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Roxee Medication Guide

Hyaluronate Sodium

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Drops Multiple FDA labelers Official label facts Owner quick guide first
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Data freshness

Reference facts
Reference refreshed
Jun 22, 2026, 10:41 a.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
Jun 22, 2026, 10:41 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
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openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:41 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
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Hyaluronate Sodium

Hyaluronate Sodium

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Drops Rx required 100% reference complete

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Hyaluronate Sodium

Treatment of joint dysfunction in horses due to noninfectious synovitis associated with equine osteoarthritis. Treatment of joint dysfunction in horses due to non-infectious synovitis associated with equine osteoarthritis. For treatment of equine carpal and fetlock joint dysfunction caused by traumatic and/or degenerative joint disease of mild to moderate severity. Species commonly shown: Both, Horse, Not For Meat Production.

Generic name
Hyaluronate Sodium
Brand names
Hyvisc®, Equron®, Synacid™, Hyalovet®
Manufacturer
Multiple FDA labelers
Species
Both, Horse
Dosage forms
Drops, Liquid (Solution), Injectable Solution
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
Hyvisc® Equron® Synacid™ Hyalovet® Legend® Multi Dose Legend® Injectable Solution NexHA™ Hylartin® V Injection Hylartin® V Hyvisc Hyalovet BEPPEN FRESH DROP OphtHAvet Legend Multi Dose Legend NexHA
Dosage forms
Drops Liquid (Solution) Injectable Solution

Indications / Uses

Treatment of joint dysfunction in horses due to noninfectious synovitis associated with equine osteoarthritis. Treatment of joint dysfunction in horses due to non-infectious synovitis associated with equine osteoarthritis. For treatment of equine carpal and fetlock joint dysfunction caused by traumatic and/or degenerative joint disease of mild to moderate severity.

Warnings / Contraindications

For intra-articular injection in horses only. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horse intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intra-articular injection in horses only; must not be administered intravascularly. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intraarticular injection in horses only. Treatment may be repeated at weekly intervals for a total of four treatments. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • For intra-articular injection in horses only. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horse intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intra-articular injection in horses only; must not be administered intravascularly. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intraarticular injection in horses only. Treatment may be repeated at weekly intervals for a total of four treatments. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FAQ

Both, Horse, Not For Meat Production

Yes. Roxee shows this as prescription-only.

Drops, Liquid (Solution), Injectable Solution

Related Conditions

Osteoarthritis (Degenerative Joint Disease) Osteoarthritis (Degenerative Joint Disease) Trauma (HBC, falls, bite wounds)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

Treatment of carpal or fetlock joint dysfunction due to acute or chronic noninfectious synovitis associated with equine osteoarthritis.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • For intra-articular injection in horses only
  • Treatment may be repeated at weekly intervals for a total of three treatments
  • Do not use in horse intended for human consumption
  • must not be administered intravascularly
  • Do not use in horses intended for human consumption
  • For intraarticular injection in horses only
  • Treatment may be repeated at weekly intervals for a total of four treatments
  • Not for use in horses intended for food

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Limited Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Hyaluronate Sodium; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA adverse-event data
Safety signal coverage No signal rollup

No source-backed adverse-reaction rollup is linked yet. That is a data gap, not proof that no reactions occur.

Source: openFDA adverse-event data
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA adverse-event data
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Reaction signal map Limited data

No source-backed adverse-reaction rollup is linked yet for this medication. Use the owner watch list, official documents, and veterinary guidance.

