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Emodepside

Detailed information about Emodepside

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

For the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections caused by Toxocara cati (adults and fourth stage larvae), and...

What to watch for:

  • Safe use of this product has not been evaluated in cats less that 8 weeks of age or weighing less than 2.2 lbs (1 kg), in cats used for breeding, during pregnancy, or in lactating queens
  • Oral ingestion or exposure should be avoided
  • very low energy (1 reports)
  • Sleepiness - systemic disorder (1 reports)
  • Moist dermatitis (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Safe use of this product has not been evaluated in cats less that 8 weeks of age or weighing less than 2.2 lbs (1 kg), in cats used for breeding, during pregnancy, or in lactating queens
  • Oral ingestion or exposure should be avoided
  • very low energy
  • Sleepiness - systemic disorder
  • Moist dermatitis

Most reported reactions:

  • Tiredness (lethargy) (1 reports)
  • Sleepiness - systemic disorder (1 reports)
  • Moist dermatitis (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 17, 2026, 10:03 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 12, 2026, 10:42 PM UTC
Image coming soon
Emodepside

Emodepside

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available
Form: Liquid
Identifiers:
NADA: 141275 NDC Package: 58198-0059-1 NDC Package: 58198-0059-2 NDC Package: 58198-0059-3 NDC Package: 58198-0060-1 NDC Package: 58198-0060-2 NDC Package: 58198-0060-3 NDC Package: 58198-0061-1 NDC Package: 58198-0061-2 NDC Package: 58198-0061-3 NDC Package: 58198-0062-1 NDC Product: 58198
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Safe use of this product has not been evaluated in cats less that 8 weeks of age or weighing less than 2.2 lbs (1 kg), in cats used for breeding, during pregnancy, or in lactating queens. Oral ingestion or exposure should be avoided.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Safe use of this product has not been evaluated in cats less that 8 weeks of age or weighing less than 2.2 lbs (1 kg), in cats used for breeding, during pregnancy, or in lactating queens. Oral ingestion or exposure should be avoided.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
21
Reported cases
19
Serious reports
0
Species represented
2
Grouped by Body System
Digestive (1) · Drooling Skin & allergy (3) · Ear twitching, Application site hair loss, Hair loss at application site Neurologic (1) · Tiredness (lethargy) Behavior (1) · Behavioral disorder (unspecified) Effectiveness (3) · Lack of efficacy - NOS, Lack of efficacy (endoparasite) - tapeworm, Lack of efficacy (endoparasite) - roundworm NOS Other (12) · Sleepiness - systemic disorder, Moist dermatitis, Irritability
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Cat 0
Other 1 Cat 0
Other 1 Cat 0
Effectiveness 1 Dog 0
Effectiveness 1 Cat 0
Effectiveness 1 Dog 0
Other 1 Cat 0
Other 1 Cat 0

Species coverage: Cat (15) Dog (6)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Cat Non-serious - 1
Effectiveness Dog Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Skin & allergy Cat Non-serious - 1
Digestive Dog Non-serious - 1
Behavior Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Skin & allergy Cat Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Skin & allergy Cat Unknown - -
Other Dog Unknown - -
Source metadata:

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)
  • No owner handouts linked yet.
Official label / PI (0)
  • No official label or package insert links yet.
SPL (1)
  • Profender™ · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/211/Profender%E2%84%A2
FOI (1)
  • ucm062332.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/834
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 17, 2026, 10:03 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 12, 2026, 10:42 PM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Profender™
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat
Rx/OTC: RX
Form/route: Liquid • Topical
Applications: NADA 141-275
Documents: 1 (FOI: 1) • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 12 • Cat 15 • View
Case summaries: 11 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Pica
Linked using: Fda_Label (0.95)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. Safe use of this product has not been evaluated in cats less that 8 weeks of age or weighing less than 2.2 lbs (1 kg), in cats used for breeding, during pregnancy, or in lactating queens. Oral ingestion or exposure should be avoided. (Contraindication, High)
Top reaction signals
Tiredness (lethargy) (1) Sleepiness - systemic disorder (1) Moist dermatitis (1) Lack of efficacy - NOS (1) Lack of efficacy (endoparasite) - tapeworm (1) Lack of efficacy (endoparasite) - roundworm NOS (1) Irritability (1) Hypersensitivity NOS (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141275 NDC Package: 58198-0059-1 NDC Package: 58198-0059-2 NDC Package: 58198-0059-3 NDC Package: 58198-0060-1 NDC Package: 58198-0060-2 NDC Package: 58198-0060-3 NDC Package: 58198-0061-1 NDC Package: 58198-0061-2 NDC Package: 58198-0061-3 NDC Package: 58198-0062-1 NDC Product: 58198
Package NDC Product NDC Form / Route Status
58198-0059-1 58198 -
58198-0059-2 58198 -
58198-0059-3 58198 -
58198-0060-1 58198 -
58198-0060-2 58198 -
58198-0060-3 58198 -
58198-0061-1 58198 -
58198-0061-2 58198 -
58198-0061-3 58198 -
58198-0062-1 58198 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • ucm062332.pdf • FOI summary • Official • April 29, 2021
    FDA FOI summary for application 141275

