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Roxee Medication Guide
Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.
Veterinary professional?
Roxee is still reviewing source support for this medication profile.
Roxee has safety or ingredient evidence for this medication, but a regulatory product/application match is still pending.
openFDA reaction terms and case summaries are supporting evidence, not proof of causality.
Drug type: Generic ingredient • Generic profile • Regulatory linkage incomplete
Species: Both
Approval status: Official document linked, regulatory match incomplete. An official source document is available, but Roxee has not linked this row to a confirmed FDA animal-drug application or product record yet.
Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.
For the treatment of susceptible strains of the organisms causing the following infections: Respiratory tract infections (tonsillitis, tracheobronchitis) due to Staphylococcus aureus, Streptococcus spp., Escherichia coli, and Proteus mirabilis . Genitourinary tract infections (cystitis) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Proteus mirabilis . Gastrointestinal tract infections (bacterial gastroenteritis) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Proteus mirabilis . Bacterial dermatitis due to Staphylococcus aureus, Streptococcus spp., and Proteus mirabilis . Soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Proteus mirabilis . For the treatment of susceptible strains of the organisms causing the following infections: Upper respiratory tract infections due to Staphylococcus aureus, Streptococcus spp., and E. coli . Genitourinary tract infections (cystitis) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Proteus mirabilis . Gastrointestinal tract infections due to E. coli . Skin and soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Pasteurella multocida . For the treatment of baby pigs under 10 pounds for porcine colibacillosis caused by Escherichia coli susceptible to amoxicillin. Species commonly shown: Both.
For the treatment of susceptible strains of the organisms causing the following infections: Respiratory tract infections (tonsillitis, tracheobronchitis) due to Staphylococcus aureus , Streptococcus spp., Escherichia coli , and Proteus mirabilis . Genitourinary tract infections (cystitis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Gastrointestinal tract infections (bacterial gastroenteritis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Bacterial dermatitis due to Staphylococcus aureus , Streptococcus spp., and Proteus mirabilis . Soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . For the treatment of susceptible strains of the organisms causing the following infections: Upper respiratory tract infections due to Staphylococcus aureus , Streptococcus spp., and E. coli . Genitourinary tract infections (cystitis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Gastrointestinal tract infections due to E. coli . Skin and soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Pasteurella multocida . For the treatment of baby pigs under 10 pounds for porcine colibacillosis caused by Escherichia coli susceptible to amoxicillin.
Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter animals during treatment or for 20 days after the latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment. Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Not eating, Vomiting, Death by euthanasia, Fever, Not drinking.
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Used for:
For the treatment of susceptible strains of the organisms causing the following infections: Respiratory tract infections (tonsillitis, tracheobronchitis) due to Staphylococcus aureus , Streptococcus spp., Escherichia col...
Dosing note:
Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.
What to watch for:
When to call the vet:
Regulatory restrictions are shown in Vet View.
What to tell or ask your vet today:
A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.
Roxee has limited cited overview evidence for Amoxicillin Trihydrate; use the official documents and your veterinarian's instructions for product-specific decisions.
32 tracked reaction signals; 32 reported cases; 23 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.
Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.
Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.
Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.
Unsteady walking (ataxia) (1 reports), Trouble breathing (dyspnea) (1 reports), Falling (1 reports), Elevated temperature (1 reports), Elevated cholesterol (1 reports)
Digestive (3), Neurologic (2), Behavior (1), Other (26)
Dog (19 reports), Cat (13 reports)
Dachshund - Miniature (2), Bulldog - French (1), ['Hound (unspecified)', 'Dog (unknown)'] (1), Bulldog - English (1). These are report metadata, not proof that a breed is at higher risk.
Verify whether Amoxicillin Trihydrate fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.
Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.
Do not slaughter during treatment or for 15 days after latest treatment, Do not slaughter animals during treatment or for 20 days after the latest treatment, Treated animals must not be slaughtered for food during treatment and for 25 days after the last tre, Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 mi, wobbly/unsteady walking
Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.
Review status / Updated / Sources
Review status: Clinical reviewer not listed
Updated: February 12, 2026, 10:44 PM UTC
Side effects to monitor:
Most reported reactions:
Emergency warning signs:
Source-backed clinical checkpoints for quick review.
Official label facts first, then secondary summaries. Marketing content is separated below.
Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter animals during treatment or for 20 days after the latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment. Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.
