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Propofol

Detailed information about Propofol

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

For induction of anesthesia. For maintenance of general anesthesia by intermittent bolus injections for short procedures. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.

What to watch for:

  • Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained
  • Doses may need adjustment for geriatric or debilitated patients
  • Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained
  • Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian
  • Administer by intravenous injection only
  • Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation
  • Respiratory arrest (apnea) could occur
  • When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available
  • The use of propofol in pregnant and breeding dogs has not been evaluated
  • Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression
  • Propofol has not been evaluated in dogs less than 10 weeks of age
  • trouble breathing (1 reports)
  • very low energy (1 reports)
  • Luxation/subluxation (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained
  • Doses may need adjustment for geriatric or debilitated patients
  • Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained
  • Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian
  • Administer by intravenous injection only

Most reported reactions:

  • Trouble breathing (dyspnea) (1 reports)
  • Tiredness (lethargy) (1 reports)
  • Luxation/subluxation (1 reports)

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 18, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC
Image coming soon
Propofol

Propofol

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Not available (source)

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Not available
Form: Injectable emulsion, Liquid (Emulsion), Microemulsion
Identifiers:
ANADA: 200793 NADA: 141070 NADA: 141098 NADA: 141303 NDC Package: 11695-2801-1 NDC Package: 11695-7036-1 NDC Package: 13985-740-23 NDC Package: 54771-4944-1 NDC Package: 54771-4944-2 NDC Package: 54771-5206-1 NDC Package: 68504-008-01 NDC Package: 86064-001-20 NDC Product: 11695 NDC Product: 13985 NDC Product: 54771 NDC Product: 68504 NDC Product: 86064
Source metadata:

Warnings / Contraindications

Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age

  • High: Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
27
Species represented
2
Grouped by Body System
Digestive (4) · Vomiting, Loss of appetite, Drooling Neurologic (1) · Tiredness (lethargy) Other (27) · Trouble breathing (dyspnea), Luxation/subluxation, Localised pain NOS
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Dog 1
Neurologic 1 Dog 1
Other 1 Dog 1
Digestive 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Cat 1

Species coverage: Dog (22) Cat (10)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Non-serious - 1
Other Dog Serious - 1
Neurologic Dog Serious - 1
Other Dog Serious - 1
Digestive Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Digestive Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Source metadata:

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)
  • No owner handouts linked yet.
Official label / PI (0)
  • No official label or package insert links yet.
SPL (5)
  • PropofolVet Multidose · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/16596/PropofolVet%20Multidose
  • Rapanofal® · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1823/Rapanofal%C2%AE
  • PropoFlo™ 28 · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1363/PropoFlo%E2%84%A2%2028
  • PropoFlo™ · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1362/PropoFlo%E2%84%A2
  • PropoClear™ · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2191/PropoClear%E2%84%A2
FOI (6)
  • FOI Summary oA 200-793 Approved November 18, 2024.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/16265
  • ucm116781.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/611
  • UCM488658.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/610
  • UCM248263.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/631
  • UCM355533.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/630
  • UCM224476.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/867
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Mar 18, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: PropoClear™ PropoFlo™ 28 PropoFlo™ PropofolVet Multidose Rapanofal®
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat, Dog
Rx/OTC: RX
Form/route: Injectable emulsion, Liquid (Emulsion), Microemulsion • Intravenous
Applications: ANADA 200-793 • NADA 141-070 • NADA 141-098 • NADA 141-303
NDC: Packages 68504-008-01 • Products 68504
Documents: 6 (FOI: 6) • SPL: 5 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 30 • Cat 23 • View
Case summaries: 10 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age (Contraindication, High)
Top reaction signals
Trouble breathing (dyspnea) (1) Tiredness (lethargy) (1) Luxation/subluxation (1) Loss of appetite (1) Localised pain NOS (1) Leucocytosis NOS (1) Intervertebral disc disease (1) Intentional misuse (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200793 NADA: 141070 NADA: 141098 NADA: 141303 NDC Package: 11695-2801-1 NDC Package: 11695-7036-1 NDC Package: 13985-740-23 NDC Package: 54771-4944-1 NDC Package: 54771-4944-2 NDC Package: 54771-5206-1 NDC Package: 68504-008-01 NDC Package: 86064-001-20 NDC Product: 11695 NDC Product: 13985 NDC Product: 54771 NDC Product: 68504 NDC Product: 86064
Package NDC Product NDC Form / Route Status
11695-2801-1 11695 -
11695-7036-1 11695 -
13985-740-23 13985 -
54771-4944-1 54771 -
54771-4944-2 54771 -
54771-5206-1 54771 -
68504-008-01 68504 -
86064-001-20 86064 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • FOI Summary oA 200-793 Approved November 18, 2024.pdf • FOI summary • Official • Dec. 2, 2024
    FDA FOI summary for application 200793
  • UCM488658.pdf • FOI summary • Official • April 29, 2022
    FDA FOI summary for application 141070
  • ucm116781.pdf • FOI summary • Official • April 29, 2022
    FDA FOI summary for application 141070
  • UCM355533.pdf • FOI summary • Official • Dec. 18, 2017
    FDA FOI summary for application 141098
  • UCM248263.pdf • FOI summary • Official • Dec. 18, 2017
    FDA FOI summary for application 141098
  • UCM224476.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 141303