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 4 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Safe use of this product has not been evaluated in cats less that 8 weeks… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (endoparasite) - hookworm, Incorrect route of drug administration, Vomiting, Accidental exposure, Administra… (Official, 2026-02-12)
  • usage: For the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections … (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Profender™
RX
Emodepside Praziquantel
Liquid • Topical
Label highlights
Official documents
Elanco US Inc. NADA 141-275 Approved Apr 29, 2021

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
Each mL contains 21.4 mg emodepside and 85.7 mg praziquantel
Cats
Indication
For the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections caused by Toxocara cati (adults and fourth stage larvae), and tapeworm infections caused by Dipylidium caninum (adults) and Taenia taeniaeformis (adults).
Dosage
The recommended minimum dose is 1.36 mg/pound (lb) (3 mg/kilogram (kg)) emodepside and 5.45 mg/ lb (12 mg/kg) praziquantel applied as a single topical dose.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Safe use of this product has not been evaluated in cats less that 8 weeks of age or weighing less than 2.2 lbs (1 kg), in cats used for breeding, during pregnancy, or in lactating queens. Oral ingestion or exposure should be avoided.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
  • Summary
    PROFENDER Topical Solution is indicated for the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections caused by Toxocara cati (adults and fourth stage larvae), and tapeworm infections caused by Dipylidium caninum (adults) and Taenia taeniaeformis (adults) in cats.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

For the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections caused by Toxocara cati (adults and fourth stage larvae), and tapeworm infections caused by Dipylidium caninum (adults) and Taenia taeniaeformis (adults).

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Safe use of this product has not been evaluated in cats less that 8 weeks of age or weighing less than 2.2 lbs (1 kg), in cats used for breeding, during pregnancy, or in lactating queens. Oral ingestion or exposure should be avoided.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Drooling (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Ear twitching (1) • Cat Application site hair loss (1) • Cat Hair loss at application site • Cat

Showing top 5 for Skin & allergy.

Neurologic
Tiredness (1) • Cat

Showing top 5 for Neurologic.

Behavior
Behavioral disorder (1) • Cat

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy - NOS (1) • Dog Lack of efficacy (endoparasite) - tapeworm (1) • Cat Lack of efficacy (endoparasite) - roundworm NOS (1) • Dog

Showing top 5 for Effectiveness.

Other
Sleepiness - systemic disorder (1) • Cat Moist dermatitis (1) • Cat Irritability (1) • Cat Hypersensitivity NOS (1) • Cat Application site weeping (1) • Cat
Show more (7)
Application site scratching (1) • Cat Application site reddening (1) • Cat Application site irritation (1) • Cat Application site inflammation (1) • Cat Application site dermatitis (1) • Dog Administration error NOS (1) • Dog Accidental exposure • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Shorthair, Male, 1.66 year, 4.536 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal • Reactions: Application site scratching, Application site hair loss, Application site irritation, Application site reddening, Application site inflammation… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055503
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 1.66 Year
  • Weight: 4.536 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 dose per animal
Reactions Reported:
Application site scratching Application site hair loss Application site irritation Application site reddening Application site inflammation Irritability
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 14.5 week, 1.87 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal • Reactions: Lack of efficacy (endoparasite) - tapeworm • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055700
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 14.50 Week
  • Weight: 1.870 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 dose per animal
Reactions Reported:
Lack of efficacy (endoparasite) - tapeworm
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 7 week, 0.73 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal, Frequency: 1 per month • Reactions: Lack of efficacy (endoparasite) - tapeworm • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055999
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 7.00 Week
  • Weight: 0.730 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 dose per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (endoparasite) - tapeworm
Outcomes: Outcome Unknown

Dog, Mixed (Dog), Mixed, 1.6 year, 19.7 kilogram • Drug: MSK, Solution, Topical, Dose: 3 Milligram per kilogram • Reactions: Application site dermatitis, Administration error NOS • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055792
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Mixed
  • Age: 1.60 Year
  • Weight: 19.700 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 3 Milligram per kilogram
Reactions Reported:
Application site dermatitis Administration error NOS
Outcomes: Recovered/Normal

Dog, Mixed (Dog), Mixed, 1.6 year, 19.7 kilogram • Drug: MSK, Solution, Oral, Dose: 1 Milligram per kilogram • Reactions: Drooling • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055777
  • Serious AE: No
  • Treated For AE: No
  • Sex: Mixed
  • Age: 1.60 Year
  • Weight: 19.700 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
  • Dose: 1 Milligram per kilogram
Reactions Reported:
Drooling
Outcomes: Recovered/Normal

Dog, Dog (unknown), Male • Drug: MSK, Solution, Oral • Reactions: Lack of efficacy - NOS, Administration error NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055779
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
Reactions Reported:
Lack of efficacy - NOS Administration error NOS
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 4.33 year, 6.5 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal • Reactions: Application site hair loss, Application site irritation, Moist dermatitis, Application site weeping • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-050212
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 4.33 Year
  • Weight: 6.500 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
Reactions Reported:
Application site hair loss Application site irritation Moist dermatitis Application site weeping
Outcomes: Ongoing

Dog, Foxhound - American, Mixed, 1 year • Drug: MSK, Solution, Oral, Dose: 1 dose per animal • Reactions: Lack of efficacy - NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-051638
  • Serious AE: No
  • Treated For AE: No
  • Sex: Mixed
  • Age: 1.00 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
  • Dose: 1 dose per animal
Reactions Reported:
Lack of efficacy - NOS
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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This medication has not been reviewed by a veterinarian yet.