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Sometribove

Detailed information about Sometribove

Official label facts Owner quick guide first Marketing clearly labeled
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Reviewed / Updated / Sources

Reviewed: Not available

Updated: February 12, 2026, 10:44 PM UTC

Sources:

Pet Owner Quick Guide

Start here first for the simple next-step summary.

Used for:

To increase production of marketable milk in healthy lactating dairy cows.

What to watch for:

  • Use in lactating dairy cows only
  • Safety to replacement bulls born to treated dairy cows has not been established
  • Inject subcutaneously
  • Avoid injections within 2 weeks of expected slaughter to minimize injection site blemishes on carcass.There is no milk discard or preslaughter withdrawal period.Use may reduce pregnancy rates and increase days open
  • Treated cows are at an increased risk for mastitis and higher milk somatic cell counts
  • Use care to differentiate increased body temperature due to use of this product from an increased body temperature that may occur due to illness
  • Cows treated with this product may have more enlarged hocks and disorders of the foot region
  • Use may reduce hemoglobin and hematocrit values during treatment.Human warning: Avoid prolonged or repeated contact with eyes and skin

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Safety & side effects

What to watch:

  • Use in lactating dairy cows only
  • Safety to replacement bulls born to treated dairy cows has not been established
  • Inject subcutaneously
  • Avoid injections within 2 weeks of expected slaughter to minimize injection site blemishes on carcass.There is no milk discard or preslaughter withdrawal period.Use may reduce pregnancy rates and increase days open
  • Treated cows are at an increased risk for mastitis and higher milk somatic cell counts

When to call your vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Data freshness: source data appears current.

Latest refresh: Mar 21, 2026, 10:01 a.m.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
Image coming soon
Sometribove

Sometribove

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Union Agener, Inc.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Union Agener, Inc.
Form: Liquid (Suspension)
Identifiers:
NADA: 140872 NDC Package: 86106-0225-1 NDC Package: 86106-0225-2 NDC Package: 86106-0225-3 NDC Product: 86106
Source metadata:

Warnings / Contraindications

Use in lactating dairy cows only. Safety to replacement bulls born to treated dairy cows has not been established. Inject subcutaneously. Avoid injections within 2 weeks of expected slaughter to minimize injection site blemishes on carcass.There is no milk discard or preslaughter withdrawal period.Use may reduce pregnancy rates and increase days open. Treated cows are at an increased risk for mastitis and higher milk somatic cell counts. Use care to differentiate increased body temperature due to use of this product from an increased body temperature that may occur due to illness. Cows treated with this product may have more enlarged hocks and disorders of the foot region. Use may reduce hemoglobin and hematocrit values during treatment.Human warning: Avoid prolonged or repeated contact with eyes and skin.

  • High: Use in lactating dairy cows only. Safety to replacement bulls born to treated dairy cows has not been established. Inject subcutaneously. Avoid injections within 2 weeks of expected slaughter to minimize injection site blemishes on carcass.There is no milk discard or preslaughter withdrawal period.Use may reduce pregnancy rates and increase days open. Treated cows are at an increased risk for mastitis and higher milk somatic cell counts. Use care to differentiate increased body temperature due to use of this product from an increased body temperature that may occur due to illness. Cows treated with this product may have more enlarged hocks and disorders of the foot region. Use may reduce hemoglobin and hematocrit values during treatment.Human warning: Avoid prolonged or repeated contact with eyes and skin.
Source metadata:

Documents

Owner handouts and official technical documents are grouped for faster access.

