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Roxee Meds Catalog

Buprenorphine

Medication catalog facts with explicit FDA-approval, off-label, source-limited, and safety context.

Both Catalog complete FDA data linked Rx required Injectable Solution Multiple FDA labelers Official label facts Owner quick guide first
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Data freshness

Storefront facts
Catalog refreshed
May 5, 2026, 10:00 a.m.

These are the storefront facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
May 5, 2026, 10:00 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
May 5, 2026, 10:01 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:00 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC

Evidence

Reviewed / Updated / Sources

Reviewed by: Not available

Last reviewed: February 12, 2026

Updated: February 12, 2026, 10:44 PM UTC

Sources:
Image coming soon
Buprenorphine

Buprenorphine

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Injectable Solution Rx required 100% storefront ready

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Buprenorphine

For the control of postoperative pain associated with surgical procedures in cats. Species commonly shown: Both, Cat, No Use Class Stated Or Implied.

Generic name
Buprenorphine
Brand names
Simbadol®, Zorbium™, Zorbium, Simbadol
Manufacturer
Multiple FDA labelers
Species
Both, Cat, No Use Class Stated Or Implied
Dosage forms
Injectable Solution, Transdermal Solution
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
Simbadol® Zorbium™ Zorbium Simbadol
Dosage forms
Injectable Solution Transdermal Solution

Indications / Uses

For the control of postoperative pain associated with surgical procedures in cats.

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Side Effects

Top reported reactions (openFDA): Vomiting, Lethargy (see also Central nervous system depression in 'Neurological'), Diarrhoea, Death, Death by euthanasia, Anorexia.

FAQ

Both, Cat, No Use Class Stated Or Implied

Yes. Roxee shows this as prescription-only.

Injectable Solution, Transdermal Solution

Related Conditions

Pain (acute, chronic) Pica

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the control of postoperative pain associated with surgical procedures in cats.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • wobbly/unsteady walking (1 reports)
  • Loss of appetite (1 reports)
  • Cardiac enlargement (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Major cautions & emergency warning signs

Side effects to monitor:

  • wobbly/unsteady walking
  • Loss of appetite
  • Cardiac enlargement

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Loss of appetite (1 reports)
  • Cardiac enlargement (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Multiple FDA labelers
Form: Injectable Solution, Transdermal Solution
Identifiers:
NADA: 141434 NADA: 141547 NDC Package: 54771-4131-1 NDC Package: 58198-0078-1 NDC Package: 58198-0078-2 NDC Package: 86084-100-30 NDC Product: 54771 NDC Product: 58198 NDC Product: 86084
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
22
Species represented
2
Grouped by Body System
Digestive (3) · Loss of appetite, Bloody diarrhoea, Appetite loss Skin & allergy (3) · Hair loss at application site, Application site pruritus, Application site hair loss Neurologic (1) · Unsteady walking (ataxia) Behavior (3) · Biting -aggression, Behavioral disorder (unspecified), Aggression Other (22) · Cardiac enlargement, Burn, Bruising
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Cat 1
Digestive 1 Cat 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Digestive 1 Dog 1

Species coverage: Cat (25) Dog (7)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Cat Serious - 1
Digestive Cat Serious - 1
Skin & allergy Cat Non-serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Behavior Dog Serious - 1
Other Cat Serious - 1
Behavior Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Skin & allergy Cat Non-serious - 1
Other Cat Non-serious - 1
Skin & allergy Cat Non-serious - 1
Digestive Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Behavior Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Source metadata:

Documents

Owner handouts and official technical documents open on-page first, with the original source still one click away.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

4

FOI

2

Simbadol®

SPL · SPL

Open original
FDA Structured Product Label

Simbadol®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
NADA
141-434
Status
RX
Form
Injectable Solution
Route
Subcutaneous
Species
Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of solution contains 1.8 milligrams buprenorphine.

Cats

Indication
For the control of postoperative pain associated with surgical procedures in cats.
Dosage
Administer 0.24 mg/kg (0.11 mg/lb) by subcutaneous injection once daily for up to 3 days. Administer the first dose approximately 1 hour prior to surgery.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Zorbium™

SPL · SPL

Open original
FDA Structured Product Label

Zorbium™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Elanco US Inc.
NADA
141-547
Status
RX
Form
Transdermal Solution
Route
Topical
Species
Cat, No Use Class Stated Or Implied
Composition / specifications
20mg/mL

Cats

Indication

For the control of postoperative pain associated with surgical procedures in cats.

Dosage

Administer topically to the dorsal cervical area at the base of the skull a single dose of 1.2 to 3.1 mg/lb (2.7 to 6.7 mg/kg) approximately 1 to 2 hours before surgery.

Simbadol SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Simbadol. Use the source link for the full official labeling record.

Zorbium SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Zorbium. Use the source link for the full official labeling record.

