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Roxee Meds Catalog

Butorphanol

Medication catalog facts with explicit FDA-approval, off-label, source-limited, and safety context.

Both Catalog complete FDA data linked Rx required Liquid (Solution) Multiple FDA sponsors Official label facts Owner quick guide first
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Data freshness

Storefront facts
Catalog refreshed
Apr 22, 2026, 10:07 a.m.

These are the storefront facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
May 5, 2026, 10:00 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
May 5, 2026, 10:01 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Storefront facts: Source Roxee | Refreshed Apr 22, 2026, 10:07 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC

Evidence

Reviewed / Updated / Sources

Reviewed by: Not available

Last reviewed: April 15, 2026

Updated: April 15, 2026, 10:04 AM UTC

Sources:
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Butorphanol

Butorphanol

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Both Liquid (Solution) Rx required 100% storefront ready

Species: Both

Manufacturer: Multiple FDA sponsors

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Butorphanol

For the relief of chronic nonproductive cough associated with tracheo-bronchitis, tracheitis tonsillitis, laryngitis, and pharyngitis associated with inflammatory conditions of the upper respiratory tract. For the relief of pain associated with colic and postpartum pain in adult horses and yearlings. For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures. Species commonly shown: Both, Cat, No Use Class Stated Or Implied, Horse, Not For Meat Production.

Generic name
Butorphanol
Brand names
Torbugesic-SA®, Dolorex®, Torphadine®, Butorphic™ Injection
Manufacturer
Multiple FDA sponsors
Species
Both, Cat, No Use Class Stated Or Implied, Horse, Not For Meat Production, Horse, No Use Class Stated Or Implied
Dosage forms
Liquid (Solution)
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
Torbugesic-SA® Dolorex® Torphadine® Butorphic™ Injection Butorphanol Tartrate Injection Butorphine™
Dosage forms
Liquid (Solution)

Indications / Uses

For the relief of chronic nonproductive cough associated with tracheo-bronchitis, tracheitis tonsillitis, laryngitis, and pharyngitis associated with inflammatory conditions of the upper respiratory tract. For the relief of pain associated with colic and postpartum pain in adult horses and yearlings. For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.

Warnings / Contraindications

Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Side Effects

Top reported reactions (openFDA): Lack of efficacy - NOS, Vomiting, Death, Diarrhoea, Bradycardia, Lethargy (see also Central nervous system depression in 'Neurological').

FAQ

Both, Cat, No Use Class Stated Or Implied, Horse, Not For Meat Production, Horse, No Use Class Stated Or Implied, No Use Class Stated Or Implied

Yes. Roxee shows this as prescription-only.

Liquid (Solution)

Related Conditions

Pain (acute, chronic) Trauma (HBC, falls, bite wounds) Cough (acute/chronic) Tracheitis (non-kennel cough)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Repeat at intervals of 6 to 12 hours as required
  • If necessary, increase dose to maximum of 0.05 milligram per pound of body weight
  • Treatment should not normally be required for longer than 7 days
  • For oral use in dogs only
  • If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight
  • Dose may be repeated within 3 to 4 hours
  • Treatment should not exceed 48 hours
  • Not for use in horses intended for food
  • wobbly/unsteady walking (1 reports)
  • Loss of appetite (1 reports)
  • Disorientation (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Major cautions & emergency warning signs

Side effects to monitor:

  • Repeat at intervals of 6 to 12 hours as required
  • If necessary, increase dose to maximum of 0.05 milligram per pound of body weight
  • Treatment should not normally be required for longer than 7 days
  • For oral use in dogs only
  • If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Loss of appetite (1 reports)
  • Disorientation (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Multiple FDA sponsors
Form: Liquid (Solution)
Identifiers:
ANADA: 200239 ANADA: 200322 ANADA: 200332 ANADA: 200408 ANADA: 200446 NADA: 102990 NADA: 103390 NADA: 135780 NADA: 141047 NDC Package: 11695-7044-1 NDC Package: 11695-7044-2 NDC Package: 17033-097-01 NDC Package: 17033-097-05 NDC Package: 54771-2033-1 NDC Package: 54771-2033-2 NDC Package: 57926-722-66 NDC Package: 69043-064-02 NDC Package: 69043-064-05 NDC Package: 73377-107-01 NDC Package: 86136-137-31
Source metadata:

