Roxee Medication Guide

Fenbendazole

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Paste Multiple FDA labelers Official label facts Owner quick guide first

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Data freshness

Reference facts

Reference refreshed

Jun 22, 2026, 10:40 a.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications

FDA application data refreshed

Jun 22, 2026, 10:40 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports

Safety data refreshed

Jun 13, 2026, 11:29 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details

Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:40 AM UTC
The reference fact projection used for browse cards and quick facts.
Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:40 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC

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Fenbendazole

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Both Paste Rx required 100% reference complete

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Fenbendazole

For the treatment and control of large strongyles ( Strongylus edentatus, S. equinus, S. vulgaris, Triodontophorus spp.),small strongyles ( Cyathostomum spp., Cylicocyclus spp., Cylicostephanus spp., Cylicodontophorus spp.), and pinworms ( Oxyuris equi ). For the treatment and control of ascarids ( Parascaris equorum ). For the control of infections of large strongyles (Strongylus edentatus, S. equinus, S. vulgaris), small strongyles, pinworms (Oxyuris equi), and ascarids (Parascaris equorum). Species commonly shown: Both, Horse, Not For Meat Production, Horse, Foals, Not For Food.

Generic name

Fenbendazole

Brand names

safe-guard® panacur®, Panacur® C (OTC) Safe-Guard® Canine (OTC) Panacur® Granules 22.2% (Rx), Safe-Guard®, Safe-Guard® Safe-Guard® EnProAl®

Manufacturer

Multiple FDA labelers

Species

Both, Horse, Pony, Dog

Dosage forms

Paste, Top Dressing In Feed, Liquid (Suspension), Type A Medicated Article

Prescription

Prescription required

Completeness

100%

Validation

Needs review

Brand names

safe-guard® panacur® Panacur® C (OTC) Safe-Guard® Canine (OTC) Panacur® Granules 22.2% (Rx) Safe-Guard® Safe-Guard® Safe-Guard® EnProAl® Safe-Guard® AquaSol Defendazole™

Dosage forms

Paste Top Dressing In Feed Liquid (Suspension) Type A Medicated Article Medicated Feed Block Oral Suspension

Indications / Uses

For the treatment and control of large strongyles ( Strongylus edentatus , S. equinus , S. vulgaris , Triodontophorus spp.),small strongyles ( Cyathostomum spp., Cylicocyclus spp., Cylicostephanus spp., Cylicodontophorus spp.), and pinworms ( Oxyuris equi ). For the treatment and control of ascarids ( Parascaris equorum ). For the control of infections of large strongyles (Strongylus edentatus, S. equinus, S. vulgaris), small strongyles, pinworms (Oxyuris equi), and ascarids (Parascaris equorum).

Warnings / Contraindications

Sprinkle the appropriate amount of drug on a small amount of the usual grain ration. Prepare for each horse individually. Withholding feed or water is not necessary. Retreat in 6 to 8 weeks if required. Do not use in horses intended for food. Consult your veterinarian assistance in the diagnosis, treatment, and control of parasitism. Do not use in horses intended for human consumption. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism. Mix the appropriate amount of drug with a small amount of the usual food. Dry dog food may require slight moistening to facilitate mixing. Medicated food must be fully consumed.

Sprinkle the appropriate amount of drug on a small amount of the usual grain ration. Prepare for each horse individually. Withholding feed or water is not necessary. Retreat in 6 to 8 weeks if required. Do not use in horses intended for food. Consult your veterinarian assistance in the diagnosis, treatment, and control of parasitism. Do not use in horses intended for human consumption. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism. Mix the appropriate amount of drug with a small amount of the usual food. Dry dog food may require slight moistening to facilitate mixing. Medicated food must be fully consumed.

Side Effects

Top reported reactions (openFDA): Lack of efficacy (endoparasite) - hookworm, Vomiting, INEFFECTIVE, HOOKS, Diarrhoea, Other abnormal test result NOS, Lack of efficacy (endoparasite) - tapeworm.

FAQ

Both, Horse, Not For Meat Production, Horse, Foals, Not For Food, Pony, Not For Food, Dog, Non-Lactating, Beef, Dairy, Gilts, Growing, Pregnant sows, Boars, Beef And Dairy, Zoo Animals, Swine, Feral, Wild Animals, Swine, Except For Nursing Piglets, Breeders, Broilers, Layers, Replacements

Yes. Roxee shows this as prescription-only.

Paste, Top Dressing In Feed, Liquid (Suspension), Type A Medicated Article

Related Conditions

Gastrointestinal (additional)

Source Transparency

Verified source: https://www.roxee.ai/meds/
Verified source: https://animaldrugsatfda.fda.gov
Verified source: https://animaldrugsatfda.fda.gov/adafda/views/#/search
Verified source: https://api.fda.gov/animalandveterinary/event.json
Verified source: https://www.roxee.ai/conditions/
Verified source: https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/17870
Last refreshed: Jun 22, 2026, 10:40 a.m.
Last verified: Feb 12, 2026, 10:44 p.m.
Validation status: Needs review

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the treatment and control of: Lungworms: Adult Dictyocaulus viviparus ; Stomach worms: Adult brown stomach worms ( Ostertagia ostertagi ), Adult and fourth stage larvae barberpole worms ( Haemonchus contortus ), four...

