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Roxee Medication Guide

Enalapril

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Tablet AX Pharmaceutical Corp Official label facts Owner quick guide first
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Data freshness

Reference facts
Reference refreshed
Jun 22, 2026, 10:41 a.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
Jun 22, 2026, 10:41 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
Jun 6, 2026, 10:02 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:41 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
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Enalapril

Enalapril

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Tablet Rx required 100% reference complete

Species: Both

Manufacturer: AX Pharmaceutical Corp

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Enalapril

Treatment of mild, moderate, and severe (modified New York Heart Association Class II, III, IV) heart failure in dogs. Species commonly shown: Both, Dog.

Generic name
Enalapril
Brand names
Enacard® Tablets For Dogs, Enalapril Maleate
Manufacturer
AX Pharmaceutical Corp
Species
Both, Dog
Dosage forms
Tablet
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
Enacard® Tablets For Dogs Enalapril Maleate
Dosage forms
Tablet

Indications / Uses

Treatment of mild, moderate, and severe (modified New York Heart Association Class II, III, IV) heart failure in dogs.

Warnings / Contraindications

Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of 1.0 milligram per kilogram). Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatment of dilated cardiomyopathy and furosemide with or without digoxin in the treatment of chronic valvular disease. The safety of enalapril for use in breeding dogs has not been established. Use in pregnant bitches is not recommended. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of 1.0 milligram per kilogram). Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatment of dilated cardiomyopathy and furosemide with or without digoxin in the treatment of chronic valvular disease. The safety of enalapril for use in breeding dogs has not been established. Use in pregnant bitches is not recommended. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Side Effects

Top reported reactions (openFDA): Diarrhoea, Vomiting, Lethargy (see also Central nervous system depression in 'Neurological'), Death by euthanasia, Seizure NOS, Anorexia.

FAQ

Both, Dog

Yes. Roxee shows this as prescription-only.

Tablet

Related Conditions

Dilated cardiomyopathy (dogs)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

Treatment of mild, moderate, and severe (modified New York Heart Association Class II, III, IV) heart failure in dogs.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Use 0.5 milligram per kilogram once daily
  • In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of 1.0 milligram per kilogram)
  • Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatment of dilated cardiomyopathy and furosemide with or without digoxin in the treatment of chronic valvular disease
  • The safety of enalapril for use in breeding dogs has not been established
  • Use in pregnant bitches is not recommended
  • Vomiting (1 reports)
  • wobbly/unsteady walking (1 reports)
  • trouble breathing (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Enalapril; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2025-US-045457
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 27 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2025-US-045457
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2025-US-045457
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Vomiting (1 reports), Unsteady walking (ataxia) (1 reports), Trouble breathing (dyspnea) (1 reports), Growling (1 reports), Gastroenteritis (1 reports)

Body systems represented Signal grouping

Digestive (4), Skin & allergy (1), Neurologic (1), Behavior (2)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Dog (16 reports), Cat (16 reports)

Breed metadata in reports Metadata only

Domestic Shorthair (2), Terrier - Yorkshire (1), ['Collie - Border', 'Dog (unknown)'] (1), Shepherd Dog - Australian (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Enalapril fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Use 0.5 milligram per kilogram once daily, In the absence of adequate clinical response within a 2-week period, use may be increased to twice d, Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatmen, The safety of enalapril for use in breeding dogs has not been established, Use in pregnant bitches is not recommended

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Enalapril brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2025-US-045457 · adverse_reaction · adverse reactions
  2. Contraindication source · fda_animal_drugs · warnings contraindications
  3. FDA application profile · official_label · quick facts
  4. Medication usage source · fda_animal_drugs · quick facts
  5. SPL · document · documents
  6. Structured Product Label · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 10:44 PM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Use 0.5 milligram per kilogram once daily
  • In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of 1.0 milligram per kilogram)
  • Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatment of dilated cardiomyopathy and furosemide with or without digoxin in the treatment of chronic valvular disease
  • The safety of enalapril for use in breeding dogs has not been established
  • Use in pregnant bitches is not recommended

Most reported reactions:

