Roxee Medication Guide

Imidacloprid, Moxidectin

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Liquid (Solution) Multiple FDA labelers Official label facts Owner quick guide first

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Data freshness

Reference facts

Reference refreshed

Aug 6, 2026, 7:47 p.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications

FDA application data refreshed

Aug 6, 2026, 7:47 p.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports

Safety data refreshed

Aug 6, 2026, 7:49 p.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details

Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
The reference fact projection used for browse cards and quick facts.
Animal Drugs @ FDA: Source FDA | Refreshed Aug 6, 2026, 7:46 PM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC

Illustration placeholder

Imidacloprid, Moxidectin

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Liquid (Solution) Rx required 100% reference complete

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Imidacloprid, Moxidectin

For the prevention of heartworm disease caused by Dirofilaria immitis ; and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs; and the treatment and control of intestinal roundworms ( Toxocara canis and Toxascaris leonina ), hookworms ( Ancylostoma caninum and Uncinaria stenocephala ), and whipworms ( Trichuris vulpis ); kills adult fleas and treats flea infestations ( Ctenocephalides felis ); treats and controls sarcoptic mange caused by Sarcoptes scabiei var. canis . For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis ; kills adult fleas ( Ctenocephalides felis ) and is indicated for the treatment of flea infestations on ferrets. For the prevention of heartworm disease caused by Dirofilaria immitis ; for the treatment and control of ear mite ( Otodectes cynotis ) infestations, intestinal roundworms ( Toxocara cati ), and hookworms ( Ancylostoma tubaeforme ); kills adult fleas and treats flea infestations ( Ctenocephalides felis ). Species commonly shown: Both, Dog.

Generic name

Imidacloprid, Moxidectin

Brand names

Advantage Multi™ for Dogs, advantage multi™ for cats, IMOXI™ Topical Solution for Dogs, IMOXI™ Topical Solution for Cats

Manufacturer

Multiple FDA labelers

Species

Both, Dog, Cat

Dosage forms

Liquid (Solution), Solution, Topical Solution

Prescription

Prescription required

Completeness

100%

Validation

Needs review

Brand names

Advantage Multi™ for Dogs advantage multi™ for cats IMOXI™ Topical Solution for Dogs IMOXI™ Topical Solution for Cats PARASEDGE® Multi for Dogs PARASEDGE™ Multi for Cats Barrier® for cats Midamox® for Dogs Barrier® for dogs Midamox® for Cats MoxiCloprid™ for Cats MoxiCloprid™ for Dogs IMOXI for Cats PARASEDGE Multi for Dogs 9.1 - 20 lbs BARRIER FOR DOGS ADVANTAGE MULTI FOR CATS Midamox for Cats PARASEDGE Multi for Dogs 20.1 - 55 lbs PARASEDGE Multi for Dogs 88.1 - 110 lbs PARASEDGE Multi for Dogs 55.1 - 88 lbs ADVANTAGE MULTI FOR DOGS Midamox for Dogs PARASEDGE Multi for Cats 9 - 18 lbs IMOXI for Dogs PARASEDGE Multi for Cats 2 - 5 lbs PARASEDGE Multi for Dogs 3 - 9 lbs PARASEDGE Multi for Cats 5.1 - 9 lbs BARRIER FOR CATS

Dosage forms

Liquid (Solution) Solution Topical Solution

Indications / Uses

Warnings / Contraindications

Do not administer this product orally. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use this product (containing 2.5 %moxidectin) on cats. Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets. The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick or debilitated ferrets. Do not apply to irritated skin. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick, debilitated, or underweight cats. Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight. Do not apply to irritated skin.

Do not administer this product orally. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use this product (containing 2.5 %moxidectin) on cats. Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets. The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick or debilitated ferrets. Do not apply to irritated skin. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick, debilitated, or underweight cats. Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight. Do not apply to irritated skin.

Side Effects

Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Lack of efficacy (ectoparasite) - flea, Lack of efficacy (endoparasite) - hookworm, Vomiting, Diarrhoea, Other abnormal test result NOS.

FAQ

Both, Dog, Cat

Yes. Roxee shows this as prescription-only.

Liquid (Solution), Solution, Topical Solution

Related Conditions

Fleas (Flea Infestation) Heartworm Disease Intestinal Parasites (Worms) Mange (sarcoptic mange, demodicosis) Pica Sarcoptic Mange (Scabies)

Source Transparency

Verified source: https://www.roxee.ai/meds/
Verified source: https://animaldrugsatfda.fda.gov
Verified source: https://animaldrugsatfda.fda.gov/adafda/views/#/search
Verified source: https://api.fda.gov/animalandveterinary/event.json
Verified source: https://www.roxee.ai/conditions/
Verified source: https://www.accessdata.fda.gov/spl/data/0ef5c7f2-fabc-4716-a362-1de83778c017/0ef5c7f2-fabc-4716-a362-1de83778c017.xml
Last refreshed: Aug 6, 2026, 7:47 p.m.
Last verified: Apr 22, 2026, 10:06 a.m.
Validation status: Needs review

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. Kills adult fleas and is indicated for the treatment of...

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

Do not administer this product orally
For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals
Do not use this product (containing 2.5 %moxidectin) on cats
Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets
The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose
Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian
Do not use on sick or debilitated ferrets
Do not apply to irritated skin
Do not use on sick, debilitated, or underweight cats
Do not use on cats less than 9 weeks of age or less than 2 lbs
body weight
Loss of appetite (1 reports)
Elevated alanine aminotransferase (1 reports)
Electrolyte disorder (1 reports)

When to call the vet:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Trouble breathing.
Facial swelling or hives.
Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

Is this medicine the right fit for my pet’s current symptoms?
Which warning signs mean I should call back right away?
How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence

Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Imidacloprid, Moxidectin; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2025-US-068758

Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 15 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2025-US-068758

Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2025-US-068758

Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Loss of appetite (1 reports), Elevated alanine aminotransferase (1 reports), Electrolyte disorder (1 reports), Drug dose administration interval too short (1 reports), Discoloured urine (1 reports)

Body systems represented Signal grouping

Digestive (4), Skin & allergy (1), Behavior (1), Other (26)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Dog (23 reports), Cat (9 reports)

Breed metadata in reports Metadata only

Domestic Shorthair (2), Pit Bull (1), Retriever - Golden (1), Spaniel - King Charles Cavalier (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Imidacloprid, Moxidectin fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Do not administer this product orally, For the first 30 minutes after application ensure that dogs cannot lick the product from application, Do not use this product (containing 2.5 %moxidectin) on cats, Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets, The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Imidacloprid, Moxidectin brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.

