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Roxee Meds Catalog

Imidacloprid, Moxidectin

Medication catalog facts with explicit FDA-approval, off-label, source-limited, and safety context.

Both Catalog complete FDA data linked Rx required Liquid (Solution) Multiple FDA labelers Official label facts Owner quick guide first
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Source timing details
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    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
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Evidence

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Last reviewed: April 22, 2026

Updated: April 22, 2026, 10:06 AM UTC

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Imidacloprid, Moxidectin

Imidacloprid, Moxidectin

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Liquid (Solution) Rx required 100% storefront ready

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Imidacloprid, Moxidectin

For the prevention of heartworm disease caused by Dirofilaria immitis ; and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs; and the treatment and control of intestinal roundworms ( Toxocara canis and Toxascaris leonina ), hookworms ( Ancylostoma caninum and Uncinaria stenocephala ), and whipworms ( Trichuris vulpis ); kills adult fleas and treats flea infestations ( Ctenocephalides felis ); treats and controls sarcoptic mange caused by Sarcoptes scabiei var. canis . For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis ; kills adult fleas ( Ctenocephalides felis ) and is indicated for the treatment of flea infestations on ferrets. For the prevention of heartworm disease caused by Dirofilaria immitis ; for the treatment and control of ear mite ( Otodectes cynotis ) infestations, intestinal roundworms ( Toxocara cati ), and hookworms ( Ancylostoma tubaeforme ); kills adult fleas and treats flea infestations ( Ctenocephalides felis ). Species commonly shown: Both, Dog, No Use Class Stated Or Implied, No Use Class Stated Or Implied.

Generic name
Imidacloprid, Moxidectin
Brand names
Advantage Multi™ for Dogs, advantage multi™ for cats, IMOXI™ Topical Solution for Dogs, IMOXI™ Topical Solution for Cats
Manufacturer
Multiple FDA labelers
Species
Both, Dog, No Use Class Stated Or Implied, No Use Class Stated Or Implied, Cat, No Use Class Stated Or Implied
Dosage forms
Liquid (Solution), Solution, Topical Solution
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
Advantage Multi™ for Dogs advantage multi™ for cats IMOXI™ Topical Solution for Dogs IMOXI™ Topical Solution for Cats PARASEDGE® Multi for Dogs PARASEDGE™ Multi for Cats Barrier® for cats Midamox® for Dogs Barrier® for dogs Midamox® for Cats MoxiCloprid™ for Cats MoxiCloprid™ for Dogs IMOXI for Cats PARASEDGE Multi for Dogs 9.1 - 20 lbs BARRIER FOR DOGS ADVANTAGE MULTI FOR CATS Midamox for Cats PARASEDGE Multi for Dogs 20.1 - 55 lbs PARASEDGE Multi for Dogs 88.1 - 110 lbs PARASEDGE Multi for Dogs 55.1 - 88 lbs ADVANTAGE MULTI FOR DOGS Midamox for Dogs PARASEDGE Multi for Cats 9 - 18 lbs IMOXI for Dogs PARASEDGE Multi for Cats 2 - 5 lbs PARASEDGE Multi for Dogs 3 - 9 lbs PARASEDGE Multi for Cats 5.1 - 9 lbs BARRIER FOR CATS
Dosage forms
Liquid (Solution) Solution Topical Solution

Indications / Uses

For the prevention of heartworm disease caused by Dirofilaria immitis ; and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs; and the treatment and control of intestinal roundworms ( Toxocara canis and Toxascaris leonina ), hookworms ( Ancylostoma caninum and Uncinaria stenocephala ), and whipworms ( Trichuris vulpis ); kills adult fleas and treats flea infestations ( Ctenocephalides felis ); treats and controls sarcoptic mange caused by Sarcoptes scabiei var. canis . For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis ; kills adult fleas ( Ctenocephalides felis ) and is indicated for the treatment of flea infestations on ferrets. For the prevention of heartworm disease caused by Dirofilaria immitis ; for the treatment and control of ear mite ( Otodectes cynotis ) infestations, intestinal roundworms ( Toxocara cati ), and hookworms ( Ancylostoma tubaeforme ); kills adult fleas and treats flea infestations ( Ctenocephalides felis ).

Warnings / Contraindications

Do not administer this product orally. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use this product (containing 2.5 %moxidectin) on cats. Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets. The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick or debilitated ferrets. Do not apply to irritated skin. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick, debilitated, or underweight cats. Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight. Do not apply to irritated skin.

  • Do not administer this product orally. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use this product (containing 2.5 %moxidectin) on cats. Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets. The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick or debilitated ferrets. Do not apply to irritated skin. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick, debilitated, or underweight cats. Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight. Do not apply to irritated skin.

Side Effects

Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Lack of efficacy (ectoparasite) - flea, Lack of efficacy (endoparasite) - hookworm, Vomiting, Diarrhoea, Other abnormal test result NOS.

FAQ

Both, Dog, No Use Class Stated Or Implied, No Use Class Stated Or Implied, Cat, No Use Class Stated Or Implied

Yes. Roxee shows this as prescription-only.

Liquid (Solution), Solution, Topical Solution

Related Conditions

Fleas (Flea Infestation) Heartworm Disease Intestinal Parasites (Worms) Mange (sarcoptic mange, demodicosis) Pica Sarcoptic Mange (Scabies)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. Kills adult fleas and is indicated for the treatment of...

