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Roxee Medication Guide

Cyclosporin Ointment

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Source review pending Source coverage pending Owner quick guide first
Start Symptom Intake Talk to a Vet / Find a Vet Near You

Veterinary professional?

Showing simplified owner view. Switch to Vet View for full technical detail.

Data freshness

Reference facts
Source review pending
No refresh timestamp yet

Roxee is still reviewing source support for this medication profile.

FDA applications
Regulatory match pending
No refresh timestamp yet

Roxee has safety or ingredient evidence for this medication, but a regulatory product/application match is still pending.

Safety reports
Safety data refreshed
Aug 6, 2026, 7:49 p.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Jul 22, 2026, 7:08 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Illustration placeholder
Cyclosporin Ointment

Cyclosporin Ointment

Drug type: Generic ingredient • Generic profile • Source coverage pending

Both 80% reference complete

Species: Both

Approval status: Source coverage pending. Roxee has limited supporting content for this record, but no on-page official FDA animal-drug document is linked yet. Treat it as source-limited until the ETL backfill adds official coverage.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Cyclosporin Ointment

Senvelgo (velagliflozin oral solution) is approved in cats for control of hyperglycemia associated with diabetes mellitus. Species commonly shown: Both.

Generic name
Cyclosporin Ointment
Species
Both
Completeness
80%
Validation
Incomplete

Indications / Uses

Senvelgo (velagliflozin oral solution) is approved in cats for control of hyperglycemia associated with diabetes mellitus.

Side Effects

Top reported reactions (openFDA): Squinting, Eye irritation, Lack of efficacy - NOS, Corneal ulcer, Behavioural disorder NOS, Death by euthanasia.

FAQ

Both

Source Transparency

Add to My Pet's Medications

Choose a pet, confirm current or past, and optionally add reminder notes.

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Roxee still has limited plain-language guidance for this medication. Use the official documents and your veterinarian's instructions for product-specific details.

Used for:

Your vet decides this. Here's what owners typically ask/watch for.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • wobbly/unsteady walking (1 reports)
  • Loss of appetite (1 reports)
  • Deafness (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Cyclosporin Ointment; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2026-US-014358
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 21 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2026-US-014358
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2026-US-014358
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Unsteady walking (ataxia) (1 reports), Loss of appetite (1 reports), Deafness (1 reports), Cyanotic mucous membranes (1 reports), Crackles on auscultation (1 reports)

Body systems represented Signal grouping

Digestive (1), Skin & allergy (1), Neurologic (1), Behavior (2)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Dog (21 reports), Cat (11 reports)

Breed metadata in reports Metadata only

Domestic Shorthair (3), Shepherd Dog - German (2), ['Retriever - Golden', 'Poodle - Standard'] (1), Dog (unknown) (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Cyclosporin Ointment fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

wobbly/unsteady walking, Loss of appetite, Deafness

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Cyclosporin Ointment brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2026-US-014358 · adverse_reaction · adverse reactions

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: April 15, 2026, 10:04 AM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • wobbly/unsteady walking
  • Loss of appetite
  • Deafness

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Loss of appetite (1 reports)
  • Deafness (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Not linked yet
Indication / use
Your vet decides this. Here's what owners typically ask/watch for.
Form / route / dose
Confirm product label and patient-specific plan.
Warnings
No structured warnings linked yet.
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs
No source documents linked yet.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Manufacturer not confirmed

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
34
Matching reports
34
Active filters
0
Reset
Drill into common report signals
Behavioural disorder NOS (6) Lack of efficacy - NOS (6) Lethargy (see also Central nervous system depression in Neurological) (6) UNPALATABLE (6) Other (29) Neurologic (12) Behavior (7) Digestive (7)
Showing up to 50 matching reports.

