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Roxee Medication Guide

Frunevetmab

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Sources vary Rx required Injection Zoetis Inc. Official label facts Owner quick guide first
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Showing simplified owner view. Switch to Vet View for full technical detail.
Source variance noted. Roxee found source differences in non-clinical fields such as brand, manufacturer, source URL, or display metadata. Core owner guidance and official source links are still available.
Source variance fields
  • Dosage forms (Official label describes Solensia as frunevetmab injection.)

Data freshness

Reference facts
Reference refreshed
Aug 6, 2026, 7:58 p.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
Aug 6, 2026, 7:47 p.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
Aug 6, 2026, 7:49 p.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:58 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Aug 6, 2026, 7:46 PM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed May 15, 2026, 10:00 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Illustration placeholder
Frunevetmab

Frunevetmab

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Injection Rx required 100% reference complete

Species: Both

Manufacturer: Zoetis Inc.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Frunevetmab

For the control of pain associated with osteoarthritis in cats. Species commonly shown: Cats.

Generic name
Frunevetmab
Brand names
Solensia™, Solensia
Medication class
branded
Manufacturer
Zoetis Inc.
Species
Cat
Dosage forms
Injection
Strengths
7 mg/mL
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
Solensia™ Solensia
Dosage forms
Injection
Strengths
7 mg/mL

Indications / Uses

For the control of pain associated with osteoarthritis in cats.

Administration / How To Give

Administer by subcutaneous injection once a month, dosed by weight range, as directed and given by a veterinarian.

Warnings / Contraindications

Do not administer Solensia to cats with known hypersensitivity to frunevetmab.

  • Do not administer Solensia to cats with known hypersensitivity to frunevetmab; accidental self-injection can cause hypersensitivity reactions in people.

Side Effects

Top reported reactions (openFDA): General illness, Lethargy (see also Central nervous system depression in Neurological), Prescribing error, Anorexia, Behavioural disorder NOS, Confusion.

FAQ

Cats

Yes. Roxee shows this as prescription-only.

Injection, Injectable Solution

Related Conditions

Osteoarthritis (Degenerative Joint Disease) Osteoarthritis (Degenerative Joint Disease) Pain (acute, chronic)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the control of pain associated with osteoarthritis in cats.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • wobbly/unsteady walking (1 reports)
  • Hair loss (1 reports)
  • Blood clot (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Frunevetmab; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2025-US-069686
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 27 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2025-US-069686
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2025-US-069686
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Unsteady walking (ataxia) (1 reports), Hair loss (1 reports), Blood clot (1 reports), Blindness (1 reports), Bladder distension (1 reports)

Body systems represented Signal grouping

Digestive (1), Skin & allergy (3), Neurologic (1), Behavior (1)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Cat (31 reports), Dog (1 reports)

Breed metadata in reports Metadata only

Domestic Shorthair (4), Cat (other) (2), Domestic Mediumhair (2). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Frunevetmab fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

wobbly/unsteady walking, Hair loss, Blood clot

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Frunevetmab brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2025-US-069686 · adverse_reaction · adverse reactions
  2. Contraindication and user safety warning from the official Solensia label. · safety_warning · warnings contraindications
  3. FDA application profile · official_label · quick facts
  4. Medication usage source · fda_animal_drugs · quick facts
  5. FOI · document · documents
  6. SPL · document · documents
  7. Safety communication · document · documents
  8. Official label · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: May 15, 2026, 10:04 AM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • wobbly/unsteady walking
  • Hair loss
  • Blood clot

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Hair loss (1 reports)
  • Blood clot (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Cat
Indication / use
For the control of pain associated with osteoarthritis in cats.
Form / route / dose
Form: Injectable Solution
Route: Subcutaneous
Confirm product label and patient-specific plan.
Warnings
No structured warnings linked yet.
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Zoetis Inc.
Form: Injectable Solution
Identifiers:
NADA: 141546 NDC Package: 54771-3520-1 NDC Package: 54771-3520-2 NDC Product: 54771
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
90
Matching reports
4
Active filters
2
Selected filters
Reaction: Decreased appetite Clear Body system: Neurologic Clear
Reset
Drill into common report signals
Intentional misuse (11) Lethargy (see also Central nervous system depression in Neurological) (11) Abnormal radiograph finding (10) Decreased appetite (10) Other (83) Digestive (26) Neurologic (23) Skin & allergy (19)
Showing up to 50 matching reports.