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

Sprinkle the appropriate amount of drug on a small amount of the usual grain ration
Prepare for each horse individually
Withholding feed or water is not necessary
Retreat in 6 to 8 weeks if required
Do not use in horses intended for food
Consult your veterinarian assistance in the diagnosis, treatment, and control of parasitism
Do not use in horses intended for human consumption
Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism
Mix the appropriate amount of drug with a small amount of the usual food
Dry dog food may require slight moistening to facilitate mixing
Medicated food must be fully consumed
wobbly/unsteady walking (1 reports)
trouble breathing (1 reports)
Head tremor (1 reports)

When to call the vet:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Facial swelling or hives.
Blood in vomit or stool.

What to tell or ask your vet today:

Is this medicine the right fit for my pet’s current symptoms?
Which warning signs mean I should call back right away?
How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence

Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Fenbendazole; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2025-US-070682

Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 25 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2025-US-070682

Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2025-US-070682

Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Unsteady walking (ataxia) (1 reports), Trouble breathing (dyspnea) (1 reports), Head tremor (1 reports), Head down (1 reports), Gingivitis (1 reports)

Body systems represented Signal grouping

Digestive (3), Skin & allergy (1), Neurologic (2), Behavior (1)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Cat (19 reports), Dog (13 reports)

Breed metadata in reports Metadata only

Greyhound (3), Terrier - Yorkshire (1), Hound (unspecified) (1), Domestic Shorthair (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Fenbendazole fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Sprinkle the appropriate amount of drug on a small amount of the usual grain ration, Prepare for each horse individually, Withholding feed or water is not necessary, Retreat in 6 to 8 weeks if required, Do not use in horses intended for food

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Fenbendazole brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.

Vet source depth

openFDA case USA-USFDACVM-2025-US-070682 · adverse_reaction · adverse reactions
Contraindication source · fda_animal_drugs · warnings contraindications
FDA application profile · official_label · quick facts
FDA application profile · official_label · quick facts
Medication usage source · fda_animal_drugs · quick facts
FOI · document · documents
FOI · document · documents
SPL · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 10:44 PM UTC

Sources:

FDA application profile · official_label
FDA application profile · official_label
Medication usage source · fda_animal_drugs
Defendazole™ · official_label
openFDA case USA-USFDACVM-2025-US-070682 · adverse_reaction

Safety & side effects

Side effects to monitor:

Sprinkle the appropriate amount of drug on a small amount of the usual grain ration
Prepare for each horse individually
Withholding feed or water is not necessary
Retreat in 6 to 8 weeks if required
Do not use in horses intended for food

Most reported reactions:

Unsteady walking (ataxia) (1 reports)
Trouble breathing (dyspnea) (1 reports)
Head tremor (1 reports)

Explore reported case details

Emergency warning signs:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Facial swelling or hives.

Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species

Beef, Beef And Dairy, Boars, Breeders, Broilers, Dairy, Dog, Gilts, Growing, Horse, Layers, Non-Lactating, Pony, Pregnant sows, Replacements, Swine, Wild Animals, Zoo Animals

Indication / use

For the treatment and control of: Lungworms: Adult Dictyocaulus viviparus ; Stomach worms: Adult brown stomach worms ( Ostertagia ostertagi ), Adult and fourth stage larvae barber…

Form / route / dose

Form: Liquid (Suspension), Medicated Feed Block, Oral Suspension, Paste, Top Dressing In Feed, Type A Medicated Article
Route: Oral
Confirm product label and patient-specific plan.

Warnings

High: Sprinkle the appropriate amount of drug on a small amount of the usual grain ration. Prepare for each horse individuall…

Adverse-event caveat

openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.

Source docs

131-675 Official label / PI
131-675 Official label / PI
131-675 Official label / PI

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both

Manufacturer: Multiple FDA labelers

Form: Liquid (Suspension), Medicated Feed Block, Oral Suspension, Paste, Top Dressing In Feed, Type A Medicated Article

Identifiers:

ANADA: 200831 NADA: 104494 NADA: 111278 NADA: 120648 NADA: 121473 NADA: 128620 NADA: 131675 NADA: 132872 NADA: 136116 NADA: 139189 NADA: 140954 NADA: 141144 NADA: 141449 NDC Package: 0061-1433-01 NDC Package: 0061-1433-02 NDC Package: 0061-1433-03 NDC Package: 43457-650-25 NDC Package: 49452-3035-1 NDC Package: 49452-3035-2 NDC Package: 49452-3035-3

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/139189 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/131675 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source

Warnings / Contraindications

High: Sprinkle the appropriate amount of drug on a small amount of the usual grain ration. Prepare for each horse individually. Withholding feed or water is not necessary. Retreat in 6 to 8 weeks if required. Do not use in horses intended for food. Consult your veterinarian assistance in the diagnosis, treatment, and control of parasitism. Do not use in horses intended for human consumption. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism. Mix the appropriate amount of drug with a small amount of the usual food. Dry dog food may require slight moistening to facilitate mixing. Medicated food must be fully consumed.

Source metadata:

https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters

openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.