USA-USFDACVM-2026-US-014235

Received 2026-03-24 · MSK · MSK

Non-serious
Species
Dog
Breed
['Retriever - Golden', 'Poodle - Standard']
Size / weight
50-99 lb (29.48 Kilogram)
Age
8+ years (8 Year)
Sex
Male Neutered
Region
USA
Reactions
InappetenceLethargy (see also Central nervous system depression in Neurological)
Body systems
OtherNeurologic
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-014199

Received 2026-03-24 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (8.61 Kilogram)
Age
8+ years (1 Year)
Sex
Male Neutered
Region
USA
Reactions
RashScratchingBehavioural disorder NOSUNPALATABLEINEFFECTIVE, ATOPY CONTROL
Body systems
Skin & allergyOtherBehavior
Outcomes
Ongoing

USA-USFDACVM-2026-US-013208

Received 2026-03-23 · MSK · MSK

Serious
Species
Dog
Breed
Shepherd Dog - German
Size / weight
100+ lb (46.72 Kilogram)
Age
8+ years (9 Year)
Sex
Male Neutered
Region
USA
Reactions
Seizure NOSAtaxiaWeight gain
Body systems
NeurologicOther
Outcomes
Ongoing

USA-USFDACVM-2026-US-012926

Received 2026-03-21 · MSK · MSK

Non-serious
Species
Dog
Breed
Shepherd Dog - German
Size / weight
50-99 lb (39.009 Kilogram)
Age
4-7 years (6 Year)
Sex
Female Neutered
Region
USA
Reactions
PolyuriaPolydipsiaIncreased appetiteLethargy (see also Central nervous system depression in Neurological)Elevated liver enzymes NOS
Body systems
OtherDigestiveNeurologic

USA-USFDACVM-2026-US-014240

Received 2026-03-20 · MSK · MSK

Serious
Species
Dog
Breed
Dog (unknown)
Sex
Unknown Unknown
Region
USA
Reactions
Acute renal failureElevated creatinineDrug dose administration interval too short
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2026-US-013311

Received 2026-03-19 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.44 Kilogram)
Age
8+ years (9 Year)
Sex
Male Neutered
Region
USA
Reactions
PolydipsiaPolyuriaHyperglycaemiaDiabetes mellitusUNPALATABLEProduct defect, product difficult to use/handle (see also 'Drug device difficult to use/handle')Intentional misuseOdor, Abnormal
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2026-US-014242

Received 2026-03-18 · MSK · MSK

Non-serious
Species
Dog
Breed
Spaniel - Cocker English
Size / weight
25-49 lb (12.88 Kilogram)
Age
4-7 years (5.8 Year)
Sex
Female Neutered
Region
USA
Reactions
Behavioural disorder NOSUNPALATABLEIntentional misuse
Body systems
BehaviorOther
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-013333

Received 2026-03-18 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.63 Kilogram)
Age
1-3 years (3.5 Year)
Sex
Female Neutered
Region
USA
Reactions
Neutropenia
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2026-US-012931

Received 2026-03-18 · MSK · MSK

Non-serious
Species
Cat
Breed
Tonkinese
Size / weight
10-24 lb (5.6 Kilogram)
Age
8+ years (16 Year)
Sex
Male Neutered
Region
USA
Reactions
PolyuriaPolydipsia
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2026-US-014358

Received 2026-03-16 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.37 Kilogram)
Age
1-3 years (2 Year)
Sex
Female Neutered
Region
USA
Reactions
VomitingLethargy (see also Central nervous system depression in Neurological)High pancreatic-specific lipaseDehydrationNeutrophiliaPancreatitis NOSNot eatingLeukocytosis NOSDepressionElevated gamma-glutamyl transferase (GGT)AzotaemiaAnaemia NOSHypoalbuminaemiaAbdominal effusionHyperglycaemiaElevated symmetrical dimethylarginine (SDMA)Elevated blood urea nitrogen (BUN)Elevated creatinineHyponatremiaHypochloraemiaLow serum alkaline phosphatase (ALP)Decreased red blood cell countDecreased haemoglobinProteinuria
Body systems
DigestiveNeurologicOther
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-013537