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Do not administer this product orally
  • For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals
  • Do not use this product (containing 2.5 %moxidectin) on cats
  • Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets
  • The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose
  • Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian
  • Do not use on sick or debilitated ferrets
  • Do not apply to irritated skin
  • Do not use on sick, debilitated, or underweight cats
  • Do not use on cats less than 9 weeks of age or less than 2 lbs
  • body weight
  • Vomiting (1 reports)
  • Loss of appetite (1 reports)
  • Elevated total bilirubin (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Major cautions & emergency warning signs

Side effects to monitor:

  • Do not administer this product orally
  • For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals
  • Do not use this product (containing 2.5 %moxidectin) on cats
  • Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets
  • The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose

Most reported reactions:

  • Vomiting (1 reports)
  • Loss of appetite (1 reports)
  • Elevated total bilirubin (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
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Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Multiple FDA labelers
Form: Liquid (Solution), Solution, Topical Solution
Identifiers:
ANADA: 200615 ANADA: 200638 ANADA: 200700 ANADA: 200701 ANADA: 200714 ANADA: 200716 ANADA: 200718 ANADA: 200721 ANADA: 200811 ANADA: 200818 NADA: 141251 NADA: 141254 NDC Package: 17030-023-01 NDC Package: 17030-023-03 NDC Package: 17030-025-01 NDC Package: 17030-025-06 NDC Package: 17030-043-01 NDC Package: 17030-043-06 NDC Package: 17030-044-01 NDC Package: 17030-044-06
Source metadata:

Warnings / Contraindications

Do not administer this product orally. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use this product (containing 2.5 %moxidectin) on cats. Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets. The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick or debilitated ferrets. Do not apply to irritated skin. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick, debilitated, or underweight cats. Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight. Do not apply to irritated skin.

  • High: Do not administer this product orally. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use this product (containing 2.5 %moxidectin) on cats. Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets. The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick or debilitated ferrets. Do not apply to irritated skin. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick, debilitated, or underweight cats. Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight. Do not apply to irritated skin.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
24
Species represented
2
Grouped by Body System
Digestive (5) · Vomiting, Loss of appetite, Diarrhea Skin & allergy (1) · Hair loss at application site Behavior (1) · Behavioral disorder (unspecified) Other (25) · Elevated total bilirubin, Elevated temperature, Elevated symmetrical dimethylarginine
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Digestive 1 Dog 1
Digestive 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (24) Cat (8)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Serious - 1
Digestive Dog Serious - 1
Skin & allergy Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Digestive Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Digestive Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Digestive Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Behavior Cat Non-serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Source metadata:

Documents

Owner handouts and official technical documents open on-page first, with the original source still one click away.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

24

FOI

16

PARASEDGE® Multi for Dogs

SPL · SPL

Open original
FDA Structured Product Label

PARASEDGE® Multi for Dogs

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Virbac AH, Inc.
ANADA
200-700
Status
RX
Form
Topical Solution
Route
Topical
Species
Dog, No Use Class Stated Or Implied
Composition / specifications
100 mg/mL (10%) imidacloprid and 25 mg/mL (2.5%) moxidectin

Dogs

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. Kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). For the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. canis. It is also indicated for the treatment and control of the following intestinal parasites: adult, immature adult and fourth stage larvae in hookworm species (Ancylostoma caninum and Uncinaria stenocephala); adult and fourth stage larvae in roundworm species (Toxocara canis); and adult stage in roundworm species (Toxascaris leonina) and whipworm (Trichuris vulpis).

Dosage

The recommended minimum dose is 4.5 mg/lb. (10 mg/kg) imidacloprid and 1.1mg/lb. (2.5 mg/kg) moxidectin, once a month, by topical administration.

Barrier® for cats

SPL · SPL

Open original
FDA Structured Product Label

Barrier® for cats

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Aurora Pharmaceutical, Inc.
ANADA
200-714
Status
RX
Form
Topical Solution
Route
Topical
Species
No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
10% imidacloprid and 1% moxidectin

Cats

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis. Kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. For the treatment and control of ear mite (Otodectes cynotis) infestations and the following intestinal parasites: adult, immature adult, and fourth stage larvae in hookworms (Ancylostoma tubaeforme); and adult and fourth stage larvae in roundworms (Toxocara cati).

Dosage

The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.

Ferrets

Indication

For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis. Kills adult fleas (Ctenophalides felis) and is indicated for the treatment of flea infestations on ferrets.

Dosage

The recommended minimum dose for a ferret is 9 m/lb (20 mg/kg) imidacloprid and 0.9 mg/lb (2 mg/kg) moxidectin, once a month, by topical administration.

MoxiCloprid™ for Dogs

SPL · SPL

Open original
FDA Structured Product Label

MoxiCloprid™ for Dogs

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Bimeda Animal Health Limited
ANADA
200-818
Status
RX
Form
Topical Solution
Route
Topical
Composition / specifications
100 mg/mL (10%) imidacloprid and 25 mg/mL (2.5%) moxidectin

Dogs

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis; and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs; and the treatment and control of intestinal roundworms (Toxocara canis and Toxascaris leonina), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and whipworms (Trichuris vulpis); kills adult fleas and treats flea infestations (Ctenocephalides felis); treats and controls sarcoptic mange caused by Sarcoptes scabiei var. canis.

Dosage

The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration.