What your vet may verify

Fit for this patient Vet check

Verify whether Hyaluronate Sodium fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

For intra-articular injection in horses only, Treatment may be repeated at weekly intervals for a total of three treatments, Do not use in horse intended for human consumption, must not be administered intravascularly, Do not use in horses intended for human consumption

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Roxee has limited reaction-signal depth for Hyaluronate Sodium right now. Use veterinary instructions, official documents, and direct clinic guidance for decisions.
Vet source depth
  1. openFDA adverse-event data · openfda · adverse reactions
  2. Contraindication source · fda_animal_drugs · warnings contraindications
  3. FDA application profile · official_label · quick facts
  4. FDA application profile · official_label · quick facts
  5. Medication usage source · fda_animal_drugs · quick facts
  6. FOI · document · documents
  7. SPL · document · documents
  8. FOI · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 10:44 PM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • For intra-articular injection in horses only
  • Treatment may be repeated at weekly intervals for a total of three treatments
  • Do not use in horse intended for human consumption
  • must not be administered intravascularly
  • Do not use in horses intended for human consumption

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Horse
Indication / use
Treatment of carpal or fetlock joint dysfunction due to acute or chronic noninfectious synovitis associated with equine osteoarthritis.
Form / route / dose
Form: Injectable Solution, Liquid (Solution)
Route: Intra-Articular, Intravenous
Confirm product label and patient-specific plan.
Warnings
  • High: For intra-articular injection in horses only. Treatment may be repeated at weekly intervals for a total of three treatm…
Adverse-event caveat
No stored openFDA case explorer rows are linked yet.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Multiple FDA labelers
Form: Injectable Solution, Liquid (Solution)
Identifiers:
ANADA: 200432 NADA: 112048 NADA: 122578 NADA: 139913 NADA: 140474 NADA: 140806 NADA: 140883 NDC Package: 0010-3140-01 NDC Package: 0010-3141-01 NDC Package: 0010-3142-01 NDC Package: 0010-4130-01 NDC Package: 0010-4705-01 NDC Package: 0010-4705-02 NDC Package: 17030-098-01 NDC Package: 17030-098-12 NDC Package: 17033-045-10 NDC Package: 86243-0002-1 NDC Package: 86243-0003-1 NDC Product: 0010 NDC Product: 17030
Source metadata:

Warnings / Contraindications

For intra-articular injection in horses only. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horse intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intra-articular injection in horses only; must not be administered intravascularly. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intraarticular injection in horses only. Treatment may be repeated at weekly intervals for a total of four treatments. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: For intra-articular injection in horses only. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horse intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intra-articular injection in horses only; must not be administered intravascularly. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intraarticular injection in horses only. Treatment may be repeated at weekly intervals for a total of four treatments. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

Hyalovet® SPL · SPL Legend® Multi Dose SPL · SPL Legend® Injectable Solution SPL · SPL

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

18

FOI

7

Hyalovet®

SPL · SPL

Open original
FDA Structured Product Label

Hyalovet®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Boehringer Ingelheim Animal Health USA, Inc.
NADA
140-806
Status
RX
Form
Liquid (Solution)
Route
Intra-Articular
Species
Horse
Composition / specifications
Each milliliter of sterile aqueous solution contains 10 milligrams of hyaluronate sodium.

Horses

Indication
Treatment of carpal or fetlock joint dysfunction due to acute or chronic noninfectious synovitis associated with equine osteoarthritis.
Dosage

Small and medium-sized joints (carpal, fetlock)-20 milligrams. Treatment may be repeated after 1 or more weeks but not to exceed 2 injections per week for a total of 4 weeks.

Legend® Multi Dose

SPL · SPL

Open original
FDA Structured Product Label

Legend® Multi Dose Legend® Injectable Solution

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Boehringer Ingelheim Animal Health USA, Inc.
NADA
140-883
Status
RX
Form
Liquid (Solution)
Route
Intra-Articular, Intravenous
Species
Horse
Composition / specifications
Each milliliter of sterile aqueous solution contains 10 milligrams of hyaluronate sodium.

Horses

Indication
Treatment of carpal or fetlock joint dysfunction in horses due to noninfectious synovitis associated with equine osteoarthritis.
Dosage

4 mL (40 milligrams) by slow intravenous injection into the jugular vein. Intra-articular- 2 mL (20 mg) in the carpus or fetlock. Treatment may be repeated at weekly intervals for a total of three treatments.

