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Roxee Medication Guide

Eprinomectin

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete Livestock/food-animal use Rx required Liquid Multiple FDA labelers Official label facts Owner quick guide first
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Eprinomectin

Eprinomectin

Drug type: Food-animal record • Branded profile • Livestock/food-animal use

Both Liquid Rx required 100% reference complete

Species: Both

Approval status: Food-animal or livestock record. This source record is for livestock or food-animal use, not a dog/cat medication profile. Food-animal rules, withdrawal intervals, and residue restrictions may apply.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Eprinomectin

The drug is used in beef and dairy cattle for treatment and control of gastrointestinal roundworms ( Haemonchus placei (adult and L4), Ostertagia ostertagi (adult and L4, including inhibited L4), Trichostrongylus axei (adult and L4), T. colubriformis (adult and L4), T. longispicularis (adult), Cooperia oncophora (adult and L4), C. punctate (adult and L4), C. surnabada (adult and L4), Nematodirus helvetianus (adult and L4), Bunostomum phlebotomum (adult and L4), Oesophagostomum radiatum (adult and L4), Strongyloides papillosus (adults), Trichuris species (adults)); lungworms ( Dictyocaulus viviparous, adult and L4); cattle grubs (all parasitic stages Hypoderma lineatum, H. bovis ); lice ( Damalinia bovis, Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus ); mange mites ( Chorioptes bovis, Sarcoptes scabiei ); and horn flies ( Haematobia irritans ). Controls and protects from reinfection of D. viviparous for 21 days after treatment and H. irritans for 7 days after treatment. Persistent Activity LONGRANGE ® (eprinomectin) has been proven to effectively protect cattle from reinfection with the following parasites for the indicated amounts of time following treatment:Parasites Duration of Persistent Effectiveness Gastrointestinal Roundworms Bunostomum phlebotomum 150 days Cooperia oncophora 100 days Cooperia punctata 100 days Haemonchus placei 120 days Oesophagostomum radiatum 120 days Ostertagia lyrata 120 days Ostertagia ostertagi 120 days Trichostrongylus axei 100 days Lungworms Dictyocaulus viviparous 150 days For the treatment and control of the following parasites: Gastrointestinal Roundworms Bunostomum phlebotomum : Adults and L4 Cooperia oncophora : Adults and L4 Cooperia punctata : Adults and L4 Cooperia surnabada : Adults and L4 Haemonchus placei : Adults Oesophagostomum radiatum : Adults Ostertagia lyrata : Adults Ostertagia ostertagi : Adults, L4, and inhibited L4 Trichostrongylus axei : Adults and L4 Trichostrongylus colubriformis : Adults Lungworms Dictyocaulus viviparus : Adults Grubs Hypoderma bovis Mites Sarcoptes scabiei var. bovis Species commonly shown: Both, Pasture.

Generic name
Eprinomectin
Brand names
Eprinex®, Longrange®, Eprizero®, Eprimectin™ Pour-On
Manufacturer
Multiple FDA labelers
Species
Both, Pasture, Beef And Dairy, Dairy
Dosage forms
Liquid, Liquid (Solution), Topical Solution
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
Eprinex® Longrange® Eprizero® Eprimectin™ Pour-On EpriGard® LongRange Eprinomectin Eprinomectine EpriGard Pour-On for Beef and Dairy Cattle EPRINEX Pour-On for Beef and Dairy Cattle Eprizero Eprimectin
Dosage forms
Liquid Liquid (Solution) Topical Solution

Indications / Uses

The drug is used in beef and dairy cattle for treatment and control of gastrointestinal roundworms ( Haemonchus placei (adult and L4), Ostertagia ostertagi (adult and L4, including inhibited L4), Trichostrongylus axei (adult and L4), T. colubriformis (adult and L4), T. longispicularis (adult), Cooperia oncophora (adult and L4), C. punctate (adult and L4), C. surnabada (adult and L4), Nematodirus helvetianus (adult and L4), Bunostomum phlebotomum (adult and L4), Oesophagostomum radiatum (adult and L4), Strongyloides papillosus (adults), Trichuris species (adults)); lungworms ( Dictyocaulus viviparous , adult and L4); cattle grubs (all parasitic stages Hypoderma lineatum , H. bovis ); lice ( Damalinia bovis , Linognathus vituli , Haematopinus eurysternus , Solenopotes capillatus ); mange mites ( Chorioptes bovis , Sarcoptes scabiei ); and horn flies ( Haematobia irritans ). Controls and protects from reinfection of D. viviparous for 21 days after treatment and H. irritans for 7 days after treatment. Persistent Activity LONGRANGE ® (eprinomectin) has been proven to effectively protect cattle from reinfection with the following parasites for the indicated amounts of time following treatment:Parasites Duration of Persistent Effectiveness Gastrointestinal Roundworms Bunostomum phlebotomum 150 days Cooperia oncophora 100 days Cooperia punctata 100 days Haemonchus placei 120 days Oesophagostomum radiatum 120 days Ostertagia lyrata 120 days Ostertagia ostertagi 120 days Trichostrongylus axei 100 days Lungworms Dictyocaulus viviparous 150 days For the treatment and control of the following parasites: Gastrointestinal Roundworms Bunostomum phlebotomum : Adults and L4 Cooperia oncophora : Adults and L4 Cooperia punctata : Adults and L4 Cooperia surnabada : Adults and L4 Haemonchus placei : Adults Oesophagostomum radiatum : Adults Ostertagia lyrata : Adults Ostertagia ostertagi : Adults, L4, and inhibited L4 Trichostrongylus axei : Adults and L4 Trichostrongylus colubriformis : Adults Lungworms Dictyocaulus viviparus : Adults Grubs Hypoderma bovis Mites Sarcoptes scabiei var. bovis