Vet source depth

openFDA case USA-USFDACVM-2025-US-068758 · adverse_reaction · adverse reactions
Contraindication source · fda_animal_drugs · warnings contraindications
FDA application profile · official_label · quick facts
FDA application profile · official_label · quick facts
Medication usage source · fda_animal_drugs · quick facts
FOI · document · documents
SPL · document · documents
FOI · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: April 22, 2026, 10:06 AM UTC

Sources:

FDA application profile · official_label
FDA application profile · official_label
Medication usage source · fda_animal_drugs
MoxiCloprid™ for Dogs · official_label
openFDA case USA-USFDACVM-2025-US-068758 · adverse_reaction

Safety & side effects

Side effects to monitor:

Do not administer this product orally
For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals
Do not use this product (containing 2.5 %moxidectin) on cats
Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets
The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose

Most reported reactions:

Loss of appetite (1 reports)
Elevated alanine aminotransferase (1 reports)
Electrolyte disorder (1 reports)

Explore reported case details

Emergency warning signs:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Trouble breathing.

Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species

Cat, Dog

Indication / use

For the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. Kills adult fl…

Form / route / dose

Form: Liquid (Solution), Solution, Topical Solution
Route: Topical
Confirm product label and patient-specific plan.

Warnings

High: Do not administer this product orally. For the first 30 minutes after application ensure that dogs cannot lick the prod…

Adverse-event caveat

openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.

Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both

Manufacturer: Multiple FDA labelers

Form: Liquid (Solution), Solution, Topical Solution

Identifiers:

ANADA: 200615 ANADA: 200638 ANADA: 200700 ANADA: 200701 ANADA: 200714 ANADA: 200716 ANADA: 200718 ANADA: 200721 ANADA: 200811 ANADA: 200818 NADA: 141251 NADA: 141254 NDC Package: 17030-023-01 NDC Package: 17030-023-03 NDC Package: 17030-025-01 NDC Package: 17030-025-06 NDC Package: 17030-043-01 NDC Package: 17030-043-06 NDC Package: 17030-044-01 NDC Package: 17030-044-06

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200700 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200714 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source

Warnings / Contraindications

High: Do not administer this product orally. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use this product (containing 2.5 %moxidectin) on cats. Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets. The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick or debilitated ferrets. Do not apply to irritated skin. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick, debilitated, or underweight cats. Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight. Do not apply to irritated skin.

Source metadata:

https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters

openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.

Stored reports

Matching reports

Active filters

Species

Breed

Size / weight

Age

Sex

Seriousness

Outcome

Reaction

Body system

Region

Received after

Received before

Reset

Drill into common report signals

Lack of efficacy (endoparasite) - heartworm (4) Vomiting (4) Diarrhoea (3) Lack of efficacy (ectoparasite) - flea (3) Other (16) Effectiveness (12) Digestive (5) Neurologic (5)

Showing up to 50 matching reports.

USA-USFDACVM-2026-US-014097

Received 2026-03-24 · MSK · MSK

Non-serious

Species: Dog
Breed: Pit Bull
Size / weight: 50-99 lb (29.48 Kilogram)
Age: 4-7 years (4.25 Year)
Sex: Male Intact
Region: USA
Reactions: Lack of efficacy (endoparasite) - heartwormDrug dose omission
Body systems: EffectivenessOther
Outcomes: Outcome Unknown

USA-USFDACVM-2026-US-013874

Received 2026-03-23 · MSK · MSK

Serious

Species: Dog
Breed: Retriever - Golden
Size / weight: 50-99 lb (37.194 Kilogram)
Age: 4-7 years (7 Year)
Sex: Female Unknown
Region: USA
Reactions: Seizure NOS
Body systems: Neurologic
Outcomes: Outcome Unknown

USA-USFDACVM-2026-US-013525

Received 2026-03-23 · MSK · MSK

Non-serious

Species: Dog
Breed: Spaniel - King Charles Cavalier
Size / weight: 10-24 lb (9.53 Kilogram)
Age: 1-3 years (1.33 Year)
Sex: Male Unknown
Region: USA
Reactions: VomitingDecreased appetiteNot eatingLethargy (see also Central nervous system depression in Neurological)RollingDiarrhoeaWalking slowly
Body systems: DigestiveOtherNeurologic
Outcomes: Recovered/Normal

USA-USFDACVM-2026-US-013518

Received 2026-03-22 · MSK · MSK

Non-serious

Species: Dog
Breed: ['Beagle', 'Hound - Basset']
Size / weight: 25-49 lb (22.67 Kilogram)
Age: 8+ years (13 Year)
Sex: Male Neutered
Region: USA
Reactions: DiarrhoeaVomitingLethargy (see also Central nervous system depression in Neurological)InappetencePale mucous membraneDistension of abdomenMass NOS
Body systems: DigestiveNeurologicOther
Outcomes: Ongoing

USA-USFDACVM-2026-US-013926

Received 2026-03-19 · MSK · MSK

Non-serious

Species: Dog
Breed: ['Pit Bull', 'Crossbred Canine/dog']
Age: 1-3 years (2.67 Year)
Sex: Female Neutered
Region: USA
Reactions: CoughAbnormal radiograph findingHeart murmurEosinophiliaLack of efficacy (endoparasite) - heartworm
Body systems: OtherEffectiveness
Outcomes: Ongoing

USA-USFDACVM-2026-US-012371

Received 2026-03-17 · MSK · MSK

Non-serious

Species: Dog
Breed: Retriever - Labrador
Size / weight: 50-99 lb (36.73 Kilogram)
Age: 4-7 years (5 Year)
Sex: Female Neutered
Region: USA
Reactions: Lack of efficacy (endoparasite) - hookworm
Body systems: Effectiveness
Outcomes: Outcome Unknown

USA-USFDACVM-2026-US-013859

Received 2026-03-16 · MSK · MSK

Non-serious

Species: Cat
Breed: Domestic Shorthair
Size / weight: Under 10 lb (3.63 Kilogram)
Age: Under 1 year (11 Month)
Sex: Female Neutered
Region: USA
Reactions: Lack of efficacy (endoparasite) - tapewormSurgical site disorderSelf trauma
Body systems: EffectivenessOther
Outcomes: Outcome Unknown