Limitations

Use aseptic technique and inject slowly into the jugular vein. Horses should be given stall rest after treatment before gradually resuming normal activity. Not for intra-articular use - 4 mL (40 milligrams). Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Legend® Injectable Solution

SPL · SPL

Open original
FDA Structured Product Label

Legend® Multi Dose Legend® Injectable Solution

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Boehringer Ingelheim Animal Health USA, Inc.
NADA
140-883
Status
RX
Form
Liquid (Solution)
Route
Intra-Articular, Intravenous
Species
Horse
Composition / specifications
Each milliliter of sterile aqueous solution contains 10 milligrams of hyaluronate sodium.

Horses

Indication
Treatment of carpal or fetlock joint dysfunction in horses due to noninfectious synovitis associated with equine osteoarthritis.
Dosage

4 mL (40 milligrams) by slow intravenous injection into the jugular vein. Intra-articular- 2 mL (20 mg) in the carpus or fetlock. Treatment may be repeated at weekly intervals for a total of three treatments.

Limitations

Use aseptic technique and inject slowly into the jugular vein. Horses should be given stall rest after treatment before gradually resuming normal activity. Not for intra-articular use - 4 mL (40 milligrams). Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Hyvisc®

SPL · SPL

Open original
FDA Structured Product Label

Hyvisc®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Anika Therapeutics
NADA
122-578
Status
RX
Form
Liquid (Solution)
Route
Intra-Articular

Horses

Indication
Treatment of joint dysfunction in horses due to non-infectious synovitis associated with equine osteoarthritis.
Dosage
The recommended dose is 2 mL (22 mg) given intra-articularly in small and medium-size joints (carpal, fetlock) and 4 mL (44 mg) in larger joints (hock).
Limitations
For intra-articular injection in horses only; must not be administered intravascularly. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Equron®

SPL · SPL

Open original
FDA Structured Product Label

Equron®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
NADA
139-913
Status
RX
Form
Liquid (Solution)
Route
Intra-Articular
Species
Horse
Composition / specifications
Each milliliter of sterile aqueous solution contains 5 milligrams of hyaluronate sodium.

Horses

Indication
Treatment of joint dysfunction in horses due to noninfectious synovitis associated with equine osteoarthritis.
Dosage
Small and medium-size joints (carpal, fetlock)-10 milligrams; larger joint (hock)-20 milligrams.
Limitations
For intraarticular injection in horses only. Treatment may be repeated at weekly intervals for a total of four treatments. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Hylartin® V Injection

SPL · SPL

Open original
FDA Structured Product Label

Hylartin® V Injection Hylartin® V

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
NADA
112-048
Status
RX
Form
Liquid (Solution)
Route
Intra-Articular
Species
Horse
Composition / specifications
Each milliliter of sterile aqueous solution contains 10 milligrams of hyaluronate sodium.

Horses

Indication
Treatment of joint dysfunction in horses due to noninfectious synovitis associated with equine osteoarthritis.
Dosage
Small and medium-size joints (carpal, fetlock)-20 milligrams; larger joint (hock)-40 milligrams.
Limitations
For intra-articular injection in horses only. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horse intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Hylartin® V

SPL · SPL

Open original
FDA Structured Product Label

Hylartin® V Injection Hylartin® V

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
NADA
112-048
Status
RX
Form
Liquid (Solution)
Route
Intra-Articular
Species
Horse
Composition / specifications
Each milliliter of sterile aqueous solution contains 10 milligrams of hyaluronate sodium.

Horses

Indication
Treatment of joint dysfunction in horses due to noninfectious synovitis associated with equine osteoarthritis.
Dosage
Small and medium-size joints (carpal, fetlock)-20 milligrams; larger joint (hock)-40 milligrams.
Limitations
For intra-articular injection in horses only. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horse intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

NexHA™

SPL · SPL

Open original
FDA Structured Product Label

NexHA™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Vetoquinol USA, Inc.
ANADA
200-432
Status
RX
Form
Injectable Solution
Route
Intra-Articular, Intravenous
Composition / specifications
10 mg/ml

Horses

Indication
Treatment of joint dysfunction of the carpus or fetlock in horses due to non-infectious synovitis associated with equine osteoarthritis.
Dosage
Administer 2 mL (20 mg) by intra-articular injection into the carpus or fetlock or 4 mL (40 mg) by slow intravenous injection into the jugular vein. Treatment may be repeated at weekly intervals for a total of three treatments.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption.