USA-USFDACVM-2026-US-003352

Received 2026-01-27 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.992 Kilogram)
Age
8+ years (13 Year)
Sex
Female Neutered
Region
USA
Reactions
DiarrhoeaDecreased appetiteLethargy (see also Central nervous system depression in Neurological)Bloody diarrhoeaDry mucous membraneOpen mouth breathingUnresponsive to stimuliDecreased haematocritIncreased percentage reticulocytesRegenerative anaemiaIntentional misuseThrombocytopeniaHypersalivationHeart murmur
Body systems
DigestiveNeurologicOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-073134

Received 2025-12-10 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (9.172 Kilogram)
Age
4-7 years (7 Year)
Sex
Female Unknown
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)Decreased appetiteInjection site lumpInjection site bleedingWoundInjection site complication NOS
Body systems
NeurologicDigestiveOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-075182

Received 2025-11-24 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (4.76 Kilogram)
Age
8+ years (11 Year)
Sex
Male Neutered
Region
USA
Reactions
Cold feeling to the touchDecreased appetiteLack of efficacy - NOSBehavioural disorder NOSVomitingRenal disorder NOSLethargy (see also Central nervous system depression in Neurological)Elevated renal parametersArthritisReluctant to moveWeight gainWobblinessDental diseaseRespiratory tract infection NOSAnaemia NOSElevated creatinineHypercalcaemiaFeverDehydrationDiarrhoeaDecreased haematocritDecreased red blood cell countDigestive tract disorder NOSSicknessDistressDiabetesDecreased body temperatureDeath by euthanasia
Body systems
OtherDigestiveEffectivenessBehaviorNeurologic
Outcomes
Euthanized

USA-USFDACVM-2025-US-067000

Received 2025-11-14 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.992 Kilogram)
Age
8+ years (13 Year)
Sex
Female Unknown
Region
USA
Reactions
DiarrhoeaDecreased appetiteLethargy (see also Central nervous system depression in Neurological)Bloody diarrhoeaDry mucous membraneOpen mouth breathingUnresponsive to stimuliDecreased haematocritIncreased percentage reticulocytesRegenerative anaemiaIntentional misuseUnderdoseThrombocytopeniaHeart murmurHypersalivation
Body systems
DigestiveNeurologicOther
Outcomes
Ongoing

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
27
Species represented
2
Grouped by Body System
Digestive (1) · Loss of appetite Skin & allergy (3) · Hair loss, Alopecia NOS, Alopecia local Neurologic (1) · Unsteady walking (ataxia) Behavior (1) · Behavioral disorder (unspecified) Other (26) · Blood clot, Blindness, Bladder distension
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Cat 1
Skin & allergy 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Behavior 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1

Species coverage: Cat (31) Dog (1)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Cat Serious - 1
Digestive Dog Non-serious - 1
Skin & allergy Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Behavior Cat Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Skin & allergy Cat Serious - 1
Skin & allergy Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Source metadata:

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

FDA Osteoarthritis in Cats Official label / PI · Safety communication Solensia Official Label (DailyMed) Official label / PI · Official label Solensia™ SPL · SPL

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

2

SPL

3

FOI

1

FDA Osteoarthritis in Cats

Official label / PI · Safety communication

Open original

This source does not expose a safe inline preview. Use the original source link for the full document.

FDA owner-facing context for osteoarthritis and Solensia in cats.

Solensia Official Label (DailyMed)

Official label / PI · Official label

Open original

This source does not expose a safe inline preview. Use the original source link for the full document.

Official Solensia label.

Solensia™

SPL · SPL

Open original
FDA Structured Product Label

Solensia™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
NADA
141-546
Status
RX
Form
Injectable Solution
Route
Subcutaneous
Species
Cat
Composition / specifications
7 mg/mL

Label highlights

Indication

For the control of pain associated with osteoarthritis in cats.

Dosage

The full content of 1 or 2 vials based on body weight to target a minimum dosage of 0.45 mg/lb. (1 mg/kg) body weight, administered subcutaneously once a month.

Solensia SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Solensia. Use the source link for the full official labeling record.

Solensia SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Solensia. Use the source link for the full official labeling record.

FOI Summary oN 141-546 Approved January 13, 2022.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:58 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Aug 6, 2026, 7:46 PM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed May 15, 2026, 10:00 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Solensia
Manufacturer mapping: Zoetis Inc.
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat
Rx/OTC: RX
Form/route: Injectable Solution • Subcutaneous
Applications: NADA 141-546
NDC: Packages 54771-3520-1 54771-3520-2 • Products 54771
Documents: 1 (FOI: 1) • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 3 • Cat 281 • View
Case summaries: 90 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: M19.90
Unspecified osteoarthritis, unspecified site