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 9 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated pati… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Death, Vomiting, Lack of efficacy - NOS, Bradycardia, Seizure NOS, Diarrhoea. (Official, 2026-02-12)
  • usage: The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for short procedures, for induction and maintena… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
PropofolVet Multidose
RX
Propofol
Injectable emulsion • Intravenous
Label highlights
Official documents
Parnell Technologies Pty. Ltd. ANADA 200-793 Approved Dec 2, 2024
Rapanofal®
RX
Propofol
Liquid (Emulsion) • Intravenous
Label highlights
Official documents
Ivaoes Animal Health NADA 141-070 Approved Apr 29, 2022
PropoFlo™ 28 PropoFlo™
RX
Propofol
Liquid (Emulsion) • Intravenous
Label highlights
Official documents
Zoetis Inc. NADA 141-098 Approved Dec 18, 2017
PropoClear™
RX
Propofol
Microemulsion • Intravenous
Label highlights
Official documents
Zoetis Inc. NADA 141-303 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Composition / specifications
10 mg/mL propofol
Dogs
Indication

For induction of anesthesia. For maintenance of general anesthesia by intermittent bolus injections for short procedures. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.

Dosage

For induction of general anesthesia without the use of preanesthetics, the dosage is 7.6 milligrams per kilogram titrated against the response of the patient over 60-90 seconds or until clinical signs show the onset of anesthesia (5.0 to 7.6 mg/kg/min).The use of preanesthetic medication reduces propofol dose requirements. For the maintenance of general anesthesia without the use of preanesthetics, the dosage is 3.2 milligrams per kilogram The use of preanesthetic medication reduces propofol dose requirements. Due to the rapid metabolism of propofol, additional low doses of propofol, similar to those used for maintenance with propofol, may be required to complete the transition to inhalant maintenance anesthesia.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
The drug is a sterile, nonpyrogenic, oil-in-water emulsion containing 10 milligrams of propofol per milliliter.
Cats
Indication
The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for short procedures, for induction and maintenance of general anesthesia using incremental doses to effect, and for induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Dosage
The drug is administered by intravenous injection as follows: For induction of general anesthesia without the use of preanesthetics the dosage is 8.0 to 13.2 milligrams per kilogram (3.6 to 6.0 milligrams per pound). For the maintenance of general anesthesia without the use of preanesthetics the dosage is 1.1 to 4.4 milligrams per kilogram (0.5 to 2.0 milligrams per pound). The use of preanesthetic medication reduces propofol dose requirements.
Limitations
Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for procedures lasting up to 5 minutes; for induction and maintenance of general anesthesia using incremental doses to effect; for induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Dosage
The drug is administered by intravenous injection as follows: For induction of general anesthesia without the use of preanesthetics the dosage is 5.5 to 7.0 milligrams per kilogram (2.5 to 3.2 milligrams per pound); for the maintenance of general anesthesia without the use of preanesthetics the dosage is 1.1 to 3.3 milligrams per kilogram (0.5 to 1.5 milligrams per pound). The use of preanesthetic medication reduces propofol dose requirements.
Limitations
Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each mL contains 10 mg propofol.
Dogs
Indication
For induction of anesthesia. For maintenance of general anesthesia for up to 20 minutes. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Dosage
