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Roxee Medication Guide

Amoxicillin Trihydrate

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Source review pending Regulatory linkage incomplete Owner quick guide first
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Data freshness

Reference facts
Source review pending
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Roxee is still reviewing source support for this medication profile.

FDA applications
Regulatory match pending
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Roxee has safety or ingredient evidence for this medication, but a regulatory product/application match is still pending.

Safety reports
Safety data refreshed
Jun 13, 2026, 11:29 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:45 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
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Amoxicillin Trihydrate

Amoxicillin Trihydrate

Drug type: Generic ingredient • Generic profile • Regulatory linkage incomplete

Both 77% reference complete

Species: Both

Approval status: Official document linked, regulatory match incomplete. An official source document is available, but Roxee has not linked this row to a confirmed FDA animal-drug application or product record yet.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Amoxicillin Trihydrate

For the treatment of susceptible strains of the organisms causing the following infections: Respiratory tract infections (tonsillitis, tracheobronchitis) due to Staphylococcus aureus, Streptococcus spp., Escherichia coli, and Proteus mirabilis . Genitourinary tract infections (cystitis) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Proteus mirabilis . Gastrointestinal tract infections (bacterial gastroenteritis) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Proteus mirabilis . Bacterial dermatitis due to Staphylococcus aureus, Streptococcus spp., and Proteus mirabilis . Soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Proteus mirabilis . For the treatment of susceptible strains of the organisms causing the following infections: Upper respiratory tract infections due to Staphylococcus aureus, Streptococcus spp., and E. coli . Genitourinary tract infections (cystitis) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Proteus mirabilis . Gastrointestinal tract infections due to E. coli . Skin and soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Pasteurella multocida . For the treatment of baby pigs under 10 pounds for porcine colibacillosis caused by Escherichia coli susceptible to amoxicillin. Species commonly shown: Both.

Generic name
Amoxicillin Trihydrate
Species
Both
Completeness
77%
Validation
Incomplete

Indications / Uses

For the treatment of susceptible strains of the organisms causing the following infections: Respiratory tract infections (tonsillitis, tracheobronchitis) due to Staphylococcus aureus , Streptococcus spp., Escherichia coli , and Proteus mirabilis . Genitourinary tract infections (cystitis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Gastrointestinal tract infections (bacterial gastroenteritis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Bacterial dermatitis due to Staphylococcus aureus , Streptococcus spp., and Proteus mirabilis . Soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . For the treatment of susceptible strains of the organisms causing the following infections: Upper respiratory tract infections due to Staphylococcus aureus , Streptococcus spp., and E. coli . Genitourinary tract infections (cystitis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Gastrointestinal tract infections due to E. coli . Skin and soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Pasteurella multocida . For the treatment of baby pigs under 10 pounds for porcine colibacillosis caused by Escherichia coli susceptible to amoxicillin.

Warnings / Contraindications

Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter animals during treatment or for 20 days after the latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment. Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter animals during treatment or for 20 days after the latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment. Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Side Effects

Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Not eating, Vomiting, Death by euthanasia, Fever, Not drinking.

FAQ

Both

Related Conditions

Abscesses (cat bite abscess) Gastroenteritis (nonspecific) Gastrointestinal (additional) Urinary tract infection (cystitis)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the treatment of susceptible strains of the organisms causing the following infections: Respiratory tract infections (tonsillitis, tracheobronchitis) due to Staphylococcus aureus , Streptococcus spp., Escherichia col...

