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Ketamine Hydrochloride

Detailed information about Ketamine Hydrochloride

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

It is used for restraint.

What to watch for:

  • Store in a cool place
  • Protect from light
  • Do not use if precipitate appears
  • Neutrophilia (1 reports)
  • Necropsy performed (1 reports)
  • Nausea (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Store in a cool place
  • Protect from light
  • Do not use if precipitate appears
  • Neutrophilia
  • Necropsy performed

Most reported reactions:

  • Neutrophilia (1 reports)
  • Necropsy performed (1 reports)
  • Nausea (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 15, 2026, 10:03 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC
Image coming soon
Ketamine Hydrochloride

Ketamine Hydrochloride

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available
Form: Liquid (Solution)
Identifiers:
ANADA: 200029 ANADA: 200042 ANADA: 200055 ANADA: 200073 ANADA: 200257 ANADA: 200279 NADA: 45290 NADA: 92116 NDC Package: 11695-0703-1 NDC Package: 11695-7039-1 NDC Package: 13985-584-10 NDC Package: 17033-101-10 NDC Package: 54771-2013-1 NDC Package: 69043-063-01 NDC Package: 86136-144-31 NDC Product: 11695 NDC Product: 13985 NDC Product: 17033 NDC Product: 54771 NDC Product: 69043
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
29
Species represented
2
Grouped by Body System
Digestive (3) · Nausea, Loss of appetite, Haemorrhagic diarrhoea Effectiveness (1) · Lack of efficacy - NOS Other (28) · Neutrophilia, Necropsy performed, Monocytosis
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Cat 1
Other 1 Cat 1
Digestive 1 Cat 1
Other 1 Dog 1
Digestive 1 Cat 1
Other 1 Cat 1
Effectiveness 1 Cat 1
Other 1 Cat 1

Species coverage: Cat (21) Dog (11)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Other Cat Serious - 1
Other Cat Serious - 1
Digestive Cat Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Digestive Cat Serious - 1
Other Cat Serious - 1
Effectiveness Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Digestive Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Source metadata:

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)
  • No owner handouts linked yet.
Official label / PI (0)
  • No official label or package insert links yet.
SPL (8)
  • Ketamine HCL · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/120/Ketamine%20HCL
  • VetaKet® · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/253/VetaKet%C2%AE
  • Vetalar® · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/781/Vetalar%C2%AE
  • Ketamine Hydrochloride Injection · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/462/Ketamine%20Hydrochloride%20Injection
  • Ketamine Hydrochloride Injection, USP · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/494/Ketamine%20Hydrochloride%20Injection%2C%20USP
  • Ketamine Hydrochloride Injection, USP · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/447/Ketamine%20Hydrochloride%20Injection%2C%20USP
  • KetaFlo™ · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/122/KetaFlo%E2%84%A2
  • Ketaset® Plus · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1233/Ketaset%C2%AE%20Plus
FOI (6)
  • ucm061682.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/978
  • A200055_Orig_08_03_1998.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/2042
  • A200029_Org_8_16_1995.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1388
  • A200042_Orig_06_30_1994.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/2022
  • A200073_Org_7_21_1994.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1401
  • ucm061704.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1033
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 15, 2026, 10:03 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: KetaFlo™ Ketamine HCL Ketamine Hydrochloride Injection Ketamine Hydrochloride Injection, USP Ketaset® Plus VetaKet® Vetalar®
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat, Primates
Rx/OTC: RX
Form/route: Liquid (Solution) • Intramuscular
Applications: ANADA 200-257 • ANADA 200-055 • NADA 45290 • ANADA 200-029 • ANADA 200-042 • ANADA 200-073 • ANADA 200-279 • NADA 92116
Documents: 6 (FOI: 6) • SPL: 8 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 16 • Cat 20 • View
Case summaries: 10 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Neutrophilia (1) Necropsy performed (1) Nausea (1) Monocytosis (1) Loss of appetite (1) Lip disorder NOS (1) Lack of efficacy - NOS (1) Inappropriate defecation (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200029 ANADA: 200042 ANADA: 200055 ANADA: 200073 ANADA: 200257 ANADA: 200279 NADA: 45290 NADA: 92116 NDC Package: 11695-0703-1 NDC Package: 11695-7039-1 NDC Package: 13985-584-10 NDC Package: 17033-101-10 NDC Package: 54771-2013-1 NDC Package: 69043-063-01 NDC Package: 86136-144-31 NDC Product: 11695 NDC Product: 13985 NDC Product: 17033 NDC Product: 54771 NDC Product: 69043 NDC Product: 86136
Package NDC Product NDC Form / Route Status
11695-0703-1 11695 -
11695-7039-1 11695 -
13985-584-10 13985 -
17033-101-10 17033 -
54771-2013-1 54771 -
69043-063-01 69043 -
86136-144-31 86136 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 9 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appe… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Seizure NOS, INEFFECTIVE, ANESTHESIA, Death, Cardiac arrest, Drug administration error, Vomiting. (Official, 2026-02-12)
  • usage: It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation. It i… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Ketamine HCL
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Mylan Institutional LLC, a Viatris Company ANADA 200-257 W Jan 21, 2025
VetaKet®
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Cronus Pharma Specialities India Private Ltd. ANADA 200-055 Approved Jun 13, 2024
Vetalar®
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Boehringer lngelheim Animal Health USA, Inc. NADA 45290 Approved Jan 8, 2024
Ketamine Hydrochloride Injection
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Cronus Pharma Specialities India Private Ltd. ANADA 200-029 Approved Feb 1, 2018
Ketamine Hydrochloride Injection, USP
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Elanco US Inc. ANADA 200-042 Approved Aug 4, 2017
Ketamine Hydrochloride Injection, USP
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Dechra Veterinary Products LLC ANADA 200-073 Approved May 19, 2017
KetaFlo™
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Abbott Laboratories ANADA 200-279 W Jun 1, 2016
Ketaset® Plus
RX
Aminopentamide Hydrogen Sulfate Ketamine Hydrochloride Promazine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Zoetis Inc. NADA 92116 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Primates, Non-Human Primates • Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter contains ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Subhuman primates
Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Primates, Non-Human Primates • Cat, Restricted During Pregnancy
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.
Subhuman primates
Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