Barrier® for dogs

SPL · SPL

Open original
FDA Structured Product Label

Barrier® for dogs

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Aurora Pharmaceutical, Inc.
ANADA
200-718
Status
RX
Form
Topical Solution
Route
Topical
Species
Dog, No Use Class Stated Or Implied
Composition / specifications
10% (100 mg) imidacloprid and 2.5% (25 mg) moxidectin per milliliter

Dogs

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs; kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis); for the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. canis; and for the treatment and control of intestinal roundworms (Toxocara canis and Toxascaris leonina), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and whipworms (Trichuris vulpis).

Dosage

The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration.

MoxiCloprid™ for Cats

SPL · SPL

Open original
FDA Structured Product Label

MoxiCloprid™ for Cats

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Bimeda Animal Health Limited
ANADA
200-811
Status
RX
Form
Topical Solution
Route
Topical
Composition / specifications
100 mg/mL (10%) imidacloprid and 10 mg/mL (1%) moxidectin

Cats

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis; kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. It is also indicated for the treatment and control of ear mite (Otodectes cynotis) infestations, intestinal roundworms (Toxocara cati), and hookworms (Ancylostoma tubaeforme).

Dosage

The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.

Ferrets

Indication

For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis; kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets.

Dosage

The recommended minimum dose is 9 mg/lb (20 mg/kg) imidacloprid and 0.9 mg/lb (2 mg/kg) moxidectin, once a month, by topical administration.

PARASEDGE™ Multi for Cats

SPL · SPL

Open original
FDA Structured Product Label

PARASEDGE™ Multi for Cats

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Virbac AH, Inc.
ANADA
200-701
Status
RX
Form
Topical Solution
Route
Topical
Species
No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
100 mg/mL (10%) imidacloprid and 10 mg/mL (1%) moxidectin

Cats

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis. Kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. It is also indicated for the treatment and control of ear mite (Otodectes cynotis) infestations and the following intestinal parasites: adult, immature adult, and fourth stage larvae in hookworms (Ancyclostoma tubaeforme); and adult and fourth stage larvae in roundworms (Toxacara cati).

Dosage

The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 0.45 mg/lb (1 mg/kg) moxidectin, once a month, by topical administration.

Ferrets

Indication

For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis. Kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets.

Dosage

9 mg/lb (20 mg/kg) imidacloprid and 0.9 mg/lb (2 mg/kg) moxidectin, once a month, by topical administration. Only
the 0.4 mL applicator tube volume (PARASEDGE™ Multi 9) should be used on ferrets.

Midamox® for Cats

SPL · SPL

Open original
FDA Structured Product Label

Midamox® for Cats

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Norbrook Laboratories, Ltd.
ANADA
200-721
Status
RX
Form
Topical Solution
Route
Topical
Species
Cat, No Use Class Stated Or Implied
Composition / specifications
100 mg/mL (10%) imidacloprid and 10 mg/mL (1%) moxidectin

Cats

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis; kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. It is also indicated for the treatment and control of ear mite (Otodectes cynotis) infestations, intestinal roundworms (Toxocara cati), and hookworms (Ancylostoma tubaeforme).

Dosage

The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.

Ferrets

Indication

For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis. Kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets.

Dosage

The recommended minimum dose for a ferret is 9 mg/lb (20 mg/kg) imidacloprid and 0.9 mg/lb (2mg/kg) moxidectin, once a month, by topical administration. Only the 0.4 mL applicator volume (Midamox 9) should be used on ferrets.

Midamox® for Dogs

SPL · SPL

Open original
FDA Structured Product Label

Midamox® for Dogs

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Norbrook Laboratories, Ltd.
ANADA
200-716
Status
RX
Form
Topical Solution
Route
Topical
Species
Dog, No Use Class Stated Or Implied
Composition / specifications
100 mg/mL (10%) imidacloprid and 25 mg/mL (2.5%) moxidectin

Dogs

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs; kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis); for the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. canis; and for the treatment and control of intestinal roundworms (Toxocara canis and Toxascaris leonina), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and whipworms (Trichuris vulpis).

Dosage

The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration.

Advantage Multi™ for Dogs

SPL · SPL

Open original
FDA Structured Product Label

Advantage Multi™ for Dogs

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Sponsor
Elanco US Inc.
NADA
141-251
Status
RX
Form
Liquid (Solution)
Route
Topical
Species
Dog, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of solution contains 100 milligrams (mg) imidacloprid and 25 mg moxidectin.

Dogs

Indication
For the prevention of heartworm disease caused by Dirofilaria immitis; and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs; and the treatment and control of intestinal roundworms (Toxocara canis and Toxascaris leonina), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and whipworms (Trichuris vulpis); kills adult fleas and treats flea infestations (Ctenocephalides felis); treats and controls sarcoptic mange caused by Sarcoptes scabiei var. canis.
Dosage
Apply 4.5 mg/lb body weight (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg)moxidectin, once a month.
Limitations

Do not administer this product orally. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use this product (containing 2.5 %moxidectin) on cats.

advantage multi™ for cats

SPL · SPL

Open original
FDA Structured Product Label

advantage multi™ for cats

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Elanco US Inc.
NADA
141-254
Status
RX
Form
Solution
Route
Topical
Species
No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of solution contains 100 mg imidacloprid and 10 mg moxidectin

Ferrets

Indication
For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis; kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets.
Dosage
The recommended minimum dose is 9 mg/lb (20 mg/kg) imidacloprid and 0.9 mg/lb (2 mg/kg) moxidectin, once a month, by topical administration.
Limitations
Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets. The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick or debilitated ferrets. Do not apply to irritated skin.

