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Isoflurane

Detailed information about Isoflurane

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

For induction and maintenance of general anesthesia.

What to watch for:

  • Administer by inhalation
  • Not for use in horses sensitive to halogenated agents
  • Increasing depth of anesthesia may increase hypotension and respiratory depression
  • Use less than usual amounts of nondepolarizing relaxants
  • Use with vaporizers producing predictable percentage concentrations
  • Not for use in horses intended for food
  • Not for use in dogs sensitive to halogenated agents
  • very low energy (1 reports)
  • Temporary blindness (1 reports)
  • Sleepiness - neurological disorder (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Administer by inhalation
  • Not for use in horses sensitive to halogenated agents
  • Increasing depth of anesthesia may increase hypotension and respiratory depression
  • Use less than usual amounts of nondepolarizing relaxants
  • Use with vaporizers producing predictable percentage concentrations

Most reported reactions:

  • Tiredness (lethargy) (1 reports)
  • Temporary blindness (1 reports)
  • Sleepiness - neurological disorder (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:02 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Mar 3, 2026, 11:00 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 17, 2026, 11:06 AM UTC
Image coming soon
Isoflurane

Isoflurane

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available
Form: Liquid
Identifiers:
ANADA: 200070 ANADA: 200129 ANADA: 200141 ANADA: 200237 ANADA: 200821 ANADA: 200822 NADA: 135773 NDC Package: 11695-6777-1 NDC Package: 11695-6777-2 NDC Package: 13985-528-40 NDC Package: 13985-528-60 NDC Package: 17033-091-25 NDC Package: 46066-115-03 NDC Package: 46066-115-04 NDC Package: 50989-150-12 NDC Package: 50989-150-15 NDC Package: 66794-013-10 NDC Package: 66794-013-25 NDC Package: 68504-010-01 NDC Product: 11695
Source metadata:

Warnings / Contraindications

Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
23
Species represented
2
Grouped by Body System
Digestive (3) · Vomiting, Haemorrhagic diarrhoea, Diarrhea Neurologic (2) · Tiredness (lethargy), Sleepiness - neurological disorder Other (27) · Temporary blindness, Tachycardia, Slow heart rate
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Cat 1
Other 1 Cat 1
Neurologic 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Dog 1

Species coverage: Dog (18) Cat (14)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Non-serious - 1
Neurologic Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Neurologic Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Digestive Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Digestive Dog Non-serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Source metadata:

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)
  • No owner handouts linked yet.
Official label / PI (0)
  • No official label or package insert links yet.
SPL (7)
  • ANIRANE · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/18469/ANIRANE
  • Isoflurane · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/17696/Isoflurane
  • ATTANE™ · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/304/ATTANE%E2%84%A2
  • Isoflurane, USP · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/137/Isoflurane%2C%20USP
  • Isospire™ · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/338/Isospire%E2%84%A2
  • IsoFlo™ · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/440/IsoFlo%E2%84%A2
  • Aerrane® · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1756/Aerrane%C2%AE
FOI (6)
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Mar 3, 2026, 11:00 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 21, 2026, 10:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 17, 2026, 11:06 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: ANIRANE ATTANE™ Aerrane® IsoFlo™ Isoflurane Isoflurane, USP Isospire™
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Dog, Horse
Rx/OTC: RX
Form/route: Liquid • Inhalation
Applications: ANADA 200-822 • ANADA 200-821 • ANADA 200-141 • ANADA 200-237 • ANADA 200-129 • ANADA 200-070 • NADA 135-773
NDC: Packages 11695-6777-1 11695-6777-2 46066-115-03 46066-115-04 66794-013-10 66794-013-25 • Products 11695 11695 46066 46066 66794 66794
Documents: 6 (FOI: 6) • SPL: 7 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 25 • Cat 26 • View
Case summaries: 11 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Tiredness (lethargy) (1) Temporary blindness (1) Sleepiness - neurological disorder (1) Shaking (1) Reduced responses (1) Peritonitis (1) Overdose (1) Neutropenia (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200070 ANADA: 200129 ANADA: 200141 ANADA: 200237 ANADA: 200821 ANADA: 200822 NADA: 135773 NDC Package: 11695-6777-1 NDC Package: 11695-6777-2 NDC Package: 13985-528-40 NDC Package: 13985-528-60 NDC Package: 17033-091-25 NDC Package: 46066-115-03 NDC Package: 46066-115-04 NDC Package: 50989-150-12 NDC Package: 50989-150-15 NDC Package: 66794-013-10 NDC Package: 66794-013-25 NDC Package: 68504-010-01 NDC Product: 11695 NDC Product: 13985 NDC Product: 17033 NDC Product: 46066 NDC Product: 50989
Package NDC Product NDC Form / Route Status
11695-6777-1 11695 -
11695-6777-2 11695 -
13985-528-40 13985 -
13985-528-60 13985 -
17033-091-25 17033 -
46066-115-03 46066 -
46066-115-04 46066 -
50989-150-12 50989 -
50989-150-15 50989 -
66794-013-10 66794 -
66794-013-25 66794 -
68504-010-01 68504 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 9 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depres… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Vomiting, Death, Bradycardia, Lack of efficacy - NOS, Lethargy (see also Central nervous system depression in 'Neurological')… (Official, 2026-02-12)
  • usage: For induction and maintenance of surgical anesthesia. For induction and maintenance of general anesthesia. (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
ANIRANE
RX
Isoflurane
Liquid • Inhalation
Label highlights
Official documents
Baxter Healthcare Corp. ANADA 200-822 Approved Mar 2, 2026
Isoflurane
RX
Isoflurane
Liquid • Inhalation
Label highlights
Official documents
Parnell Technologies Pty. Ltd. ANADA 200-821 Approved Sep 2, 2025
ATTANE™
RX
Isoflurane
Liquid • Inhalation
Label highlights
Official documents
Piramal Pharma Ltd. ANADA 200-141 Approved Mar 14, 2024
Isoflurane, USP
RX
Isoflurane
Liquid • Inhalation
Label highlights
Official documents
Piramal Pharma Ltd. ANADA 200-237 Approved Mar 14, 2024
Isospire™
RX
Isoflurane
Liquid • Inhalation
Label highlights
Official documents
Dechra Veterinary Products LLC ANADA 200-129 Approved Nov 16, 2022
IsoFlo™
RX
Isoflurane
Liquid • Inhalation
Label highlights
Official documents
Zoetis Inc. ANADA 200-070 Approved May 17, 2017
Aerrane®
RX
Isoflurane
Liquid • Inhalation
Label highlights
Official documents
Baxter Healthcare Corp. NADA 135-773 W Apr 4, 2017

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Composition / specifications
Each mL contains 99.9% isoflurane
Horses
Indication

For induction and maintenance of general anesthesia.

Dosage

For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).

Limitations
Dogs
Indication

For induction and maintenance of general anesthesia.

Dosage

For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications
Each mL contains 99.9% isoflurane
Horses
Indication

For induction and maintenance of general anesthesia.

Dosage

For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes, For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).

Limitations
Dogs
Indication

For induction and maintenance of general anesthesia.

Dosage

For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Horse, Not For Meat Production
Composition / specifications
The drug is a clear, colorless, stable liquid containing no additives or chemical stabilizers. It is nonflammable and non-explosive
Dogs
Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Horses
Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Horse, Not For Meat Production
Horses
Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Horse, Not For Meat Production
Horses
Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Horse, Not For Meat Production
Composition / specifications
The drug is a clear, colorless, stable liquid containing no additives or chemical stabilizers. It is nonflammable and non-explosive.
Dogs
Indication
For induction and maintenance of general anesthesia.
Dosage
For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Horses
Indication
For induction and maintenance of general anesthesia.
Dosage
For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Horse, Not For Meat Production
Composition / specifications
The drug is a clear, colorless, stable liquid containing no additives or chemical stabilizers. It is nonflammable and non-explosive.
Horses
Indication
For induction and maintenance of surgical anesthesia.
Dosage
3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes, then 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
For induction and maintenance of surgical anesthesia.
Dosage
2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes, then 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    Isoflurane, USP is used for induction and maintenance of general anesthesia in horses and dogs.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    Isoflurane, USP is used for induction and maintenance of general anesthesia in horses and dogs.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    Isoflurane, USP is used for induction and maintenance of general anesthesia in dogs and horses.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    IsoFlo (isoflurane, USP) is used for induction and maintenance of general anesthesia in horses and dogs.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

For induction and maintenance of surgical anesthesia. For induction and maintenance of general anesthesia.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Haemorrhagic diarrhoea (1) • Dog Diarrhea (1) • Dog

Showing top 5 for Digestive.