Warnings / Contraindications

Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
25
Species represented
2
Grouped by Body System
Digestive (4) · Loss of appetite, Diarrhea, Decreased appetite Skin & allergy (1) · Hair loss at application site Neurologic (2) · Unsteady walking (ataxia), Depression Behavior (2) · Circling - behavioural disorder, Behavioral disorder (unspecified) Other (23) · Disorientation, Dilated pupils, Decreased pulse oxygenation
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Cat 1
Digestive 1 Cat 1
Other 1 Cat 1
Digestive 1 Cat 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Dog 1
Digestive 1 Dog 1

Species coverage: Cat (20) Dog (12)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Cat Serious - 1
Digestive Cat Serious - 1
Skin & allergy Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Digestive Cat Serious - 1
Neurologic Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Behavior Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Digestive Cat Serious - 1
Behavior Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Source metadata:

Documents

Owner handouts and official technical documents open on-page first, with the original source still one click away.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

6

FOI

6

Butorphanol Tartrate Injection

SPL · SPL

Open original
FDA Structured Product Label

Butorphanol Tartrate Injection

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Dechra Veterinary Products LLC
ANADA
200-408
Status
RX
Form
Liquid (Solution)
Route
Subcutaneous
Species
Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of aqueous solution contains 2 milligrams of butorphanol (as butorphanol tartrate).

Cats

Indication
For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures
Dosage
0.2 milligram of butorphanol base activity per pound of body weight (0.4 milligrams per kilogram), using 2 milligrams per milliliter solution. For subcutaneous injection.
Limitations
Dose may be repeated up to 4 times per day. Do not treat for more than 2 days. Safety for use in pregnant female cats, breeding male cats of kittens less than 4 months of age has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian

Butorphic™ Injection

SPL · SPL

Open original
FDA Structured Product Label

Butorphic™ Injection

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Cronus Pharma Specialities India Private Ltd.
ANADA
200-332
Status
RX
Form
Liquid (Solution)
Route
Intravenous
Species
No Use Class Stated Or Implied
Composition / specifications
Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).

Horses

Indication
For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.
Dosage
0.05 milligram of butorphanol per pound of body weight (0.1 milligram per kilogram of body weight). Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours.
Limitations
Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Torphadine®

SPL · SPL

Open original
FDA Structured Product Label

Torphadine®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Dechra Veterinary Products LLC
ANADA
200-322
Status
RX
Form
Liquid (Solution)
Route
Intravenous
Species
Horse, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).

Horses

Indication
For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.
Dosage
0.05 milligram of butorphanol base activity per pound of body weight (0.1 milligram/kilogram) using 10 milligrams per milliliter solution. For intravenous use.
Limitations
Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Butorphine™

SPL · SPL

Open original
FDA Structured Product Label

Butorphine™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Modern Veterinary Therapeutics, LLC
ANADA
200-446
Status
RX
Form
Liquid (Solution)
Route
Subcutaneous
Species
Cat, No Use Class Stated Or Implied
Composition / specifications
Each mL contains 2 mg butorphanol base (as butorphanol tartrate, USP).

Cats

Indication
For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.
Dosage
Administer 0.4 mg of butorphanol per kilogram body weight (0.2 mg/lb). This is equivalent to 1.0 mL solution per 10 lbs body weight.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Dolorex®

SPL · SPL

Open original
FDA Structured Product Label

Dolorex®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Intervet, Inc.
ANADA
200-239
Status
RX
Form
Liquid (Solution)
Route
Intravenous
Species
Horse, Not For Meat Production
Composition / specifications
Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).

Horses

Indication
For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.
Dosage
0.05 milligram of butorphanol base activity per pound of body weight (0.1 milligram/kilogram) using 10 milligrams per milliliter solution. For intravenous use.
Limitations
Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Torbugesic-SA®

SPL · SPL

Open original
FDA Structured Product Label

Torbugesic-SA®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
NADA
141-047
Status
RX
Form
Liquid (Solution)
Route
Subcutaneous
Species
Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of aqueous solution contains 2 milligrams of butorphanol (as butorphanol tartrate).

Cats

Indication
For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.
Dosage
0.2 milligram of butorphanol base activity per pound of body weight (0.4 milligrams per kilogram)
Limitations
For subcutaneous injection. Dose may be repeated up to 4 times per day. Do not treat for more than 2 days. Safety for use in pregnant female cats, breeding male cats of kittens less than 4 months of age has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

