dog Unknown - -
Digestive Dog Unknown - -
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 10, 2026, 10:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 8 • Cat 8 • View
Case summaries: 10 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Vocalisation (1) Tachycardia (1) Shaking (1) Panting (1) Open mouth breathing (1) Lack of efficacy (endoparasite) - heartworm (1) Hypophosphataemia (1) Hypokalaemia (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NDC Package: 0061-5354-01 NDC Package: 0061-5354-02 NDC Package: 0061-5355-01 NDC Package: 0061-5355-02 NDC Package: 0061-5356-01 NDC Package: 0061-5356-02 NDC Package: 0061-5357-01 NDC Package: 0061-5357-02 NDC Product: 0061
Package NDC Product NDC Form / Route Status
0061-5354-01 0061 -
0061-5354-02 0061 -
0061-5355-01 0061 -
0061-5355-02 0061 -
0061-5356-01 0061 -
0061-5356-02 0061 -
0061-5357-01 0061 -
0061-5357-02 0061 -

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 1 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (endoparasite) - hookworm, INEFFECTIVE, HEARTWORM LARVAE, Vomiting, INEFFECTIVE, ASCARIDS NOS, Diarrhoea, Le… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Cat Drooling (1) • Cat Diarrhea • Dog

Showing top 5 for Digestive.

Neurologic
Tiredness (1) • Cat Tiredness (lethargy) • Dog

Showing top 5 for Neurologic.

Behavior
Anxiety (1) • Cat

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy (endoparasite) - heartworm (1) • Dog Lack of efficacy (endoparasite) - whipworm • Dog Lack of efficacy (endoparasite) - hookworm • Dog

Showing top 5 for Effectiveness.

Other
Vocalisation (1) • Cat Uncomfortable (1) • Dog Tachycardia (1) • Cat Shaking (1) • Cat Rapid pulse rate (1) • Dog
Show more (14)
Panting (1) • Cat Open mouth breathing (1) • Cat Not drinking (1) • Cat Inappetence (1) • Cat Hypophosphataemia (1) • Cat Hypokalaemia (1) • Cat Elevated temperature (1) • Cat Distress (1) • Cat Decreased body temperature (1) • Cat Barking (1) • Dog Accidental exposure (1) • Cat INEFFECTIVE, HOOKS • Dog INEFFECTIVE, HEARTWORM LARVAE • Dog INEFFECTIVE, ASCARIDS NOS • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Bulldog - English, Male, 7 year, 45.359 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Vomiting • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055385
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 7.00 Year
  • Weight: 45.359 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
Reactions Reported:
Vomiting
Outcomes: Recovered/Normal

Dog, ['Terrier - Bull - American Pit', 'Dog (unknown)'], Male, 13 year, 30.3 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Anxiety, Rapid pulse rate, Barking, Panting, Uncomfortable • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-034204
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 13.00 Year
  • Weight: 30.300 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
Reactions Reported:
Anxiety Rapid pulse rate Barking Panting Uncomfortable
Outcomes: Recovered/Normal

Dog, ['Terrier - Irish Soft-coated Wheaten', 'Dog (unknown)'], Female, 6 year, 15.604 kilogram • Drug: MSK, Tablet, Oral • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-030552
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 6.00 Year
  • Weight: 15.604 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
Reactions Reported:
Lack of efficacy (endoparasite) - heartworm
Outcomes: Ongoing

Dog, Retriever - Labrador, Male, 1 year, 44.452 kilogram • Drug: MSK, Tablet, chewable, Oral • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2024-US-059028
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 1.00 Year
  • Weight: 44.452 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
Reactions Reported:
Lack of efficacy (endoparasite) - heartworm
Outcomes: Ongoing

Dog, Retriever - Golden, Female, 4 year, 28.6 kilogram • Drug: MSK, Unknown • Reactions: Tiredness (lethargy), Tachycardia • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2024-US-055311
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 4.00 Year
  • Weight: 28.600 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Tiredness (lethargy) Tachycardia
Outcomes: Recovered/Normal

Cat, Domestic Mediumhair, Male, 11 year, 3.629 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per dose, Frequency: 1 per day • Reactions: Vomiting, Inappetence, Not drinking, Accidental exposure • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2017-US-046549
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 11.00 Year
  • Weight: 3.629 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per dose
  • Frequency: 1 per day
Reactions Reported:
Vomiting Inappetence Not drinking Accidental exposure
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 3 year, 6.804 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per dose, Frequency: 1 per day • Reactions: Panting, Drooling, Decreased body temperature, Distress, Open mouth breathing… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2017-US-014138
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 3.00 Year
  • Weight: 6.804 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per dose
  • Frequency: 1 per day
Reactions Reported:
Panting Drooling Decreased body temperature Distress Open mouth breathing Vocalisation Hypophosphataemia Hypokalaemia Accidental exposure
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 2.5 year, 8.618 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per dose, Frequency: 1 per day • Reactions: Vomiting, Accidental exposure • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2017-US-014818
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 2.50 Year
  • Weight: 8.618 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per dose
  • Frequency: 1 per day
Reactions Reported:
Vomiting Accidental exposure
Outcomes: Recovered/Normal

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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