Synacid™

SPL · SPL

Open original
FDA Structured Product Label

Synacid™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Intervet, Inc.
NADA
140-474
Status
RX
Form
Liquid (Solution)
Route
Intra-Articular
Species
Horse
Composition / specifications
Each milliliter of sterile aqueous solution contains 10 milligrams of hyaluronate sodium.

Horses

Indication
For treatment of equine carpal and fetlock joint dysfunction caused by traumatic and/or degenerative joint disease of mild to moderate severity.
Dosage
50 milligrams in carpal and fetlock joints.
Limitations
For intraarticular injection in horses only. Not for use in horses intended for food. Not intended for use in breeding animals. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Hyalovet SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Hyalovet. Use the source link for the full official labeling record.

Hyvisc SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Hyvisc. Use the source link for the full official labeling record.

NexHA SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for NexHA. Use the source link for the full official labeling record.

Legend SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Legend. Use the source link for the full official labeling record.

Legend SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Legend. Use the source link for the full official labeling record.

Legend Multi Dose SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Legend Multi Dose. Use the source link for the full official labeling record.

BEPPEN FRESH DROP SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for BEPPEN FRESH DROP. Use the source link for the full official labeling record.

OphtHAvet SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for OphtHAvet. Use the source link for the full official labeling record.

BEPPEN FRESH DROP SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for BEPPEN FRESH DROP. Use the source link for the full official labeling record.

N140806_Org_5_31_88.pdf

FOI · FOI

Open original

ucm054829.pdf

FOI · FOI

Open original

N140883_Orig_9_12_1991.pdf

FOI · FOI

Open original

N122578_Supp_09_30_1998.pdf

FOI · FOI

Open original

UCM478007.pdf

FOI · FOI

Open original

UCM381702.pdf

FOI · FOI

Open original

UCM478013.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:41 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: BEPPEN FRESH DROP Hyalovet Hyvisc Legend Legend Multi Dose NexHA OphtHAvet
Manufacturer mapping: Multiple FDA labelers
Catalog species: Both • FDA-labeled species: Horse
Rx/OTC: RX
Form/route: Injectable Solution, Liquid (Solution) • Intra-Articular, Intravenous
Applications: NADA 140-806 • NADA 140-883 • NADA 122-578 • NADA 139-913 • NADA 112-048 • ANADA 200-432 • NADA 140-474
NDC: Packages 0010-3140-01 0010-3141-01 0010-3142-01 0010-4130-01 0010-4705-01 0010-4705-02 • Products 0010 17030 17033 86243
Documents: 7 (FOI: 7) • SPL: 9 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 0 • Cat 0
Case summaries: 0
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: M19.90
Unspecified osteoarthritis, unspecified site