Warnings / Contraindications

Apply topically along backbone from withers to tailhead. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Do not use in calves to be processed for veal. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal. Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal.Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing.

  • Apply topically along backbone from withers to tailhead. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Do not use in calves to be processed for veal. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal. Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal.Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing.

Side Effects

Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia.

FAQ

Both, Pasture, Beef And Dairy, Dairy, lactating

Yes. Roxee shows this as prescription-only.

Liquid, Liquid (Solution), Topical Solution

Related Conditions

Gastrointestinal (additional) Mange (sarcoptic mange, demodicosis) Pica Sarcoptic Mange (Scabies)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi) , lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy...

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Apply topically along backbone from withers to tailhead
  • Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism
  • Do not use in calves to be processed for veal
  • This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows
  • Use in these cattle may cause drug residues in milk and/or in calves born to these cows
  • Not for use in breeding bulls, or in calves less than 3 months of age
  • Not for use in cattle managed in feedlots or under intensive rotational grazing
  • Do not use in calves to be processed for veal.Not for use in breeding bulls, or in calves less than 3 months of age
  • Death (1 reports)
  • Blindness (1 reports)
  • Vomiting (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Eprinomectin; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2025-US-055900
Safety signal coverage Reported signals

32 tracked reaction signals; 31 reported cases; 2 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2025-US-055900
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2025-US-055900
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Death (1 reports), Blindness (1 reports), Vomiting (1 reports), Urinary tract infection (1 reports), Unsteady walking (ataxia) (1 reports)

Body systems represented Signal grouping

Digestive (3), Skin & allergy (2), Neurologic (4), Effectiveness (2)

Species and breed lens

Species represented in reports Species lens

Cat (21 reports), Dog (11 reports)

What your vet may verify

Fit for this patient Vet check

Verify whether Eprinomectin fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Apply topically along backbone from withers to tailhead, Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism, Do not use in calves to be processed for veal, This drug product is not approved for use in female dairy cattle 20 months of age or older, includin, Use in these cattle may cause drug residues in milk and/or in calves born to these cows

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Eprinomectin brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2025-US-055900 · adverse_reaction · adverse reactions
  2. Contraindication source · fda_animal_drugs · warnings contraindications
  3. FDA application profile · official_label · quick facts
  4. FDA application profile · official_label · quick facts
  5. Medication usage source · fda_animal_drugs · quick facts
  6. FOI · document · documents
  7. SPL · document · documents
  8. FOI · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 10:44 PM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Apply topically along backbone from withers to tailhead
  • Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism
  • Do not use in calves to be processed for veal
  • This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows
  • Use in these cattle may cause drug residues in milk and/or in calves born to these cows

Most reported reactions:

  • Death (1 reports)
  • Blindness (1 reports)
  • Vomiting (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Beef And Dairy, Dairy, Pasture
Indication / use
For the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi) , lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange…
Form / route / dose
Form: Liquid, Liquid (Solution), Topical Solution
Route: Subcutaneous, Topical
Confirm product label and patient-specific plan.
Warnings
  • High: Apply topically along backbone from withers to tailhead. Consult your veterinarian for assistance in the diagnosis, tre…
Adverse-event caveat
No stored openFDA case explorer rows are linked yet.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Multiple FDA labelers
Form: Liquid, Liquid (Solution), Topical Solution
Identifiers:
ANADA: 200563 ANADA: 200626 ANADA: 200741 NADA: 141079 NADA: 141327 NADA: 141492 NADA: 6686 NDC Package: 0010-4120-01 NDC Package: 0010-4120-02 NDC Package: 0010-4120-03 NDC Package: 0010-4121-01 NDC Package: 0010-4121-02 NDC Package: 0010-4121-03 NDC Package: 0010-4251-01 NDC Package: 0010-4251-02 NDC Package: 0010-4751-01 NDC Package: 0010-4751-02 NDC Package: 0010-4751-03 NDC Package: 0010-4751-04 NDC Package: 0010-4751-05
Source metadata:

Warnings / Contraindications

Apply topically along backbone from withers to tailhead. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Do not use in calves to be processed for veal. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal. Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal.Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing.