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Do not slaughter during treatment or for 15 days after latest treatment
  • Do not slaughter animals during treatment or for 20 days after the latest treatment
  • Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment
  • Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment
  • wobbly/unsteady walking (1 reports)
  • trouble breathing (1 reports)
  • Falling (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Amoxicillin Trihydrate; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2024-US-065151
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 23 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2024-US-065151
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2024-US-065151
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Unsteady walking (ataxia) (1 reports), Trouble breathing (dyspnea) (1 reports), Falling (1 reports), Elevated temperature (1 reports), Elevated cholesterol (1 reports)

Body systems represented Signal grouping

Digestive (3), Neurologic (2), Behavior (1), Other (26)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Dog (19 reports), Cat (13 reports)

Breed metadata in reports Metadata only

Dachshund - Miniature (2), Bulldog - French (1), ['Hound (unspecified)', 'Dog (unknown)'] (1), Bulldog - English (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Amoxicillin Trihydrate fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Do not slaughter during treatment or for 15 days after latest treatment, Do not slaughter animals during treatment or for 20 days after the latest treatment, Treated animals must not be slaughtered for food during treatment and for 25 days after the last tre, Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 mi, wobbly/unsteady walking

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Amoxicillin Trihydrate brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2024-US-065151 · adverse_reaction · adverse reactions
  2. Medication contraindications · safety_warning · warnings contraindications
  3. FOI summary · document · documents
  4. FOI summary · document · documents
  5. FOI summary · document · documents
  6. FOI summary · document · documents
  7. FOI summary · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 10:44 PM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Do not slaughter during treatment or for 15 days after latest treatment
  • Do not slaughter animals during treatment or for 20 days after the latest treatment
  • Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment
  • Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment
  • wobbly/unsteady walking

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Trouble breathing (dyspnea) (1 reports)
  • Falling (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Not linked yet
Indication / use
For the treatment of susceptible strains of the organisms causing the following infections: Respiratory tract infections (tonsillitis, tracheobronchitis) due to Staphylococcus aur…
Form / route / dose
Confirm product label and patient-specific plan.
Warnings
  • High: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or o…
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Manufacturer not confirmed
Identifiers:
ANADA: 200592 ANADA: 200604 ANADA: 200702 ANADA: 200709 NADA: 141004 NADA: 141005 NADA: 55078 NADA: 55080 NADA: 55081 NADA: 55085 NADA: 55087 NADA: 55088 NADA: 55089 NADA: 55091 NADA: 55100 NADA: 55101 NADA: 65492 NADA: 65495 NDC Package: 32903-122-25 NDC Package: 62157-527-01

Warnings / Contraindications

Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter animals during treatment or for 20 days after the latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment. Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter animals during treatment or for 20 days after the latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment. Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
8
Matching reports
0
Active filters
2
Selected filters
Reaction: Haemorrhagic gastroenteritis Clear Body system: Behavior Clear
Reset
Drill into common report signals
Diarrhoea (3) Death (2) Ear infection NOS (2) Haemorrhagic gastroenteritis (2) Other (7) Digestive (3) Effectiveness (3) Behavior (1)
No stored openFDA reports match the selected filters. openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
23
Species represented
2
Grouped by Body System
Digestive (3) · Vomiting, Diarrhea, Bloody diarrhoea Neurologic (2) · Unsteady walking (ataxia), Circling - neurological disorder Behavior (1) · Anxiety Other (26) · Trouble breathing (dyspnea), Fever, Falling
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1

Species coverage: Dog (19) Cat (13)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Non-serious - 1
Neurologic Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Digestive Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Neurologic Cat Non-serious - 1
Digestive Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Behavior Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Source metadata:

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Only technical FDA review documents are linked right now. Owner handouts, official label / PI, and SPL documents are not linked yet.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

FOI Summary oA 200-709 Approved August 18, 2021.pdf FOI · FOI summary FOI Summary oA 200-702 Approved April 23, 2021.pdf FOI · FOI summary N055101_Supp_12_23_1997.pdf FOI · FOI summary

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

0
No SPL links yet.

FOI

5

FOI Summary oA 200-709 Approved August 18, 2021.pdf

FOI · FOI summary

Open original

FOI Summary oA 200-702 Approved April 23, 2021.pdf

FOI · FOI summary

Open original

N055101_Supp_12_23_1997.pdf

FOI · FOI summary

Open original

FOI Summary oA 200-604 Approved October 20, 2021.pdf

FOI · FOI summary

Open original

UCM524262.pdf

FOI · FOI summary

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:45 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 36 • Cat 3 • View
Case summaries: 8 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Usage_Inferred (0.78), Usage_Inferred (0.78), Usage_Inferred (0.78)
Diagnosis Codes
ICD10_CM: K05.6
Periodontal disease, unspecified