  • Vomiting (1 reports)
  • Unsteady walking (ataxia) (1 reports)
  • Trouble breathing (dyspnea) (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Dog
Indication / use
Treatment of mild, moderate, and severe (modified New York Heart Association Class II, III, IV) heart failure in dogs.
Form / route / dose
Form: Tablet
Route: Oral
Confirm product label and patient-specific plan.
Warnings
  • High: Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may…
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: AX Pharmaceutical Corp
Form: Tablet
Identifiers:
NADA: 141015 NDC Package: 73377-124-02 NDC Package: 73377-124-03 NDC Product: 73377
Source metadata:

Warnings / Contraindications

Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of 1.0 milligram per kilogram). Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatment of dilated cardiomyopathy and furosemide with or without digoxin in the treatment of chronic valvular disease. The safety of enalapril for use in breeding dogs has not been established. Use in pregnant bitches is not recommended. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of 1.0 milligram per kilogram). Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatment of dilated cardiomyopathy and furosemide with or without digoxin in the treatment of chronic valvular disease. The safety of enalapril for use in breeding dogs has not been established. Use in pregnant bitches is not recommended. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
12
Matching reports
2
Active filters
2
Selected filters
Reaction: Pacing Clear Body system: Other Clear
Reset
Drill into common report signals
Elevated blood urea nitrogen (BUN) (2) Hyperphosphataemia (2) Lethargy (see also Central nervous system depression in Neurological) (2) Pacing (2) Other (10) Neurologic (4) Digestive (3) Behavior (1)
Showing up to 50 matching reports.

USA-USFDACVM-2025-US-071646

Received 2025-12-04 · MSK · MSK

Serious
Species
Dog
Breed
['Collie - Border', 'Dog (unknown)']
Size / weight
25-49 lb (20.321 Kilogram)
Age
8+ years (14 Year)
Sex
Female Unknown
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)GrowlingBiting -aggression (see also Skin and appendages disorders)Not himself/herselfPacingCoughEmesis (multiple)RegurgitationWeaknessAtaxiaNot eatingElevated alanine aminotransferase (ALT)Elevated serum alkaline phosphatase (ALP)Elevated renal parametersHyperphosphataemiaUnable to walk
Body systems
NeurologicOtherBehaviorDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-071041

Received 2025-11-11 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (4.99 Kilogram)
Age
8+ years (15 Year)
Sex
Female Neutered
Region
USA
Reactions
VocalisationRestlessnessPacing
Body systems
Other
Outcomes
Recovered/Normal

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
27
Species represented
2
Grouped by Body System
Digestive (4) · Vomiting, Diarrhea, Decreased appetite Skin & allergy (1) · Biting - pruritus Neurologic (1) · Unsteady walking (ataxia) Behavior (2) · Biting -aggression, Behavioral disorder (unspecified) Other (24) · Trouble breathing (dyspnea), Growling, Gastroenteritis
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Digestive 1 Dog 1
Neurologic 1 Dog 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (16) Cat (16)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Serious - 1
Neurologic Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Digestive Cat Serious - 1
Other Cat Serious - 1
Digestive Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Behavior Dog Serious - 1
Skin & allergy Cat Non-serious - 1
Behavior Dog Serious - 1
Digestive Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Source metadata:

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

Enacard® Tablets For Dogs SPL · SPL Enalapril Maleate SPL SPL · Structured Product Label

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

2

FOI

0
No FOI links yet.

Enacard® Tablets For Dogs

SPL · SPL

Open original
FDA Structured Product Label

Enacard® Tablets For Dogs

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Boehringer Ingelheim Animal Health USA Inc.
NADA
141-015
Status
RX
Form
Tablet
Route
Oral
Species
Dog
Composition / specifications
Each tablet contains either 1.0, 2.5, 5.0, 10.0, or 20.0 milligrams of enalapril maleate.