USA-USFDACVM-2026-US-010812

Received 2026-03-09 · MSK · MSK

Serious

Species: Cat
Breed: Domestic Shorthair
Size / weight: 10-24 lb (7.1 Kilogram)
Age: 8+ years (9 Year)
Sex: Male Neutered
Region: USA
Reactions: Found dead
Body systems: Other
Outcomes: Died

USA-USFDACVM-2026-US-011072

Received 2026-03-04 · MSK · MSK

Non-serious

Species: Cat
Size / weight: 10-24 lb (5 Kilogram)
Age: 1-3 years (18 Month)
Sex: Female Neutered
Region: USA
Reactions: Application site alopeciaApplication site crustApplication site erythema
Body systems: Skin & allergyOther
Outcomes: Outcome Unknown

USA-USFDACVM-2026-US-009483

Received 2026-02-25 · MSK · MSK

Non-serious

Species: Dog
Breed: Pit Bull
Size / weight: 25-49 lb (12.7 Kilogram)
Age: Under 1 year (5 Month)
Sex: Female Intact
Region: USA
Reactions: Soft stoolVomitingAdministration error NOSAccidental exposureEmesis (multiple)
Body systems: OtherDigestive
Outcomes: Ongoing

USA-USFDACVM-2026-US-008464

Received 2026-02-24 · MSK · MSK

Non-serious

Species: Dog
Breed: Bulldog - French
Size / weight: 25-49 lb (11.4 Kilogram)
Age: 4-7 years (4 Year)
Sex: Male Neutered
Region: USA
Reactions: TwitchingIntention tremorAdministration error NOSTremor
Body systems: Skin & allergyNeurologicOther
Outcomes: Outcome Unknown

USA-USFDACVM-2026-US-008346

Received 2026-02-23 · MSK · MSK

Non-serious

Species: Cat
Breed: Domestic Shorthair
Size / weight: Under 10 lb (4.4 Kilogram)
Age: 4-7 years (4 Year)
Sex: Female Neutered
Region: USA
Reactions: MonocytosisLow creatinineGait abnormalityMuscle atrophy (see also Muscle wasting)Unkempt hair coatPlantigrade postureSedationGreasy skin
Body systems: Other
Outcomes: Ongoing

USA-USFDACVM-2026-US-003405

Received 2026-01-16 · MSK · MSK

Non-serious

Species: Cat
Breed: Domestic Shorthair
Size / weight: Under 10 lb (4.39 Kilogram)
Age: 4-7 years (4 Year)
Sex: Female Neutered
Region: USA
Reactions: Balance problemPlantigrade postureLimpingWobblinessMonocytosisGait abnormality
Body systems: Other
Outcomes: Outcome Unknown

USA-USFDACVM-2025-US-074899

Received 2025-12-22 · MSK · MSK

Non-serious

Species: Dog
Breed: Shepherd Dog - Australian
Size / weight: 25-49 lb (20.41 Kilogram)
Age: 8+ years (9 Year)
Sex: Female Neutered
Region: USA
Reactions: Lack of efficacy (bacteria) - Borrelia
Body systems: Effectiveness
Outcomes: Outcome Unknown

USA-USFDACVM-2025-US-074714

Received 2025-12-22 · MSK · MSK

Non-serious

Species: Dog
Breed: Bulldog - English
Size / weight: 50-99 lb (44.906 Kilogram)
Age: 8+ years (8.58 Year)
Sex: Male Neutered
Region: USA
Reactions: Lack of efficacy (protozoa) - GiardiaLack of efficacy (endoparasite) - hookworm
Body systems: Effectiveness
Outcomes: Outcome Unknown

USA-USFDACVM-2025-US-073848

Received 2025-12-18 · MSK · MSK

Non-serious

Species: Dog
Breed: ['Cattle Dog (unspecified)', 'Crossbred Canine/dog']
Size / weight: 25-49 lb (14.88 Kilogram)
Age: 1-3 years (3.5 Year)
Sex: Female Neutered
Region: USA
Reactions: Lack of efficacy (endoparasite) - heartworm
Body systems: Effectiveness
Outcomes: Outcome Unknown

USA-USFDACVM-2025-US-074791

Received 2025-12-17 · MSK · MSK

Non-serious

Species: Cat
Breed: Domestic Shorthair
Size / weight: Under 10 lb (3.67 Kilogram)
Age: Under 1 year (8 Month)
Sex: Male Intact
Region: USA
Reactions: Hives (see also Skin)Blistering (see also Application site SOC)Face and neck swelling (see also Skin)
Body systems: Skin & allergyOther
Outcomes: Outcome Unknown

USA-USFDACVM-2025-US-074174

Received 2025-12-17 · MSK · MSK

Non-serious

Species: Dog
Breed: Terrier - Yorkshire
Size / weight: Under 10 lb (1.81 Kilogram)
Age: 1-3 years (2 Year)
Sex: Female Unknown
Region: USA
Reactions: Behavioural disorder NOSShaking
Body systems: BehaviorOther
Outcomes: Outcome Unknown

USA-USFDACVM-2025-US-073617

Received 2025-12-15 · MSK · MSK

Non-serious

Species: Dog
Breed: Cattle Dog (unspecified)
Age: 1-3 years (3 Year)
Sex: Female Neutered
Region: USA
Reactions: Injection site swellingLack of efficacy (endoparasite) - heartworm
Body systems: Skin & allergyEffectiveness
Outcomes: Outcome Unknown

USA-USFDACVM-2025-US-073618

Received 2025-12-12 · MSK · MSK

Non-serious

Species: Cat
Breed: Domestic Shorthair
Age: 1-3 years (2 Year)
Sex: Female Neutered
Region: USA
Reactions: Lethargy (see also Central nervous system depression in Neurological)HidingBehavioural disorder NOSAbnormal urine odour
Body systems: NeurologicOtherBehavior
Outcomes: Ongoing

USA-USFDACVM-2025-US-073358

Received 2025-12-12 · MSK · MSK

Non-serious

Species: Cat
Breed: ['Domestic Longhair', 'Manx']
Size / weight: 10-24 lb (8.165 Kilogram)
Age: 8+ years (1 Year)
Sex: Male Neutered
Region: USA
Reactions: Lack of efficacy (ectoparasite) - flea
Body systems: Effectiveness
Outcomes: Outcome Unknown

USA-USFDACVM-2025-US-072060

Received 2025-12-04 · MSK · MSK

Non-serious

Species: Cat
Breed: Domestic Shorthair
Size / weight: Under 10 lb (4.1 Kilogram)
Age: 4-7 years (4 Year)
Sex: Male Neutered
Region: USA
Reactions: HyperactivityFoaming at the mouthExpired drug administered
Body systems: Other
Outcomes: Recovered/Normal