Cats

Indication
For the prevention of heartworm disease caused by Dirofilaria immitis; for the treatment and control of ear mite (Otodectes cynotis) infestations, intestinal roundworms (Toxocara cati), and hookworms (Ancylostoma tubaeforme); kills adult fleas and treats flea infestations (Ctenocephalides felis).
Dosage

Apply 4.5 mg/lb body weight (10 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month.

Limitations
Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick, debilitated, or underweight cats. Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight. Do not apply to irritated skin.

IMOXI™ Topical Solution for Cats

SPL · SPL

Open original
FDA Structured Product Label

IMOXI™ Topical Solution for Cats

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Vetoquinol USA, Inc.
ANADA
200-638
Status
RX
Form
Topical Solution
Route
Topical
Species
Cat, No Use Class Stated Or Implied
Composition / specifications
100 mg/mL (10%) imidacloprid and 10 mg/mL (1%) moxidectin

Cats

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis. Kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. It is also indicated for the treatment and control of ear mite (Otodectes cynotis) infestations and the following intestinal parasites: adult, immature adult, and fourth stage larvae in hookworms (Ancylostoma tubaeforme); and adult and fourth stage larvae in roundworm (Toxocara cati).

Dosage

The recommended minimum dose is 4.5 mg/lb. (10.0 mg/kg) imidacloprid and 0.45 mg/lb. (1.0 mg/kg) moxidectin, once a month, by topical administration.

IMOXI™ Topical Solution for Dogs

SPL · SPL

Open original
FDA Structured Product Label

IMOXI™ Topical Solution for Dogs

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Vetoquinol USA, Inc.
ANADA
200-615
Status
RX
Form
Topical Solution
Route
Topical
Species
Dog, No Use Class Stated Or Implied
Composition / specifications
100 mg/mL (10%) imidacloprid and 25 mg/mL (2.5%) moxidectin

Dogs

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. Kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). For the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. canis. For the treatment and control of intestinal roundworms (Toxocara canis and Toxascaris leonina), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and whipworms (Trichuris vulpis).

Dosage

The recommended minimum dose is 4.5 mg/lb. (10 mg/kg) imidacloprid and 1.1 mg/lb. (2.5 mg/kg) moxidectin, once a month, by topical administration.

ADVANTAGE MULTI FOR DOGS SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for ADVANTAGE MULTI FOR DOGS. Use the source link for the full official labeling record.

BARRIER FOR CATS SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for BARRIER FOR CATS. Use the source link for the full official labeling record.

IMOXI for Dogs SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for IMOXI for Dogs. Use the source link for the full official labeling record.

Midamox for Dogs SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Midamox for Dogs. Use the source link for the full official labeling record.

IMOXI for Cats SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for IMOXI for Cats. Use the source link for the full official labeling record.

Midamox for Cats SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Midamox for Cats. Use the source link for the full official labeling record.

Midamox for Dogs SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Midamox for Dogs. Use the source link for the full official labeling record.

ADVANTAGE MULTI FOR CATS SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for ADVANTAGE MULTI FOR CATS. Use the source link for the full official labeling record.

PARASEDGE Multi for Cats 5.1 - 9 lbs SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for PARASEDGE Multi for Cats 5.1 - 9 lbs. Use the source link for the full official labeling record.

Midamox for Cats SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Midamox for Cats. Use the source link for the full official labeling record.

PARASEDGE Multi for Dogs 3 - 9 lbs SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for PARASEDGE Multi for Dogs 3 - 9 lbs. Use the source link for the full official labeling record.

BARRIER FOR DOGS SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for BARRIER FOR DOGS. Use the source link for the full official labeling record.