Received 2025-11-28 · MSK · MSK
Received 2025-11-25 · MSK · MSK
Tap or hover a reaction to see what it means in plain language.
| Reaction | Body system | Cases | Species | Serious cases |
|---|---|---|---|---|
| Neurologic | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 | |
| Other | 1 | Cat | 1 | |
| Other | 1 | Cat | 1 | |
| Other | 1 | Cat | 1 | |
| Other | 1 | Cat | 1 |
Species coverage: Dog (19) Cat (13)
| Reaction | Body system | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|---|
| Digestive | Dog | Non-serious | - | 1 | |
| Neurologic | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Dog | Non-serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Digestive | Dog | Non-serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Neurologic | Cat | Non-serious | - | 1 | |
| Digestive | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Behavior | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 |
The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.
Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.
Full source previews and metadata remain in the veterinary/professional layer.
FOI · FOI summary
FOI · FOI summary
FOI · FOI summary
FOI · FOI summary
FOI · FOI summary
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
Quick facts and links to official labeling and safety signals.
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.
| Package NDC | Product NDC | Form / Route | Status |
|---|---|---|---|
| 32903-122-25 | 32903 | - | |
| 62157-527-01 | 62157 | - | |
| 62157-585-01 | 62157 | - | |
| 73309-210-01 | 73309 | - | |
| 73309-210-02 | 73309 | - | |
| 73309-210-03 | 73309 | - |
Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.
Every non-trivial field is expected to include provenance and update timestamps.
For the treatment of susceptible strains of the organisms causing the following infections: Respiratory tract infections (tonsillitis, tracheobronchitis) due to Staphylococcus aureus , Streptococcus spp., Escherichia coli , and Proteus mirabilis . Genitourinary tract infections (cystitis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Gastrointestinal tract infections (bacterial gastroenteritis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Bacterial dermatitis due to Staphylococcus aureus , Streptococcus spp., and Proteus mirabilis . Soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . For the treatment of susceptible strains of the organisms causing the following infections: Upper respiratory tract infections due to Staphylococcus aureus , Streptococcus spp., and E. coli . Genitourinary tract infections (cystitis) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Proteus mirabilis . Gastrointestinal tract infections due to E. coli . Skin and soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus , Streptococcus spp., E. coli , and Pasteurella multocida . For the treatment of baby pigs under 10 pounds for porcine colibacillosis caused by Escherichia coli susceptible to amoxicillin.
Do not slaughter during treatment or for 15 days after latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter animals during treatment or for 20 days after the latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment. Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).
Showing top 5 for Digestive.
Showing top 5 for Neurologic.
Showing top 5 for Behavior.
Showing top 5 for Other.
Data source: FDA openFDA Animal & Veterinary adverse event reports.
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Dog, Bulldog - French, Male, 4.96 month, 6.57 kilogram • Drug: MSK, Suspension, Unknown • Reactions: Anal and rectal disorder NOS • Outcome: Outcome Unknown
Dog, ['Hound (unspecified)', 'Dog (unknown)'], Male, 14.5 year, 35.83 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Aspiration pneumonia, Lack of efficacy - NOS, Medication error NOS, Anaemia NOS, Mass NOS… • Outcome: Ongoing
Dog, Bulldog - English, Female, 1 day, 34.473 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Offspring only event, Rigidity, Stiffness NOS, Falling, Death… • Outcome: Died
Dog, Dachshund - Miniature, Male, 5.25 year, 6.07 kilogram • Drug: MSK, Powder, Unknown • Reactions: Haemorrhagic gastroenteritis, Lack of efficacy (endoparasite) - roundworm NOS, Diarrhea, Ear infection NOS, Hypochloraemia… • Outcome: Ongoing
Dog, Dachshund - Miniature, Male, 5.25 year, 6.07 kilogram • Drug: MSK, Unknown • Reactions: Haemorrhagic gastroenteritis, Lack of efficacy (endoparasite) - roundworm NOS, Diarrhea, Ear infection NOS, Hypochloraemia… • Outcome: Ongoing
Dog, ['Sheepdog (unspecified)', 'Poodle (unspecified)'], Male, 4 year, 49.895 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Injection site swelling, Abnormal cytology, Injection site abscess, Painful urination, Vocalisation… • Outcome: Ongoing
Cat, Cat (unknown), Female, 18 year, 2.72 kilogram • Drug: MSK, Unknown • Reactions: Grand mal seizure • Outcome: Recovered/Normal
Cat, Domestic Shorthair, Male, 7 week, 0.363 kilogram • Drug: MSK, Unassigned, Oral, Dose: 1 dose per animal, Frequency: 1 per day • Reactions: Death, Dehydration • Outcome: Died
Data source: FDA openFDA Animal & Veterinary adverse event reports.
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.
Let others know your experience or advice regarding this medication.
This medication has not been reviewed by a veterinarian yet.