Stored reports

Matching reports

Active filters

Selected filters

Reaction: Weight loss Clear Body system: Effectiveness Clear

Species

Breed

Size / weight

Age

Sex

Seriousness

Outcome

Reaction

Body system

Region

Received after

Received before

Reset

Drill into common report signals

Lack of efficacy (endoparasite) - hookworm (4) Abnormal radiograph finding (3) Medication error NOS (3) Weight loss (3) Other (11) Effectiveness (8) Digestive (5) Behavior (2)

Showing up to 50 matching reports.

USA-USFDACVM-2025-US-062768

Received 2025-10-17 · MSK · MSK

Serious

Species: Cat
Breed: Domestic Shorthair
Size / weight: Under 10 lb (0.52 Kilogram)
Age: Under 1 year (2 Month)
Sex: Female Intact
Region: USA
Reactions: Lack of efficacy - NOSIntentional misuseHepatomegalyAbnormal radiograph findingHypothermiaWeight loss
Body systems: EffectivenessOther
Outcomes: Ongoing

Tap or hover a reaction to see what it means in plain language.

Tracked signals

Reported cases

Serious reports

Species represented

Grouped by Body System

Digestive (3) · Vomiting, Diarrhea, Bloody diarrhoea Skin & allergy (1) · Hair loss Neurologic (2) · Unsteady walking (ataxia), Head tremor Behavior (1) · Behavioral disorder (unspecified) Other (25) · Trouble breathing (dyspnea), Head down, Gingivitis

Most Reported Reactions

Body system	Cases	Species	Serious cases
Neurologic	1	Dog	1
Other	1	Cat	1
Neurologic	1	Dog	1
Other	1	Cat	1
Other	1	Cat	1
Other	1	Cat	1
Other	1	Cat	1
Other	1	Dog	1

Species coverage: Cat (19) Dog (13)

View detailed reaction table

Body system	Species	Seriousness	Frequency	Reports
Digestive	Dog	Non-serious	-	1
Neurologic	Dog	Serious	-	1
Other	Cat	Serious	-	1
Neurologic	Dog	Serious	-	1
Other	Cat	Serious	-	1
Skin & allergy	Dog	Non-serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Serious	-	1
Digestive	Dog	Non-serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Dog	Non-serious	-	1
Other	Dog	Non-serious	-	1
Digestive	Dog	Non-serious	-	1
Behavior	Cat	Serious	-	1
Other	Dog	Non-serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1

Source metadata:

https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-070682

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

131-675 Official label / PI · EA 131-675 Official label / PI · FONSI 131-675 Official label / PI · EA

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

No owner handouts linked yet.

Official label / PI

SPL

Open original

FDA Structured Product Label

Safe-Guard® Safe-Guard® EnProAl®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Intervet, Inc.
NADA: 139-189
Status: OTC
Form: Medicated Feed Block
Route: Oral
Species: Beef

Composition / specifications

Each pound of molasses block contains 750 milligrams of fenbendazole. Each pound of protein block contains 750 milligrams of fenbendazole.

Cattle (beef)

Indication

For the treatment and control of: Lungworms: Adult Dictyocaulus viviparus; Stomach worms: Adult brown stomach worms (Ostertagia ostertagi), Adult and fourth stage larvae barberpole worms (Haemonchus contortus), fourth stage larvae barberpole worms (H. placei), and Adult and fourth stage larvae small stomach worms (Trichostrongylus axei); Intestinal worms (Adult and fourth stage larvae): hookworms (Bunostomum phlebotomum), thread-necked intestinal worms (Nematodirus helvetianus), small intestinal worms (Cooperia punctata & C. oncophora), bankrupt worms (Trichostrongylus colubriformis), and nodular worms (Oesophagostomum radiatum).

Dosage

Feed free-choice at a rate of 0.1 pound of block per 100 lb body weight (BW) per day for 3 days to deliver a total of 2.27 mg fenbendazole/lb BW (5 mg/kg BW). Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance. Consult a veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

Limitations

Administer free choice of beef cattle on pasture that have become accustomed to non-medicated block feeding during an adaptation period of 12 to 19 days. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

Safe-Guard®

SPL · SPL

Open original

FDA Structured Product Label

Safe-Guard®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Intervet, Inc.
NADA: 131-675
Status: OTC
Form: Type A Medicated Article
Route: Oral
Species: Gilts • Growing • Pregnant sows • Boars • Beef And Dairy • Zoo Animals • Swine • Wild Animals

SPL · SPL

Open original

FDA Structured Product Label

Defendazole™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Norbrook Laboratories, Ltd.
ANADA: 200-831
Status: OTC
Form: Oral Suspension
Route: Oral
Species: Beef And Dairy

Composition / specifications

100 mg/mL (10%)

Beef and Dairy Cattle

Indication

For the treatment and control of:
Lungworms: Adult Dictyocaulus viviparus;
Stomach worms: Adult brown stomach worms (Ostertagia ostertagi), Adult and fourth stage larvae barberpole worms (Haemonchus contortus & H. placei), and Adult and fourth stage larvae small stomach worms (Trichostrongylus axei);
Intestinal worms (Adult and fourth stage larvae): hookworms (Bunostomum phlebotomum), thread-necked intestinal worms (Nematodirus helvetianus), small intestinal worms (Cooperia punctata & C. oncophora), bankrupt worms (Trichostrongylus colubriformis), and nodular worms (Oesophagostomum radiatum).

Dosage

2.3 mg/lb (5 mg/kg) body weight

Goats

Indication

For the treatment and control of:
Stomach worms (adults): Haemonchus contortus and Teladorsagia circumcincta.