ANADA 200-700 FOI Summar.pdf

FOI · FOI

Open original

FOI Summary oA 200-714 Approved November 24, 2021.pdf

FOI · FOI

Open original

FOI Summary oA 200-818 Approved August 5, 2025.pdf

FOI · FOI

Open original

FOI Summary oA 200-718 Approved February 7, 2022.pdf

FOI · FOI

Open original

FOI Summary oA 200-811 Approved March 24, 2025.pdf

FOI · FOI

Open original

FOI Summary sA 200-701 Approved February 9, 2023.pdf

FOI · FOI

Open original

FOI Summary oA 200-701 Approved June 10, 2021.pdf

FOI · FOI

Open original

FOI Summary sA 200-721 Approved January 12, 2023.pdf

FOI · FOI

Open original

FOI Summary oA 200-721 Approved March 28, 2022.pdf

FOI · FOI

Open original

FOI Summary oA 200-716 Approved January 28, 2022.pdf

FOI · FOI

Open original

UCM381705.pdf

FOI · FOI

Open original

UCM051438.pdf

FOI · FOI

Open original

UCM381709.pdf

FOI · FOI

Open original

UCM051423.pdf

FOI · FOI

Open original

FOI Summary oA 200-638 Approved May 27, 2020.pdf

FOI · FOI

Open original

FOI Summary oA 200-615 Approved December 19, 2019.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Storefront facts: Source Roxee | Refreshed Apr 22, 2026, 10:06 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: ADVANTAGE MULTI FOR CATS ADVANTAGE MULTI FOR DOGS BARRIER FOR CATS BARRIER FOR DOGS IMOXI for Cats IMOXI for Dogs Midamox for Cats Midamox for Dogs PARASEDGE Multi for Cats 2 - 5 lbs PARASEDGE Multi for Cats 5.1 - 9 lbs PARASEDGE Multi for Cats 9 - 18 lbs PARASEDGE Multi for Dogs 20.1 - 55 lbs PARASEDGE Multi for Dogs 3 - 9 lbs PARASEDGE Multi for Dogs 55.1 - 88 lbs PARASEDGE Multi for Dogs 88.1 - 110 lbs PARASEDGE Multi for Dogs 9.1 - 20 lbs
Manufacturer mapping: Multiple FDA labelers
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat, Dog, No Use Class Stated Or Implied
Rx/OTC: RX
Form/route: Liquid (Solution), Solution, Topical Solution • Topical
Applications: ANADA 200-700 • ANADA 200-714 • ANADA 200-818 • ANADA 200-718 • ANADA 200-811 • ANADA 200-701 • ANADA 200-721 • ANADA 200-716 • NADA 141-251 • NADA 141-254 • ANADA 200-638 • ANADA 200-615
NDC: Packages 17030-023-01 17030-023-03 17030-025-01 17030-025-06 17030-043-01 17030-043-06 • Products 17030 51072 51311 55529 58198 86136
Documents: 16 (FOI: 16) • SPL: 12 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 10 • Cat 15 • View
Case summaries: 12 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: B74.8 ICD10_CM: B82.9 ICD10_CM: B86 ICD10_CM: B88.1
Other filariases

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Do not administer this product orally. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use this product (containing 2.5 %moxidectin) on cats. Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets. The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick or debilitated ferrets. Do not apply to irritated skin. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick, debilitated, or underweight cats. Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight. Do not apply to irritated skin. (Contraindication, High)
Top reaction signals
Vomiting (1) Loss of appetite (1) Elevated total bilirubin (1) Elevated temperature (1) Elevated symmetrical dimethylarginine (1) Elevated serum alkaline phosphatase (1) Elevated haematocrit (1) Elevated creatinine (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200615 ANADA: 200638 ANADA: 200700 ANADA: 200701 ANADA: 200714 ANADA: 200716 ANADA: 200718 ANADA: 200721 ANADA: 200811 ANADA: 200818 NADA: 141251 NADA: 141254 NDC Package: 17030-023-01 NDC Package: 17030-023-03 NDC Package: 17030-025-01 NDC Package: 17030-025-06 NDC Package: 17030-043-01 NDC Package: 17030-043-06 NDC Package: 17030-044-01 NDC Package: 17030-044-06 NDC Package: 17030-080-01 NDC Package: 17030-080-06 NDC Package: 17030-103-01 NDC Package: 17030-103-06
Package NDC Product NDC Form / Route Status
17030-023-01 17030 -
17030-023-03 17030 -
17030-025-01 17030 -
17030-025-06 17030 -
17030-043-01 17030 -
17030-043-06 17030 -
17030-044-01 17030 -
17030-044-06 17030 -
17030-080-01 17030 -
17030-080-06 17030 -
17030-103-01 17030 -
17030-103-06 17030 -
17030-400-01 17030 -
17030-400-06 17030 -
17030-500-01 17030 -
17030-500-06 17030 -
51072-100-01 51072 -
51072-100-02 51072 -
51072-100-03 51072 -
51072-100-04 51072 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 69 Clinical 8 Manufacturer 0 Marketing 0
Current Field Facts
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-21)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-20)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-19)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-17)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-15)
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Lack of efficacy (ectoparasite) - flea, Lack of efficacy (endoparasite) - hookwo… (Clinical, 2026-04-11)
  • contraindications: Do not administer this product orally. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves… (Official, 2026-04-22)
  • indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-05-05)
  • indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-05-03)
  • indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-05-02)
  • indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-04-29)
  • indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-04-28)
  • indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-04-27)
  • indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-04-26)
  • indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-04-25)
  • indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-04-22)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-05-05)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-05-03)
Recent Revisions
  • side_effects updated 2026-04-22 10:06 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-22 10:06 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-22 10:06 by etl_backfill • Backfilled from existing medication fields
  • monitoring updated 2026-04-21 10:06 by curated_loader • Clinical monitoring context for feline diabetes management.
  • usage updated 2026-04-21 10:06 by curated_loader • Usage statement from FDA warning letter and approved-product context.
  • drug_profile_type updated 2026-04-21 10:06 by curated_loader • FDA source confirms Senvelgo as a branded approved product.
  • manufacturer_name updated 2026-04-21 10:06 by curated_loader • FDA warning letter identifies the approved sponsor/manufacturer.
  • brand_names updated 2026-04-21 10:06 by curated_loader • FDA warning letter references Senvelgo as the approved animal drug.
  • approval_reference updated 2026-04-21 10:06 by curated_loader • Official FDA application reference for Senvelgo.
  • monitoring updated 2026-04-20 10:08 by curated_loader • Clinical monitoring context for feline diabetes management.
  • usage updated 2026-04-20 10:08 by curated_loader • Usage statement from FDA warning letter and approved-product context.
  • drug_profile_type updated 2026-04-20 10:08 by curated_loader • FDA source confirms Senvelgo as a branded approved product.
  • manufacturer_name updated 2026-04-20 10:08 by curated_loader • FDA warning letter identifies the approved sponsor/manufacturer.
  • brand_names updated 2026-04-20 10:08 by curated_loader • FDA warning letter references Senvelgo as the approved animal drug.
  • approval_reference updated 2026-04-20 10:08 by curated_loader • Official FDA application reference for Senvelgo.
  • monitoring updated 2026-04-19 10:07 by curated_loader • Clinical monitoring context for feline diabetes management.
  • usage updated 2026-04-19 10:07 by curated_loader • Usage statement from FDA warning letter and approved-product context.
  • drug_profile_type updated 2026-04-19 10:07 by curated_loader • FDA source confirms Senvelgo as a branded approved product.
  • manufacturer_name updated 2026-04-19 10:07 by curated_loader • FDA warning letter identifies the approved sponsor/manufacturer.
  • brand_names updated 2026-04-19 10:07 by curated_loader • FDA warning letter references Senvelgo as the approved animal drug.