USA-USFDACVM-2025-US-072047

Received 2025-12-04 · MSK · MSK

Non-serious

Species: Cat
Breed: Domestic Shorthair
Size / weight: Under 10 lb (1.81 Kilogram)
Age: Under 1 year (4 Month)
Sex: Male Intact
Region: USA
Reactions: Lack of efficacy (ectoparasite) - ear mite
Body systems: Effectiveness
Outcomes: Outcome Unknown

USA-USFDACVM-2025-US-068100

Received 2025-11-14 · MSK · MSK

Non-serious

Species: Cat
Breed: Cat (unknown)
Size / weight: Under 10 lb (0.907 Kilogram)
Age: Under 1 year (11 Week)
Sex: Mixed Intact
Region: USA
Reactions: Lack of efficacy (ectoparasite) - fleaDehydrationDiarrhoeaNot eating
Body systems: EffectivenessOtherDigestive
Outcomes: Ongoing

USA-USFDACVM-2025-US-061673

Received 2025-10-15 · MSK · MSK

Non-serious

Species: Dog
Breed: Borzoi
Sex: Male Unknown
Region: USA
Reactions: VomitingLack of efficacy (ectoparasite) - fleaPruritus
Body systems: DigestiveEffectivenessSkin & allergy
Outcomes: Outcome Unknown

Tap or hover a reaction to see what it means in plain language.

Tracked signals

Reported cases

Serious reports

Species represented

Grouped by Body System

Digestive (4) · Loss of appetite, Diarrhea, Decreased appetite Skin & allergy (1) · Hair loss at application site Behavior (1) · Behavioral disorder (unspecified) Other (26) · Elevated alanine aminotransferase, Electrolyte disorder, Drug dose omission

Most Reported Reactions

Body system	Cases	Species	Serious cases
Digestive	1	Dog	1
Other	1	Dog	1
Other	1	Dog	1
Other	1	Dog	1
Other	1	Dog	1
Other	1	Dog	1
Other	1	Dog	1
Other	1	Dog	1

Species coverage: Dog (23) Cat (9)

View detailed reaction table

Body system	Species	Seriousness	Frequency	Reports
Digestive	Dog	Serious	-	1
Skin & allergy	Cat	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Digestive	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Digestive	Dog	Non-serious	-	1
Other	Dog	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Digestive	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Non-serious	-	1
Behavior	Dog	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Non-serious	-	1
Other	Dog	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Dog	Non-serious	-	1
Other	Dog	Serious	-	1

Source metadata:

https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-068758

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

PARASEDGE® Multi for Dogs SPL · SPL Barrier® for cats SPL · SPL MoxiCloprid™ for Dogs SPL · SPL

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

No owner handouts linked yet.

Official label / PI

No official label or package insert links yet.

SPL

FOI

PARASEDGE® Multi for Dogs

SPL · SPL

Open original

FDA Structured Product Label

PARASEDGE® Multi for Dogs

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Virbac AH, Inc.
ANADA: 200-700
Status: RX
Form: Topical Solution
Route: Topical
Species: Dog

Composition / specifications

100 mg/mL (10%) imidacloprid and 25 mg/mL (2.5%) moxidectin

Dogs

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. Kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). For the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. canis. It is also indicated for the treatment and control of the following intestinal parasites: adult, immature adult and fourth stage larvae in hookworm species (Ancylostoma caninum and Uncinaria stenocephala); adult and fourth stage larvae in roundworm species (Toxocara canis); and adult stage in roundworm species (Toxascaris leonina) and whipworm (Trichuris vulpis).

Dosage

The recommended minimum dose is 4.5 mg/lb. (10 mg/kg) imidacloprid and 1.1mg/lb. (2.5 mg/kg) moxidectin, once a month, by topical administration.

Barrier® for cats

SPL · SPL

Open original

FDA Structured Product Label

Barrier® for cats

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Aurora Pharmaceutical, Inc.
ANADA: 200-714
Status: RX
Form: Topical Solution
Route: Topical
Species: Cat

For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis; kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets.

Dosage

The recommended minimum dose is 9 mg/lb (20 mg/kg) imidacloprid and 0.9 mg/lb (2 mg/kg) moxidectin, once a month, by topical administration.

PARASEDGE™ Multi for Cats

SPL · SPL

Open original

FDA Structured Product Label

PARASEDGE™ Multi for Cats

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Virbac AH, Inc.
ANADA: 200-701
Status: RX
Form: Topical Solution
Route: Topical
Species: Cat

Composition / specifications

100 mg/mL (10%) imidacloprid and 10 mg/mL (1%) moxidectin

Cats

Indication

Indication

Dosage

The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration.

Advantage Multi™ for Dogs

SPL · SPL

Open original

FDA Structured Product Label

Advantage Multi™ for Dogs

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Elanco US Inc.
NADA: 141-251
Status: RX
Form: Liquid (Solution)
Route: Topical
Species: Dog

Composition / specifications

Each milliliter of solution contains 100 milligrams (mg) imidacloprid and 25 mg moxidectin.

Dogs

Indication

Dosage

Apply 4.5 mg/lb body weight (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg)moxidectin, once a month.

Limitations

advantage multi™ for cats

SPL · SPL

Open original

FDA Structured Product Label

advantage multi™ for cats

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Elanco US Inc.
NADA: 141-254
Status: RX
Form: Solution
Route: Topical
Species: Cat

Composition / specifications

Each milliliter of solution contains 100 mg imidacloprid and 10 mg moxidectin

Ferrets

Indication

For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis; kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets.

Dosage

The recommended minimum dose is 9 mg/lb (20 mg/kg) imidacloprid and 0.9 mg/lb (2 mg/kg) moxidectin, once a month, by topical administration.

Limitations

Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets. The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick or debilitated ferrets. Do not apply to irritated skin.

Cats

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis; for the treatment and control of ear mite (Otodectes cynotis) infestations, intestinal roundworms (Toxocara cati), and hookworms (Ancylostoma tubaeforme); kills adult fleas and treats flea infestations (Ctenocephalides felis).

Dosage

Apply 4.5 mg/lb body weight (10 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month.

Limitations

Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick, debilitated, or underweight cats. Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight. Do not apply to irritated skin.