UCM408852.pdf

FOI · FOI

Open original

FOI Summary oN 141-547 Approved January 20, 2022.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:00 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Simbadol Zorbium
Manufacturer mapping: Multiple FDA labelers
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat
Rx/OTC: RX
Form/route: Injectable Solution, Transdermal Solution • Subcutaneous, Topical
Applications: NADA 141-434 • NADA 141-547
NDC: Packages 54771-4131-1 58198-0078-1 58198-0078-2 • Products 54771 58198
Documents: 2 (FOI: 2) • SPL: 2 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 74 • Cat 162 • View
Case summaries: 46 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Pain (acute, chronic) Pica
Linked using: Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Unsteady walking (ataxia) (1) Loss of appetite (1) Cardiac enlargement (1) Burn (1) Bruising (1) Bronchopulmonary inflammation (1) Breathing difficulty (1) Bloody diarrhoea (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141434 NADA: 141547 NDC Package: 54771-4131-1 NDC Package: 58198-0078-1 NDC Package: 58198-0078-2 NDC Package: 86084-100-30 NDC Product: 54771 NDC Product: 58198 NDC Product: 86084
Package NDC Product NDC Form / Route Status
54771-4131-1 54771 -
58198-0078-1 58198 -
58198-0078-2 58198 -
86084-100-30 86084 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • Simbadol SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Zorbium SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • UCM408852.pdf • FOI summary • Official • Feb. 8, 2023
    FDA FOI summary for application 141434
  • FOI Summary oN 141-547 Approved January 20, 2022.pdf • FOI summary • Official • Feb. 1, 2022
    FDA FOI summary for application 141547

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 39 Clinical 1 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Vomiting, Lethargy (see also Central nervous system depression in 'Neurological'), Diarrhoea, Death, Death by euthanasia, Ano… (Clinical, 2026-04-11)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Official, 2026-04-12)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Official, 2026-04-11)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Official, 2026-02-12)
  • indications: For the control of postoperative pain associated with surgical procedures in cats For the control of postoperative pain associated with surgical procedures in … (Official, 2026-05-05)
  • indications: For the control of postoperative pain associated with surgical procedures in cats For the control of postoperative pain associated with surgical procedures in … (Official, 2026-05-03)
  • indications: For the control of postoperative pain associated with surgical procedures in cats For the control of postoperative pain associated with surgical procedures in … (Official, 2026-05-02)
  • indications: For the control of postoperative pain associated with surgical procedures in cats For the control of postoperative pain associated with surgical procedures in … (Official, 2026-04-29)
  • indications: For the control of postoperative pain associated with surgical procedures in cats For the control of postoperative pain associated with surgical procedures in … (Official, 2026-04-28)
  • indications: For the control of postoperative pain associated with surgical procedures in cats For the control of postoperative pain associated with surgical procedures in … (Official, 2026-04-27)
  • indications: For the control of postoperative pain associated with surgical procedures in cats For the control of postoperative pain associated with surgical procedures in … (Official, 2026-04-26)
  • indications: For the control of postoperative pain associated with surgical procedures in cats For the control of postoperative pain associated with surgical procedures in … (Official, 2026-04-25)
  • indications: For the control of postoperative pain associated with surgical procedures in cats For the control of postoperative pain associated with surgical procedures in … (Official, 2026-04-22)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-05-05)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-05-03)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-05-02)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-04-29)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-04-28)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-04-27)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-04-26)
Recent Revisions
  • side_effects updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Simbadol®
RX
Buprenorphine
Injectable Solution • Subcutaneous
Label highlights
Official documents
Zoetis Inc. NADA 141-434 Approved Feb 8, 2023
Zorbium™
RX
Buprenorphine
Transdermal Solution • Topical
Label highlights
Official documents
Elanco US Inc. NADA 141-547 Approved Feb 1, 2022

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of solution contains 1.8 milligrams buprenorphine.
Cats
Indication
For the control of postoperative pain associated with surgical procedures in cats.
Dosage
Administer 0.24 mg/kg (0.11 mg/lb) by subcutaneous injection once daily for up to 3 days. Administer the first dose approximately 1 hour prior to surgery.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
20mg/mL
Cats
Indication

For the control of postoperative pain associated with surgical procedures in cats.

Dosage

Administer topically to the dorsal cervical area at the base of the skull a single dose of 1.2 to 3.1 mg/lb (2.7 to 6.7 mg/kg) approximately 1 to 2 hours before surgery.

Limitations

FDA page: Open in Animal Drugs @ FDA

Usage

For the control of postoperative pain associated with surgical procedures in cats.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Cat Bloody diarrhoea (1) • Dog Appetite loss (1) • Cat

Showing top 5 for Digestive.

Skin & allergy
Hair loss at application site (1) • Cat Application site pruritus (1) • Cat Application site hair loss (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Cat

Showing top 5 for Neurologic.

Behavior
Biting -aggression (1) • Dog Behavioral disorder (1) • Cat Aggression (1) • Cat

Showing top 5 for Behavior.