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Unsteady walking (ataxia) (1) Hair loss (1) Blood clot (1) Blindness (1) Bladder distension (1) Behavioral disorder (unspecified) (1) Basophilia (1) Azotaemia (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141546 NDC Package: 54771-3520-1 NDC Package: 54771-3520-2 NDC Product: 54771
Package NDC Product NDC Form / Route Status
54771-3520-1 54771 -
54771-3520-2 54771 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 117 Clinical 8 Manufacturer 0 Marketing 0
Current Field Facts
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-21)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-20)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-19)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-17)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-15)
  • side_effects: Top reported reactions (openFDA): General illness, Lethargy (see also Central nervous system depression in Neurological), Prescribing error, Anorexia, Behaviou… (Clinical, 2026-04-11)
  • administration: Administer by subcutaneous injection once a month, dosed by weight range, as directed and given by a veterinarian. (Official, 2026-04-22)
  • approval_reference: NADA 141-546 (Official, 2026-04-22)
  • brand_names: Solensia (Official, 2026-04-22)
  • contraindications: Do not administer Solensia to cats with known hypersensitivity to frunevetmab. (Official, 2026-04-22)
  • dosage_forms: Injection (Official, 2026-04-22)
  • drug_profile_type: branded (Official, 2026-04-22)
  • indications: For the control of pain associated with osteoarthritis in cats. (Official, 2026-08-06)
  • indications: For the control of pain associated with osteoarthritis in cats. (Official, 2026-08-05)
  • indications: For the control of pain associated with osteoarthritis in cats. (Official, 2026-08-04)
  • indications: For the control of pain associated with osteoarthritis in cats. (Official, 2026-08-03)
  • indications: For the control of pain associated with osteoarthritis in cats. (Official, 2026-08-02)
  • indications: For the control of pain associated with osteoarthritis in cats. (Official, 2026-08-01)
Recent Revisions
  • monitoring updated 2026-08-06 19:58 by curated_loader • Monitoring summary based on official label adverse-reaction and administration sections.
  • contraindications updated 2026-08-06 19:58 by curated_loader • Official contraindication from the Solensia label.
  • prescription_required updated 2026-08-06 19:58 by curated_loader • Federal law restricts Solensia to use by or on the order of a licensed veterinarian.
  • administration updated 2026-08-06 19:58 by curated_loader • Official dosage and administration directions from the Solensia label.
  • strengths updated 2026-08-06 19:58 by curated_loader • Official label lists Solensia as 7 mg/mL frunevetmab injection.
  • dosage_forms updated 2026-08-06 19:58 by curated_loader • Official label describes Solensia as frunevetmab injection.
  • species updated 2026-08-06 19:58 by curated_loader • Official label states Solensia is for use in cats.
  • usage updated 2026-08-06 19:58 by curated_loader • Official indication from the Solensia label.
  • drug_profile_type updated 2026-08-06 19:58 by curated_loader • Solensia is the branded FDA-approved animal drug for frunevetmab injection.
  • manufacturer_name updated 2026-08-06 19:58 by curated_loader • Official Solensia label identifies Zoetis as the labeler/manufacturer.
  • brand_names updated 2026-08-06 19:58 by curated_loader • Official label identifies Solensia as the proprietary product name.
  • approval_reference updated 2026-08-06 19:58 by curated_loader • Official FDA application reference for Solensia.
  • monitoring updated 2026-08-05 10:11 by curated_loader • Monitoring summary based on official label adverse-reaction and administration sections.
  • contraindications updated 2026-08-05 10:11 by curated_loader • Official contraindication from the Solensia label.
  • prescription_required updated 2026-08-05 10:11 by curated_loader • Federal law restricts Solensia to use by or on the order of a licensed veterinarian.
  • administration updated 2026-08-05 10:11 by curated_loader • Official dosage and administration directions from the Solensia label.
  • strengths updated 2026-08-05 10:11 by curated_loader • Official label lists Solensia as 7 mg/mL frunevetmab injection.
  • dosage_forms updated 2026-08-05 10:11 by curated_loader • Official label describes Solensia as frunevetmab injection.
  • species updated 2026-08-05 10:11 by curated_loader • Official label states Solensia is for use in cats.
  • usage updated 2026-08-05 10:11 by curated_loader • Official indication from the Solensia label.

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Solensia™
RX
Frunevetmab
Injectable Solution • Subcutaneous
Label highlights
Official documents
Zoetis Inc. NADA 141-546 Approved May 14, 2026

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Cat
Composition / specifications
7 mg/mL
Label highlights
Indication

For the control of pain associated with osteoarthritis in cats.

Dosage

The full content of 1 or 2 vials based on body weight to target a minimum dosage of 0.45 mg/lb. (1 mg/kg) body weight, administered subcutaneously once a month.

Limitations

FDA page: Open in Animal Drugs @ FDA

Usage

For the control of pain associated with osteoarthritis in cats.

Source: FDA Animal Drugs @ FDA • Reference

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Hair loss (1) • Cat Alopecia NOS (1) • Cat Alopecia local (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Cat

Showing top 5 for Neurologic.