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter animals during treatment or for 20 days after the latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment. Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Unsteady walking (ataxia) (1) Trouble breathing (dyspnea) (1) Falling (1) Elevated temperature (1) Elevated cholesterol (1) Elevated amylase (1) Elevated alanine aminotransferase (1) Disorientation (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200592 ANADA: 200604 ANADA: 200702 ANADA: 200709 NADA: 141004 NADA: 141005 NADA: 55078 NADA: 55080 NADA: 55081 NADA: 55085 NADA: 55087 NADA: 55088 NADA: 55089 NADA: 55091 NADA: 55100 NADA: 55101 NADA: 65492 NADA: 65495 NDC Package: 32903-122-25 NDC Package: 62157-527-01 NDC Package: 62157-585-01 NDC Package: 73309-210-01 NDC Package: 73309-210-02 NDC Package: 73309-210-03
Package NDC Product NDC Form / Route Status
32903-122-25 32903 -
62157-527-01 62157 -
62157-585-01 62157 -
73309-210-01 73309 -
73309-210-02 73309 -
73309-210-03 73309 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 5 Clinical 120 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-22)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-22)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-21)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-20)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-13)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-12)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-12)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-11)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-11)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-10)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-08)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-07)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-06)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-05)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-04)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-03)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-02)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-01)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-06-01)
  • contraindications: Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. … (Clinical, 2026-05-31)
Recent Revisions
  • side_effects updated 2026-06-22 10:45 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-22 10:45 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-22 10:45 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-22 10:04 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-22 10:04 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-22 10:04 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-21 05:18 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-21 05:18 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-21 05:18 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-20 20:58 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-20 20:58 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-20 20:58 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-13 11:33 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-13 11:33 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-13 11:33 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-12 10:42 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-12 10:42 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-12 10:42 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-12 10:04 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-12 10:04 by etl_backfill • Backfilled from existing medication fields

Usage

For the treatment of susceptible strains of the organisms causing the following infections: Respiratory tract infections (tonsillitis, tracheobronchitis) due to Staphylococcus aureus , Streptococcus spp., Escherichia coli , and Proteus mirabilis . Genitourinary tract infections (cystitis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Gastrointestinal tract infections (bacterial gastroenteritis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Bacterial dermatitis due to Staphylococcus aureus , Streptococcus spp., and Proteus mirabilis . Soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . For the treatment of susceptible strains of the organisms causing the following infections: Upper respiratory tract infections due to Staphylococcus aureus , Streptococcus spp., and E. coli . Genitourinary tract infections (cystitis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Gastrointestinal tract infections due to E. coli . Skin and soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Pasteurella multocida . For the treatment of baby pigs under 10 pounds for porcine colibacillosis caused by Escherichia coli susceptible to amoxicillin.

Contraindications

Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter animals during treatment or for 20 days after the latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment. Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Diarrhea (1) • Dog Bloody diarrhoea (1) • Dog

Showing top 5 for Digestive.

Neurologic
Unsteady walking (1) • Dog Circling - neurological disorder (1) • Cat

Showing top 5 for Neurologic.

Behavior
Anxiety (1) • Dog

Showing top 5 for Behavior.