ucm061350.pdf

FOI · FOI

Open original

ucm061797.pdf

FOI · FOI

Open original

ucm061785.pdf

FOI · FOI

Open original

UCM214392.pdf

FOI · FOI

Open original

UCM061667.pdf

FOI · FOI

Open original

UCM490962.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Storefront facts: Source Roxee | Refreshed Apr 22, 2026, 10:07 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat, Horse, No Use Class Stated Or Implied
Rx/OTC: RX
Form/route: Liquid (Solution) • Intravenous, Subcutaneous
Applications: ANADA 200-408 • ANADA 200-332 • ANADA 200-322 • ANADA 200-446 • ANADA 200-239 • NADA 141-047
Documents: 6 (FOI: 6) • SPL: 6 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 61 • Cat 87 • View
Case summaries: 37 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95), Usage_Inferred (0.78)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Unsteady walking (ataxia) (1) Loss of appetite (1) Disorientation (1) Diarrhea (1) Decreased heart rate (1) Decreased haematocrit (1) Decreased drinking (1) Decreased appetite (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200239 ANADA: 200322 ANADA: 200332 ANADA: 200408 ANADA: 200446 NADA: 102990 NADA: 103390 NADA: 135780 NADA: 141047 NDC Package: 11695-7044-1 NDC Package: 11695-7044-2 NDC Package: 17033-097-01 NDC Package: 17033-097-05 NDC Package: 54771-2033-1 NDC Package: 54771-2033-2 NDC Package: 57926-722-66 NDC Package: 69043-064-02 NDC Package: 69043-064-05 NDC Package: 73377-107-01 NDC Package: 86136-137-31 NDC Package: 86136-137-69 NDC Product: 11695 NDC Product: 17033 NDC Product: 54771
Package NDC Product NDC Form / Route Status
11695-7044-1 11695 -
11695-7044-2 11695 -
17033-097-01 17033 -
17033-097-05 17033 -
54771-2033-1 54771 -
54771-2033-2 54771 -
57926-722-66 57926 -
69043-064-02 69043 -
69043-064-05 69043 -
73377-107-01 73377 -
86136-137-31 86136 -
86136-137-69 86136 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • ucm061350.pdf • FOI summary • Official • Feb. 27, 2026
    FDA FOI summary for application 200408
  • ucm061797.pdf • FOI summary • Official • June 13, 2024
    FDA FOI summary for application 200332
  • ucm061785.pdf • FOI summary • Official • Oct. 7, 2022
    FDA FOI summary for application 200322
  • UCM214392.pdf • FOI summary • Official • April 26, 2022
    FDA FOI summary for application 200446
  • UCM061667.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 200239
  • UCM490962.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 141047