Behavior
Behavioral disorder (1) • Cat

Showing top 5 for Behavior.

Other
Blood clot (1) • Cat Blindness (1) • Cat Bladder distension (1) • Cat Basophilia (1) • Cat Barbering (1) • Cat
Show more (21)
Azotaemia (1) • Cat Ascites (1) • Cat Arthritis (1) • Cat Arrhythmia (1) • Cat Anisocoria (1) • Cat Anaphylaxis (1) • Cat Anaemia NOS (1) • Cat Agonal breathing (1) • Cat Agitation (1) • Cat Acute renal failure (1) • Cat Accidental exposure (1) • Cat Abrasion (1) • Cat Abnormal ultrasound finding (1) • Cat Abnormal radiograph finding (1) • Cat Abnormal posture NOS (1) • Cat Abnormal movement NOS (1) • Cat Abnormal menace reflex test (1) • Cat Abnormal histology NOS (1) • Cat Abnormal cytology (1) • Cat Abnormal breathing (1) • Cat Abdominal pain (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Shorthair, Female, 11 year, 3.992 kilogram • Drug: MSK, Solution, Subcutaneous, Dose: 7 Milligram per animal • Reactions: Facial pruritus, Medication error NOS • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-014454
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 11.00 Year
  • Weight: 3.992 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Solution
  • Dose: 7 Milligram per animal
Reactions Reported:
Facial pruritus Medication error NOS
Outcomes: Recovered/Normal

Cat, Cat (other), Female, 17 year • Drug: MSK, Solution, Subcutaneous • Reactions: Acute renal failure, Listless • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-014418
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 17.00 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Solution
Reactions Reported:
Acute renal failure Listless
Outcomes: Recovered/Normal

Cat, Cat (other), Male, 12.5 year, 8.278 kilogram • Drug: MSK, Solution, Subcutaneous, Dose: 2 Vial per animal • Reactions: Weakness, Unsteady walking (ataxia), Gait abnormality, Luxation/subluxation, Joint pain… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-014416
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 12.50 Year
  • Weight: 8.278 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Solution
  • Dose: 2 Vial per animal
Reactions Reported:
Weakness Unsteady walking (ataxia) Gait abnormality Luxation/subluxation Joint pain Abnormal breathing Spondylosis
Outcomes: Ongoing

Cat, Domestic Shorthair, Female, 4 year • Drug: MSK, Solution, Subcutaneous, Dose: 7 Milligram per animal • Reactions: Constipation • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-014414
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 4.00 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Solution
  • Dose: 7 Milligram per animal
Reactions Reported:
Constipation
Outcomes: Ongoing

Cat, Domestic Mediumhair, Female, 19 year, 5.053 kilogram • Drug: MSK, Solution, Subcutaneous, Dose: 7 Milligram per animal • Reactions: Hind limb paralysis, Musculoskeletal disorder NOS, Urinary incontinence, Proprioception loss • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-014412
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 19.00 Year
  • Weight: 5.053 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Solution
  • Dose: 7 Milligram per animal
Reactions Reported:
Hind limb paralysis Musculoskeletal disorder NOS Urinary incontinence Proprioception loss
Outcomes: Ongoing

Cat, Domestic Mediumhair, Male, 13 year, 5.897 kilogram • Drug: MSK, Solution, Subcutaneous, Dose: 7 Milligram per animal, Frequency: 1 per month • Reactions: Skin scab • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-014388
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 13.00 Year
  • Weight: 5.897 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Solution
  • Dose: 7 Milligram per animal
  • Frequency: 1 per month
Reactions Reported:
Skin scab
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Female, 14 year, 6.895 kilogram • Drug: MSK, Solution, Subcutaneous, Dose: 7 Milligram per animal • Reactions: Licking, Localised hair loss, Skin scab, Elevated creatine-kinase, Medication error NOS • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-014453
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 14.00 Year
  • Weight: 6.895 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Solution
  • Dose: 7 Milligram per animal
Reactions Reported:
Licking Localised hair loss Skin scab Elevated creatine-kinase Medication error NOS
Outcomes: Ongoing

Cat, Domestic Shorthair, Female, 20 year, 2.631 kilogram • Drug: MSK, Solution, Subcutaneous, Dose: 7 Milligram per animal, Frequency: 1 per month • Reactions: Agitation, Vocalisation, Unsteady walking (ataxia), Weakness • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-014011
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 20.00 Year
  • Weight: 2.631 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Solution
  • Dose: 7 Milligram per animal
  • Frequency: 1 per month
Reactions Reported:
Agitation Vocalisation Unsteady walking (ataxia) Weakness
Outcomes: Recovered/Normal

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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