  • High: Apply topically along backbone from withers to tailhead. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Do not use in calves to be processed for veal. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal. Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal.Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
31
Serious reports
2
Species represented
2
Grouped by Body System
Digestive (3) · Vomiting, Loss of appetite, Blood in vomit Skin & allergy (2) · Itching, Application site itching Neurologic (4) · Unsteady walking (ataxia), Tremors, Tiredness (lethargy) Effectiveness (2) · Lack of efficacy (endoparasite) - roundworm NOS, Lack of efficacy (endoparasite) - hookworm Other (21) · Urinary tract infection, Scaly condition NOS, Peeling skin
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Cat 1
Other 1 Dog 1
Digestive 1 Cat 0
Other 1 Dog 0
Neurologic 1 Cat 0
Neurologic 1 Dog 0
Neurologic 1 Cat 0
Other 1 Cat 0

Species coverage: Cat (21) Dog (11)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Cat Non-serious - 1
Other Dog Non-serious - 1
Neurologic Cat Non-serious - 1
Neurologic Dog Non-serious - 1
Neurologic Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Neurologic Dog Non-serious - 1
Digestive Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Effectiveness Cat Non-serious - 1
Effectiveness Cat Non-serious - 1
Skin & allergy Dog Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Digestive Cat Non-serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Skin & allergy Cat Non-serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Unknown - -
Source metadata:

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

141-327 Official label / PI · EA 141-327 Official label / PI · FONSI 141-079 Official label / PI · EA

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

4

SPL

14

FOI

9

141-327

Official label / PI · EA

Open original

141-327

Official label / PI · FONSI

Open original

141-079

Official label / PI · EA

Open original

141-079

Official label / PI · FONSI

Open original

Eprimectin™ Pour-On

SPL · SPL

Open original
FDA Structured Product Label

Eprimectin™ Pour-On

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Bimeda Animal Health Ltd.
ANADA
200-626
Status
OTC
Form
Topical Solution
Route
Topical
Species
Beef And Dairy • Dairy
Composition / specifications
5 mg eprinomectin/mL

Beef and dairy cattle, including lactating dairy cattle

Indication

For the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle.
Applied at the recommended dose volume of 1 mL/10 kg (22 lb) body weight, to achieve a dose level of 500 mcg eprinomectin/kg body weight, Eprimectin™ Pour-On is indicated for the effective treatment and control of the following parasites:

Gastrointestinal Roundworms
Haemonchus placei (adults and L4)
Ostertagia ostertagi (adults and L4) (including inhibited L4)
Trichostrongylus axei (adults and L4)
Trichostrongylus colubriformis (adults and L4)
Trichostrongylus longispicularis (adults only)
Cooperia oncophora (adults and L4)
Cooperia punctata (adults and L4)
Cooperia surnabada (adults and L4)
Nematodirus helvetianus (adults and L4)
Oesophagostomum radiatum (adults and L4)
Bunostomum phlebotomum (adults and L4)
Strongyloides papillosus (adults only)
Trichuris spp. (adults only)

Lungworms
Dictyocaulus viviparus (adults and L4)

Cattle Grubs (all parasitic stages)
Hypoderma lineatum
Hypoderma bovis

Lice
Damalinia bovis
Linognathus vituli
Haematopinus eurysternus
Solenopotes capillatus

Mange Mites
Chorioptes bovis
Sarcoptes scabiei

Horn Flies
Haematobia irritans

Persistent Activity
Eprinomectin pour-on for beef and dairy cattle has been proved to effectively control infections and to protect cattle from re-infection with Dictyocaulus viviparus for 21 days after treatment and Haematobia irritans for 7 days after treatment.

Dosage

The dose rate is 1 mL/10 kg (22 lb) of body weight. The product should be applied topically along the backline in a narrow strip extending from the withers to the tail head.

EpriGard®

SPL · SPL

Open original
FDA Structured Product Label

EpriGard®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Aurora Pharmaceutical, Inc.
ANADA
200-741
Status
OTC
Form
Topical Solution
Route
Topical
Species
Beef And Dairy • Dairy
Composition / specifications
5 mg/mL

Beef and Dairy Cattle, including Lactating Dairy Cattle

Indication

For the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle.
Applied at the recommended dose volume of 1 mL/10 kg (22 lb) body weight, to achieve a dose level of 500 mcg eprinomectin/kg body weight, it is indicated for the effective treatment and control of the following parasites:

Gastrointestinal Roundworms
Haemonchus placei (adults and L4)
Ostertagia ostertagi (adults and L4)
(including inhibited L4)
Trichostrongylus axei (adults and L4)
Trichostrongylus colubriformis (adults and L4)
Trichostrongylus longispicularis (adults only)
Cooperia oncophora (adults and L4)
Cooperia punctata (adults and L4)
Cooperia surnabada (adults and L4)
Nematodirus helvetianus (adults and L4)
Oesophagostomum radiatum (adults and L4)
Bunostomum phlebotomum (adults and L4)
Strongyloides papillosus (adults only)
Trichuris spp. (adults only)
Lungworms
Dictyocaulus viviparus (adults and L4)
Cattle Grubs (all parasitic stages)
Hypoderma lineatum
Hypoderma bovis
Lice
Damalinia bovis
Linognathus vituli
Haematopinus eurysternus
Solenopotes capillatus
Mange Mites
Chorioptes bovis
Sarcoptes scabiei
Horn Flies
Haematobia irritans
Persistent Activity
EpriGard™ (eprinomectin) Pour-On for Beef and Dairy Cattle has been proved to effectively control infections and to protect cattle from re-infection with Dictyocaulus viviparus for 21 days after treatment and Haematobia irritans for 7 days after treatment.

Dosage

The dose rate is 1 mL/10 kg (22 lb) of body weight. The product should be applied topically along the backline in a narrow strip extending from the withers to the tailhead.

Longrange®

SPL · SPL

Open original
FDA Structured Product Label

Longrange®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Boehringer Ingelheim Animal Health USA, Inc.
NADA
141-327
Status
RX
Form
Liquid (Solution)
Route
Subcutaneous
Species
Pasture
Composition / specifications
Each milliliter of solution contains 50 milligrams (mg) eprinomectin.

Cattle (On Pasture)

Indication

Persistent Activity LONGRANGE® (eprinomectin) has been proven to effectively protect cattle from reinfection with the following parasites for the indicated amounts of time following treatment:Parasites Duration of Persistent Effectiveness Gastrointestinal Roundworms Bunostomum phlebotomum 150 daysCooperia oncophora 100 days Cooperia punctata 100 days Haemonchus placei 120 days Oesophagostomum radiatum 120 days Ostertagia lyrata 120 days Ostertagia ostertagi 120 days Trichostrongylus axei 100 days Lungworms Dictyocaulus viviparous 150 days

Dosage
Administer 1 mg eprinomectin per kg body weight (1 mL/110 lb body weight).
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal. Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing.
Indication
For the treatment and control of the following parasites: Gastrointestinal Roundworms Bunostomum phlebotomum: Adults and L4 Cooperia oncophora : Adults and L4 Cooperia punctata : Adults and L4 Cooperia surnabada : Adults and L4 Haemonchus placei : Adults Oesophagostomum radiatum : Adults Ostertagia lyrata : Adults Ostertagia ostertagi : Adults, L4, and inhibited L4 Trichostrongylus axei : Adults and L4 Trichostrongylus colubriformis : Adults Lungworms Dictyocaulus viviparus : Adults Grubs Hypoderma bovis Mites Sarcoptes scabiei var. bovis
Dosage
Administer 1 mg eprinomectin per kg body weight (1 mL/110 lb body weight).
Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal.Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing.

Eprinex®

SPL · SPL

Open original
FDA Structured Product Label

Eprinex®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Boehringer Ingelheim Animal Health USA, Inc.
NADA
141-079
Status
OTC
Form
Liquid
Route
Topical
Composition / specifications
Each milliliter contains 5 milligrams of eprinomectin.

Beef and Dairy Cattle

Indication
The drug is used in beef and dairy cattle for treatment and control of gastrointestinal roundworms (Haemonchus placei (adult and L4), Ostertagia ostertagi (adult and L4, including inhibited L4), Trichostrongylus axei (adult and L4), T. colubriformis (adult and L4), T. longispicularis (adult), Cooperia oncophora (adult and L4), C. punctate (adult and L4), C. surnabada (adult and L4), Nematodirus helvetianus (adult and L4), Bunostomum phlebotomum (adult and L4), Oesophagostomum radiatum (adult and L4), Strongyloides papillosus (adults), Trichuris species (adults)); lungworms (Dictyocaulus viviparous, adult and L4); cattle grubs (all parasitic stages Hypoderma lineatum, H. bovis); lice (Damalinia bovis, Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus); mange mites (Chorioptes bovis, Sarcoptes scabiei); and horn flies (Haematobia irritans). Controls and protects from reinfection of D. viviparous for 21 days after treatment and H. irritans for 7 days after treatment.
Dosage
One milliliter (5 milligrams) per 10 kilograms (22 Lbs) of body weight
Limitations
Apply topically along backbone from withers to tailhead. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Do not use in calves to be processed for veal.