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 25 Clinical 9 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not norma… (Clinical, 2026-04-15)
  • contraindications: Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not norma… (Clinical, 2026-04-15)
  • contraindications: Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not norma… (Clinical, 2026-04-11)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-15)
  • side_effects: Top reported reactions (openFDA): Lack of efficacy - NOS, Vomiting, Death, Diarrhoea, Bradycardia, Lethargy (see also Central nervous system depression in 'Neu… (Clinical, 2026-04-11)
  • usage: For the relief of chronic nonproductive cough associated with tracheo-bronchitis, tracheitis tonsillitis, laryngitis, and pharyngitis associated with inflammat… (Clinical, 2026-04-15)
  • usage: For the relief of chronic nonproductive cough associated with tracheo-bronchitis, tracheitis tonsillitis, laryngitis, and pharyngitis associated with inflammat… (Clinical, 2026-04-15)
  • usage: For the relief of chronic nonproductive cough associated with tracheo-bronchitis, tracheitis tonsillitis, laryngitis, and pharyngitis associated with inflammat… (Clinical, 2026-04-11)
  • contraindications: Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not norma… (Official, 2026-04-22)
  • contraindications: Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not norma… (Official, 2026-02-12)
  • indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-05-05)
  • indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-05-03)
  • indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-05-02)
  • indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-04-29)
  • indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-04-28)
  • indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-04-27)
  • indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-04-26)
  • indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-04-25)
  • indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-04-22)
Recent Revisions
  • side_effects updated 2026-04-22 10:07 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-22 10:07 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-22 10:07 by etl_backfill • Backfilled from existing medication fields
  • monitoring updated 2026-04-16 13:28 by curated_loader • Clinical monitoring context for feline diabetes management.
  • usage updated 2026-04-16 13:28 by curated_loader • Usage statement from FDA warning letter and approved-product context.
  • drug_profile_type updated 2026-04-16 13:28 by curated_loader • FDA source confirms Senvelgo as a branded approved product.
  • manufacturer_name updated 2026-04-16 13:28 by curated_loader • FDA warning letter identifies the approved sponsor/manufacturer.
  • brand_names updated 2026-04-16 13:28 by curated_loader • FDA warning letter references Senvelgo as the approved animal drug.
  • approval_reference updated 2026-04-16 13:28 by curated_loader • Official FDA application reference for Senvelgo.
  • side_effects updated 2026-04-15 10:07 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-15 10:07 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-15 10:07 by etl_backfill • Backfilled from existing medication fields
  • monitoring updated 2026-04-15 10:07 by curated_loader • Clinical monitoring context for feline diabetes management.
  • usage updated 2026-04-15 10:07 by curated_loader • Usage statement from FDA warning letter and approved-product context.
  • drug_profile_type updated 2026-04-15 10:07 by curated_loader • FDA source confirms Senvelgo as a branded approved product.
  • manufacturer_name updated 2026-04-15 10:07 by curated_loader • FDA warning letter identifies the approved sponsor/manufacturer.
  • brand_names updated 2026-04-15 10:07 by curated_loader • FDA warning letter references Senvelgo as the approved animal drug.
  • approval_reference updated 2026-04-15 10:07 by curated_loader • Official FDA application reference for Senvelgo.
  • side_effects updated 2026-04-15 10:04 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-15 10:04 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Butorphanol Tartrate Injection
RX
Butorphanol Tartrate
Liquid (Solution) • Subcutaneous
Label highlights
Official documents
Dechra Veterinary Products LLC ANADA 200-408 W Feb 27, 2026
Butorphic™ Injection
RX
Butorphanol Tartrate
Liquid (Solution) • Intravenous
Label highlights
Official documents
Cronus Pharma Specialities India Private Ltd. ANADA 200-332 Approved Jun 13, 2024
Torphadine®
RX
Butorphanol Tartrate
Liquid (Solution) • Intravenous
Label highlights
Official documents
Dechra Veterinary Products LLC ANADA 200-322 Approved Oct 7, 2022
Butorphine™
RX
Butorphanol Tartrate
Liquid (Solution) • Subcutaneous
Label highlights
Official documents
Modern Veterinary Therapeutics, LLC ANADA 200-446 W Apr 26, 2022
Dolorex®
RX
Butorphanol Tartrate
Liquid (Solution) • Intravenous
Label highlights
Official documents
Intervet, Inc. ANADA 200-239 Approved Jun 1, 2016
Torbugesic-SA®
RX
Butorphanol Tartrate
Liquid (Solution) • Subcutaneous
Label highlights
Official documents
Zoetis Inc. NADA 141-047 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of aqueous solution contains 2 milligrams of butorphanol (as butorphanol tartrate).
Cats
Indication
For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures
Dosage
0.2 milligram of butorphanol base activity per pound of body weight (0.4 milligrams per kilogram), using 2 milligrams per milliliter solution. For subcutaneous injection.
Limitations
Dose may be repeated up to 4 times per day. Do not treat for more than 2 days. Safety for use in pregnant female cats, breeding male cats of kittens less than 4 months of age has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian

FDA page: Open in Animal Drugs @ FDA

Species: No Use Class Stated Or Implied
Composition / specifications
Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).
Horses
Indication
For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.
Dosage
0.05 milligram of butorphanol per pound of body weight (0.1 milligram per kilogram of body weight). Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours.
Limitations
Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).
Horses
Indication
For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.
Dosage
0.05 milligram of butorphanol base activity per pound of body weight (0.1 milligram/kilogram) using 10 milligrams per milliliter solution. For intravenous use.
Limitations
Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
Each mL contains 2 mg butorphanol base (as butorphanol tartrate, USP).
Cats
Indication
For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.
Dosage
Administer 0.4 mg of butorphanol per kilogram body weight (0.2 mg/lb). This is equivalent to 1.0 mL solution per 10 lbs body weight.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production
Composition / specifications
Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).
Horses
Indication
For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.
Dosage
0.05 milligram of butorphanol base activity per pound of body weight (0.1 milligram/kilogram) using 10 milligrams per milliliter solution. For intravenous use.
Limitations
Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of aqueous solution contains 2 milligrams of butorphanol (as butorphanol tartrate).
Cats
Indication
For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.
Dosage
0.2 milligram of butorphanol base activity per pound of body weight (0.4 milligrams per kilogram)
Limitations
For subcutaneous injection. Dose may be repeated up to 4 times per day. Do not treat for more than 2 days. Safety for use in pregnant female cats, breeding male cats of kittens less than 4 months of age has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Usage

For the relief of chronic nonproductive cough associated with tracheo-bronchitis, tracheitis tonsillitis, laryngitis, and pharyngitis associated with inflammatory conditions of the upper respiratory tract. For the relief of pain associated with colic and postpartum pain in adult horses and yearlings. For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Cat Diarrhea (1) • Cat Decreased appetite (1) • Dog Bloody diarrhoea (1) • Cat

Showing top 5 for Digestive.