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
PARASEDGE® Multi for Dogs
RX
Imidacloprid Moxidectin
Topical Solution • Topical
Label highlights
Official documents
Virbac AH, Inc. ANADA 200-700 Approved Dec 16, 2025
Barrier® for cats
RX
Imidacloprid Moxidectin
Topical Solution • Topical
Label highlights
Official documents
Aurora Pharmaceutical, Inc. ANADA 200-714 Approved Dec 5, 2025
MoxiCloprid™ for Dogs
RX
Imidacloprid Moxidectin
Topical Solution • Topical
Label highlights
Official documents
Bimeda Animal Health Limited ANADA 200-818 Approved Aug 28, 2025
Barrier® for dogs
RX
Imidacloprid Moxidectin
Topical Solution • Topical
Label highlights
Official documents
Aurora Pharmaceutical, Inc. ANADA 200-718 Approved Jun 2, 2025
MoxiCloprid™ for Cats
RX
Imidacloprid Moxidectin
Topical Solution • Topical
Label highlights
Official documents
Bimeda Animal Health Limited ANADA 200-811 Approved Mar 28, 2025
PARASEDGE™ Multi for Cats
RX
Imidacloprid Moxidectin
Topical Solution • Topical
Label highlights
Official documents
Virbac AH, Inc. ANADA 200-701 Approved Oct 24, 2023
Midamox® for Cats
RX
Imidacloprid Moxidectin
Topical Solution • Topical
Label highlights
Official documents
Norbrook Laboratories, Ltd. ANADA 200-721 Approved Oct 10, 2023
Midamox® for Dogs
RX
Imidacloprid Moxidectin
Topical Solution • Topical
Label highlights
Official documents
Norbrook Laboratories, Ltd. ANADA 200-716 Approved Aug 23, 2023
Advantage Multi™ for Dogs
RX
Imidacloprid Moxidectin
Liquid (Solution) • Topical
Label highlights
Official documents
Elanco US Inc. NADA 141-251 Approved Feb 2, 2023
advantage multi™ for cats
RX
Imidacloprid Moxidectin
Solution • Topical
Label highlights
Official documents
Elanco US Inc. NADA 141-254 Approved Aug 22, 2022
IMOXI™ Topical Solution for Cats
RX
Imidacloprid Moxidectin
Topical Solution • Topical
Label highlights
Official documents
Vetoquinol USA, Inc. ANADA 200-638 Approved Jun 1, 2020
IMOXI™ Topical Solution for Dogs
RX
Imidacloprid Moxidectin
Topical Solution • Topical
Label highlights
Official documents
Vetoquinol USA, Inc. ANADA 200-615 Approved Dec 30, 2019

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
100 mg/mL (10%) imidacloprid and 25 mg/mL (2.5%) moxidectin
Dogs
Indication

For the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. Kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). For the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. canis. It is also indicated for the treatment and control of the following intestinal parasites: adult, immature adult and fourth stage larvae in hookworm species (Ancylostoma caninum and Uncinaria stenocephala); adult and fourth stage larvae in roundworm species (Toxocara canis); and adult stage in roundworm species (Toxascaris leonina) and whipworm (Trichuris vulpis).

Dosage

The recommended minimum dose is 4.5 mg/lb. (10 mg/kg) imidacloprid and 1.1mg/lb. (2.5 mg/kg) moxidectin, once a month, by topical administration.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
10% imidacloprid and 1% moxidectin
Cats
Indication

For the prevention of heartworm disease caused by Dirofilaria immitis. Kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. For the treatment and control of ear mite (Otodectes cynotis) infestations and the following intestinal parasites: adult, immature adult, and fourth stage larvae in hookworms (Ancylostoma tubaeforme); and adult and fourth stage larvae in roundworms (Toxocara cati).

Dosage

The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.

Limitations
Ferrets
Indication

For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis. Kills adult fleas (Ctenophalides felis) and is indicated for the treatment of flea infestations on ferrets.

Dosage

The recommended minimum dose for a ferret is 9 m/lb (20 mg/kg) imidacloprid and 0.9 mg/lb (2 mg/kg) moxidectin, once a month, by topical administration.

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications
100 mg/mL (10%) imidacloprid and 25 mg/mL (2.5%) moxidectin
Dogs
Indication

For the prevention of heartworm disease caused by Dirofilaria immitis; and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs; and the treatment and control of intestinal roundworms (Toxocara canis and Toxascaris leonina), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and whipworms (Trichuris vulpis); kills adult fleas and treats flea infestations (Ctenocephalides felis); treats and controls sarcoptic mange caused by Sarcoptes scabiei var. canis.