Received 2026-03-16 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Longhair
Size / weight
Under 10 lb (4.47 Kilogram)
Age
4-7 years (7 Year)
Sex
Female Neutered
Region
USA
Reactions
Localised hair lossReddening of the skinItchy skinWoundDermal thickeningAbnormal cytologyIntentional misuseLocal swelling (not application site)Reverse sneezingLeukocytosis NOSThrombocytopeniaNeutrophiliaMonocytosisSkin lesion NOS
Body systems
Skin & allergyOther
Outcomes
Ongoing

USA-USFDACVM-2026-US-012599

Received 2026-03-12 · MSK · MSK

Serious
Species
Dog
Breed
Bulldog - English
Size / weight
50-99 lb (22.68 Kilogram)
Age
4-7 years (4 Year)
Sex
Female Neutered
Region
USA
Reactions
Head tremorFly biting behaviourLack of efficacy - NOSPolydipsiaPruritusPolyuriaPyodermaElevated blood urea nitrogen (BUN)Urinary tract infectionProteinuriaHaematuria
Body systems
NeurologicBehaviorEffectivenessOtherSkin & allergy
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-011652

Received 2026-03-11 · MSK · MSK

Non-serious
Species
Dog
Breed
Shiba Inu
Size / weight
25-49 lb (14.88 Kilogram)
Age
8+ years (10.5 Year)
Sex
Female Unknown
Region
USA
Reactions
Lack of efficacy - NOSIntentional misuse
Body systems
EffectivenessOther
Outcomes
Ongoing

USA-USFDACVM-2026-US-010815

Received 2026-03-06 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (4.6 Kilogram)
Age
4-7 years (5 Year)
Sex
Female Neutered
Region
USA
Reactions
Lack of efficacy - NOS
Body systems
Effectiveness
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-008733

Received 2026-02-25 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.622 Kilogram)
Age
8+ years (15 Year)
Sex
Female Unknown
Region
USA
Reactions
Death by euthanasiaOpen mouth breathingDehydrationEnophthalmos (see also Sunken eyes in Systemic disorders)HypersalivationWeak pulseCrackles on auscultationLateral recumbencyPale mucous membraneDepressionAnaphylaxisDecreased haematocritLeukocytosis NOSMonocytosisBasophiliaThrombocytosisHyperglycaemiaElevated creatinineElevated symmetrical dimethylarginine (SDMA)HypocalcaemiaHypokalaemiaProlonged bleeding NOSAbnormal radiograph finding
Body systems
OtherDigestiveNeurologic
Outcomes
Euthanized

USA-USFDACVM-2026-US-007281

Received 2026-02-19 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.3 Kilogram)
Age
4-7 years (4 Year)
Sex
Female Intact
Region
USA
Reactions
Lack of efficacy - NOS
Body systems
Effectiveness
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-003824

Received 2026-01-26 · MSK · MSK

Non-serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (37 Kilogram)
Age
8+ years (9 Year)
Sex
Male Intact
Region
USA
Reactions
Elevated serum alkaline phosphatase (ALP)Lethargy (see also Central nervous system depression in Neurological)Anaemia NOS
Body systems
OtherNeurologic
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-075064

Received 2025-12-23 · MSK · MSK

Non-serious
Species
Dog
Breed
Terrier - Boston
Size / weight
10-24 lb (8.16 Kilogram)
Age
1-3 years (2 Year)
Sex
Female Neutered
Region
USA
Reactions
RashAlopecia
Body systems
Skin & allergy
Outcomes
Ongoing