IMOXI™ Topical Solution for Cats

SPL · SPL

Open original

FDA Structured Product Label

IMOXI™ Topical Solution for Cats

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Vetoquinol USA, Inc.
ANADA: 200-638
Status: RX
Form: Topical Solution
Route: Topical
Species: Cat

Composition / specifications

100 mg/mL (10%) imidacloprid and 10 mg/mL (1%) moxidectin

Cats

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis. Kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. It is also indicated for the treatment and control of ear mite (Otodectes cynotis) infestations and the following intestinal parasites: adult, immature adult, and fourth stage larvae in hookworms (Ancylostoma tubaeforme); and adult and fourth stage larvae in roundworm (Toxocara cati).

Dosage

The recommended minimum dose is 4.5 mg/lb. (10.0 mg/kg) imidacloprid and 0.45 mg/lb. (1.0 mg/kg) moxidectin, once a month, by topical administration.

IMOXI™ Topical Solution for Dogs

SPL · SPL

Open original

FDA Structured Product Label

IMOXI™ Topical Solution for Dogs

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Vetoquinol USA, Inc.
ANADA: 200-615
Status: RX
Form: Topical Solution
Route: Topical
Species: Dog

Composition / specifications

100 mg/mL (10%) imidacloprid and 25 mg/mL (2.5%) moxidectin

Dogs

Indication

FOI · FOI

Open original

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/11585 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/10973/PARASEDGE%C2%AE%20Multi%20for%20Dogs · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/11607 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/11695/Barrier%C2%AE%20for%20cats · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/17355 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/17608/MoxiCloprid%E2%84%A2%20for%20Dogs · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/11988 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/12057/Barrier%C2%AE%20for%20dogs · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/16707 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/16987/MoxiCloprid%E2%84%A2%20for%20Cats · document · SPL

Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness

Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
The reference fact projection used for browse cards and quick facts.
Animal Drugs @ FDA: Source FDA | Refreshed Aug 6, 2026, 7:46 PM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC

Official (FDA)

Identity: Generic ingredient • FDA branded products available

Official FDA brands: ADVANTAGE MULTI FOR CATS ADVANTAGE MULTI FOR DOGS BARRIER FOR CATS BARRIER FOR DOGS IMOXI for Cats IMOXI for Dogs Midamox for Cats Midamox for Dogs PARASEDGE Multi for Cats 2 - 5 lbs PARASEDGE Multi for Cats 5.1 - 9 lbs PARASEDGE Multi for Cats 9 - 18 lbs PARASEDGE Multi for Dogs 20.1 - 55 lbs PARASEDGE Multi for Dogs 3 - 9 lbs PARASEDGE Multi for Dogs 55.1 - 88 lbs PARASEDGE Multi for Dogs 88.1 - 110 lbs PARASEDGE Multi for Dogs 9.1 - 20 lbs

Manufacturer mapping: Multiple FDA labelers

Case-reported brands (openFDA): MSK

Catalog species: Both • FDA-labeled species: Cat, Dog

Rx/OTC: RX

Form/route: Liquid (Solution), Solution, Topical Solution • Topical

Applications: ANADA 200-700 • ANADA 200-714 • ANADA 200-818 • ANADA 200-718 • ANADA 200-811 • ANADA 200-701 • ANADA 200-721 • ANADA 200-716 • NADA 141-251 • NADA 141-254 • ANADA 200-638 • ANADA 200-615

NDC: Packages 17030-023-01 17030-023-03 17030-025-01 17030-025-06 17030-043-01 17030-043-06 • Products 17030 51072 51311 55529 58198 86136

Documents: 16 (FOI: 16) • SPL: 12 • Label highlights • Official documents

Safety (openFDA)

Top reactions: Dog 33 • Cat 33 • View

Case summaries: 25 (showing 8) • View

openFDA reports are unverified and do not prove causation.

Explore

Related conditions: Fleas (Flea Infestation) Heartworm Disease Intestinal Parasites (Worms) Mange (sarcoptic mange, demodicosis) Pica Sarcoptic Mange (Scabies)

Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)

Diagnosis Codes

ICD10_CM: B74.8 ICD10_CM: B82.9 ICD10_CM: B86 ICD10_CM: B88.1

Other filariases

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points

Do not administer this product orally. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Federal Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use this product (containing 2.5 %moxidectin) on cats. Use only the 0.4 mL ADVANTAGE MULTI for Cats in ferrets. The 0.23 mL size does not provide an effective dose and the 0.8mL size could result in an overdose. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick or debilitated ferrets. Do not apply to irritated skin. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Do not use on sick, debilitated, or underweight cats. Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight. Do not apply to irritated skin. (Contraindication, High)

Top reaction signals

Loss of appetite (1) Elevated alanine aminotransferase (1) Electrolyte disorder (1) Drug dose administration interval too short (1) Discoloured urine (1) Difficulty standing (1) Decreased drinking (1) Decreased cholesterol (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers

Package NDC	Product NDC	Status
17030-023-01	17030	-
17030-023-03	17030	-
17030-025-01	17030	-
17030-025-06	17030	-
17030-043-01	17030	-
17030-043-06	17030	-
17030-044-01	17030	-
17030-044-06	17030	-
17030-080-01	17030	-
17030-080-06	17030	-
17030-103-01	17030	-
17030-103-06	17030	-
17030-400-01	17030	-
17030-400-06	17030	-
17030-500-01	17030	-
17030-500-06	17030	-
51072-100-01	51072	-
51072-100-02	51072	-
51072-100-03	51072	-
51072-100-04	51072	-

