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Roxee Medication Guide

Cephapirin Sodium

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete Livestock/food-animal use Rx required Suspension Boehringer Ingelheim Animal Health USA Inc. Official label facts Owner quick guide first
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Data freshness

Reference facts
Reference refreshed
Jun 22, 2026, 10:45 a.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
Jun 22, 2026, 10:41 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
No safety reports linked
No refresh timestamp yet

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:45 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
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Cephapirin Sodium

Cephapirin Sodium

Drug type: Food-animal record • Branded profile • Livestock/food-animal use

Both Suspension Rx required 100% reference complete

Species: Both

Approval status: Food-animal or livestock record. This source record is for livestock or food-animal use, not a dog/cat medication profile. Food-animal rules, withdrawal intervals, and residue restrictions may apply.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Cephapirin Sodium

ToDAY (cephapirin sodium intramammary infusion) should be used should be used at the first signs of inflammation or at the first indication of any alteration in the milk. Treatment is indicated immediately upon determining, by C.M.T. or other tests, that the leukocyte count is elevated, or that a susceptible pathogen has been cultured from the milk. ToDAY has been shown to be efficacious in the treatment of mastitis in lactating cows caused by susceptible strains of Streptococcus agalactiae and Staphylococcus aureus including strains resistant to penicillin. Species commonly shown: Both, Lactating cows.

Generic name
Cephapirin Sodium
Brand names
ToDAY®, ToDAY
Manufacturer
Boehringer Ingelheim Animal Health USA Inc.
Species
Both, Lactating cows
Dosage forms
Suspension
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
ToDAY® ToDAY
Dosage forms
Suspension

Indications / Uses

ToDAY (cephapirin sodium intramammary infusion) should be used should be used at the first signs of inflammation or at the first indication of any alteration in the milk. Treatment is indicated immediately upon determining, by C.M.T. or other tests, that the leukocyte count is elevated, or that a susceptible pathogen has been cultured from the milk. ToDAY has been shown to be efficacious in the treatment of mastitis in lactating cows caused by susceptible strains of Streptococcus agalactiae and Staphylococcus aureus including strains resistant to penicillin.

Side Effects

Top reported reactions (openFDA): Deafness, Skin lump.

FAQ

Both, Lactating cows

Yes. Roxee shows this as prescription-only.

Suspension

Related Conditions

Mastitis

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

ToDAY (cephapirin sodium intramammary infusion) should be used should be used at the first signs of inflammation or at the first indication of any alteration in the milk. Treatment is indicated immediately upon determini...

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Skin lump (1 reports)
  • Deafness (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Cephapirin Sodium; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2016-US-029480
Safety signal coverage Reported signals

2 tracked reaction signals; 2 reported cases; 2 serious reports; 1 species group. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2016-US-029480
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2016-US-029480
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Skin lump (1 reports), Deafness (1 reports)

Body systems represented Signal grouping

Other (2)

Species and breed lens

Species represented in reports Species lens

Dog (2 reports)

What your vet may verify

Fit for this patient Vet check

Verify whether Cephapirin Sodium fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Skin lump, Deafness

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Cephapirin Sodium brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2016-US-029480 · adverse_reaction · adverse reactions
  2. FDA application profile · official_label · quick facts
  3. Medication usage source · fda_animal_drugs · quick facts
  4. SPL · document · documents
  5. Structured Product Label · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 10:44 PM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Skin lump
  • Deafness

Most reported reactions:

  • Skin lump (1 reports)
  • Deafness (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Lactating cows
Indication / use
ToDAY (cephapirin sodium intramammary infusion) should be used should be used at the first signs of inflammation or at the first indication of any alteration in the milk. Treatmen…
Form / route / dose
Form: Suspension
Route: Intramammary
Confirm product label and patient-specific plan.
Warnings
No structured warnings linked yet.
Adverse-event caveat
No stored openFDA case explorer rows are linked yet.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Boehringer Ingelheim Animal Health USA Inc.
Form: Suspension
Identifiers:
NADA: 97222 NDC Package: 0010-4754-01 NDC Package: 0010-4754-02 NDC Product: 0010
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
2
Reported cases
2
Serious reports
2
Species represented
1
Grouped by Body System
Other (2) · Skin lump, Deafness
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (2)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Other Dog Serious - 1
Other Dog Serious - 1
Source metadata:

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

ToDAY® SPL · SPL ToDAY SPL SPL · Structured Product Label

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

2

FOI

0
No FOI links yet.

ToDAY®

SPL · SPL

Open original
FDA Structured Product Label

ToDAY®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Boehringer Ingelheim Animal Health USA, Inc.
NADA
97222
Status
RX
Form
Suspension
Route
Intramammary
Species
Lactating cows
Composition / specifications
Each 10 mL syringe contains 200 mg of cephapirin activity