Dosage

2.3 mg/lb (5 mg/kg) body weight

Safe-Guard®

SPL · SPL

Open original

FDA Structured Product Label

Safe-Guard®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Intervet, Inc.
NADA: 132-872
Status: OTC
Form: Paste
Route: Oral
Species: Beef • Dairy

Composition / specifications

The product is an aqueous paste containing 10 percent fenbendazole.

Beef and dairy cattle

Indication

Dosage

Administer orally 5 milligrams per kilogram of body weight (2.3 milligrams per pound).

Limitations

Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance. Consult a veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

Safe-Guard®

SPL · SPL

Open original

FDA Structured Product Label

Safe-Guard® Panacur®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Intervet, Inc.
NADA: 128-620
Status: OTC
Form: Liquid (Suspension)
Route: Oral
Species: Non-Lactating • Beef • Dairy

Composition / specifications

The drug is a suspension containing 10 percent (100 milligrams per milliliter) fenbendazole.

Cattle (beef and dairy)

Indication

Indication

For the treatment and control of large strongyles (Strongylus edentatus, S. equinus, S. vulgaris), encysted early 3rd stage (hypobiotic), late 3rd stage and 4th stage cyathostome larvae, small strongyles, pinworms (Oxyuris equi), ascarids (Parascaris equorum), and for the control of arteritis caused by 4th stage larvae of Strongylus vulgaris in horses.

Dosage

For large strongyles, small strongyles, and pinworms, the recommended dose is 5 mg/kg (2.3 mb/lb) administered once orally. For ascarids, the recommended dose is 10 mg/kg (4.6 mg/lb) administered once orally. For treatment and control of hypobiotic (encysted early 3rd stage), late 3rd stage, and 4th stage cyathostome larvae, as well as 4th stage Strongylus vulgaris larvae, the recommended dose is 10 mg/kg (4.6 mg/lb) administered orally daily for 5 consecutive days.

Limitations

Do not use in horses intended for human consumption. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.

panacur®

SPL · SPL

Open original

FDA Structured Product Label

safe-guard® panacur®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Intervet, Inc.
NADA: 120-648
Status: OTC
Form: Paste
Route: Oral
Species: Horse • Pony

Composition / specifications

The product is an aqueous paste containing 10 percent fenbendazole.

Horses

Indication

Dosage

Limitations

Do not use in horses intended for human consumption. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.

Panacur® C (OTC)

SPL · SPL

Open original

FDA Structured Product Label

Panacur® C (OTC) Safe-Guard® Canine (OTC) Panacur® Granules 22.2% (Rx)

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Intervet, Inc.
NADA: 121-473
Status: OTC
Form: Top Dressing In Feed
Route: Oral
Species: Dog

Composition / specifications

The drug is in granular form containing 22 percent (222 milligrams per gram) fenbendazole.

Dogs

Indication

For the treatment and control of ascarids (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala), whipworms (Trichuris vulpis), and tapeworms (Taenia pisiformis).

Dosage

50 milligrams per kilogram (22.7 milligrams per pound) daily for 3 consecutive days.

Limitations

Mix the appropriate amount of drug with a small amount of the usual food. Dry dog food may require slight moistening to facilitate mixing. Medicated food must be fully consumed.

Safe-Guard® Canine (OTC)

SPL · SPL

Open original

FDA Structured Product Label

Panacur® C (OTC) Safe-Guard® Canine (OTC) Panacur® Granules 22.2% (Rx)

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Intervet, Inc.
NADA: 121-473
Status: OTC
Form: Top Dressing In Feed
Route: Oral
Species: Dog

Composition / specifications

The drug is in granular form containing 22 percent (222 milligrams per gram) fenbendazole.

Dogs

Indication

Dosage

50 milligrams per kilogram (22.7 milligrams per pound) daily for 3 consecutive days.

Limitations

Mix the appropriate amount of drug with a small amount of the usual food. Dry dog food may require slight moistening to facilitate mixing. Medicated food must be fully consumed.

Panacur® Granules 22.2% (Rx)

SPL · SPL

Open original

FDA Structured Product Label

Panacur® C (OTC) Safe-Guard® Canine (OTC) Panacur® Granules 22.2% (Rx)

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Intervet, Inc.
NADA: 121-473
Status: OTC
Form: Top Dressing In Feed
Route: Oral
Species: Dog

Composition / specifications

The drug is in granular form containing 22 percent (222 milligrams per gram) fenbendazole.

Dogs

Indication

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/10769 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/448 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1780/Safe-Guard%C2%AE · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/15493 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/11816 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/402 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/401 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/400 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/399 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1633 · document · FOI

Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness

Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:40 AM UTC
The reference fact projection used for browse cards and quick facts.
Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:40 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC

Official (FDA)

Identity: Generic ingredient • No FDA branded products linked

No official FDA brand rows linked yet for this ingredient.