USA-USFDACVM-2025-US-075291

Received 2025-12-22 · MSK · MSK

Serious
Species
Dog
Breed
Shepherd Dog - German
Size / weight
50-99 lb (44.45 Kilogram)
Age
8+ years (10.9 Year)
Sex
Female Unknown
Region
USA
Reactions
Lack of efficacy - NOSSeizure NOSOther abnormal test result NOSAtaxiaMusculoskeletal disorder NOSElevated serum alkaline phosphatase (ALP)
Body systems
EffectivenessNeurologicOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-074793

Received 2025-12-22 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.12 Kilogram)
Age
4-7 years (4.16 Year)
Sex
Male Neutered
Region
USA
Reactions
Foaming at the mouthUNPALATABLEBehavioural disorder NOS
Body systems
OtherBehavior
Outcomes
Recovered/Normal

USA-USFDACVM-2025-US-075362

Received 2025-12-19 · MSK · MSK

Non-serious
Species
Dog
Breed
['Retriever - Labrador', 'Mastiff (unspecified)']
Size / weight
100+ lb (57.606 Kilogram)
Age
8+ years (8 Year)
Sex
Male Neutered
Region
USA
Reactions
FallingLateral recumbencyVomiting
Body systems
OtherDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-074702

Received 2025-12-19 · MSK · MSK

Non-serious
Species
Dog
Breed
Spaniel - King Charles Cavalier
Age
4-7 years (6.5 Year)
Sex
Male Neutered
Region
USA
Reactions
Inflammatory bowel disorderAtopic allergy NOS (see also Skin)Allergic skin reactionBlepharitis
Body systems
Other
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-075225

Received 2025-12-18 · MSK · MSK

Non-serious
Species
Cat
Breed
Cat (unknown)
Size / weight
Under 10 lb (3.6 Kilogram)
Sex
Unknown Unknown
Region
USA
Reactions
Lack of efficacy - NOS
Body systems
Effectiveness
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-074991

Received 2025-12-17 · MSK · MSK

Non-serious
Species
Cat
Breed
Cat (unknown)
Sex
Unknown Unknown
Region
USA
Reactions
Behavioural disorder NOS
Body systems
Behavior
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-074916

Received 2025-12-17 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.03 Kilogram)
Age
8+ years (11 Year)
Sex
Male Neutered
Region
USA
Reactions
TremorShaking
Body systems
NeurologicOther
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-074165

Received 2025-12-17 · MSK · MSK

Non-serious
Species
Dog
Breed
Dog (unknown)
Sex
Male Unknown
Region
USA
Reactions
Behavioural disorder NOSUNPALATABLE
Body systems
BehaviorOther
Outcomes
Recovered/Normal

USA-USFDACVM-2025-US-074459

Received 2025-12-16 · MSK · MSK

Serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (33.339 Kilogram)
Age
8+ years (8 Year)
Sex
Female Unknown
Region
USA
Reactions
Immune mediated haemolytic anaemiaDeathAnaemia NOSThrombocytopeniaNeutrophiliaHeart murmurVomitingIcterusPantingNot eatingOther abnormal test result NOSElevated alanine aminotransferase (ALT)Elevated total bilirubinElevated serum alkaline phosphatase (ALP)ThrombocytosisHaemolysis NOSMedication error NOSMonocytosisLarge plateletsSpherocytosisAgglutination test, positive
Body systems
OtherDigestive
Outcomes
Died

USA-USFDACVM-2025-US-074210

Received 2025-12-16 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (4.536 Kilogram)
Age
1-3 years (3 Year)
Sex
Female Unknown
Region
USA
Reactions
Injection site mass NOSAbnormal cytology
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2025-US-073819

Received 2025-12-09 · MSK · MSK

Serious
Species
Dog
Breed
Crossbred Canine/dog
Size / weight
50-99 lb (26.49 Kilogram)
Age
8+ years (12 Year)
Sex
Female Neutered
Region
USA
Reactions
UnwellNot eatingWoundDeathNecropsy performed
Body systems
Other
Outcomes
Died

