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Roxee Medication Guide

Ceftiofur Crystalline Free Acid

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete Livestock/food-animal use Rx required Sterile suspension Zoetis Inc. Official label facts Owner quick guide first
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Data freshness

Reference facts
Reference refreshed
Jun 22, 2026, 10:45 a.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
Jun 22, 2026, 10:41 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
No safety reports linked
No refresh timestamp yet

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:45 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
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Ceftiofur Crystalline Free Acid

Ceftiofur Crystalline Free Acid

Drug type: Food-animal record • Generic profile • Livestock/food-animal use

Both Sterile suspension Rx required 100% reference complete

Species: Both

Approval status: Food-animal or livestock record. This source record is for livestock or food-animal use, not a dog/cat medication profile. Food-animal rules, withdrawal intervals, and residue restrictions may apply.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Ceftiofur Crystalline Free Acid

For the treatment of bovine respiratory disease (BRD, shipping fever, pneumonia) associated with Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni in beef, non-lactating dairy, and lactating dairy cattle. For the treatment of bovine foot rot (interdigital necrobacillosis) associated with Fusobacterium necrophorum and Porphyromonas levii in beef, non-lactating dairy, and lactating dairy cattle. For the control of respiratory disease in beef and non-lactating dairy catte which are at high risk of developing BRD associated with M. haemolytica, P. multocida, and H. somni . Species commonly shown: Both, Beef, Dairy, lactating.

Generic name
Ceftiofur Crystalline Free Acid
Brand names
EXCEDE®, EXCEDE® FOR SWINE
Manufacturer
Zoetis Inc.
Species
Both, Beef, Dairy
Dosage forms
Sterile suspension
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
EXCEDE® EXCEDE® FOR SWINE
Dosage forms
Sterile suspension

Indications / Uses

For the treatment of bovine respiratory disease (BRD, shipping fever, pneumonia) associated with Mannheimia haemolytica , Pasteurella multocida , and Histophilus somni in beef, non-lactating dairy, and lactating dairy cattle. For the treatment of bovine foot rot (interdigital necrobacillosis) associated with Fusobacterium necrophorum and Porphyromonas levii in beef, non-lactating dairy, and lactating dairy cattle. For the control of respiratory disease in beef and non-lactating dairy catte which are at high risk of developing BRD associated with M. haemolytica , P. multocida , and H. somni .

Warnings / Contraindications

Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Side Effects

Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disorder NOS, Decreased appetite.

FAQ

Both, Beef, Dairy, lactating, Dairy, non-lactating

Yes. Roxee shows this as prescription-only.

Sterile suspension

Related Conditions

Metritis Pneumonia (aspiration, bacterial, viral)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the treatment of bovine respiratory disease (BRD, shipping fever, pneumonia) associated with Mannheimia haemolytica , Pasteurella multocida , and Histophilus somni in beef, non-lactating dairy, and lactating dairy ca...

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Do not use in horses intended for human consumption
  • very low energy (1 reports)
  • Medication error NOS (1 reports)
  • Loss of appetite (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Ceftiofur Crystalline Free Acid; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2023-US-027209
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 23 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2023-US-027209
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2023-US-027209
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Tiredness (lethargy) (1 reports), Medication error NOS (1 reports), Loss of appetite (1 reports), Limping (1 reports), Leucocytosis NOS (1 reports)

Body systems represented Signal grouping

Digestive (3), Skin & allergy (2), Neurologic (2), Effectiveness (1)

Species and breed lens

Species represented in reports Species lens

Cat (21 reports), Dog (11 reports)

What your vet may verify

Fit for this patient Vet check

Verify whether Ceftiofur Crystalline Free Acid fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Do not use in horses intended for human consumption, very low energy, Medication error NOS, Loss of appetite

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Ceftiofur Crystalline Free Acid brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2023-US-027209 · adverse_reaction · adverse reactions
  2. Contraindication source · fda_animal_drugs · warnings contraindications
  3. FDA application profile · official_label · quick facts
  4. FDA application profile · official_label · quick facts
  5. Medication usage source · fda_animal_drugs · quick facts
  6. FOI · document · documents
  7. FOI · document · documents
  8. FOI · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 10:44 PM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Do not use in horses intended for human consumption
  • very low energy
  • Medication error NOS
  • Loss of appetite

Most reported reactions:

  • Tiredness (lethargy) (1 reports)
  • Medication error NOS (1 reports)
  • Loss of appetite (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Beef, Dairy
Indication / use
For the treatment of bovine respiratory disease (BRD, shipping fever, pneumonia) associated with Mannheimia haemolytica , Pasteurella multocida , and Histophilus somni in beef, no…
Form / route / dose
Form: Sterile suspension
Route: Intramuscular, Subcutaneous
Confirm product label and patient-specific plan.
Warnings
  • High: Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a lic…
Adverse-event caveat
No stored openFDA case explorer rows are linked yet.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Zoetis Inc.
Form: Sterile suspension
Identifiers:
NADA: 141209 NADA: 141235
Source metadata:

Warnings / Contraindications

Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
23
Species represented
2
Grouped by Body System
Digestive (3) · Loss of appetite, Diarrhea, Bloody diarrhoea Skin & allergy (2) · Injection site swelling, Eye itching Neurologic (2) · Unsteady walking (ataxia), Tiredness (lethargy) Effectiveness (1) · Lack of efficacy - NOS Other (24) · Medication error NOS, Limping, Leucocytosis NOS
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Cat 1
Other 1 Dog 1
Digestive 1 Cat 1
Other 1 Dog 1
Other 1 Dog 1
Effectiveness 1 Dog 1
Skin & allergy 1 Cat 1
Other 1 Cat 1

Species coverage: Cat (21) Dog (11)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Cat Non-serious - 1
Neurologic Cat Serious - 1
Other Dog Serious - 1
Digestive Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Effectiveness Dog Serious - 1
Other Cat Non-serious - 1
Skin & allergy Cat Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Skin & allergy Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Digestive Cat Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Digestive Dog Non-serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Source metadata:

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

EXCEDE® SPL · SPL EXCEDE® FOR SWINE SPL · SPL UCM307680.pdf FOI · FOI

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

2

FOI

7

EXCEDE®

SPL · SPL

Open original
FDA Structured Product Label

EXCEDE®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
NADA
141-209
Status
RX
Form
Sterile suspension
Route
Subcutaneous, Intramuscular
Species
Beef • Dairy
Composition / specifications
Each milliliter of suspension contains 200 milligrams ceftiofur equivalents.

Beef, non-lactating dairy, and lactating dairy cattle

Indication

For the treatment of bovine respiratory disease (BRD, shipping fever, pneumonia) associated with Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni in beef, non-lactating dairy, and lactating dairy cattle.

Dosage

Administer as a single subcutaneous injection in the posterior aspect of the ear where it attaches to the head (base of the ear) to cattle at a dosage of 3.0 mg ceftiofur equivalents (CE)/lb (6.6 mg CE/kg) body weight (BW). In beef and non-lactating dairy cattle, EXCEDE Sterile Suspension may also be administered as a single subcutaneous injection in the middle third of the posterior aspect of the ear at a dosage of 3.0 mg CE/lb (6.6 mg CE/kg) BW.

Limitations

Indication

For the treatment of bovine foot rot (interdigital necrobacillosis) associated with Fusobacterium necrophorum and Porphyromonas levii in beef, non-lactating dairy, and lactating dairy cattle.

Dosage

Administer as a single subcutaneous injection in the posterior aspect of the ear where it attaches to the head (base of the ear) to cattle at a dosage of 3.0 mg CE/lb (6.6 mg CE/kg) BW. In beef and non-lactating dairy cattle, may also be administered as a single subcutaneous injection in the middle third of the posterior aspect of the ear at a dosage of 3.0 mg CE/lb (6.6 mg CE/kg) BW.

Beef and non-lactating dairy cattle

Indication

For the control of respiratory disease in beef and non-lactating dairy catte which are at high risk of developing BRD associated with M. haemolytica, P. multocida, and H. somni.

Dosage

Administer as a subcutaneous injection either in the middle third of the posterior aspect of the ear or in the posterior aspect of the ear where it attaches to the head (base of the ear) to beef and non-lactating dairy cattle at a dosage of 3.0 mg CE/lb (6.6 mg CE/kg) BW.

Horses

Indication
For the treatment of lower respiratory tract infections in horses caused by susceptible strains of Streptococcus equi ssp. zooepidemicus.
Dosage
Administer two intramuscular injections to horses, 4 days apart, at a dose of 6.6 mg/kg. A maximum of 20 mL per injection site may be administered.
Limitations
Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Cattle (lactating dairy)

Indication

For treatment of acute metritis (0-10 days post-partum) associated with bacterial organisms susceptible to ceftiofur in lactating dairy cattle.

Dosage

Administer as a subcutaneous injection in the posterior aspect of the ear where it attaches to the head (base of the ear) to lactating dairy cattle at a dosage of 3.0 mg CE/lb (6.6 mg CE/kg) BW. Repeat this dose in the contra-lateral (opposite) ear approximately 72 hours following the initial dose.