For induction of general anesthesia without the use of preanesthetics, the dosage is 5.5 to 7.6 milligrams per kilogram (2.5 to 3.2 milligrams per pound)The use of preanesthetic medication reduces propofol dose requirements. For the maintenance of general anesthesia without the use of preanesthetics, the dosage is 2.2 to 3.2 milligrams per kilogram (0.5 to 1.5 milligrams per pound. The use of preanesthetic medication reduces propofol dose requirements.
Limitations
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each mL contains 10 mg propofol.
Dogs
Indication
For the induction and maintenance of anesthesia and for induction followed by maintenance with an inhalant anesthetic.
Dosage
Induction of General Anesthesia in Dogs: Induction dose guidelines are 4.0 to 6.5 mg/kg in dogs that do not receive a preanesthetic, and 1.4 to 6.5 mg/kg in dogs that receive a preanesthetic. The mean PROPOCLEAR induction dose is reduced by 20 to 30% for dogs that receive a preanesthetic (dose sparing effect). Anesthesia is usually observed within 60 seconds after the end of the induction dose administration. Duration of anesthesia following the recommended induction dose is approximately 4 minutes without a preanesthetic and 4 to 11 minutes with a preanesthetic. Individual anesthesia times may vary. Maintenance of General Anesthesia in Dogs: Anesthesia can be maintained by administration of PROPOCLEAR using intermittent IV injections. For dogs, the duration of anesthesia following a PROPOCLEAR maintenance dose is approximately 3 to 5 minutes. Clinical response may vary, and is determined by the dose, the rate of administration, and the frequency of maintenance injections. The maintenance dose and frequency should be based on the patient’s response. Sighthounds may need lower maintenance doses of PROPOCLEAR, and the time between maintenance dose administration and for recovery may be longer.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using propofol, patients should be continuously monitored and facilities for the maintenance of a patient airway, artificial ventilation, and oxygen supplementation must be immediately available.
Cats
Indication
For the induction and maintenance of anesthesia and for induction followed by maintenance with an inhalant anesthetic.
Dosage
Induction of General Anesthesia in Cats: Induction dose guidelines are 4.1 to 8.0 mg/kg for cats that do not receive a preanesthetic, and 2.7 to 8.0 mg/kg for cats that receive a preanesthetic. The PROPOCLEAR induction dose is reduced by 16 to 24% for cats that receive a preanesthetic (dose sparing effect). Anesthesia is usually observed within 60 seconds after the end of the induction dose administration. Duration of anesthesia following the recommended induction dose is approximately 3 minutes without a preanesthetic and 3 to 6 minutes with a preanesthetic. Full standing recovery occurs within approximately 30 minutes in cats. Individual anesthesia times vary. The actual induction dose should be based on patient response. Maintenance of General Anesthesia in Cats: Anesthesia can be maintained by administration of PROPOCLEAR using intermittent IV injections. For cats, the duration of anesthesia following each PROPOCLEAR maintenance dose is approximately 3 to 5 minutes. Clinical response may vary, and is determined by the dose, rate of administration and frequency of maintenance injections. PROPOCLEAR maintenance dose sparing is greater in cats that receive a preanesthetic. The maintenance dose and frequency should be based on the patient’s response.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using propofol, patients should be continuously monitored and facilities for the maintenance of a patient airway, artificial ventilation, and oxygen supplementation must be immediately available.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
  • Summary