Lactating cows

Indication

ToDAY (cephapirin sodium intramammary infusion) should be used should be used at the first signs of inflammation or at the first indication of any alteration in the milk. Treatment is indicated immediately upon determining, by C.M.T. or other tests, that the leukocyte count is elevated, or that a susceptible pathogen has been cultured from the milk. ToDAY has been shown to be efficacious in the treatment of mastitis in lactating cows caused by susceptible strains of Streptococcus agalactiae and Staphylococcus aureus including strains resistant to penicillin.

Dosage

Infuse the entire contents of one syringe (10 mL) into each infected quarter immediately after the quarter has been completely milked out. Repeat once only in 12 hours. If definite improvement is not noted within 48 hours after treatment, the causal organism should be further investigated. Consult your veterinarian. Do not milk out for 12 hours.

ToDAY SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for ToDAY. Use the source link for the full official labeling record.
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:45 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: ToDAY
Manufacturer mapping: Boehringer Ingelheim Animal Health USA Inc.
Catalog species: Both • FDA-labeled species: Lactating cows
Rx/OTC: RX
Form/route: Suspension • Intramammary
Applications: NADA 97222
NDC: Packages 0010-4754-01 0010-4754-02 • Products 0010
Documents: • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 0 • Cat 0 • View
Case summaries: 0
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Mastitis
Linked using: Fda_Label (0.95)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Skin lump (1) Deafness (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 97222 NDC Package: 0010-4754-01 NDC Package: 0010-4754-02 NDC Product: 0010
Package NDC Product NDC Form / Route Status
0010-4754-01 0010 -
0010-4754-02 0010 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • ToDAY SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 61 Clinical 60 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-22)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-22)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-21)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-20)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-13)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-12)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-12)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-11)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-11)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-10)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-08)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-07)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-06)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-05)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-04)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-03)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-02)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-01)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-06-01)
  • side_effects: Top reported reactions (openFDA): Deafness, Skin lump. (Clinical, 2026-05-31)
Recent Revisions
  • side_effects updated 2026-06-22 10:45 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-22 10:45 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-22 10:04 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-22 10:04 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-21 05:18 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-21 05:18 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-20 20:58 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-20 20:58 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-13 11:33 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-13 11:33 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-12 10:42 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-12 10:42 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-12 10:04 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-12 10:04 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-11 19:22 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-11 19:22 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-11 18:40 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-11 18:40 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-10 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-10 10:05 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
ToDAY®
RX
Cephapirin Sodium
Suspension • Intramammary
Label highlights
Official documents
Boehringer Ingelheim Animal Health USA, Inc. NADA 97222 Approved Jul 31, 2025

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Lactating cows
Composition / specifications
Each 10 mL syringe contains 200 mg of cephapirin activity
Lactating cows
Indication

ToDAY (cephapirin sodium intramammary infusion) should be used should be used at the first signs of inflammation or at the first indication of any alteration in the milk. Treatment is indicated immediately upon determining, by C.M.T. or other tests, that the leukocyte count is elevated, or that a susceptible pathogen has been cultured from the milk. ToDAY has been shown to be efficacious in the treatment of mastitis in lactating cows caused by susceptible strains of Streptococcus agalactiae and Staphylococcus aureus including strains resistant to penicillin.

Dosage

Infuse the entire contents of one syringe (10 mL) into each infected quarter immediately after the quarter has been completely milked out. Repeat once only in 12 hours. If definite improvement is not noted within 48 hours after treatment, the causal organism should be further investigated. Consult your veterinarian. Do not milk out for 12 hours.

Limitations

FDA page: Open in Animal Drugs @ FDA

Usage

ToDAY (cephapirin sodium intramammary infusion) should be used should be used at the first signs of inflammation or at the first indication of any alteration in the milk. Treatment is indicated immediately upon determining, by C.M.T. or other tests, that the leukocyte count is elevated, or that a susceptible pathogen has been cultured from the milk. ToDAY has been shown to be efficacious in the treatment of mastitis in lactating cows caused by susceptible strains of Streptococcus agalactiae and Staphylococcus aureus including strains resistant to penicillin.

Source: FDA Animal Drugs @ FDA • Reference

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Other
Skin lump (1) • Dog Deafness (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

No case-level openFDA reports are linked for this medication yet.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

Share Your Thoughts

Let others know your experience or advice regarding this medication.

This medication has not been reviewed by a veterinarian yet.