Dosage

The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
10% (100 mg) imidacloprid and 2.5% (25 mg) moxidectin per milliliter
Dogs
Indication

For the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs; kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis); for the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. canis; and for the treatment and control of intestinal roundworms (Toxocara canis and Toxascaris leonina), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and whipworms (Trichuris vulpis).

Dosage

The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration.

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications
100 mg/mL (10%) imidacloprid and 10 mg/mL (1%) moxidectin
Cats
Indication

For the prevention of heartworm disease caused by Dirofilaria immitis; kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. It is also indicated for the treatment and control of ear mite (Otodectes cynotis) infestations, intestinal roundworms (Toxocara cati), and hookworms (Ancylostoma tubaeforme).

Dosage

The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.

Limitations
Ferrets
Indication

For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis; kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets.

Dosage

The recommended minimum dose is 9 mg/lb (20 mg/kg) imidacloprid and 0.9 mg/lb (2 mg/kg) moxidectin, once a month, by topical administration.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
100 mg/mL (10%) imidacloprid and 10 mg/mL (1%) moxidectin
Cats
Indication

For the prevention of heartworm disease caused by Dirofilaria immitis. Kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. It is also indicated for the treatment and control of ear mite (Otodectes cynotis) infestations and the following intestinal parasites: adult, immature adult, and fourth stage larvae in hookworms (Ancyclostoma tubaeforme); and adult and fourth stage larvae in roundworms (Toxacara cati).

Dosage

The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 0.45 mg/lb (1 mg/kg) moxidectin, once a month, by topical administration.

Limitations
Ferrets
Indication

For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis. Kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets.

Dosage

9 mg/lb (20 mg/kg) imidacloprid and 0.9 mg/lb (2 mg/kg) moxidectin, once a month, by topical administration. Only
the 0.4 mL applicator tube volume (PARASEDGE™ Multi 9) should be used on ferrets.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
100 mg/mL (10%) imidacloprid and 10 mg/mL (1%) moxidectin
Cats
Indication

For the prevention of heartworm disease caused by Dirofilaria immitis; kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. It is also indicated for the treatment and control of ear mite (Otodectes cynotis) infestations, intestinal roundworms (Toxocara cati), and hookworms (Ancylostoma tubaeforme).

Dosage

The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.

Limitations
Ferrets
Indication

For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis. Kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets.

Dosage

The recommended minimum dose for a ferret is 9 mg/lb (20 mg/kg) imidacloprid and 0.9 mg/lb (2mg/kg) moxidectin, once a month, by topical administration. Only the 0.4 mL applicator volume (Midamox 9) should be used on ferrets.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
100 mg/mL (10%) imidacloprid and 25 mg/mL (2.5%) moxidectin
Dogs
Indication

For the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs; kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis); for the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. canis; and for the treatment and control of intestinal roundworms (Toxocara canis and Toxascaris leonina), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and whipworms (Trichuris vulpis).

Dosage

The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of solution contains 100 milligrams (mg) imidacloprid and 25 mg moxidectin.
Dogs
Indication
For the prevention of heartworm disease caused by Dirofilaria immitis; and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs; and the treatment and control of intestinal roundworms (Toxocara canis and Toxascaris leonina), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and whipworms (Trichuris vulpis); kills adult fleas and treats flea infestations (Ctenocephalides felis); treats and controls sarcoptic mange caused by Sarcoptes scabiei var. canis.
Dosage
Apply 4.5 mg/lb body weight (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg)moxidectin, once a month.
Limitations

Do not administer this product orally. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use this product (containing 2.5 %moxidectin) on cats.

FDA page: Open in Animal Drugs @ FDA

Species: No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of solution contains 100 mg imidacloprid and 10 mg moxidectin
Ferrets
Indication
For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis; kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets.
Dosage
The recommended minimum dose is 9 mg/lb (20 mg/kg) imidacloprid and 0.9 mg/lb (2 mg/kg) moxidectin, once a month, by topical administration.
Limitations
Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets. The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick or debilitated ferrets. Do not apply to irritated skin.
Cats
Indication
For the prevention of heartworm disease caused by Dirofilaria immitis; for the treatment and control of ear mite (Otodectes cynotis) infestations, intestinal roundworms (Toxocara cati), and hookworms (Ancylostoma tubaeforme); kills adult fleas and treats flea infestations (Ctenocephalides felis).
Dosage

Apply 4.5 mg/lb body weight (10 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month.

Limitations
Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick, debilitated, or underweight cats. Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight. Do not apply to irritated skin.

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
100 mg/mL (10%) imidacloprid and 10 mg/mL (1%) moxidectin
Cats
Indication

For the prevention of heartworm disease caused by Dirofilaria immitis. Kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. It is also indicated for the treatment and control of ear mite (Otodectes cynotis) infestations and the following intestinal parasites: adult, immature adult, and fourth stage larvae in hookworms (Ancylostoma tubaeforme); and adult and fourth stage larvae in roundworm (Toxocara cati).

Dosage

The recommended minimum dose is 4.5 mg/lb. (10.0 mg/kg) imidacloprid and 0.45 mg/lb. (1.0 mg/kg) moxidectin, once a month, by topical administration.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
100 mg/mL (10%) imidacloprid and 25 mg/mL (2.5%) moxidectin
Dogs
Indication

For the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. Kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). For the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. canis. For the treatment and control of intestinal roundworms (Toxocara canis and Toxascaris leonina), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and whipworms (Trichuris vulpis).