Eprizero®

SPL · SPL

Open original
FDA Structured Product Label

Eprizero®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Norbrook Laboratories, Ltd.
ANADA
200-563
Status
OTC
Form
Topical Solution
Route
Topical
Species
Beef And Dairy • Dairy
Composition / specifications
5 mg/mL

Beef and dairy cattle, including lactating dairy cattle

Indication

For the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle. Eprizero™ Pour-On is indicated for the effective treatment and control of the following parasites:

Gastrointestinal Roundworms

  • Haemonchus placei (adults and L4)
  • Ostertagia ostertagi (adults and L4) (including inhibited L4)
  • Trichostrongylus axei (adults and L4)
  • Trichostrongylus colubriformis (adults and L4)
  • Trichostrongylus longispicularis (adults only)
  • Cooperia onchophora (adults and L4) 
  • Cooperia punctata (adults and L4) 
  • Cooperia surnabada (adults and L4)
  • Nematodirus helvetianus (adults and L4)
  • Oesophagostomum radiatum (adults and L4)
  • Bunostomum phlebotomum (adults and L4)
  • Strongyloides papillosus (adults only) 
  • Trichuris spp. (adults only)

 Lungworms

  • Dictyocaulus viviparus (adults and L4) 

Cattle Grubs (all parasitic stages)
  • Hypoderma lineatum 
  • Hypoderma bovis 
Lice 
  • Damalinia bovis 
  • Linognathus vituli 
  • Haematopinus eurysternus 
  • Solenopotes capillatus 
Mange Mites 
  • Chorioptes bovis 
  • Sarcoptes scabiei 
Horn Flies 
  • Haematobia irritans

Dosage

1 mL/10 kg (22 lb) body weight, to achieve a dose level of 500 mcg eprinomectin/kg body weight.

EpriGard Pour-On for Beef and Dairy Cattle SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for EpriGard Pour-On for Beef and Dairy Cattle. Use the source link for the full official labeling record.

Eprinomectin SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Eprinomectin. Use the source link for the full official labeling record.

Eprinomectine SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Eprinomectine. Use the source link for the full official labeling record.

Eprinomectine SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Eprinomectine. Use the source link for the full official labeling record.

LongRange SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for LongRange. Use the source link for the full official labeling record.

Eprizero SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Eprizero. Use the source link for the full official labeling record.

Eprimectin SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Eprimectin. Use the source link for the full official labeling record.

EPRINEX Pour-On for Beef and Dairy Cattle SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for EPRINEX Pour-On for Beef and Dairy Cattle. Use the source link for the full official labeling record.

EpriGard Pour-On for Beef and Dairy Cattle SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for EpriGard Pour-On for Beef and Dairy Cattle. Use the source link for the full official labeling record.

FOI Summary oA 200-626 Approved January 13, 2025.pdf

FOI · FOI

Open original

FOI Summary oA 200-741 Approved February 24, 2023.pdf

FOI · FOI

Open original

UCM409097.pdf

FOI · FOI

Open original

N-141327-Q-0106-OT-AA_foi.pdf

FOI · FOI

Open original

N141079_Supp_8_9_1998.pdf

FOI · FOI

Open original

N141079_Orig_4_16_1997.pdf

FOI · FOI

Open original

FOI Summary oA 200-563 Approved January 16, 2018.pdf

FOI · FOI

Open original

FOI Summary 006-686 Granted February 18, 2026.pdf

FOI · FOI summary

Open original

FOI Summary oN 141-492 Approved March 8, 2018.pdf

FOI · FOI summary

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:45 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:40 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: EPRINEX Pour-On for Beef and Dairy Cattle EpriGard Pour-On for Beef and Dairy Cattle Eprimectin Eprinomectin Eprinomectine Eprizero LongRange
Manufacturer mapping: Multiple FDA labelers
Catalog species: Both • FDA-labeled species: Beef And Dairy, Dairy, Pasture
Rx/OTC: OTC, RX
Form/route: Liquid, Liquid (Solution), Topical Solution • Subcutaneous, Topical
Applications: ANADA 200-626 • ANADA 200-741 • NADA 141-327 • NADA 141-079 • ANADA 200-563
NDC: Packages 0010-4751-01 0010-4751-02 0010-4751-03 0010-4751-04 0010-4751-05 0010-4751-06 • Products 0010 51072 55529 61133 68171 82298
Documents: 11 (FOI: 7) • SPL: 5 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 0 • Cat 0 • View
Case summaries: 0
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: B74.8 ICD10_CM: B86
Other filariases