Owner handouts (0)
  • No owner handouts linked yet.
Official label / PI (2)
  • 140-872 · EA
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadEA/76
  • 140-872 · FONSI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFonsi/76
SPL (1)
  • Posilac™ · SPL
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1427/Posilac%E2%84%A2
FOI (3)
  • ucm050024.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/514
  • ucm050023.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/513
  • ucm050022.pdf · FOI
    https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/512
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source Roxee | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Mar 21, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Mar 21, 2026, 10:01 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Posilac™
Catalog species: Both • FDA-labeled species: Dairy
Rx/OTC: OTC
Form/route: Liquid (Suspension) • Subcutaneous
Applications: NADA 140-872
Documents: 5 (FOI: 3) • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 0 • Cat 0
Case summaries: 0
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Mastitis
Linked using: Fda_Label (0.95)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Use in lactating dairy cows only. Safety to replacement bulls born to treated dairy cows has not been established. Inject subcutaneously. Avoid injections within 2 weeks of expected slaughter to minimize injection site blemishes on carcass.There is no milk discard or preslaughter withdrawal period.Use may reduce pregnancy rates and increase days open. Treated cows are at an increased risk for mastitis and higher milk somatic cell counts. Use care to differentiate increased body temperature due to use of this product from an increased body temperature that may occur due to illness. Cows treated with this product may have more enlarged hocks and disorders of the foot region. Use may reduce hemoglobin and hematocrit values during treatment.Human warning: Avoid prolonged or repeated contact with eyes and skin. (Contraindication, High)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 140872 NDC Package: 86106-0225-1 NDC Package: 86106-0225-2 NDC Package: 86106-0225-3 NDC Product: 86106
Package NDC Product NDC Form / Route Status
86106-0225-1 86106 -
86106-0225-2 86106 -
86106-0225-3 86106 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • ucm050022.pdf • FOI summary • Official • May 6, 2020
    FDA FOI summary for application 140872
  • ucm050023.pdf • FOI summary • Official • May 6, 2020
    FDA FOI summary for application 140872
  • ucm050024.pdf • FOI summary • Official • May 6, 2020
    FDA FOI summary for application 140872

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 5 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Use in lactating dairy cows only. Safety to replacement bulls born to treated dairy cows has not been established. Inject subcutaneously. Avoid injections with… (Official, 2026-02-12)
  • usage: To increase production of marketable milk in healthy lactating dairy cows. (Official, 2026-02-12)
Recent Revisions
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Posilac™
OTC
Bovine Somatotropin (Sometribove Zinc)
Liquid (Suspension) • Subcutaneous
Label highlights
Official documents
Union Agener, Inc. NADA 140-872 Approved May 6, 2020

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dairy, lactating
Composition / specifications
Each single-dose syringe contains 500 milligrams sometribove zinc in a prolonged-release suspension.
Cattle (lactating dairy)
Indication

To increase production of marketable milk in healthy lactating dairy cows.

Dosage

Inject 500 milligrams every 14 days beginning during the 9th or 10th week (57 to 70 days) after calving and continue until the end of lactation.

Limitations

Use in lactating dairy cows only. Safety to replacement bulls born to treated dairy cows has not been established. Inject subcutaneously. Avoid injections within 2 weeks of expected slaughter to minimize injection site blemishes on carcass.There is no milk discard or preslaughter withdrawal period.Use may reduce pregnancy rates and increase days open. Treated cows are at an increased risk for mastitis and higher milk somatic cell counts. Use care to differentiate increased body temperature due to use of this product from an increased body temperature that may occur due to illness. Cows treated with this product may have more enlarged hocks and disorders of the foot region. Use may reduce hemoglobin and hematocrit values during treatment.Human warning: Avoid prolonged or repeated contact with eyes and skin.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
  • Summary
    This Freedom of Information Summary describes the basis for labeling changes to modify/remove precautions pertaining to target animal safety and reproduction.
  • Summary
    A study was conducted to evaluate the effectiveness and animal safety of sometribove given by subcutaneous injection in the neck area.
  • Summary
    For increased production of marketable milk in lactating dairy cows.
  • EA 140-872
  • FONSI 140-872
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

To increase production of marketable milk in healthy lactating dairy cows.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Use in lactating dairy cows only. Safety to replacement bulls born to treated dairy cows has not been established. Inject subcutaneously. Avoid injections within 2 weeks of expected slaughter to minimize injection site blemishes on carcass.There is no milk discard or preslaughter withdrawal period.Use may reduce pregnancy rates and increase days open. Treated cows are at an increased risk for mastitis and higher milk somatic cell counts. Use care to differentiate increased body temperature due to use of this product from an increased body temperature that may occur due to illness. Cows treated with this product may have more enlarged hocks and disorders of the foot region. Use may reduce hemoglobin and hematocrit values during treatment.Human warning: Avoid prolonged or repeated contact with eyes and skin.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

No case-level openFDA reports are linked for this medication yet.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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This medication has not been reviewed by a veterinarian yet.