USA-USFDACVM-2025-US-072925

Received 2025-12-05 · MSK · MSK

Serious
Species
Dog
Breed
['Bulldog - American', 'Dog (unknown)']
Size / weight
50-99 lb (27.941 Kilogram)
Age
8+ years (9 Year)
Sex
Male Intact
Region
USA
Reactions
UnwellRecumbencyReduced responsesSeizure NOSStrokeDeathOverdose
Body systems
OtherNeurologic
Outcomes
Died

USA-USFDACVM-2025-US-072451

Received 2025-12-01 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.69 Kilogram)
Age
4-7 years (7 Year)
Sex
Male Neutered
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)AnorexiaElevated total bilirubinElevated gamma-glutamyl transferase (GGT)Elevated serum alkaline phosphatase (ALP)Elevated alanine aminotransferase (ALT)JaundiceEnlarged liverHidingNausea
Body systems
NeurologicDigestiveOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-072217

Received 2025-11-26 · MSK · MSK

Serious
Species
Dog
Breed
Pug
Size / weight
10-24 lb (9.979 Kilogram)
Age
4-7 years (7 Year)
Sex
Male Intact
Region
USA
Reactions
Deafness
Body systems
Other
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-072109

Received 2025-11-11 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Longhair
Size / weight
10-24 lb (4.98 Kilogram)
Age
4-7 years (4 Year)
Sex
Female Neutered
Region
USA
Reactions
Behavioural disorder NOSUNPALATABLE
Body systems
BehaviorOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-065982

Received 2025-11-03 · MSK · MSK

Serious
Species
Dog
Breed
Dachshund (unspecified)
Size / weight
10-24 lb (9.344 Kilogram)
Age
8+ years (14 Year)
Sex
Male Neutered
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)AnorexiaPale mucous membraneDecreased haematocritThrombocytopeniaImmune mediated haemolytic anaemiaHyperthermiaHeavy breathingFluid in abdomen NOSWeight lossIntentional misuse
Body systems
NeurologicDigestiveOther
Outcomes
Ongoing

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
21
Species represented
2
Grouped by Body System
Digestive (1) · Loss of appetite Skin & allergy (1) · Hair loss Neurologic (1) · Unsteady walking (ataxia) Behavior (2) · Behavioral disorder (unspecified), Aggression Other (27) · Deafness, Cyanotic mucous membranes, Crackles on auscultation
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Dog 1
Digestive 1 Cat 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (21) Cat (11)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Dog Serious - 1
Digestive Cat Serious - 1
Skin & allergy Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Behavior Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Behavior Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Jul 22, 2026, 7:08 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 69 • Cat 76 • View
Case summaries: 34 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Unsteady walking (ataxia) (1) Loss of appetite (1) Deafness (1) Cyanotic mucous membranes (1) Crackles on auscultation (1) Cough (1) Corneal ulcer (1) Congestive heart failure (1)