FDA page: Open in Animal Drugs @ FDA

Species: Primates, Non-Human Primates • Cat, No Use Class Stated Or Implied
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.
Subhuman primates
Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

FDA page: Open in Animal Drugs @ FDA

Species: Primates, Non-Human Primates • Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter contains ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Subhuman primates
Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Primates, Non-Human Primates • Cat, No Use Class Stated Or Implied
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.
Subhuman primates
Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

FDA page: Open in Animal Drugs @ FDA

Species: Primates, Non-Human Primates • Cat, No Use Class Stated Or Implied
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Subhuman primates
Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity, 7.5 milligrams of promazine hydrochloride, and 0.0625 milligram of aminopentamide hydrogen sulfate, with 1:10,000 benzethonium chloride.
Cats
Indication
It is used in cats as the sole anesthetic agent for ovariohysterectomy and general surgery.
Dosage
It is administered intramuscularly at a recommended dose from 15 to 20 milligrams ketamine base per pound of body weight, depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
  • Summary
    Used in cats for restraint or as the sole anesthetic agent for diagnostic or minor, brief, surgical procedures that do not require skeletal muscle relaxation. Used in subhuman primates for restraint.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    VetaKetâ¿¢ may be used in cats for restraint or as the sole anesthetic agent for diagnostic or minor, brief, surgical procedures that do not require skeletal muscle relaxation. It may be used in subhuman primates for restraint.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    Ketamine Hydrochloride Injection may be used in cats for restraint or as the sole anesthetic agent for diagnostic or minor, brief, surgical procedures that do not require skeletal muscle relaxation. It may be used in subhuman primates for restraint.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    Ketaject® (ketamine hydrochloride injection. USP) may be used in cats for restraint or as the sole anesthetic agent for diagnostic or minor brief, surgical procedures that do not require skeletal muscle relaxation. It may be used in subhuman primates for restraint.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    Ketamine hydrochloride injection, USP may be used in cats for restraint or as the sole anesthetic agent for diagnostic or minor, brief, surgical procedures that do not require skeletal muscle relaxation. It may be used in subhuman primates for restraint.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For restraint or as the sole anesthetic agent for diagnostic or minor, brief, surgical procedures that do not require skeletal muscle relaxation. It may be used in subhuman primates for restraint.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation. It is used for restraint. It is used in cats as the sole anesthetic agent for ovariohysterectomy and general surgery.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Nausea (1) • Cat Loss of appetite (1) • Cat Haemorrhagic diarrhoea (1) • Cat

Showing top 5 for Digestive.

Effectiveness
Lack of efficacy - NOS (1) • Cat

Showing top 5 for Effectiveness.