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

ADVANTAGE MULTI FOR DOGS SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
BARRIER FOR CATS SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
IMOXI for Dogs SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Midamox for Dogs SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
IMOXI for Cats SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Midamox for Cats SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Midamox for Dogs SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
ADVANTAGE MULTI FOR CATS SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
PARASEDGE Multi for Cats 5.1 - 9 lbs SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Midamox for Cats SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
PARASEDGE Multi for Dogs 3 - 9 lbs SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
BARRIER FOR DOGS SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
BARRIER FOR CATS SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
ANADA 200-700 FOI Summar.pdf • FOI summary • Official • Dec. 16, 2025
FDA FOI summary for application 200700
FOI Summary oA 200-714 Approved November 24, 2021.pdf • FOI summary • Official • Dec. 5, 2025
FDA FOI summary for application 200714
FOI Summary oA 200-818 Approved August 5, 2025.pdf • FOI summary • Official • Aug. 28, 2025
FDA FOI summary for application 200818
FOI Summary oA 200-718 Approved February 7, 2022.pdf • FOI summary • Official • June 2, 2025
FDA FOI summary for application 200718
FOI Summary oA 200-811 Approved March 24, 2025.pdf • FOI summary • Official • March 28, 2025
FDA FOI summary for application 200811
FOI Summary oA 200-701 Approved June 10, 2021.pdf • FOI summary • Official • Oct. 24, 2023
FDA FOI summary for application 200701
FOI Summary sA 200-701 Approved February 9, 2023.pdf • FOI summary • Official • Oct. 24, 2023
FDA FOI summary for application 200701
FOI Summary oA 200-721 Approved March 28, 2022.pdf • FOI summary • Official • Oct. 10, 2023
FDA FOI summary for application 200721
FOI Summary sA 200-721 Approved January 12, 2023.pdf • FOI summary • Official • Oct. 10, 2023
FDA FOI summary for application 200721
FOI Summary oA 200-716 Approved January 28, 2022.pdf • FOI summary • Official • Aug. 23, 2023
FDA FOI summary for application 200716
UCM051438.pdf • FOI summary • Official • Feb. 2, 2023
FDA FOI summary for application 141251
UCM381705.pdf • FOI summary • Official • Feb. 2, 2023
FDA FOI summary for application 141251
UCM051423.pdf • FOI summary • Official • Aug. 22, 2022
FDA FOI summary for application 141254
UCM381709.pdf • FOI summary • Official • Aug. 22, 2022
FDA FOI summary for application 141254
FOI Summary oA 200-638 Approved May 27, 2020.pdf • FOI summary • Official • June 1, 2020
FDA FOI summary for application 200638
FOI Summary oA 200-615 Approved December 19, 2019.pdf • FOI summary • Official • Dec. 30, 2019
FDA FOI summary for application 200615

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 141 Clinical 8 Manufacturer 0 Marketing 0

Current Field Facts

monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-21)
monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-20)
monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-19)
monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-17)
monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-15)
side_effects: Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Lack of efficacy (ectoparasite) - flea, Lack of efficacy (endoparasite) - hookwo… (Clinical, 2026-04-11)
contraindications: Do not administer this product orally. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves… (Official, 2026-04-22)
indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-08-06)
indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-08-05)
indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-08-04)
indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-08-03)
indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-08-02)
indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-08-01)
indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-07-31)
indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-07-30)
indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-07-29)
indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-07-28)
indications: ADVANTAGE MULTI for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. ADVANTAGE MULTI for Cats kills adult fleas ( Cteno… (Official, 2026-07-27)

Recent Revisions

side_effects updated 2026-04-22 10:06 by etl_backfill • Backfilled from existing medication fields
contraindications updated 2026-04-22 10:06 by etl_backfill • Backfilled from existing medication fields
usage updated 2026-04-22 10:06 by etl_backfill • Backfilled from existing medication fields
monitoring updated 2026-04-21 10:06 by curated_loader • Clinical monitoring context for feline diabetes management.
usage updated 2026-04-21 10:06 by curated_loader • Usage statement from FDA warning letter and approved-product context.
drug_profile_type updated 2026-04-21 10:06 by curated_loader • FDA source confirms Senvelgo as a branded approved product.
manufacturer_name updated 2026-04-21 10:06 by curated_loader • FDA warning letter identifies the approved sponsor/manufacturer.
brand_names updated 2026-04-21 10:06 by curated_loader • FDA warning letter references Senvelgo as the approved animal drug.
approval_reference updated 2026-04-21 10:06 by curated_loader • Official FDA application reference for Senvelgo.
monitoring updated 2026-04-20 10:08 by curated_loader • Clinical monitoring context for feline diabetes management.
usage updated 2026-04-20 10:08 by curated_loader • Usage statement from FDA warning letter and approved-product context.
drug_profile_type updated 2026-04-20 10:08 by curated_loader • FDA source confirms Senvelgo as a branded approved product.
manufacturer_name updated 2026-04-20 10:08 by curated_loader • FDA warning letter identifies the approved sponsor/manufacturer.
brand_names updated 2026-04-20 10:08 by curated_loader • FDA warning letter references Senvelgo as the approved animal drug.
approval_reference updated 2026-04-20 10:08 by curated_loader • Official FDA application reference for Senvelgo.
monitoring updated 2026-04-19 10:07 by curated_loader • Clinical monitoring context for feline diabetes management.
usage updated 2026-04-19 10:07 by curated_loader • Usage statement from FDA warning letter and approved-product context.
drug_profile_type updated 2026-04-19 10:07 by curated_loader • FDA source confirms Senvelgo as a branded approved product.
manufacturer_name updated 2026-04-19 10:07 by curated_loader • FDA warning letter identifies the approved sponsor/manufacturer.
brand_names updated 2026-04-19 10:07 by curated_loader • FDA warning letter references Senvelgo as the approved animal drug.

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product	Sponsor	Application	Status	Published
PARASEDGE® Multi for Dogs RX Imidacloprid Moxidectin Topical Solution • Topical Label highlights Official documents	Virbac AH, Inc.	ANADA 200-700	Approved	Dec 16, 2025
Barrier® for cats RX Imidacloprid Moxidectin Topical Solution • Topical Label highlights Official documents	Aurora Pharmaceutical, Inc.	ANADA 200-714	Approved	Dec 5, 2025
MoxiCloprid™ for Dogs RX Imidacloprid Moxidectin Topical Solution • Topical Label highlights Official documents	Bimeda Animal Health Ltd.	ANADA 200-818	Approved	Aug 28, 2025
Barrier® for dogs RX Imidacloprid Moxidectin Topical Solution • Topical Label highlights Official documents	Aurora Pharmaceutical, Inc.	ANADA 200-718	Approved	Jun 2, 2025
MoxiCloprid™ for Cats RX Imidacloprid Moxidectin Topical Solution • Topical Label highlights Official documents	Bimeda Animal Health Ltd.	ANADA 200-811	Approved	Mar 28, 2025
PARASEDGE™ Multi for Cats RX Imidacloprid Moxidectin Topical Solution • Topical Label highlights Official documents	Virbac AH, Inc.	ANADA 200-701	Approved	Oct 24, 2023
Midamox® for Cats RX Imidacloprid Moxidectin Topical Solution • Topical Label highlights Official documents	Norbrook Laboratories, Ltd.	ANADA 200-721	Approved	Oct 10, 2023
Midamox® for Dogs RX Imidacloprid Moxidectin Topical Solution • Topical Label highlights Official documents	Norbrook Laboratories, Ltd.	ANADA 200-716	Approved	Aug 23, 2023
Advantage Multi™ for Dogs RX Imidacloprid Moxidectin Liquid (Solution) • Topical Label highlights Official documents	Elanco US Inc.	NADA 141-251	Approved	Feb 2, 2023
advantage multi™ for cats RX Imidacloprid Moxidectin Solution • Topical Label highlights Official documents	Elanco US Inc.	NADA 141-254	Approved	Aug 22, 2022
IMOXI™ Topical Solution for Cats RX Imidacloprid Moxidectin Topical Solution • Topical Label highlights Official documents	Vetoquinol USA, Inc.	ANADA 200-638	Approved	Jun 1, 2020
IMOXI™ Topical Solution for Dogs RX Imidacloprid Moxidectin Topical Solution • Topical Label highlights Official documents	Vetoquinol USA, Inc.	ANADA 200-615	Approved	Dec 30, 2019