Manufacturer mapping: Multiple FDA labelers

Case-reported brands (openFDA): MSK

Catalog species: Both • FDA-labeled species: Beef, Beef And Dairy, Boars, Breeders, Broilers, Dairy, Dog, Gilts, Growing, Horse, Layers, Non-Lactating, Pony, Pregnant sows, Replacements, Swine, Wild Animals, Zoo Animals

Rx/OTC: OTC

Form/route: Liquid (Suspension), Medicated Feed Block, Oral Suspension, Paste, Top Dressing In Feed, Type A Medicated Article • Oral

Applications: NADA 139-189 • NADA 131-675 • ANADA 200-831 • NADA 132-872 • NADA 128-620 • NADA 120-648 • NADA 121-473 • NADA 141-449

Documents: 38 (FOI: 24) • SPL: 12 • Label highlights • Official documents

Safety (openFDA)

Top reactions: Dog 34 • Cat 28 • View

Case summaries: 14 (showing 8) • View

openFDA reports are unverified and do not prove causation.

Explore

Related conditions: Gastrointestinal (additional)

Linked using: Fda_Label (0.95)

Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points

Sprinkle the appropriate amount of drug on a small amount of the usual grain ration. Prepare for each horse individually. Withholding feed or water is not necessary. Retreat in 6 to 8 weeks if required. Do not use in horses intended for food. Consult your veterinarian assistance in the diagnosis, treatment, and control of parasitism. Do not use in horses intended for human consumption. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism. Mix the appropriate amount of drug with a small amount of the usual food. Dry dog food may require slight moistening to facilitate mixing. Medicated food must be fully consumed. (Contraindication, High)

Top reaction signals

Unsteady walking (ataxia) (1) Trouble breathing (dyspnea) (1) Head tremor (1) Head down (1) Gingivitis (1) Fibrosarcoma (1) Eye neoplasm NOS (1) Eosinophilia (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers

Package NDC	Product NDC	Status
0061-1433-01	0061	-
0061-1433-02	0061	-
0061-1433-03	0061	-
43457-650-25	43457	-
49452-3035-1	49452	-
49452-3035-2	49452	-
49452-3035-3	49452	-
49452-3035-4	49452	-
49452-3035-5	49452	-
49452-3035-6	49452	-
55529-165-06	55529	-
55529-165-08	55529	-
57926-081-44	57926	-
57926-081-48	57926	-
57926-083-44	57926	-
57926-084-46	57926	-
57926-085-47	57926	-
57926-086-01	57926	-
57926-087-01	57926	-
57926-088-01	57926	-

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Ozipco SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Panacur SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Panacur SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Panacur SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Panacur SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Panacur C Canine SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Safe-guard SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Safe-Guard SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Safe-guard SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Safe-Guard AquaSol SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Defendazole SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Safe-Guard SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Safe-Guard SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
UCM472706.pdf • FOI summary • Official • April 28, 2026
FDA FOI summary for application 139189
FOI Summary sN 139-189 Approved April 26, 2021.pdf • FOI summary • Official • April 28, 2026
FDA FOI summary for application 139189
UCM470924.pdf • FOI summary • Official • April 10, 2026
FDA FOI summary for application 131675
N131675_Supp_03_30_1991.pdf • FOI summary • Official • April 10, 2026
FDA FOI summary for application 131675
ucm069858.pdf • FOI summary • Official • April 10, 2026
FDA FOI summary for application 131675
ucm069862.pdf • FOI summary • Official • April 10, 2026
FDA FOI summary for application 131675
ucm069865.pdf • FOI summary • Official • April 10, 2026
FDA FOI summary for application 131675
UCM364715.pdf • FOI summary • Official • April 10, 2026
FDA FOI summary for application 131675
FOI Summary sN 131-675 Approved January 10, 2022.pdf • FOI summary • Official • April 10, 2026
FDA FOI summary for application 131675
FOI Summary sN 131-675 Approved May 23, 2024.pdf • FOI summary • Official • April 10, 2026
FDA FOI summary for application 131675
FOI Summary oA 200-831 Approved January 13, 2026.pdf • FOI summary • Official • Feb. 2, 2026
FDA FOI summary for application 200831
ucm117184.pdf • FOI summary • Official • Nov. 12, 2024
FDA FOI summary for application 141144
N-132872-Q-0140-OT-AA_foi.pdf • FOI summary • Official • Oct. 12, 2023
FDA FOI summary for application 132872
FOI Summary sN 132-872 Approved March 24, 2021.pdf • FOI summary • Official • Oct. 12, 2023
FDA FOI summary for application 132872
UCM478252.pdf • FOI summary • Official • Aug. 25, 2023
FDA FOI summary for application 140954
N128620_Supp_04_25_1994.pdf • FOI summary • Official • June 6, 2022
FDA FOI summary for application 128620
N-128620-Q-0179-OT-AA_foi.pdf • FOI summary • Official • June 6, 2022
FDA FOI summary for application 128620
ucm069823.pdf • FOI summary • Official • June 6, 2022
FDA FOI summary for application 128620
ucm069824.pdf • FOI summary • Official • June 6, 2022
FDA FOI summary for application 128620
FOI Summary sN 128-620 Approved June 14, 2021.pdf • FOI summary • Official • June 6, 2022
FDA FOI summary for application 128620
N120648_Supp_May_28_1985.pdf • FOI summary • Official • Jan. 25, 2022
FDA FOI summary for application 120648
N121473_Suppl_5_31_1994.pdf • FOI summary • Official • May 6, 2021
FDA FOI summary for application 121473
ucm069818.pdf • FOI summary • Official • May 6, 2021
FDA FOI summary for application 121473
UCM471258.pdf • FOI summary • Official • April 12, 2021
FDA FOI summary for application 141449
UCM488824.pdf • FOI summary • Official • April 12, 2021
FDA FOI summary for application 141449
FOI Summary sN 141-449 Approved January 5, 2018.pdf • FOI summary • Official • April 12, 2021
FDA FOI summary for application 141449