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Apply topically along backbone from withers to tailhead. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Do not use in calves to be processed for veal. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal. Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal.Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing. (Contraindication, High)
Top reaction signals
Death (1) Blindness (1) Vomiting (1) Urinary tract infection (1) Unsteady walking (ataxia) (1) Tremors (1) Tiredness (lethargy) (1) Scaly condition NOS (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200563 ANADA: 200626 ANADA: 200741 NADA: 141079 NADA: 141327 NADA: 141492 NADA: 6686 NDC Package: 0010-4120-01 NDC Package: 0010-4120-02 NDC Package: 0010-4120-03 NDC Package: 0010-4121-01 NDC Package: 0010-4121-02 NDC Package: 0010-4121-03 NDC Package: 0010-4251-01 NDC Package: 0010-4251-02 NDC Package: 0010-4751-01 NDC Package: 0010-4751-02 NDC Package: 0010-4751-03 NDC Package: 0010-4751-04 NDC Package: 0010-4751-05 NDC Package: 0010-4751-06 NDC Package: 0010-7216-02 NDC Package: 0010-7216-03 NDC Package: 0010-7216-04
Package NDC Product NDC Form / Route Status
0010-4120-01 0010 -
0010-4120-02 0010 -
0010-4120-03 0010 -
0010-4121-01 0010 -
0010-4121-02 0010 -
0010-4121-03 0010 -
0010-4251-01 0010 -
0010-4251-02 0010 -
0010-4751-01 0010 -
0010-4751-02 0010 -
0010-4751-03 0010 -
0010-4751-04 0010 -
0010-4751-05 0010 -
0010-4751-06 0010 -
0010-7216-02 0010 -
0010-7216-03 0010 -
0010-7216-04 0010 -
51072-109-00 51072 -
51072-109-01 51072 -
51072-109-02 51072 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 78 Clinical 60 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-22)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-22)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-21)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-20)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-13)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-12)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-12)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-11)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-11)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-10)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-08)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-07)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-06)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-05)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-04)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-03)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-02)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-01)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-06-01)
  • side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Clinical, 2026-05-31)
Recent Revisions
  • side_effects updated 2026-06-22 10:45 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-22 10:45 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-22 10:45 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-22 10:04 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-22 10:04 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-22 10:04 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-21 05:18 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-21 05:18 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-21 05:18 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-20 20:58 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-20 20:58 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-20 20:58 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-13 11:33 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-13 11:33 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-13 11:33 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-12 10:42 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-12 10:42 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-12 10:42 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-12 10:04 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-12 10:04 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Eprimectin™ Pour-On
OTC
Eprinomectin
Topical Solution • Topical
Label highlights
Official documents
Bimeda Animal Health Ltd. ANADA 200-626 Approved Feb 5, 2025
EpriGard®
OTC
Eprinomectin
Topical Solution • Topical
Label highlights
Official documents
Aurora Pharmaceutical, Inc. ANADA 200-741 Approved Nov 12, 2024
Longrange®
RX
Eprinomectin
Liquid (Solution) • Subcutaneous
Label highlights
Official documents
Boehringer Ingelheim Animal Health USA, Inc. NADA 141-327 Approved Apr 30, 2024
Eprinex®
OTC
Eprinomectin
Liquid • Topical
Label highlights
Official documents
Boehringer Ingelheim Animal Health USA, Inc. NADA 141-079 Approved Mar 18, 2024
Eprizero®
OTC
Eprinomectin
Topical Solution • Topical
Label highlights
Official documents
Norbrook Laboratories, Ltd. ANADA 200-563 Approved Jul 2, 2018

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Beef And Dairy • Dairy
Composition / specifications
5 mg eprinomectin/mL
Beef and dairy cattle, including lactating dairy cattle
Indication

For the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle.
Applied at the recommended dose volume of 1 mL/10 kg (22 lb) body weight, to achieve a dose level of 500 mcg eprinomectin/kg body weight, Eprimectin™ Pour-On is indicated for the effective treatment and control of the following parasites:

Gastrointestinal Roundworms
Haemonchus placei (adults and L4)
Ostertagia ostertagi (adults and L4) (including inhibited L4)
Trichostrongylus axei (adults and L4)
Trichostrongylus colubriformis (adults and L4)
Trichostrongylus longispicularis (adults only)
Cooperia oncophora (adults and L4)
Cooperia punctata (adults and L4)
Cooperia surnabada (adults and L4)
Nematodirus helvetianus (adults and L4)
Oesophagostomum radiatum (adults and L4)
Bunostomum phlebotomum (adults and L4)
Strongyloides papillosus (adults only)
Trichuris spp. (adults only)

Lungworms
Dictyocaulus viviparus (adults and L4)

Cattle Grubs (all parasitic stages)
Hypoderma lineatum
Hypoderma bovis

Lice
Damalinia bovis
Linognathus vituli
Haematopinus eurysternus
Solenopotes capillatus

Mange Mites
Chorioptes bovis
Sarcoptes scabiei

Horn Flies
Haematobia irritans

Persistent Activity
Eprinomectin pour-on for beef and dairy cattle has been proved to effectively control infections and to protect cattle from re-infection with Dictyocaulus viviparus for 21 days after treatment and Haematobia irritans for 7 days after treatment.