Dogs

Indication
Treatment of mild, moderate, and severe (modified New York Heart Association Class II, III, IV) heart failure in dogs.
Dosage
0.5 to 1.0 milligram of enalapril maleate per kilogram of body weight per day.
Limitations
Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of 1.0 milligram per kilogram). Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatment of dilated cardiomyopathy and furosemide with or without digoxin in the treatment of chronic valvular disease. The safety of enalapril for use in breeding dogs has not been established. Use in pregnant bitches is not recommended. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Enalapril Maleate SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Enalapril Maleate. Use the source link for the full official labeling record.
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:41 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Enalapril Maleate
Manufacturer mapping: AX Pharmaceutical Corp
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Tablet • Oral
Applications: NADA 141-015
NDC: Packages 73377-124-02 73377-124-03 • Products 73377
Documents: • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 33 • Cat 20 • View
Case summaries: 12 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Dilated cardiomyopathy (dogs)
Linked using: Fda_Label (0.95)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of 1.0 milligram per kilogram). Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatment of dilated cardiomyopathy and furosemide with or without digoxin in the treatment of chronic valvular disease. The safety of enalapril for use in breeding dogs has not been established. Use in pregnant bitches is not recommended. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Vomiting (1) Unsteady walking (ataxia) (1) Trouble breathing (dyspnea) (1) Growling (1) Gastroenteritis (1) Elevated serum alkaline phosphatase (1) Elevated renal parameters (1) Elevated globulins (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141015 NDC Package: 73377-124-02 NDC Package: 73377-124-03 NDC Product: 73377
Package NDC Product NDC Form / Route Status
73377-124-02 73377 -
73377-124-03 73377 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • Enalapril Maleate SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 70 Clinical 1 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Diarrhoea, Vomiting, Lethargy (see also Central nervous system depression in 'Neurological'), Death by euthanasia, Seizure NO… (Clinical, 2026-04-11)
  • contraindications: Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of… (Official, 2026-04-12)
  • contraindications: Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of… (Official, 2026-04-11)
  • contraindications: Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of… (Official, 2026-02-12)
  • manufacturer_name: AX Pharmaceutical Corp (Official, 2026-06-22)
  • manufacturer_name: AX Pharmaceutical Corp (Official, 2026-06-22)
  • manufacturer_name: AX Pharmaceutical Corp (Official, 2026-06-21)
  • manufacturer_name: AX Pharmaceutical Corp (Official, 2026-06-20)
  • manufacturer_name: AX Pharmaceutical Corp (Official, 2026-06-13)
  • manufacturer_name: AX Pharmaceutical Corp (Official, 2026-06-12)
  • manufacturer_name: AX Pharmaceutical Corp (Official, 2026-06-12)
  • manufacturer_name: AX Pharmaceutical Corp (Official, 2026-06-11)
  • manufacturer_name: AX Pharmaceutical Corp (Official, 2026-06-11)
  • manufacturer_name: AX Pharmaceutical Corp (Official, 2026-06-10)
  • manufacturer_name: AX Pharmaceutical Corp (Official, 2026-06-09)
  • manufacturer_name: AX Pharmaceutical Corp (Official, 2026-06-08)
  • manufacturer_name: AX Pharmaceutical Corp (Official, 2026-06-07)
  • manufacturer_name: AX Pharmaceutical Corp (Official, 2026-06-06)
  • manufacturer_name: AX Pharmaceutical Corp (Official, 2026-06-05)
  • manufacturer_name: AX Pharmaceutical Corp (Official, 2026-06-04)
Recent Revisions
  • side_effects updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Enacard® Tablets For Dogs
RX
Enalapril Maleate
Tablet • Oral
Label highlights
Official documents
Boehringer Ingelheim Animal Health USA Inc. NADA 141-015 W May 15, 2024

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog
Composition / specifications
Each tablet contains either 1.0, 2.5, 5.0, 10.0, or 20.0 milligrams of enalapril maleate.
Dogs
Indication
Treatment of mild, moderate, and severe (modified New York Heart Association Class II, III, IV) heart failure in dogs.
Dosage
0.5 to 1.0 milligram of enalapril maleate per kilogram of body weight per day.
Limitations
Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of 1.0 milligram per kilogram). Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatment of dilated cardiomyopathy and furosemide with or without digoxin in the treatment of chronic valvular disease. The safety of enalapril for use in breeding dogs has not been established. Use in pregnant bitches is not recommended. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Usage

Treatment of mild, moderate, and severe (modified New York Heart Association Class II, III, IV) heart failure in dogs.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Use 0.5 milligram per kilogram once daily. In the absence of adequate clinical response within a 2-week period, use may be increased to twice daily (a total of 1.0 milligram per kilogram). Enalapril maleate is administered as conjunctive therapy with furosemide and digoxin in the treatment of dilated cardiomyopathy and furosemide with or without digoxin in the treatment of chronic valvular disease. The safety of enalapril for use in breeding dogs has not been established. Use in pregnant bitches is not recommended. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Diarrhea (1) • Cat Decreased appetite (1) • Cat Appetite disorder NOS (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Biting - pruritus (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Dog

Showing top 5 for Neurologic.