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 110 Clinical 1 Manufacturer 0 Marketing 0

Current Field Facts

side_effects: Top reported reactions (openFDA): Lack of efficacy (endoparasite) - hookworm, Vomiting, INEFFECTIVE, HOOKS, Diarrhoea, Other abnormal test result NOS, Lack of … (Clinical, 2026-04-11)
contraindications: Sprinkle the appropriate amount of drug on a small amount of the usual grain ration. Prepare for each horse individually. Withholding feed or water is not nece… (Official, 2026-04-12)
contraindications: Sprinkle the appropriate amount of drug on a small amount of the usual grain ration. Prepare for each horse individually. Withholding feed or water is not nece… (Official, 2026-04-11)
contraindications: Sprinkle the appropriate amount of drug on a small amount of the usual grain ration. Prepare for each horse individually. Withholding feed or water is not nece… (Official, 2026-02-12)
indications: For the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment … (Official, 2026-06-22)
indications: For the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment … (Official, 2026-06-22)
indications: For the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment … (Official, 2026-06-21)
indications: For the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment … (Official, 2026-06-20)
indications: For the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment … (Official, 2026-06-13)
indications: For the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment … (Official, 2026-06-12)
indications: For the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment … (Official, 2026-06-12)
indications: For the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment … (Official, 2026-06-11)
indications: For the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment … (Official, 2026-06-11)
indications: For the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment … (Official, 2026-06-10)
indications: For the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment … (Official, 2026-06-09)
indications: For the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment … (Official, 2026-06-08)
indications: For the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment … (Official, 2026-06-07)
indications: For the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment … (Official, 2026-06-06)
indications: For the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment … (Official, 2026-06-05)
indications: For the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment … (Official, 2026-06-04)

Recent Revisions

side_effects updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
contraindications updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
usage updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
contraindications updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product	Sponsor	Application	Status	Published
Safe-Guard® Safe-Guard® EnProAl® OTC Fenbendazole Medicated Feed Block • Oral Label highlights Official documents	Intervet, Inc.	NADA 139-189	Approved	Apr 28, 2026
Safe-Guard® OTC Fenbendazole Type A Medicated Article • Oral Label highlights Official documents	Intervet, Inc.	NADA 131-675	Approved	Apr 10, 2026
Defendazole™ OTC Fenbendazole Oral Suspension • Oral Label highlights Official documents	Norbrook Laboratories, Ltd.	ANADA 200-831	Approved	Feb 2, 2026
Safe-Guard® OTC Fenbendazole Paste • Oral Label highlights Official documents	Intervet, Inc.	NADA 132-872	Approved	Oct 12, 2023
Safe-Guard® Panacur® OTC Fenbendazole Liquid (Suspension) • Oral Label highlights Official documents	Intervet, Inc.	NADA 128-620	Approved	Jun 6, 2022
safe-guard® panacur® OTC Fenbendazole Paste • Oral Label highlights Official documents	Intervet, Inc.	NADA 120-648	Approved	Jan 25, 2022
Panacur® C (OTC) Safe-Guard® Canine (OTC) Panacur® Granules 22.2% (Rx) OTC Fenbendazole Top Dressing In Feed • Oral Label highlights Official documents	Intervet, Inc.	NADA 121-473	Approved	May 6, 2021
Safe-Guard® AquaSol OTC Fenbendazole Oral Suspension • Oral Label highlights Official documents	Intervet, Inc.	NADA 141-449	Approved	Apr 12, 2021

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Beef

Composition / specifications

Each pound of molasses block contains 750 milligrams of fenbendazole. Each pound of protein block contains 750 milligrams of fenbendazole.

Cattle (beef)

Indication

Dosage

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Gilts • Growing • Pregnant sows • Boars • Beef And Dairy • Zoo Animals • Swine • Wild Animals

Composition / specifications

Type A medicated articles conatianing 4 percent (18.1 grams per pound), 8 percent (36.2 grams per pound), and 20 percent (90.7 grams per pound) fenbendazole.

Bighorn sheep

Indication

For the treatment and control of: Lungworms (Protostrongylus spp.).

Dosage

10 mg fenbendazole/kg body weight/day x 3 days of treatment

Limitations

Feral Swine

Indication

For the treatment and control of: kidney worms (Stephanurus dentatus), roundworms (Ascaris suum), and nodular worms (Oesophagostomum dentatum).

Dosage

3 mg fenbendazole/kg body weight/day x 3 days of treatment

Limitations

Wildlife and Zoo Ruminants (Subfamily Antilopinae, Hippotraginae, and Caprinae)

Indication

Dosage

2.5 mg fenbendazole/kg body weight/day x 3 days of treatment

Limitations

Growing Turkeys

Indication

Dosage

14.5 g fenbendazole/ton of feed, to be fed as the sole ration for 6 days

Limitations

Swine (Growing pigs, gilts, pregnant sows, and boars)

Indication

Dosage

9 mg fenbendazole per kg body weight (4.08 mg fenbendazole per pound) to be fed as the sole ration over a period of 3 to 12 days.