EXCEDE® FOR SWINE

SPL · SPL

Open original
FDA Structured Product Label

EXCEDE® FOR SWINE

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
NADA
141-235
Status
RX
Form
Sterile suspension
Route
Intramuscular
Composition / specifications
100 mg ceftiofur equivalents (CE) per mL suspension.

Swine

Indication

For the treatment of swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Haemophilus parasuis, and Streptococcus suis; and for the control of SRD associated with A. pleuropneumoniae, P. multocida, H. parasuis, and S. suis in groups of pigs where SRD has been diagnosed.

Dosage

Administer by intramuscular (IM) injection in the post-auricular region of the neck as a single dosage of 5.0 mg ceftiofur equivalents (CE)/kg body weight (BW). No more than 2 mL should be injected in a single injection site.

UCM307680.pdf

FOI · FOI

Open original

UCM203951.pdf

FOI · FOI

Open original

ucm117772.pdf

FOI · FOI

Open original

ucm117768.pdf

FOI · FOI

Open original

ucm117761.pdf

FOI · FOI

Open original

UCM235349.pdf

FOI · FOI

Open original

ucm118047.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:45 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Catalog species: Both • FDA-labeled species: Beef, Dairy
Rx/OTC: RX
Form/route: Sterile suspension • Intramuscular, Subcutaneous
Applications: NADA 141-209 • NADA 141-235
Documents: 7 (FOI: 7) • SPL: 2 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 0 • Cat 0 • View
Case summaries: 0
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Tiredness (lethargy) (1) Medication error NOS (1) Loss of appetite (1) Limping (1) Leucocytosis NOS (1) Lack of efficacy - NOS (1) Injection site swelling (1) Immune mediated haemolytic anaemia (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141209 NADA: 141235

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • ucm118047.pdf • FOI summary • Official • Feb. 28, 2024
    FDA FOI summary for application 141235
  • UCM235349.pdf • FOI summary • Official • Feb. 28, 2024
    FDA FOI summary for application 141235
  • ucm117761.pdf • FOI summary • Official • Feb. 28, 2024
    FDA FOI summary for application 141209
  • ucm117768.pdf • FOI summary • Official • Feb. 28, 2024
    FDA FOI summary for application 141209
  • ucm117772.pdf • FOI summary • Official • Feb. 28, 2024
    FDA FOI summary for application 141209
  • UCM203951.pdf • FOI summary • Official • Feb. 28, 2024
    FDA FOI summary for application 141209
  • UCM307680.pdf • FOI summary • Official • Feb. 28, 2024
    FDA FOI summary for application 141209

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 67 Clinical 60 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-22)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-22)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-21)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-20)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-13)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-12)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-12)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-11)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-11)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-10)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-08)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-07)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-06)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-05)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-04)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-03)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-02)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-01)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-06-01)
  • side_effects: Top reported reactions (openFDA): Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Blindness, Bloody diarrhoea, Corneal disor… (Clinical, 2026-05-31)
Recent Revisions
  • side_effects updated 2026-06-22 10:45 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-22 10:45 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-22 10:45 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-22 10:04 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-22 10:04 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-22 10:04 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-21 05:18 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-21 05:18 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-21 05:18 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-20 20:58 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-20 20:58 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-20 20:58 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-13 11:33 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-13 11:33 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-13 11:33 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-12 10:42 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-12 10:42 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-12 10:42 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-12 10:04 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-12 10:04 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
EXCEDE®
RX
Ceftiofur Crystalline Free Acid
Sterile suspension • Subcutaneous, Intramuscular
Label highlights
Official documents
Zoetis Inc. NADA 141-209 Approved Feb 28, 2024
EXCEDE® FOR SWINE
RX
Ceftiofur Crystalline Free Acid
Sterile suspension • Intramuscular
Label highlights
Official documents
Zoetis Inc. NADA 141-235 Approved Feb 28, 2024

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Beef • Dairy
Composition / specifications
Each milliliter of suspension contains 200 milligrams ceftiofur equivalents.
Beef, non-lactating dairy, and lactating dairy cattle
Indication

For the treatment of bovine respiratory disease (BRD, shipping fever, pneumonia) associated with Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni in beef, non-lactating dairy, and lactating dairy cattle.

Dosage

Administer as a single subcutaneous injection in the posterior aspect of the ear where it attaches to the head (base of the ear) to cattle at a dosage of 3.0 mg ceftiofur equivalents (CE)/lb (6.6 mg CE/kg) body weight (BW). In beef and non-lactating dairy cattle, EXCEDE Sterile Suspension may also be administered as a single subcutaneous injection in the middle third of the posterior aspect of the ear at a dosage of 3.0 mg CE/lb (6.6 mg CE/kg) BW.