Neurologic
Tiredness (1) • Cat Sleepiness - neurological disorder (1) • Cat

Showing top 5 for Neurologic.

Other
Temporary blindness (1) • Cat Tachycardia (1) • Dog Slow heart rate (1) • Cat Shaking (1) • Cat Reduced responses (1) • Cat
Show more (22)
Recovery prolonged (1) • Cat Peritonitis (1) • Dog Overdose (1) • Cat Neutropenia (1) • Dog Mydriasis (1) • Cat Medication error NOS (1) • Cat Malaise (1) • Dog Lymphocytosis (1) • Dog Intentional misuse (1) • Cat Increased heart rate (1) • Cat Hypotension (1) • Dog Hyperthermia (1) • Dog Hyperactivity (1) • Cat Haematochezia (1) • Dog Gastric ulcer (1) • Dog Fluid in abdomen NOS (1) • Dog Eosinophilia (1) • Dog Enamel disorder (1) • Dog Death by euthanasia (1) • Cat Death (1) • Dog Abnormal ultrasound finding (1) • Dog Abdominal pain (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Shorthair, Male, 5 year, 8.61 kilogram • Drug: MSK, Unknown • Reactions: Hyperthermia, Hyperactivity • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055972
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 5.00 Year
  • Weight: 8.610 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Hyperthermia Hyperactivity
Outcomes: Ongoing

Dog, ['Shepherd Dog - German', 'Dog (unknown)'], Female, 2.5 year • Drug: MSK, Respiratory (Inhalation) • Reactions: Neutropenia, Eosinophilia, Lymphocytosis, Enamel disorder, Tooth disorder • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055809
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 2.50 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Respiratory (Inhalation)
Reactions Reported:
Neutropenia Eosinophilia Lymphocytosis Enamel disorder Tooth disorder
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Female, 10 month, 3.629 kilogram • Drug: MSK, Solution, Respiratory (Inhalation) • Reactions: Shaking, Overdose, Medication error NOS, Increased heart rate, Intentional misuse • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054487
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 10.00 Month
  • Weight: 3.629 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Respiratory (Inhalation)
  • Form: Solution
Reactions Reported:
Shaking Overdose Medication error NOS Increased heart rate Intentional misuse
Outcomes: Ongoing

Cat, Cat (other), Male, 13 year, 3.49 kilogram • Drug: MSK, Unknown • Reactions: Slow heart rate, Recovery prolonged • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055510
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 13.00 Year
  • Weight: 3.490 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Slow heart rate Recovery prolonged
Outcomes: Recovered/Normal

Cat, Maine Coon, Female, 11 year, 4.58 kilogram • Drug: MSK, Unknown • Reactions: Recovery prolonged • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055867
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 11.00 Year
  • Weight: 4.580 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Recovery prolonged
Outcomes: Recovered/Normal

Cat, Domestic Mediumhair, Female, 19 week, 2.06 kilogram • Drug: MSK, Unknown • Reactions: Sleepiness - neurological disorder, Temporary blindness, Tiredness (lethargy), Reduced responses, Mydriasis… • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2025-US-055689
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 19.00 Week
  • Weight: 2.060 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Sleepiness - neurological disorder Temporary blindness Tiredness (lethargy) Reduced responses Mydriasis Death by euthanasia
Outcomes: Euthanized

Dog, Sheepdog - Old English (Bobtail), Male, 4 year, 37.8 kilogram • Drug: MSK, Solution, Unknown • Reactions: Malaise, Gastric ulcer, Peritonitis, Fluid in abdomen NOS, Abdominal pain… • Outcome: Euthanized

  • Report ID: DEU-USFDACVM-2025-DE-000039
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 4.00 Year
  • Weight: 37.800 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Solution
Reactions Reported:
Malaise Gastric ulcer Peritonitis Fluid in abdomen NOS Abdominal pain Vomiting Abnormal ultrasound finding Death Hyperthermia
Outcomes: Euthanized

Dog, ['Chihuahua', 'Mixed (Dog)'], Female, 9 year, 5.534 kilogram • Drug: MSK, Solution, Respiratory (Inhalation) • Reactions: Tachycardia, Hypotension • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055949
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 9.00 Year
  • Weight: 5.534 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Respiratory (Inhalation)
  • Form: Solution
Reactions Reported:
Tachycardia Hypotension
Outcomes: Recovered/Normal

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

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