Limitations

Cattle (Dairy and Beef Cattle)

Indication

Dosage

Limitations

Horses

Indication

Dosage

Limitations

Wild quail

Indication

For the treatment and control of Gastrointestinal worms: Cecal worms, (Aulonocephalus spp.).

Dosage

90.7 g of fenbendazole/ton of Type C medicated feed, to be fed for 21 consecutive days.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Beef And Dairy

Composition / specifications

100 mg/mL (10%)

Beef and Dairy Cattle

Indication

Dosage

2.3 mg/lb (5 mg/kg) body weight

Limitations

Goats

Indication

For the treatment and control of:
Stomach worms (adults): Haemonchus contortus and Teladorsagia circumcincta.

Dosage

2.3 mg/lb (5 mg/kg) body weight

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Beef • Dairy

Composition / specifications

The product is an aqueous paste containing 10 percent fenbendazole.

Beef and dairy cattle

Indication

Dosage

Administer orally 5 milligrams per kilogram of body weight (2.3 milligrams per pound).

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Non-Lactating • Beef • Dairy

Composition / specifications

The drug is a suspension containing 10 percent (100 milligrams per milliliter) fenbendazole.

Cattle (beef and dairy)

Indication

Dosage

Administer orally at a dose of 2.3 mg/lb (5 mg/kg) body weight.

Limitations

Goats

Indication

For the treatment and control of: Stomach worms (adults): Haemonchus contortus and Teladorsagia circumcincta.

Dosage

Administer orally at a dose of 2.3 mg/lb (5 mg/kg) body weight.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Horse • Pony

Composition / specifications

The product is an aqueous paste containing 10 percent fenbendazole.

Horses

Indication

Dosage

Limitations

Do not use in horses intended for human consumption. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.

FDA page: Open in Animal Drugs @ FDA

Species: Dog

Composition / specifications

The drug is in granular form containing 22 percent (222 milligrams per gram) fenbendazole.

Dogs

Indication

Dosage

50 milligrams per kilogram (22.7 milligrams per pound) daily for 3 consecutive days.

Limitations

Mix the appropriate amount of drug with a small amount of the usual food. Dry dog food may require slight moistening to facilitate mixing. Medicated food must be fully consumed.

FDA page: Open in Animal Drugs @ FDA

Species: Swine • Breeders • Broilers • Layers • Replacements

Composition / specifications

200 mg/mL

Swine (Except Nursing Piglets)

Indication

Dosage

2.2 mg fenbendazole/kg body weight (BW) (1 mg/lb) daily for 3 consecutive days

Limitations

Chickens (broilers, replacements, breeding, and laying hens)

Indication

Dosage

1 mg/kg BW (0.454 mg/lb)/day for 5 consecutive days

Limitations

FDA page: Open in Animal Drugs @ FDA

Usage

For the treatment and control of large strongyles ( Strongylus edentatus , S. equinus , S. vulgaris , Triodontophorus spp.),small strongyles ( Cyathostomum spp., Cylicocyclus spp., Cylicostephanus spp., Cylicodontophorus spp.), and pinworms ( Oxyuris equi ). For the treatment and control of ascarids ( Parascaris equorum ). For the control of infections of large strongyles (Strongylus edentatus, S. equinus, S. vulgaris), small strongyles, pinworms (Oxyuris equi), and ascarids (Parascaris equorum).

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive

Vomiting (1) • Dog Diarrhea (1) • Dog Bloody diarrhoea (1) • Dog

Showing top 5 for Digestive.

Skin & allergy

Hair loss (1) • Dog

Showing top 5 for Skin & allergy.

Neurologic

Unsteady walking (1) • Dog Head tremor (1) • Dog

Showing top 5 for Neurologic.

Behavior

Behavioral disorder (1) • Cat

Showing top 5 for Behavior.

Other

Trouble breathing (1) • Cat Head down (1) • Cat Gingivitis (1) • Cat Fibrosarcoma (1) • Cat Eye neoplasm NOS (1) • Cat

Show more (20)

Eosinophilia (1) • Dog Elevated renal parameters (1) • Cat Elevated globulins (1) • Cat Elevated gamma-glutamyl transferase (1) • Dog Elevated amylase (1) • Cat Dry mucous membrane (1) • Dog Drug dose administration interval too short (1) • Dog Digestive tract neoplasm NOS (1) • Cat Decreased packed cell volume (1) • Cat Decreased body temperature (1) • Cat Decreased blood urea nitrogen (BUN) or creatinine (1) • Cat Decreased activity (1) • Cat Death by euthanasia (1) • Cat Death (1) • Cat Cough (1) • Dog Bloody stool (1) • Dog Bacterial skin infection NOS (1) • Dog Anaemia NOS (1) • Cat Abnormal radiograph finding (1) • Cat Abnormal cytology (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Terrier - Yorkshire, Female, 2 month, 0.395 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Shaking, Drooling, Tiredness (lethargy), Head tremor, Unsteady walking (ataxia)… • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-074155
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 2.00 Month
Weight: 0.395 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown
Form: Unassigned

Reactions Reported:

Shaking Drooling Tiredness (lethargy) Head tremor Unsteady walking (ataxia) Not eating Not drinking Dry mucous membrane Eosinophilia Thrombocytosis Elevated gamma-glutamyl transferase Hypoglycaemia Hypokalaemia Seizure NOS

Outcomes: Ongoing

Dog, Hound (unspecified), Male, 3 year, 23.133 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy (endoparasite) - tapeworm • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-074732
Serious AE: No
Treated For AE: No
Sex: Male
Age: 3.00 Year
Weight: 23.133 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown

Reactions Reported:

Lack of efficacy (endoparasite) - tapeworm

Outcomes: Outcome Unknown

Dog, Female, 8.07 year, 29.3 kilogram • Drug: MSK • Reactions: Lack of efficacy (endoparasite) - heartworm, Weight fluctuation • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-073892
Serious AE: No
Treated For AE: Yes
Sex: Female
Age: 8.07 Year
Weight: 29.300 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK

Reactions Reported:

Lack of efficacy (endoparasite) - heartworm Weight fluctuation

Outcomes: Ongoing

Dog, Greyhound, Male, 11 year, 40.823 kilogram • Drug: MSK, Granule, Oral • Reactions: Lack of efficacy (endoparasite) - hookworm • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-073022
Serious AE: Yes
Treated For AE: Yes
Sex: Male
Age: 11.00 Year
Weight: 40.823 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Oral
Form: Granule

Reactions Reported:

Lack of efficacy (endoparasite) - hookworm

Outcomes: Ongoing

Dog, Greyhound, Male, 3 year, 33.566 kilogram • Drug: MSK, Granule, Oral, Frequency: 1 per year • Reactions: Lack of efficacy (endoparasite) - hookworm, Medication error NOS, Drug dose administration interval too short • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-073011
Serious AE: Yes
Treated For AE: Yes
Sex: Male
Age: 3.00 Year
Weight: 33.566 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Oral
Form: Granule
Frequency: 1 per year

Reactions Reported:

Lack of efficacy (endoparasite) - hookworm Medication error NOS Drug dose administration interval too short

Outcomes: Ongoing

Dog, Greyhound, Female, 7 year, 29.937 kilogram • Drug: MSK, Granule, Oral • Reactions: Lack of efficacy (endoparasite) - hookworm, Medication error NOS, Drug dose administration interval too short, Overdose • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-072921
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 7.00 Year
Weight: 29.937 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Oral
Form: Granule

Reactions Reported:

Lack of efficacy (endoparasite) - hookworm Medication error NOS Drug dose administration interval too short Overdose

Outcomes: Ongoing

Cat, Domestic Shorthair, Female, 1 month, 0.699 kilogram • Drug: MSK, Liquid, Oral, Dose: 0.20 mL per animal • Reactions: Death, Medication error NOS • Outcome: Died

Report ID: USA-USFDACVM-2025-US-072673
Serious AE: Yes
Treated For AE: No
Sex: Female
Age: 1.00 Month
Weight: 0.699 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Oral
Form: Liquid
Dose: 0.20 mL per animal

Reactions Reported:

Death Medication error NOS

Outcomes: Died

Dog, Catahoula Leopard Dog, Female, 6 year, 28.803 kilogram • Drug: MSK, Unknown • Reactions: Pica NOS, Diarrhea, Bloody stool, Weight loss • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-071202
Serious AE: No
Treated For AE: Yes
Sex: Female
Age: 6.00 Year
Weight: 28.803 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown

Reactions Reported:

Pica NOS Diarrhea Bloody stool Weight loss

Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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Medical Disclaimer: The medication details provided on Roxee are for informational purposes only and are not a substitute for professional veterinary advice. Always consult your veterinarian about your pet's specific needs.

Fenbendazole

Data freshness

Fenbendazole

Medication Snapshot

Fenbendazole

Indications / Uses

Warnings / Contraindications

Side Effects

FAQ

What species is this commonly shown for?

Does this usually require a prescription?

What dosage forms are listed?

Related Conditions

Source Transparency

Add to My Pet's Medications

Pet Owner Quick Guide

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Medication Research Insights

What to know

Evidence tension

Reaction signal map

Species and breed lens

What your vet may verify

What to watch next

Evidence

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Quick Facts

Warnings / Contraindications

Adverse Reactions

Reported case explorer

USA-USFDACVM-2025-US-062768

Grouped by Body System

Most Reported Reactions

Source Documents

Owner handouts

Official label / PI

SPL

FOI

131-675

131-675

131-675

131-675

132-872

132-872

128-620

128-620

141-449

141-449

141-449

141-449

141-449

141-449

Safe-Guard®

Safe-Guard® Safe-Guard® EnProAl®

Cattle (beef)

Safe-Guard®

Safe-Guard®

Bighorn sheep

Feral Swine

Wildlife and Zoo Ruminants (Subfamily Antilopinae, Hippotraginae, and Caprinae)

Growing Turkeys

Swine (Growing pigs, gilts, pregnant sows, and boars)

Cattle (Dairy and Beef Cattle)

Horses

Wild quail

Defendazole™

Defendazole™

Beef and Dairy Cattle

Goats

Safe-Guard®

Safe-Guard®

Beef and dairy cattle

Safe-Guard®

Safe-Guard® Panacur®

Cattle (beef and dairy)

Goats

Panacur®

Safe-Guard® Panacur®

Cattle (beef and dairy)

Goats