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • For intra-articular injection in horses only. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horse intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intra-articular injection in horses only; must not be administered intravascularly. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intraarticular injection in horses only. Treatment may be repeated at weekly intervals for a total of four treatments. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200432 NADA: 112048 NADA: 122578 NADA: 139913 NADA: 140474 NADA: 140806 NADA: 140883 NDC Package: 0010-3140-01 NDC Package: 0010-3141-01 NDC Package: 0010-3142-01 NDC Package: 0010-4130-01 NDC Package: 0010-4705-01 NDC Package: 0010-4705-02 NDC Package: 17030-098-01 NDC Package: 17030-098-12 NDC Package: 17033-045-10 NDC Package: 86243-0002-1 NDC Package: 86243-0003-1 NDC Product: 0010 NDC Product: 17030 NDC Product: 17033 NDC Product: 86243
Package NDC Product NDC Form / Route Status
0010-3140-01 0010 -
0010-3141-01 0010 -
0010-3142-01 0010 -
0010-4130-01 0010 -
0010-4705-01 0010 -
0010-4705-02 0010 -
17030-098-01 17030 -
17030-098-12 17030 -
17033-045-10 17033 -
86243-0002-1 86243 -
86243-0003-1 86243 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • Hyalovet SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Hyvisc SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • NexHA SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Legend SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Legend SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Legend Multi Dose SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • BEPPEN FRESH DROP SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • OphtHAvet SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • BEPPEN FRESH DROP SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • N140806_Org_5_31_88.pdf • FOI summary • Official • May 15, 2020
    FDA FOI summary for application 140806
  • N140883_Orig_9_12_1991.pdf • FOI summary • Official • Dec. 11, 2019
    FDA FOI summary for application 140883
  • ucm054829.pdf • FOI summary • Official • Dec. 11, 2019
    FDA FOI summary for application 140883
  • N122578_Supp_09_30_1998.pdf • FOI summary • Official • July 10, 2017
    FDA FOI summary for application 122578
  • UCM381702.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 200432
  • UCM478013.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 140474
  • UCM478007.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 139913

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 136 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: For intra-articular injection in horses only. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horse intended for h… (Official, 2026-02-12)
  • dosage_forms: Drops (Official, 2026-06-22)
  • dosage_forms: Drops (Official, 2026-06-22)
  • dosage_forms: Drops (Official, 2026-06-21)
  • dosage_forms: Drops (Official, 2026-06-20)
  • dosage_forms: Drops (Official, 2026-06-13)
  • dosage_forms: Drops (Official, 2026-06-12)
  • dosage_forms: Drops (Official, 2026-06-12)
  • dosage_forms: Drops (Official, 2026-06-11)
  • dosage_forms: Drops (Official, 2026-06-11)
  • dosage_forms: Drops (Official, 2026-06-10)
  • dosage_forms: Drops (Official, 2026-06-09)
  • dosage_forms: Drops (Official, 2026-06-08)
  • dosage_forms: Drops (Official, 2026-06-07)
  • dosage_forms: Drops (Official, 2026-06-06)
  • dosage_forms: Drops (Official, 2026-06-05)
  • dosage_forms: Drops (Official, 2026-06-04)
  • dosage_forms: Drops (Official, 2026-06-03)
  • dosage_forms: Drops (Official, 2026-06-02)
  • dosage_forms: Drops (Official, 2026-06-01)
Recent Revisions
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Hyalovet®
RX
Hyaluronate Sodium
Liquid (Solution) • Intra-Articular
Label highlights
Official documents
Boehringer Ingelheim Animal Health USA, Inc. NADA 140-806 Approved May 15, 2020
Legend® Multi Dose Legend® Injectable Solution
RX
Hyaluronate Sodium
Liquid (Solution) • Intra-Articular, Intravenous
Label highlights
Official documents
Boehringer Ingelheim Animal Health USA, Inc. NADA 140-883 Approved Dec 11, 2019
Hyvisc®
RX
Hyaluronate Sodium
Liquid (Solution) • Intra-Articular
Label highlights
Official documents
Anika Therapeutics NADA 122-578 Approved Jul 10, 2017
Equron®
RX
Hyaluronate Sodium
Liquid (Solution) • Intra-Articular
Label highlights
Official documents
Zoetis Inc. NADA 139-913 Approved Jun 1, 2016
Hylartin® V Injection Hylartin® V
RX
Hyaluronate Sodium
Liquid (Solution) • Intra-Articular
Label highlights
Official documents
Zoetis Inc. NADA 112-048 Approved Jun 1, 2016
NexHA™
RX
Hyaluronate Sodium
Injectable Solution • Intra-Articular, Intravenous
Label highlights
Official documents
Vetoquinol USA, Inc. ANADA 200-432 Approved Jun 1, 2016
Synacid™
RX
Hyaluronate Sodium
Liquid (Solution) • Intra-Articular
Label highlights
Official documents
Intervet, Inc. NADA 140-474 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Horse
Composition / specifications
Each milliliter of sterile aqueous solution contains 10 milligrams of hyaluronate sodium.
Horses
Indication
Treatment of carpal or fetlock joint dysfunction due to acute or chronic noninfectious synovitis associated with equine osteoarthritis.
Dosage