Behavior
Biting -aggression (1) • Dog Behavioral disorder (1) • Dog

Showing top 5 for Behavior.

Other
Trouble breathing (1) • Cat Growling (1) • Dog Gastroenteritis (1) • Cat Elevated symmetrical dimethylarginine (1) • Dog Elevated serum alkaline phosphatase (1) • Dog
Show more (19)
Elevated renal parameters (1) • Dog Elevated globulins (1) • Dog Elevated creatinine (1) • Cat Elevated blood urea nitrogen (1) • Dog Elevated alanine aminotransferase (1) • Dog Dull reflexes (1) • Cat Dry coat (1) • Cat Disorientation (1) • Cat Decreased haematocrit (1) • Cat Death by euthanasia (1) • Cat Crackles on auscultation (1) • Dog Cough (1) • Dog Congestive heart failure (1) • Cat Cognitive disorder NOS (1) • Dog Bronchitis (1) • Dog Anaemia NOS (1) • Cat Administration error NOS (1) • Cat Abnormal posture NOS (1) • Cat Abnormal echocardiogram (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Terrier - Yorkshire, Female, 13.5 year, 2.8 kilogram • Drug: MSK, Unknown • Reactions: Pale mucous membrane, Laboured breathing, Increased respiratory rate, Crackles on auscultation, Prolonged capillary refill time… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-072177
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 13.50 Year
  • Weight: 2.800 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Pale mucous membrane Laboured breathing Increased respiratory rate Crackles on auscultation Prolonged capillary refill time Other abnormal test result NOS
Outcomes: Ongoing

Dog, ['Collie - Border', 'Dog (unknown)'], Female, 14 year, 20.321 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Tiredness (lethargy), Growling, Biting -aggression, Not himself/herself, Pacing… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-071646
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 14.00 Year
  • Weight: 20.321 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Tiredness (lethargy) Growling Biting -aggression Not himself/herself Pacing Cough Vomiting Regurgitation Weakness Unsteady walking (ataxia) Not eating Elevated alanine aminotransferase Elevated serum alkaline phosphatase Elevated renal parameters Hyperphosphataemia Unable to walk
Outcomes: Ongoing

Dog, Shepherd Dog - Australian, Male, 12.92 year, 11.79 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Tiredness (lethargy), Inappetence, Elevated blood urea nitrogen, Vomiting • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-074767
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 12.92 Year
  • Weight: 11.790 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Tiredness (lethargy) Inappetence Elevated blood urea nitrogen Vomiting
Outcomes: Ongoing

Dog, Terrier - Boston, Female, 12 year, 9.163 kilogram • Drug: MSK, Unknown • Reactions: Head tremor • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-075069
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 12.00 Year
  • Weight: 9.163 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Head tremor
Outcomes: Ongoing

Dog, Chihuahua, Female, 1 year, 4.99 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Limb weakness, Proprioception abnormality • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-073558
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 1.00 Year
  • Weight: 4.990 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Limb weakness Proprioception abnormality
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 13.1 year, 7.66 kilogram • Drug: MSK, Unknown • Reactions: Dry coat, Dull reflexes, Elevated blood urea nitrogen, Elevated creatinine, Hyperphosphataemia… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-072103
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 13.10 Year
  • Weight: 7.660 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Dry coat Dull reflexes Elevated blood urea nitrogen Elevated creatinine Hyperphosphataemia Hypokalaemia Hypertrophic concentric cardiomyopathy Decreased haematocrit Syncope Hypertension
Outcomes: Ongoing

Dog, Dachshund - Miniature, Male, 15 year, 7.167 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Elevated globulins, Leucocytosis NOS, Neutrophilia, Monocytosis, Seizure NOS • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-073427
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 15.00 Year
  • Weight: 7.167 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Elevated globulins Leucocytosis NOS Neutrophilia Monocytosis Seizure NOS
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 7 year, 5.1 kilogram • Drug: MSK, Oral, Dose: 2.50 Milligram per animal, Frequency: 1 per day • Reactions: Loose stool • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-069860
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 7.00 Year
  • Weight: 5.100 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Dose: 2.50 Milligram per animal
  • Frequency: 1 per day
Reactions Reported:
Loose stool
Outcomes: Recovered/Normal

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

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Storage & Handling

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