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog

Composition / specifications

100 mg/mL (10%) imidacloprid and 25 mg/mL (2.5%) moxidectin

Dogs

Indication

Dosage

The recommended minimum dose is 4.5 mg/lb. (10 mg/kg) imidacloprid and 1.1mg/lb. (2.5 mg/kg) moxidectin, once a month, by topical administration.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Cat

Composition / specifications

10% imidacloprid and 1% moxidectin

Cats

Indication

Dosage

The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.

Limitations

Ferrets

Indication

For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis. Kills adult fleas (Ctenophalides felis) and is indicated for the treatment of flea infestations on ferrets.

Dosage

The recommended minimum dose for a ferret is 9 m/lb (20 mg/kg) imidacloprid and 0.9 mg/lb (2 mg/kg) moxidectin, once a month, by topical administration.

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications

100 mg/mL (10%) imidacloprid and 25 mg/mL (2.5%) moxidectin

Dogs

Indication

Dosage

The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog

Composition / specifications

10% (100 mg) imidacloprid and 2.5% (25 mg) moxidectin per milliliter

Dogs

Indication

Dosage

The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration.

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications

100 mg/mL (10%) imidacloprid and 10 mg/mL (1%) moxidectin

Cats

Indication

Dosage

The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.

Limitations

Ferrets

Indication

For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis; kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets.

Dosage

The recommended minimum dose is 9 mg/lb (20 mg/kg) imidacloprid and 0.9 mg/lb (2 mg/kg) moxidectin, once a month, by topical administration.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Cat

Composition / specifications

100 mg/mL (10%) imidacloprid and 10 mg/mL (1%) moxidectin

Cats

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis. Kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. It is also indicated for the treatment and control of ear mite (Otodectes cynotis) infestations and the following intestinal parasites: adult, immature adult, and fourth stage larvae in hookworms (Ancyclostoma tubaeforme); and adult and fourth stage larvae in roundworms (Toxacara cati).

Dosage

The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 0.45 mg/lb (1 mg/kg) moxidectin, once a month, by topical administration.

Limitations

Ferrets

Indication

For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis. Kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets.

Dosage

9 mg/lb (20 mg/kg) imidacloprid and 0.9 mg/lb (2 mg/kg) moxidectin, once a month, by topical administration. Only
the 0.4 mL applicator tube volume (PARASEDGE™ Multi 9) should be used on ferrets.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Cat

Composition / specifications

100 mg/mL (10%) imidacloprid and 10 mg/mL (1%) moxidectin

Cats

Indication

Dosage

The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.

Limitations

Ferrets

Indication

For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis. Kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets.

Dosage

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog

Composition / specifications

100 mg/mL (10%) imidacloprid and 25 mg/mL (2.5%) moxidectin

Dogs

Indication

Dosage

The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog

Composition / specifications

Each milliliter of solution contains 100 milligrams (mg) imidacloprid and 25 mg moxidectin.

Dogs

Indication

Dosage

Apply 4.5 mg/lb body weight (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg)moxidectin, once a month.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Cat

Composition / specifications

Each milliliter of solution contains 100 mg imidacloprid and 10 mg moxidectin

Ferrets

Indication

For the prevention of heartworm disease in ferrets caused by Dirofilaria immitis; kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets.

Dosage

The recommended minimum dose is 9 mg/lb (20 mg/kg) imidacloprid and 0.9 mg/lb (2 mg/kg) moxidectin, once a month, by topical administration.

Limitations

Cats

Indication

Dosage

Apply 4.5 mg/lb body weight (10 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Cat

Composition / specifications

100 mg/mL (10%) imidacloprid and 10 mg/mL (1%) moxidectin

Cats

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis. Kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. It is also indicated for the treatment and control of ear mite (Otodectes cynotis) infestations and the following intestinal parasites: adult, immature adult, and fourth stage larvae in hookworms (Ancylostoma tubaeforme); and adult and fourth stage larvae in roundworm (Toxocara cati).

Dosage

The recommended minimum dose is 4.5 mg/lb. (10.0 mg/kg) imidacloprid and 0.45 mg/lb. (1.0 mg/kg) moxidectin, once a month, by topical administration.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog

Composition / specifications

100 mg/mL (10%) imidacloprid and 25 mg/mL (2.5%) moxidectin

Dogs

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. Kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). For the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. canis. For the treatment and control of intestinal roundworms (Toxocara canis and Toxascaris leonina), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and whipworms (Trichuris vulpis).

Dosage

The recommended minimum dose is 4.5 mg/lb. (10 mg/kg) imidacloprid and 1.1 mg/lb. (2.5 mg/kg) moxidectin, once a month, by topical administration.

Limitations

FDA page: Open in Animal Drugs @ FDA

Usage

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive

Loss of appetite (1) • Dog Diarrhea (1) • Cat Decreased appetite (1) • Dog Bloody diarrhoea (1) • Dog

Showing top 5 for Digestive.

Skin & allergy

Hair loss at application site (1) • Cat

Showing top 5 for Skin & allergy.

Behavior

Behavioral disorder (1) • Dog

Showing top 5 for Behavior.