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 96 Clinical 7 Manufacturer 0 Marketing 0
Current Field Facts
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-21)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-20)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-19)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-17)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
  • side_effects: Top reported reactions (openFDA): Squinting, Eye irritation, Lack of efficacy - NOS, Corneal ulcer, Behavioural disorder NOS, Death by euthanasia. (Clinical, 2026-04-11)
  • side_effects: Top reported reactions (openFDA): Squinting, Eye irritation, Lack of efficacy - NOS, Corneal ulcer, Behavioural disorder NOS, Death by euthanasia. (Official, 2026-07-22)
  • side_effects: Top reported reactions (openFDA): Squinting, Eye irritation, Lack of efficacy - NOS, Corneal ulcer, Behavioural disorder NOS, Death by euthanasia. (Official, 2026-07-22)
  • side_effects: Top reported reactions (openFDA): Squinting, Eye irritation, Lack of efficacy - NOS, Corneal ulcer, Behavioural disorder NOS, Death by euthanasia. (Official, 2026-07-22)
  • side_effects: Top reported reactions (openFDA): Squinting, Eye irritation, Lack of efficacy - NOS, Corneal ulcer, Behavioural disorder NOS, Death by euthanasia. (Official, 2026-07-20)
  • side_effects: Top reported reactions (openFDA): Squinting, Eye irritation, Lack of efficacy - NOS, Corneal ulcer, Behavioural disorder NOS, Death by euthanasia. (Official, 2026-07-19)
  • side_effects: Top reported reactions (openFDA): Squinting, Eye irritation, Lack of efficacy - NOS, Corneal ulcer, Behavioural disorder NOS, Death by euthanasia. (Official, 2026-07-16)
  • side_effects: Top reported reactions (openFDA): Squinting, Eye irritation, Lack of efficacy - NOS, Corneal ulcer, Behavioural disorder NOS, Death by euthanasia. (Official, 2026-07-16)
  • side_effects: Top reported reactions (openFDA): Squinting, Eye irritation, Lack of efficacy - NOS, Corneal ulcer, Behavioural disorder NOS, Death by euthanasia. (Official, 2026-07-13)
  • side_effects: Top reported reactions (openFDA): Squinting, Eye irritation, Lack of efficacy - NOS, Corneal ulcer, Behavioural disorder NOS, Death by euthanasia. (Official, 2026-07-12)
  • side_effects: Top reported reactions (openFDA): Squinting, Eye irritation, Lack of efficacy - NOS, Corneal ulcer, Behavioural disorder NOS, Death by euthanasia. (Official, 2026-07-11)
  • side_effects: Top reported reactions (openFDA): Squinting, Eye irritation, Lack of efficacy - NOS, Corneal ulcer, Behavioural disorder NOS, Death by euthanasia. (Official, 2026-07-11)
  • side_effects: Top reported reactions (openFDA): Squinting, Eye irritation, Lack of efficacy - NOS, Corneal ulcer, Behavioural disorder NOS, Death by euthanasia. (Official, 2026-07-11)
  • side_effects: Top reported reactions (openFDA): Squinting, Eye irritation, Lack of efficacy - NOS, Corneal ulcer, Behavioural disorder NOS, Death by euthanasia. (Official, 2026-07-10)
Recent Revisions
  • side_effects updated 2026-07-22 19:08 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-22 18:40 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-22 08:29 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-20 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-19 13:48 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-16 16:34 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-16 15:43 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-13 10:06 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-12 17:56 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-11 19:04 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-11 08:49 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-11 08:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-10 21:24 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-07 10:06 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-06 20:16 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-06 08:13 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-03 20:16 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-03 11:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-02 22:45 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-01 23:29 by etl_backfill • Backfilled from existing medication fields

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Cat

Showing top 5 for Digestive.

Skin & allergy
Hair loss (1) • Dog

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Dog

Showing top 5 for Neurologic.

Behavior
Behavioral disorder (1) • Dog Aggression (1) • Cat

Showing top 5 for Behavior.