Other
Neutrophilia (1) • Cat Necropsy performed (1) • Cat Monocytosis (1) • Dog Low blood pressure (1) • Dog Lip disorder NOS (1) • Cat
Show more (23)
Intentional misuse (1) • Dog Inappropriate defecation (1) • Cat Icterus (1) • Dog Hyperthermia (1) • Cat Hyperglycaemia (1) • Cat Head bobbing (1) • Cat Haematemesis (1) • Cat Elevated thyroxine (1) • Cat Elevated symmetrical dimethylarginine (1) • Dog Elevated serum alkaline phosphatase (1) • Dog Elevated gamma-glutamyl transferase (1) • Dog Elevated creatinine (1) • Dog Elevated aspartate aminotransferase (1) • Dog Elevated alanine aminotransferase (1) • Dog Dehydration (1) • Cat Death (1) • Cat Cardiorespiratory arrest (1) • Cat Cardiac disorder NOS (1) • Cat Breathing difficulty (1) • Cat Bilirubinuria (1) • Dog Anaemia NOS (1) • Cat Adipsia (1) • Cat Abdominal effusion (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Cat (unknown), Female, 4.05 kilogram • Drug: MSK, Solution, Unknown, Dose: 6.67 Milligram per kilogram • Reactions: Hyperglycaemia • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-054116
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Weight: 4.050 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Solution
  • Dose: 6.67 Milligram per kilogram
Reactions Reported:
Hyperglycaemia
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 16 year, 4.36 kilogram • Drug: MSK, Solution, Intramuscular, Dose: 1.15 Milligram per kilogram • Reactions: Lack of efficacy - NOS • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055487
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 16.00 Year
  • Weight: 4.360 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Form: Solution
  • Dose: 1.15 Milligram per kilogram
Reactions Reported:
Lack of efficacy - NOS
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Female, 15 year • Drug: MSK, Unknown • Reactions: Inappropriate defecation, Hyperthermia, Dehydration, Weight loss, Adipsia… • Outcome: Ongoing

  • Report ID: GBR-USFDACVM-2025-GB-000057
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 15.00 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Inappropriate defecation Hyperthermia Dehydration Weight loss Adipsia Loss of appetite Polyuria Urine abnormalities NOS Elevated thyroxine Neutrophilia Anaemia NOS Nausea Stomatitis Lip disorder NOS Haemorrhagic diarrhoea Haematemesis
Outcomes: Ongoing

Dog, Retriever - Labrador, Female, 9 year, 24.7 kilogram • Drug: MSK, Solution, Intramuscular, Dose: 0.20 mL per animal • Reactions: Elevated serum alkaline phosphatase, Elevated aspartate aminotransferase, Elevated alanine aminotransferase, Monocytosis, Elevated symmetrical dimethylarginine… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054322
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 9.00 Year
  • Weight: 24.700 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Form: Solution
  • Dose: 0.20 mL per animal
Reactions Reported:
Elevated serum alkaline phosphatase Elevated aspartate aminotransferase Elevated alanine aminotransferase Monocytosis Elevated symmetrical dimethylarginine Elevated creatinine Proteinuria Bilirubinuria Icterus Elevated gamma-glutamyl transferase
Outcomes: Ongoing

Cat, Cat (unknown), Male, 6 month, 2.3 kilogram • Drug: MSK, Solution, Intramuscular • Reactions: Shaking, Seizure NOS, Head bobbing, Death • Outcome: Recovered/Normal, Died

  • Report ID: USA-USFDACVM-2025-US-054096
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 6.00 Month
  • Weight: 2.300 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Form: Solution
Reactions Reported:
Shaking Seizure NOS Head bobbing Death
Outcomes: Recovered/Normal, Died

Cat, Mixed (Cat), Male, 4 month, 2.331 kilogram • Drug: MSK, Injection, Intramuscular, Dose: 0.15 mL per animal • Reactions: Pale mucous membrane, Breathing difficulty, Death, Cardiac disorder NOS, Pericarditis… • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-049823
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 4.00 Month
  • Weight: 2.331 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Form: Injection
  • Dose: 0.15 mL per animal
Reactions Reported:
Pale mucous membrane Breathing difficulty Death Cardiac disorder NOS Pericarditis Cardiorespiratory arrest Pericardial effusion Pulmonary congestion Oedema NOS Pleural effusion Necropsy performed Abdominal effusion
Outcomes: Died

Dog, ['Poodle - Toy', 'Chihuahua'], Unknown, 3 year, 1 kilogram • Drug: MSK, Solution, Unknown, Dose: 4.40 Milligram per kilogram • Reactions: Seizure NOS • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-045387
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Unknown
  • Age: 3.00 Year
  • Weight: 1.000 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Solution
  • Dose: 4.40 Milligram per kilogram
Reactions Reported:
Seizure NOS
Outcomes: Recovered/Normal

Dog, ['Retriever - Labrador', 'Corso Dog', 'Dog (unknown)'], Unknown • Drug: MSK, Solution, Unknown, Dose: 3 Milligram per kilogram • Reactions: Seizure NOS • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-045388
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Unknown
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Solution
  • Dose: 3 Milligram per kilogram
Reactions Reported:
Seizure NOS
Outcomes: Recovered/Normal

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

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