Small and medium-sized joints (carpal, fetlock)-20 milligrams. Treatment may be repeated after 1 or more weeks but not to exceed 2 injections per week for a total of 4 weeks.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Horse
Composition / specifications
Each milliliter of sterile aqueous solution contains 10 milligrams of hyaluronate sodium.
Horses
Indication
Treatment of carpal or fetlock joint dysfunction in horses due to noninfectious synovitis associated with equine osteoarthritis.
Dosage

4 mL (40 milligrams) by slow intravenous injection into the jugular vein. Intra-articular- 2 mL (20 mg) in the carpus or fetlock. Treatment may be repeated at weekly intervals for a total of three treatments.

Limitations

Use aseptic technique and inject slowly into the jugular vein. Horses should be given stall rest after treatment before gradually resuming normal activity. Not for intra-articular use - 4 mL (40 milligrams). Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Horses
Indication
Treatment of joint dysfunction in horses due to non-infectious synovitis associated with equine osteoarthritis.
Dosage
The recommended dose is 2 mL (22 mg) given intra-articularly in small and medium-size joints (carpal, fetlock) and 4 mL (44 mg) in larger joints (hock).
Limitations
For intra-articular injection in horses only; must not be administered intravascularly. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Horse
Composition / specifications
Each milliliter of sterile aqueous solution contains 5 milligrams of hyaluronate sodium.
Horses
Indication
Treatment of joint dysfunction in horses due to noninfectious synovitis associated with equine osteoarthritis.
Dosage
Small and medium-size joints (carpal, fetlock)-10 milligrams; larger joint (hock)-20 milligrams.
Limitations
For intraarticular injection in horses only. Treatment may be repeated at weekly intervals for a total of four treatments. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Horse
Composition / specifications
Each milliliter of sterile aqueous solution contains 10 milligrams of hyaluronate sodium.
Horses
Indication
Treatment of joint dysfunction in horses due to noninfectious synovitis associated with equine osteoarthritis.
Dosage
Small and medium-size joints (carpal, fetlock)-20 milligrams; larger joint (hock)-40 milligrams.
Limitations
For intra-articular injection in horses only. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horse intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Composition / specifications
10 mg/ml
Horses
Indication
Treatment of joint dysfunction of the carpus or fetlock in horses due to non-infectious synovitis associated with equine osteoarthritis.
Dosage
Administer 2 mL (20 mg) by intra-articular injection into the carpus or fetlock or 4 mL (40 mg) by slow intravenous injection into the jugular vein. Treatment may be repeated at weekly intervals for a total of three treatments.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption.

FDA page: Open in Animal Drugs @ FDA

Species: Horse
Composition / specifications
Each milliliter of sterile aqueous solution contains 10 milligrams of hyaluronate sodium.
Horses
Indication
For treatment of equine carpal and fetlock joint dysfunction caused by traumatic and/or degenerative joint disease of mild to moderate severity.
Dosage
50 milligrams in carpal and fetlock joints.
Limitations
For intraarticular injection in horses only. Not for use in horses intended for food. Not intended for use in breeding animals. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Usage

Treatment of joint dysfunction in horses due to noninfectious synovitis associated with equine osteoarthritis. Treatment of joint dysfunction in horses due to non-infectious synovitis associated with equine osteoarthritis. For treatment of equine carpal and fetlock joint dysfunction caused by traumatic and/or degenerative joint disease of mild to moderate severity.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

For intra-articular injection in horses only. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horse intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intra-articular injection in horses only; must not be administered intravascularly. Treatment may be repeated at weekly intervals for a total of three treatments. Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intraarticular injection in horses only. Treatment may be repeated at weekly intervals for a total of four treatments. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

No case-level openFDA reports are linked for this medication yet.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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