Skin & allergy
Hair loss at application site (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Cat Depression (1) • Cat

Showing top 5 for Neurologic.

Behavior
Circling - behavioural disorder (1) • Cat Behavioral disorder (1) • Cat

Showing top 5 for Behavior.

Other
Disorientation (1) • Cat Dilated pupils (1) • Cat Decreased pulse oxygenation (1) • Cat Decreased heart rate (1) • Dog Decreased haematocrit (1) • Cat
Show more (18)
Decreased drinking (1) • Dog Decreased body temperature (1) • Cat Decreased activity (1) • Cat Death by euthanasia (1) • Dog Death (1) • Dog Closed eyelid (1) • Cat Cardiac arrest (1) • Cat Bruising (1) • Dog Bradycardia (1) • Dog Basophilia (1) • Cat Aspiration pneumonia (1) • Cat Application site pain (1) • Dog Application site dry skin (1) • Dog Apnoea (1) • Dog Agitation (1) • Dog Abnormal radiograph finding (1) • Cat Abnormal cytology (1) • Cat Abdominal discomfort (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Greyhound, Female, 9 year, 27.3 kilogram • Drug: MSK, Suspension, Subcutaneous • Reactions: Lack of efficacy - NOS, Unrelated death • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2025-US-075461
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 9.00 Year
  • Weight: 27.300 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Suspension
Reactions Reported:
Lack of efficacy - NOS Unrelated death
Outcomes: Euthanized

Dog, ['Retriever - Golden', 'Poodle - Standard'], Male, 5 year, 25.5 kilogram • Drug: MSK, Suspension, Subcutaneous • Reactions: Lack of efficacy - NOS, Unrelated death • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2025-US-075440
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 5.00 Year
  • Weight: 25.500 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Suspension
Reactions Reported:
Lack of efficacy - NOS Unrelated death
Outcomes: Euthanized

Dog, Crossbred Canine/dog, Male, 14 year, 17.7 kilogram • Drug: MSK, Suspension, Subcutaneous • Reactions: Lack of efficacy - NOS, Unrelated death • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2025-US-075367
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 14.00 Year
  • Weight: 17.700 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Suspension
Reactions Reported:
Lack of efficacy - NOS Unrelated death
Outcomes: Euthanized

Cat, Domestic Shorthair, Female, 4 month, 2.4 kilogram • Drug: MSK, Parenteral • Reactions: Head shake - behavioural disorder, Unable to walk, Not drinking, Not eating, Unsteady walking (ataxia)… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-074782
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 4.00 Month
  • Weight: 2.400 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Parenteral
Reactions Reported:
Head shake - behavioural disorder Unable to walk Not drinking Not eating Unsteady walking (ataxia) Circling - behavioural disorder Unsteady gait
Outcomes: Ongoing

Cat, Cat (unknown), Unknown, 3.49 kilogram • Drug: MSK, Unknown • Reactions: Pulmonary congestion, Decreased body temperature, Drowsiness - systemic disorder, Disorientation, Unable to stand… • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-074695
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Unknown
  • Weight: 3.490 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Pulmonary congestion Decreased body temperature Drowsiness - systemic disorder Disorientation Unable to stand Dysphoria
Outcomes: Recovered/Normal

Dog, Bulldog - French, Male, 8 year, 12.428 kilogram • Drug: MSK, Unassigned, Intramuscular, Dose: 0.25 mL per animal • Reactions: Decreased appetite, Decreased drinking, Tiredness (lethargy), Panting, Tense muscles… • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-074194
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 8.00 Year
  • Weight: 12.428 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Form: Unassigned
  • Dose: 0.25 mL per animal
Reactions Reported:
Decreased appetite Decreased drinking Tiredness (lethargy) Panting Tense muscles Seizure NOS Inappropriate defecation Inappropriate urination Unable to walk Proprioception deficit Generalised weakness Lameness Limb non-weight bearing Abnormal radiograph finding Medication error NOS
Outcomes: Recovered/Normal

Dog, Terrier - Bull - Staffordshire, Male, 7.5 year, 28.486 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Injection site oedema • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-074082
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 7.50 Year
  • Weight: 28.486 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Injection site oedema
Outcomes: Recovered/Normal

Cat, Maine Coon, Male, 13 year, 6.58 kilogram • Drug: MSK, Unknown • Reactions: Twitching, Focal seizure, Death, Tiredness (lethargy) • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-074994
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 13.00 Year
  • Weight: 6.580 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Twitching Focal seizure Death Tiredness (lethargy)
Outcomes: Died

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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