Dosage

The dose rate is 1 mL/10 kg (22 lb) of body weight. The product should be applied topically along the backline in a narrow strip extending from the withers to the tail head.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Beef And Dairy • Dairy
Composition / specifications
5 mg/mL
Beef and Dairy Cattle, including Lactating Dairy Cattle
Indication

For the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle.
Applied at the recommended dose volume of 1 mL/10 kg (22 lb) body weight, to achieve a dose level of 500 mcg eprinomectin/kg body weight, it is indicated for the effective treatment and control of the following parasites:

Gastrointestinal Roundworms
Haemonchus placei (adults and L4)
Ostertagia ostertagi (adults and L4)
(including inhibited L4)
Trichostrongylus axei (adults and L4)
Trichostrongylus colubriformis (adults and L4)
Trichostrongylus longispicularis (adults only)
Cooperia oncophora (adults and L4)
Cooperia punctata (adults and L4)
Cooperia surnabada (adults and L4)
Nematodirus helvetianus (adults and L4)
Oesophagostomum radiatum (adults and L4)
Bunostomum phlebotomum (adults and L4)
Strongyloides papillosus (adults only)
Trichuris spp. (adults only)
Lungworms
Dictyocaulus viviparus (adults and L4)
Cattle Grubs (all parasitic stages)
Hypoderma lineatum
Hypoderma bovis
Lice
Damalinia bovis
Linognathus vituli
Haematopinus eurysternus
Solenopotes capillatus
Mange Mites
Chorioptes bovis
Sarcoptes scabiei
Horn Flies
Haematobia irritans
Persistent Activity
EpriGard™ (eprinomectin) Pour-On for Beef and Dairy Cattle has been proved to effectively control infections and to protect cattle from re-infection with Dictyocaulus viviparus for 21 days after treatment and Haematobia irritans for 7 days after treatment.

Dosage

The dose rate is 1 mL/10 kg (22 lb) of body weight. The product should be applied topically along the backline in a narrow strip extending from the withers to the tailhead.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Pasture
Composition / specifications
Each milliliter of solution contains 50 milligrams (mg) eprinomectin.
Cattle (On Pasture)
Indication

Persistent Activity LONGRANGE® (eprinomectin) has been proven to effectively protect cattle from reinfection with the following parasites for the indicated amounts of time following treatment:Parasites Duration of Persistent Effectiveness Gastrointestinal Roundworms Bunostomum phlebotomum 150 daysCooperia oncophora 100 days Cooperia punctata 100 days Haemonchus placei 120 days Oesophagostomum radiatum 120 days Ostertagia lyrata 120 days Ostertagia ostertagi 120 days Trichostrongylus axei 100 days Lungworms Dictyocaulus viviparous 150 days

Dosage
Administer 1 mg eprinomectin per kg body weight (1 mL/110 lb body weight).
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal. Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing.
Indication
For the treatment and control of the following parasites: Gastrointestinal Roundworms Bunostomum phlebotomum: Adults and L4 Cooperia oncophora : Adults and L4 Cooperia punctata : Adults and L4 Cooperia surnabada : Adults and L4 Haemonchus placei : Adults Oesophagostomum radiatum : Adults Ostertagia lyrata : Adults Ostertagia ostertagi : Adults, L4, and inhibited L4 Trichostrongylus axei : Adults and L4 Trichostrongylus colubriformis : Adults Lungworms Dictyocaulus viviparus : Adults Grubs Hypoderma bovis Mites Sarcoptes scabiei var. bovis
Dosage
Administer 1 mg eprinomectin per kg body weight (1 mL/110 lb body weight).
Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal.Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing.

FDA page: Open in Animal Drugs @ FDA

Composition / specifications
Each milliliter contains 5 milligrams of eprinomectin.
Beef and Dairy Cattle
Indication
The drug is used in beef and dairy cattle for treatment and control of gastrointestinal roundworms (Haemonchus placei (adult and L4), Ostertagia ostertagi (adult and L4, including inhibited L4), Trichostrongylus axei (adult and L4), T. colubriformis (adult and L4), T. longispicularis (adult), Cooperia oncophora (adult and L4), C. punctate (adult and L4), C. surnabada (adult and L4), Nematodirus helvetianus (adult and L4), Bunostomum phlebotomum (adult and L4), Oesophagostomum radiatum (adult and L4), Strongyloides papillosus (adults), Trichuris species (adults)); lungworms (Dictyocaulus viviparous, adult and L4); cattle grubs (all parasitic stages Hypoderma lineatum, H. bovis); lice (Damalinia bovis, Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus); mange mites (Chorioptes bovis, Sarcoptes scabiei); and horn flies (Haematobia irritans). Controls and protects from reinfection of D. viviparous for 21 days after treatment and H. irritans for 7 days after treatment.
Dosage
One milliliter (5 milligrams) per 10 kilograms (22 Lbs) of body weight
Limitations
Apply topically along backbone from withers to tailhead. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Do not use in calves to be processed for veal.