Other

Elevated alanine aminotransferase (1) • Dog Electrolyte disorder (1) • Dog Drug dose omission (1) • Dog Drug dose administration interval too short (1) • Dog Distension of abdomen (1) • Dog

Show more (21)

Discoloured urine (1) • Dog Difficulty standing (1) • Dog Dehydration (1) • Cat Decreased drinking (1) • Dog Decreased cholesterol (1) • Dog Cough (1) • Dog Colitis (1) • Dog Bloody stool (1) • Dog Blood in urine (1) • Dog Blistering (1) • Cat Basophilia (1) • Dog Balance problem (1) • Cat Application site scab (1) • Cat Application site erythema (1) • Cat Application site crust (1) • Cat Anaemia NOS (1) • Dog Administration error NOS (1) • Dog Accidental exposure (1) • Dog Abnormal urine odour (1) • Cat Abnormal radiograph finding (1) • Dog Abnormal cytology (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Pit Bull, Male, 4.25 year, 29.48 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal, Frequency: 1 per month • Reactions: Lack of efficacy (endoparasite) - heartworm, Drug dose omission • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2026-US-014097
Serious AE: No
Treated For AE: Yes
Sex: Male
Age: 4.25 Year
Weight: 29.480 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Topical
Form: Solution
Dose: 1 tube per animal
Frequency: 1 per month

Reactions Reported:

Lack of efficacy (endoparasite) - heartworm Drug dose omission

Outcomes: Outcome Unknown

Dog, Retriever - Golden, Female, 7 year, 37.194 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal • Reactions: Seizure NOS • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2026-US-013874
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 7.00 Year
Weight: 37.194 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Topical
Form: Solution
Dose: 1 tube per animal

Reactions Reported:

Seizure NOS

Outcomes: Outcome Unknown

Dog, Spaniel - King Charles Cavalier, Male, 1.33 year, 9.53 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal, Frequency: 1 per month • Reactions: Vomiting, Decreased appetite, Not eating, Tiredness (lethargy), Rolling… • Outcome: Recovered/Normal

Report ID: USA-USFDACVM-2026-US-013525
Serious AE: No
Treated For AE: No
Sex: Male
Age: 1.33 Year
Weight: 9.530 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Topical
Form: Solution
Dose: 1 tube per animal
Frequency: 1 per month

Reactions Reported:

Vomiting Decreased appetite Not eating Tiredness (lethargy) Rolling Diarrhea Walking slowly

Outcomes: Recovered/Normal

Dog, ['Beagle', 'Hound - Basset'], Male, 13 year, 22.67 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal • Reactions: Diarrhea, Vomiting, Tiredness (lethargy), Inappetence, Pale mucous membrane… • Outcome: Ongoing

Report ID: USA-USFDACVM-2026-US-013518
Serious AE: No
Treated For AE: No
Sex: Male
Age: 13.00 Year
Weight: 22.670 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Topical
Form: Solution
Dose: 1 tube per animal

Reactions Reported:

Diarrhea Vomiting Tiredness (lethargy) Inappetence Pale mucous membrane Distension of abdomen Mass NOS

Outcomes: Ongoing

Dog, ['Pit Bull', 'Crossbred Canine/dog'], Female, 2.67 year • Drug: MSK, Solution, Topical, Dose: 1 tube per animal, Frequency: 1 per month • Reactions: Cough, Abnormal radiograph finding, Heart murmur, Eosinophilia, Lack of efficacy (endoparasite) - heartworm • Outcome: Ongoing

Report ID: USA-USFDACVM-2026-US-013926
Serious AE: No
Treated For AE: Yes
Sex: Female
Age: 2.67 Year

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Topical
Form: Solution
Dose: 1 tube per animal
Frequency: 1 per month

Reactions Reported:

Cough Abnormal radiograph finding Heart murmur Eosinophilia Lack of efficacy (endoparasite) - heartworm

Outcomes: Ongoing

Dog, Retriever - Labrador, Female, 5 year, 36.73 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal • Reactions: Lack of efficacy (endoparasite) - hookworm • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2026-US-012371
Serious AE: No
Treated For AE: No
Sex: Female
Age: 5.00 Year
Weight: 36.730 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Topical
Form: Solution
Dose: 1 tube per animal

Reactions Reported:

Lack of efficacy (endoparasite) - hookworm

Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Female, 11 month, 3.63 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal • Reactions: Lack of efficacy (endoparasite) - tapeworm, Surgical site disorder, Self trauma • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2026-US-013859
Serious AE: No
Treated For AE: No
Sex: Female
Age: 11.00 Month
Weight: 3.630 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Topical
Form: Solution
Dose: 1 dose per animal

Reactions Reported:

Lack of efficacy (endoparasite) - tapeworm Surgical site disorder Self trauma

Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 9 year, 7.1 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal, Frequency: 1 per month • Reactions: Found dead • Outcome: Died

Report ID: USA-USFDACVM-2026-US-010812
Serious AE: Yes
Treated For AE: No
Sex: Male
Age: 9.00 Year
Weight: 7.100 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Topical
Form: Solution
Dose: 1 tube per animal
Frequency: 1 per month

Reactions Reported:

Found dead

Outcomes: Died

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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Imidacloprid, Moxidectin

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Imidacloprid, Moxidectin

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Imidacloprid, Moxidectin

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Reported case explorer

USA-USFDACVM-2026-US-014097

USA-USFDACVM-2026-US-013874

USA-USFDACVM-2026-US-013525

USA-USFDACVM-2026-US-013518

USA-USFDACVM-2026-US-013926

USA-USFDACVM-2026-US-012371

USA-USFDACVM-2026-US-013859

USA-USFDACVM-2026-US-010812

USA-USFDACVM-2026-US-011072

USA-USFDACVM-2026-US-009483

USA-USFDACVM-2026-US-008464

USA-USFDACVM-2026-US-008346

USA-USFDACVM-2026-US-003405

USA-USFDACVM-2025-US-074899

USA-USFDACVM-2025-US-074714

USA-USFDACVM-2025-US-073848

USA-USFDACVM-2025-US-074791

USA-USFDACVM-2025-US-074174

USA-USFDACVM-2025-US-073617

USA-USFDACVM-2025-US-073618

USA-USFDACVM-2025-US-073358

USA-USFDACVM-2025-US-072060

USA-USFDACVM-2025-US-072047

USA-USFDACVM-2025-US-068100

USA-USFDACVM-2025-US-061673

Grouped by Body System

Most Reported Reactions

Source Documents

Owner handouts

Official label / PI

SPL

FOI

PARASEDGE® Multi for Dogs

PARASEDGE® Multi for Dogs

Dogs

Barrier® for cats

Barrier® for cats

Cats

Ferrets

MoxiCloprid™ for Dogs

MoxiCloprid™ for Dogs

Dogs

Barrier® for dogs

Barrier® for dogs

Dogs

MoxiCloprid™ for Cats

MoxiCloprid™ for Cats

Cats

Ferrets

PARASEDGE™ Multi for Cats