Other
Deafness (1) • Dog Cyanotic mucous membranes (1) • Dog Crackles on auscultation (1) • Cat Cough (1) • Dog Corneal ulcer (1) • Dog
Show more (22)
Conjunctivitis (1) • Dog Conjunctival oedema (1) • Cat Congestive heart failure (1) • Dog Collapse NOS (1) • Dog Bumps on skin (1) • Dog Bronchopulmonary inflammation (1) • Dog Blepharitis (1) • Dog Basophilia (1) • Cat Azotaemia (1) • Cat Atopic allergy NOS (1) • Dog Appearance, Abnormal (1) • Dog Anaphylaxis (1) • Cat Anaemia NOS (1) • Cat Allergic skin reaction (1) • Dog Agglutination test, positive (1) • Dog Administration error NOS (1) • Dog Acute renal failure (1) • Dog Accidental exposure (1) • Dog Abnormal radiograph finding (1) • Cat Abnormal histology NOS (1) • Dog Abnormal cytology (1) • Cat Abdominal effusion (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, ['Retriever - Golden', 'Poodle - Standard'], Male, 8 year, 29.48 kilogram • Drug: MSK, Capsule, Oral, Dose: 1 capsule per animal, Frequency: 1 per day • Reactions: Inappetence, Tiredness (lethargy) • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2026-US-014235
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 8.00 Year
  • Weight: 29.480 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Capsule
  • Dose: 1 capsule per animal
  • Frequency: 1 per day
Reactions Reported:
Inappetence Tiredness (lethargy)
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 10 year, 8.61 kilogram • Drug: MSK, Solution, Oral, Frequency: 1 per day • Reactions: Rash, Scratching, Behavioral disorder (unspecified), UNPALATABLE, INEFFECTIVE, ATOPY CONTROL • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-014199
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 10.00 Year
  • Weight: 8.610 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
  • Frequency: 1 per day
Reactions Reported:
Rash Scratching Behavioral disorder (unspecified) UNPALATABLE INEFFECTIVE, ATOPY CONTROL
Outcomes: Ongoing

Dog, Shepherd Dog - German, Male, 9 year, 46.72 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Seizure NOS, Unsteady walking (ataxia), Weight gain • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-013208
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 9.00 Year
  • Weight: 46.720 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Seizure NOS Unsteady walking (ataxia) Weight gain
Outcomes: Ongoing

Dog, Shepherd Dog - German, Female, 6 year, 39.009 kilogram • Drug: MSK, Capsule, Oral • Reactions: Polyuria, Polydipsia, Increased appetite, Tiredness (lethargy), Elevated liver enzymes NOS

  • Report ID: USA-USFDACVM-2026-US-012926
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 6.00 Year
  • Weight: 39.009 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Capsule
Reactions Reported:
Polyuria Polydipsia Increased appetite Tiredness (lethargy) Elevated liver enzymes NOS

Dog, Dog (unknown), Unknown • Drug: MSK, Capsule, Oral, Dose: 1 dose per animal, Frequency: 12 per hour • Reactions: Acute renal failure, Elevated creatinine, Drug dose administration interval too short • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-014240
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Unknown
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Capsule
  • Dose: 1 dose per animal
  • Frequency: 12 per hour
Reactions Reported:
Acute renal failure Elevated creatinine Drug dose administration interval too short
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 9 year, 5.44 kilogram • Drug: MSK, Solution, Oral, Dose: 1 dose per animal, Frequency: 1 per day • Reactions: Polydipsia, Polyuria, Hyperglycaemia, Diabetes mellitus, UNPALATABLE… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-013311
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 9.00 Year
  • Weight: 5.440 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
  • Dose: 1 dose per animal
  • Frequency: 1 per day
Reactions Reported:
Polydipsia Polyuria Hyperglycaemia Diabetes mellitus UNPALATABLE Product defect, product difficult to use/handle Intentional misuse Odor, Abnormal
Outcomes: Ongoing

Dog, Spaniel - Cocker English, Female, 5.8 year, 12.88 kilogram • Drug: MSK, Capsule, Oral, Dose: 1 capsule per animal, Frequency: 1 per day • Reactions: Behavioral disorder (unspecified), UNPALATABLE, Intentional misuse • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-014242
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 5.80 Year
  • Weight: 12.880 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Capsule
  • Dose: 1 capsule per animal
  • Frequency: 1 per day
Reactions Reported:
Behavioral disorder (unspecified) UNPALATABLE Intentional misuse
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Female, 3.5 year, 3.63 kilogram • Drug: MSK, Solution, Oral, Dose: 25 Milligram per animal, Frequency: 1 per day • Reactions: Neutropenia • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-013333
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 3.50 Year
  • Weight: 3.630 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
  • Dose: 25 Milligram per animal
  • Frequency: 1 per day
Reactions Reported:
Neutropenia
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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