    For induction of anesthesia. For maintenance of general anesthesia by intermittent bolus injections for short procedures. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.
    2. The supplement also contains changes to the original canine portions of the label and FOI Summary as follows:
    a. Information concerning the use of medetomidine prior to propofol anesthesia in dogs will appear on the label as well as in the FOI Summary. Medetomidine is approved for use in dogs for sedation and analgesia.
    b. The recommended preanesthetic medetomidine dose will be lowered from 10-40 ug/kg IM/IV to 5-10 ug/kg IM based on data already contained in the original new animal drug application (NADA) approval for propofol in dogs.

  • Summary
    Rapinovet®is an anesthetic injection for use in dogs as follows: a) as a single injection to provide general anesthesia for procedures lasting up to five minutes; b) for induction and maintenance of general anesthesia using incremental doses to effect; and c) for induction of general anesthesia where maintenance is provided by inhalant anesthetics.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    The effect of the supplement is to add a preservative (benzyl alcohol) for a multidose presentation in a 20 mL vial..
  • Summary

    a. For induction of anesthesia.
    b. For maintenance of general anesthesia for up to 20 minutes.
    c. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For the induction and maintenance of anesthesia and for induction followed by maintenance with an inhalant anesthetic, in cats and dogs.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for short procedures, for induction and maintenance of general anesthesia using incremental doses to effect, and for induction of general anesthesia where maintenance is provided by inhalant anesthetics. The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for procedures lasting up to 5 minutes; for induction and maintenance of general anesthesia using incremental doses to effect; for induction of general anesthesia where maintenance is provided by inhalant anesthetics. For induction of anesthesia. For maintenance of general anesthesia for up to 20 minutes. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Loss of appetite (1) • Dog Drooling (1) • Dog Diarrhea (1) • Dog

Showing top 5 for Digestive.

Neurologic
Tiredness (1) • Dog

Showing top 5 for Neurologic.

Other
Trouble breathing (1) • Dog Luxation/subluxation (1) • Dog Localised pain NOS (1) • Dog Leucocytosis NOS (1) • Dog Intervertebral disc disease (1) • Dog
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Intentional misuse (1) • Cat Increased heart rate (1) • Cat Hypothermia (1) • Cat Hyperthermia (1) • Dog Haematochezia (1) • Dog General pain (1) • Dog Excessive chewing, licking and/or grooming (1) • Dog Eosinophilia (1) • Dog Enamel disorder (1) • Dog Elevated serum alkaline phosphatase (1) • Dog Dysphoria (1) • Cat Disorientation (1) • Cat Decreased blood urea nitrogen (BUN) or creatinine (1) • Cat Death by euthanasia (1) • Cat Death (1) • Cat Cardiac arrest (1) • Cat Burn (1) • Dog Bacterial skin infection NOS (1) • Dog Arthritis (1) • Dog Administration error NOS (1) • Cat Acid-base disorder (1) • Dog Abnormal electrocardiogram (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, ['Shepherd Dog - German', 'Dog (unknown)'], Female, 2.5 year • Drug: MSK, Intravenous, Dose: 7 mL per animal • Reactions: Neutropenia, Eosinophilia, Lymphocytosis, Enamel disorder, Tooth disorder • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055809
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 2.50 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intravenous
  • Dose: 7 mL per animal
Reactions Reported:
Neutropenia Eosinophilia Lymphocytosis Enamel disorder Tooth disorder
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Female, 10 month, 3.629 kilogram • Drug: MSK, Injection, suspension, Intravenous, Dose: 1.50 mL per animal • Reactions: Shaking, Overdose, Medication error NOS, Increased heart rate, Intentional misuse • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054487
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 10.00 Month
  • Weight: 3.629 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intravenous
  • Form: Injection, suspension
  • Dose: 1.50 mL per animal
Reactions Reported:
Shaking Overdose Medication error NOS Increased heart rate Intentional misuse
Outcomes: Ongoing