Other
Cardiac enlargement (1) • Cat Burn (1) • Dog Bruising (1) • Cat Bronchopulmonary inflammation (1) • Cat Breathing difficulty (1) • Cat
Show more (17)
Blood in urine (1) • Cat Bladder distension (1) • Cat Bilirubinuria (1) • Cat Basophilia (1) • Cat Bacterial skin infection NOS (1) • Dog Azotaemia (1) • Cat Arthritis (1) • Cat Application site skin scaling (1) • Cat Application site irritation (1) • Cat Angioedema (1) • Dog Anaemia NOS (1) • Cat Agitation (1) • Cat Abnormal ultrasound finding (1) • Cat Abnormal radiograph finding (1) • Cat Abnormal posture NOS (1) • Dog Abdominal pain (1) • Cat Abdominal discomfort (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Shorthair, Female, 7 month, 3.08 kilogram • Drug: MSK, Solution, Topical, Dose: 1 mL per animal • Reactions: Fever, Cough, productive, Weight loss, Breathing difficulty, Abnormal radiograph finding… • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-075237
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 7.00 Month
  • Weight: 3.080 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 mL per animal
Reactions Reported:
Fever Cough, productive Weight loss Breathing difficulty Abnormal radiograph finding Pulmonary disorder NOS Tiredness (lethargy) Sedation Kidney atrophy Bilirubinuria Elevated mean corpuscular haemoglobin concentration Enlarged kidney Elevated mean corpuscular volume Eosinopenia Low serum alkaline phosphatase Neutropenia Discoloured urine Monocytosis Lymphopenia Elevated amylase Elevated alanine aminotransferase Low creatinine Hyponatremia Other abnormal test result NOS Elevated total bilirubin Hyperglycaemia Lymphocytosis Neutrophilia Leucocytosis NOS Basophilia
Outcomes: Recovered/Normal

Cat, Siamese, Male, 15 year, 3.88 kilogram • Drug: MSK, Solution, Topical, Dose: 0.40 mL per animal • Reactions: Lack of efficacy - NOS, Urinary tract infection, Behavioral disorder (unspecified), Decreased haematocrit, Oliguria • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075223
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 15.00 Year
  • Weight: 3.880 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 0.40 mL per animal
Reactions Reported:
Lack of efficacy - NOS Urinary tract infection Behavioral disorder (unspecified) Decreased haematocrit Oliguria
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 12 year, 6.8 kilogram • Drug: MSK, Solution, Topical, Dose: 1 mL per animal, Frequency: 1 per day • Reactions: Behavioral disorder (unspecified), Application site irritation, Application site pruritus, Application site hair loss • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-074920
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 12.00 Year
  • Weight: 6.800 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 mL per animal
  • Frequency: 1 per day
Reactions Reported:
Behavioral disorder (unspecified) Application site irritation Application site pruritus Application site hair loss
Outcomes: Ongoing

Cat, Siamese, Female, 11.75 year, 3.73 kilogram • Drug: MSK, Solution, Topical, Dose: 1 mL per animal • Reactions: Application site hair loss, Skin lesion NOS • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-074804
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 11.75 Year
  • Weight: 3.730 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 mL per animal
Reactions Reported:
Application site hair loss Skin lesion NOS
Outcomes: Ongoing

Cat, Domestic Shorthair, Female, 4 month, 2.4 kilogram • Drug: MSK, Solution, Topical, Dose: 0.40 mL per animal • Reactions: Head shake - behavioural disorder, Unable to walk, Not drinking, Not eating, Unsteady walking (ataxia)… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-074782
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 4.00 Month
  • Weight: 2.400 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 0.40 mL per animal
Reactions Reported:
Head shake - behavioural disorder Unable to walk Not drinking Not eating Unsteady walking (ataxia) Circling - behavioural disorder Unsteady gait
Outcomes: Ongoing

Dog, ['Great Pyrenees', 'Retriever - Labrador'], Female, 31.661 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Vomiting • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-075148
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Weight: 31.661 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Vomiting
Outcomes: Ongoing

Cat, Cat (unknown), Unknown, 3.49 kilogram • Drug: MSK, Solution, Unknown, Dose: 1 tube per animal • Reactions: Pulmonary congestion, Decreased body temperature, Drowsiness - systemic disorder, Disorientation, Unable to stand… • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-074695
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Unknown
  • Weight: 3.490 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Solution
  • Dose: 1 tube per animal
Reactions Reported:
Pulmonary congestion Decreased body temperature Drowsiness - systemic disorder Disorientation Unable to stand Dysphoria
Outcomes: Recovered/Normal

Cat, Persian, Male, 10.83 year, 4.67 kilogram • Drug: MSK, Solution, Topical, Dose: 1 mL per animal • Reactions: Hair loss at application site, Defect Unknown/Not Specified • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-074803
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 10.83 Year
  • Weight: 4.670 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 mL per animal
Reactions Reported:
Hair loss at application site Defect Unknown/Not Specified
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

Share Your Thoughts

Let others know your experience or advice regarding this medication.

This medication has not been reviewed by a veterinarian yet.