Other
Trouble breathing (1) • Dog Fever (1) • Cat Falling (1) • Dog Eye redness (1) • Cat Eye irritation (1) • Cat
Show more (21)
Elevated temperature (1) • Dog Elevated cholesterol (1) • Cat Elevated amylase (1) • Cat Elevated alanine aminotransferase (1) • Cat Ear infection NOS (1) • Dog Disorientation (1) • Cat Dehydration (1) • Cat Death (1) • Cat Cough (1) • Dog Conjunctivitis (1) • Dog Color, Abnormal (1) • Cat Blood in urine (1) • Dog Barking (1) • Dog Bacterial skin infection NOS (1) • Cat Aspiration pneumonia (1) • Dog Anal and rectal disorder NOS (1) • Dog Anaemia NOS (1) • Dog Accidental exposure (1) • Cat Abnormal posture NOS (1) • Dog Abnormal cytology (1) • Dog Abdominal pain (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Bulldog - French, Male, 4.96 month, 6.57 kilogram • Drug: MSK, Suspension, Unknown • Reactions: Anal and rectal disorder NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075322
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 4.96 Month
  • Weight: 6.570 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Suspension
Reactions Reported:
Anal and rectal disorder NOS
Outcomes: Outcome Unknown

Dog, ['Hound (unspecified)', 'Dog (unknown)'], Male, 14.5 year, 35.83 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Aspiration pneumonia, Lack of efficacy - NOS, Medication error NOS, Anaemia NOS, Mass NOS… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-074245
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 14.50 Year
  • Weight: 35.830 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Aspiration pneumonia Lack of efficacy - NOS Medication error NOS Anaemia NOS Mass NOS Skin ulcer Urine leakage Limb weakness Proprioception deficit Walking difficulty Barking Anxiety Urinary tract infection Diarrhea Cough Pain NOS
Outcomes: Ongoing

Dog, Bulldog - English, Female, 1 day, 34.473 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Offspring only event, Rigidity, Stiffness NOS, Falling, Death… • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-072861
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 1.00 Day
  • Weight: 34.473 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Offspring only event Rigidity Stiffness NOS Falling Death Abnormal posture NOS
Outcomes: Died

Dog, Dachshund - Miniature, Male, 5.25 year, 6.07 kilogram • Drug: MSK, Powder, Unknown • Reactions: Haemorrhagic gastroenteritis, Lack of efficacy (endoparasite) - roundworm NOS, Diarrhea, Ear infection NOS, Hypochloraemia… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-075298
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 5.25 Year
  • Weight: 6.070 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Powder
Reactions Reported:
Haemorrhagic gastroenteritis Lack of efficacy (endoparasite) - roundworm NOS Diarrhea Ear infection NOS Hypochloraemia Sneezing Vomiting
Outcomes: Ongoing

Dog, Dachshund - Miniature, Male, 5.25 year, 6.07 kilogram • Drug: MSK, Unknown • Reactions: Haemorrhagic gastroenteritis, Lack of efficacy (endoparasite) - roundworm NOS, Diarrhea, Ear infection NOS, Hypochloraemia… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-069774
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 5.25 Year
  • Weight: 6.070 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Haemorrhagic gastroenteritis Lack of efficacy (endoparasite) - roundworm NOS Diarrhea Ear infection NOS Hypochloraemia Sneezing Vomiting
Outcomes: Ongoing

Dog, ['Sheepdog (unspecified)', 'Poodle (unspecified)'], Male, 4 year, 49.895 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Injection site swelling, Abnormal cytology, Injection site abscess, Painful urination, Vocalisation… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-068758
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 4.00 Year
  • Weight: 49.895 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Injection site swelling Abnormal cytology Injection site abscess Painful urination Vocalisation Blood in urine Urinary tract infection Elevated temperature Medication error NOS
Outcomes: Ongoing

Cat, Cat (unknown), Female, 18 year, 2.72 kilogram • Drug: MSK, Unknown • Reactions: Grand mal seizure • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-068104
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 18.00 Year
  • Weight: 2.720 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Grand mal seizure
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Male, 7 week, 0.363 kilogram • Drug: MSK, Unassigned, Oral, Dose: 1 dose per animal, Frequency: 1 per day • Reactions: Death, Dehydration • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-067003
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 7.00 Week
  • Weight: 0.363 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
  • Dose: 1 dose per animal
  • Frequency: 1 per day
Reactions Reported:
Death Dehydration
Outcomes: Died

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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