Dog, ['Dachshund - Standard Long-haired', 'Dog (unknown)'], Female, 12 year, 5.942 kilogram • Drug: MSK, Emulsion, Intravenous, Dose: 2 mL per animal • Reactions: Localised pain NOS, Intervertebral disc disease, Excessive chewing, licking and/or grooming, Skin necrosis, Reddening of the skin… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054276
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 12.00 Year
  • Weight: 5.942 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intravenous
  • Form: Emulsion
  • Dose: 2 mL per animal
Reactions Reported:
Localised pain NOS Intervertebral disc disease Excessive chewing, licking and/or grooming Skin necrosis Reddening of the skin Burn Sedation prolonged Medication error NOS
Outcomes: Ongoing

Cat, Domestic Mediumhair, Female, 19 week, 2.06 kilogram • Drug: MSK, Unknown • Reactions: Sleepiness - neurological disorder, Temporary blindness, Tiredness (lethargy), Reduced responses, Mydriasis… • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2025-US-055689
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 19.00 Week
  • Weight: 2.060 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Sleepiness - neurological disorder Temporary blindness Tiredness (lethargy) Reduced responses Mydriasis Death by euthanasia
Outcomes: Euthanized

Dog, ['Dog (unknown)', 'Poodle (unspecified)'], Male, 8 month, 21.863 kilogram • Drug: MSK, Intravenous, Dose: 10 mL per unknown, Frequency: 31 per day • Reactions: Hyperthermia, Tachycardia, Abnormal electrocardiogram, Tachypnoea • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055950
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 8.00 Month
  • Weight: 21.863 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intravenous
  • Dose: 10 mL per unknown
  • Frequency: 31 per day
Reactions Reported:
Hyperthermia Tachycardia Abnormal electrocardiogram Tachypnoea
Outcomes: Ongoing

Dog, Dog (unknown), Male, 10 year, 32.659 kilogram • Drug: MSK, Unknown • Reactions: Mass NOS, Lymph node abscess, Lymphadenopathy, Tachycardia, Drooling… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055759
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 10.00 Year
  • Weight: 32.659 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Mass NOS Lymph node abscess Lymphadenopathy Tachycardia Drooling Elevated serum alkaline phosphatase Monocytosis Neutrophilia Leucocytosis NOS Acid-base disorder Musculoskeletal disorder NOS Luxation/subluxation Arthritis Muscle tremor Tachypnoea Trouble breathing (dyspnea) Bacterial skin infection NOS Trauma NOS Hyperthermia Loss of appetite Oedema NOS Tiredness (lethargy) General pain
Outcomes: Outcome Unknown

Dog, Pug, Female, 6 year, 7.8 kilogram • Drug: MSK, Unknown, Dose: 3 mL per unknown • Reactions: Diarrhea, Vomiting, Haematochezia • Outcome: Recovered/Normal

  • Report ID: GBR-USFDACVM-2025-GB-000062
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 6.00 Year
  • Weight: 7.800 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Dose: 3 mL per unknown
Reactions Reported:
Diarrhea Vomiting Haematochezia
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Male, 20 week, 3 kilogram • Drug: MSK, Unknown • Reactions: Dysphoria, Sedation, Decreased blood urea nitrogen (BUN) or creatinine, Intentional misuse • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-053968
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 20.00 Week
  • Weight: 3.000 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Dysphoria Sedation Decreased blood urea nitrogen (BUN) or creatinine Intentional misuse
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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This medication has not been reviewed by a veterinarian yet.