Limitations

Indication

For the treatment of bovine foot rot (interdigital necrobacillosis) associated with Fusobacterium necrophorum and Porphyromonas levii in beef, non-lactating dairy, and lactating dairy cattle.

Dosage

Administer as a single subcutaneous injection in the posterior aspect of the ear where it attaches to the head (base of the ear) to cattle at a dosage of 3.0 mg CE/lb (6.6 mg CE/kg) BW. In beef and non-lactating dairy cattle, may also be administered as a single subcutaneous injection in the middle third of the posterior aspect of the ear at a dosage of 3.0 mg CE/lb (6.6 mg CE/kg) BW.

Limitations
Beef and non-lactating dairy cattle
Indication

For the control of respiratory disease in beef and non-lactating dairy catte which are at high risk of developing BRD associated with M. haemolytica, P. multocida, and H. somni.

Dosage

Administer as a subcutaneous injection either in the middle third of the posterior aspect of the ear or in the posterior aspect of the ear where it attaches to the head (base of the ear) to beef and non-lactating dairy cattle at a dosage of 3.0 mg CE/lb (6.6 mg CE/kg) BW.

Limitations
Horses
Indication
For the treatment of lower respiratory tract infections in horses caused by susceptible strains of Streptococcus equi ssp. zooepidemicus.
Dosage
Administer two intramuscular injections to horses, 4 days apart, at a dose of 6.6 mg/kg. A maximum of 20 mL per injection site may be administered.
Limitations
Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cattle (lactating dairy)
Indication

For treatment of acute metritis (0-10 days post-partum) associated with bacterial organisms susceptible to ceftiofur in lactating dairy cattle.

Dosage

Administer as a subcutaneous injection in the posterior aspect of the ear where it attaches to the head (base of the ear) to lactating dairy cattle at a dosage of 3.0 mg CE/lb (6.6 mg CE/kg) BW. Repeat this dose in the contra-lateral (opposite) ear approximately 72 hours following the initial dose.

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications
100 mg ceftiofur equivalents (CE) per mL suspension.
Swine
Indication

For the treatment of swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Haemophilus parasuis, and Streptococcus suis; and for the control of SRD associated with A. pleuropneumoniae, P. multocida, H. parasuis, and S. suis in groups of pigs where SRD has been diagnosed.

Dosage

Administer by intramuscular (IM) injection in the post-auricular region of the neck as a single dosage of 5.0 mg ceftiofur equivalents (CE)/kg body weight (BW). No more than 2 mL should be injected in a single injection site.

Limitations

FDA page: Open in Animal Drugs @ FDA

Usage

For the treatment of bovine respiratory disease (BRD, shipping fever, pneumonia) associated with Mannheimia haemolytica , Pasteurella multocida , and Histophilus somni in beef, non-lactating dairy, and lactating dairy cattle. For the treatment of bovine foot rot (interdigital necrobacillosis) associated with Fusobacterium necrophorum and Porphyromonas levii in beef, non-lactating dairy, and lactating dairy cattle. For the control of respiratory disease in beef and non-lactating dairy catte which are at high risk of developing BRD associated with M. haemolytica , P. multocida , and H. somni .

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Cat Diarrhea (1) • Cat Bloody diarrhoea (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Injection site swelling (1) • Cat Eye itching (1) • Dog

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Cat Tiredness (1) • Cat

Showing top 5 for Neurologic.

Effectiveness
Lack of efficacy - NOS (1) • Dog

Showing top 5 for Effectiveness.

Other
Medication error NOS (1) • Dog Limping (1) • Dog Leucocytosis NOS (1) • Dog Laboured breathing (1) • Cat Immune mediated haemolytic anaemia (1) • Cat
Show more (19)
Icterus (1) • Cat Hyperproteinaemia (1) • Cat Hyperaemic mucosae (1) • Dog Hiding (1) • Cat Fracture (1) • Cat Fever (1) • Cat Eye haemorrhage (1) • Cat Elevated renal parameters (1) • Dog Elevated globulins (1) • Cat Elevated creatinine (1) • Cat Electrolyte disorder (1) • Cat Dehydration (1) • Cat Decreased intra-ocular pressure (1) • Dog Death (1) • Cat Corneal disorder NOS (1) • Dog Constipation (1) • Cat Blindness (1) • Dog Anaemia NOS (1) • Cat Agglutination test, positive (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

No case-level openFDA reports are linked for this medication yet.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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This medication has not been reviewed by a veterinarian yet.