FDA page: Open in Animal Drugs @ FDA

Species: Beef And Dairy • Dairy
Composition / specifications
5 mg/mL
Beef and dairy cattle, including lactating dairy cattle
Indication

For the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle. Eprizero™ Pour-On is indicated for the effective treatment and control of the following parasites:

Gastrointestinal Roundworms

  • Haemonchus placei (adults and L4)
  • Ostertagia ostertagi (adults and L4) (including inhibited L4)
  • Trichostrongylus axei (adults and L4)
  • Trichostrongylus colubriformis (adults and L4)
  • Trichostrongylus longispicularis (adults only)
  • Cooperia onchophora (adults and L4) 
  • Cooperia punctata (adults and L4) 
  • Cooperia surnabada (adults and L4)
  • Nematodirus helvetianus (adults and L4)
  • Oesophagostomum radiatum (adults and L4)
  • Bunostomum phlebotomum (adults and L4)
  • Strongyloides papillosus (adults only) 
  • Trichuris spp. (adults only)

 Lungworms

  • Dictyocaulus viviparus (adults and L4) 

Cattle Grubs (all parasitic stages)
  • Hypoderma lineatum 
  • Hypoderma bovis 
Lice 
  • Damalinia bovis 
  • Linognathus vituli 
  • Haematopinus eurysternus 
  • Solenopotes capillatus 
Mange Mites 
  • Chorioptes bovis 
  • Sarcoptes scabiei 
Horn Flies 
  • Haematobia irritans

Dosage

1 mL/10 kg (22 lb) body weight, to achieve a dose level of 500 mcg eprinomectin/kg body weight.

Limitations

FDA page: Open in Animal Drugs @ FDA

Usage

The drug is used in beef and dairy cattle for treatment and control of gastrointestinal roundworms ( Haemonchus placei (adult and L4), Ostertagia ostertagi (adult and L4, including inhibited L4), Trichostrongylus axei (adult and L4), T. colubriformis (adult and L4), T. longispicularis (adult), Cooperia oncophora (adult and L4), C. punctate (adult and L4), C. surnabada (adult and L4), Nematodirus helvetianus (adult and L4), Bunostomum phlebotomum (adult and L4), Oesophagostomum radiatum (adult and L4), Strongyloides papillosus (adults), Trichuris species (adults)); lungworms ( Dictyocaulus viviparous , adult and L4); cattle grubs (all parasitic stages Hypoderma lineatum , H. bovis ); lice ( Damalinia bovis , Linognathus vituli , Haematopinus eurysternus , Solenopotes capillatus ); mange mites ( Chorioptes bovis , Sarcoptes scabiei ); and horn flies ( Haematobia irritans ). Controls and protects from reinfection of D. viviparous for 21 days after treatment and H. irritans for 7 days after treatment. Persistent Activity LONGRANGE ® (eprinomectin) has been proven to effectively protect cattle from reinfection with the following parasites for the indicated amounts of time following treatment:Parasites Duration of Persistent Effectiveness Gastrointestinal Roundworms Bunostomum phlebotomum 150 days Cooperia oncophora 100 days Cooperia punctata 100 days Haemonchus placei 120 days Oesophagostomum radiatum 120 days Ostertagia lyrata 120 days Ostertagia ostertagi 120 days Trichostrongylus axei 100 days Lungworms Dictyocaulus viviparous 150 days For the treatment and control of the following parasites: Gastrointestinal Roundworms Bunostomum phlebotomum : Adults and L4 Cooperia oncophora : Adults and L4 Cooperia punctata : Adults and L4 Cooperia surnabada : Adults and L4 Haemonchus placei : Adults Oesophagostomum radiatum : Adults Ostertagia lyrata : Adults Ostertagia ostertagi : Adults, L4, and inhibited L4 Trichostrongylus axei : Adults and L4 Trichostrongylus colubriformis : Adults Lungworms Dictyocaulus viviparus : Adults Grubs Hypoderma bovis Mites Sarcoptes scabiei var. bovis

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Apply topically along backbone from withers to tailhead. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Do not use in calves to be processed for veal. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal. Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal.Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Cat Loss of appetite (1) • Cat Blood in vomit (1) • Cat

Showing top 5 for Digestive.

Skin & allergy
Itching (1) • Dog Application site itching (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Cat Tremors (1) • Dog Tiredness (1) • Cat Muscle tremor (1) • Dog

Showing top 5 for Neurologic.

Effectiveness
Lack of efficacy (endoparasite) - roundworm NOS (1) • Cat Lack of efficacy (endoparasite) - hookworm (1) • Cat

Showing top 5 for Effectiveness.

Other
Urinary tract infection (1) • Dog Scaly condition NOS (1) • Cat Peeling skin (1) • Cat Neutrophilia (1) • Dog Loose stool (1) • Cat
Show more (16)
Local erythema (1) • Dog Limb weakness (1) • Dog Leucocytosis NOS (1) • Dog Head bobbing (1) • Cat Foaming at the mouth (1) • Cat Dilated pupils (1) • Dog Death (1) • Cat Blindness (1) • Dog Blepharospasm (1) • Cat Application site scab (1) • Cat Application site reddening (1) • Cat Application site pyoderma (1) • Cat Accidental exposure (1) • Dog Abnormal posture NOS (1) • Cat Abnormal movement NOS (1) • Cat Agitation • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

No case-level openFDA reports are linked for this medication yet.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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