Dosage

The recommended minimum dose is 4.5 mg/lb. (10 mg/kg) imidacloprid and 1.1 mg/lb. (2.5 mg/kg) moxidectin, once a month, by topical administration.

Limitations

FDA page: Open in Animal Drugs @ FDA

Usage

For the prevention of heartworm disease caused by Dirofilaria immitis ; and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs; and the treatment and control of intestinal roundworms ( Toxocara canis and Toxascaris leonina ), hookworms ( Ancylostoma caninum and Uncinaria stenocephala ), and whipworms ( Trichuris vulpis ); kills adult fleas and treats flea infestations ( Ctenocephalides felis ); treats and controls sarcoptic mange caused by Sarcoptes scabiei var. canis . For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis ; kills adult fleas ( Ctenocephalides felis ) and is indicated for the treatment of flea infestations on ferrets. For the prevention of heartworm disease caused by Dirofilaria immitis ; for the treatment and control of ear mite ( Otodectes cynotis ) infestations, intestinal roundworms ( Toxocara cati ), and hookworms ( Ancylostoma tubaeforme ); kills adult fleas and treats flea infestations ( Ctenocephalides felis ).

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Do not administer this product orally. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use this product (containing 2.5 %moxidectin) on cats. Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets. The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick or debilitated ferrets. Do not apply to irritated skin. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick, debilitated, or underweight cats. Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight. Do not apply to irritated skin.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Loss of appetite (1) • Dog Diarrhea (1) • Cat Decreased appetite (1) • Dog Bloody diarrhoea (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Hair loss at application site (1) • Cat

Showing top 5 for Skin & allergy.

Behavior
Behavioral disorder (1) • Cat

Showing top 5 for Behavior.

Other
Elevated total bilirubin (1) • Dog Elevated temperature (1) • Dog Elevated symmetrical dimethylarginine (1) • Dog Elevated serum alkaline phosphatase (1) • Dog Elevated haematocrit (1) • Dog
Show more (20)
Elevated creatinine (1) • Dog Elevated alanine aminotransferase (1) • Dog Electrolyte disorder (1) • Dog Drug dose administration interval too short (1) • Dog Discoloured urine (1) • Dog Difficulty standing (1) • Dog Dehydration (1) • Cat Decreased drinking (1) • Dog Decreased cholesterol (1) • Dog Colitis (1) • Dog Bloody stool (1) • Dog Blood in urine (1) • Dog Blistering (1) • Cat Basophilia (1) • Dog Application site scab (1) • Cat Anaemia NOS (1) • Dog Administration error NOS (1) • Cat Abnormal urine odour (1) • Cat Abnormal radiograph finding (1) • Dog Abnormal cytology (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Shepherd Dog - Australian, Female, 9 year, 20.41 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal, Frequency: 1 per month • Reactions: Lack of efficacy (bacteria) - Borrelia • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-074899
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 9.00 Year
  • Weight: 20.410 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (bacteria) - Borrelia
Outcomes: Outcome Unknown

Dog, Bulldog - English, Male, 8.58 year, 44.906 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal, Frequency: 1 per month • Reactions: Lack of efficacy (protozoa) - Giardia, Lack of efficacy (endoparasite) - hookworm • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-074714
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 8.58 Year
  • Weight: 44.906 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (protozoa) - Giardia Lack of efficacy (endoparasite) - hookworm
Outcomes: Outcome Unknown

Dog, ['Cattle Dog (unspecified)', 'Crossbred Canine/dog'], Female, 3.5 year, 14.88 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal, Frequency: 1 per month • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-073848
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 3.50 Year
  • Weight: 14.880 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (endoparasite) - heartworm
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 8 month, 3.67 kilogram • Drug: MSK, Solution, Unknown • Reactions: Hives, Blistering, Face and neck swelling • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-074791
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 8.00 Month
  • Weight: 3.670 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Solution
Reactions Reported:
Hives Blistering Face and neck swelling
Outcomes: Outcome Unknown

Dog, Terrier - Yorkshire, Female, 2 year, 1.81 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal • Reactions: Behavioral disorder (unspecified), Shaking • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-074174
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 2.00 Year
  • Weight: 1.810 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
Reactions Reported:
Behavioral disorder (unspecified) Shaking
Outcomes: Outcome Unknown

Dog, Cattle Dog (unspecified), Female, 3 year • Drug: MSK, Solution, Topical, Dose: 1 dose per animal • Reactions: Injection site swelling, Lack of efficacy (endoparasite) - heartworm • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-073617
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 3.00 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 dose per animal
Reactions Reported:
Injection site swelling Lack of efficacy (endoparasite) - heartworm
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Female, 2 year • Drug: MSK, Solution, Topical, Dose: 1 tube per animal, Frequency: 1 per month • Reactions: Tiredness (lethargy), Hiding, Behavioral disorder (unspecified), Abnormal urine odour • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-073618
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 2.00 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
  • Frequency: 1 per month
Reactions Reported:
Tiredness (lethargy) Hiding Behavioral disorder (unspecified) Abnormal urine odour
Outcomes: Ongoing

Cat, ['Domestic Longhair', 'Manx'], Male, 10 year, 8.165 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal • Reactions: Lack of efficacy (ectoparasite) - flea • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-073358
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 10.00 Year
  • Weight: 8.165 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
Reactions Reported:
Lack of efficacy (ectoparasite) - flea
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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