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Roxee Medication Guide

Isoflurane

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Liquid Multiple FDA labelers Official label facts Owner quick guide first
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Data freshness

Reference facts
Reference refreshed
Aug 6, 2026, 7:47 p.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
Aug 6, 2026, 7:47 p.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
Aug 6, 2026, 7:49 p.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Mar 3, 2026, 11:00 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Illustration placeholder
Isoflurane

Isoflurane

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Liquid Rx required 100% reference complete

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Isoflurane

For induction and maintenance of surgical anesthesia. For induction and maintenance of general anesthesia. Species commonly shown: Both, Dog, Horse, Not For Meat Production.

Generic name
Isoflurane
Brand names
IsoFlo™, Isospire™, ATTANE™, Isoflurane, USP
Manufacturer
Multiple FDA labelers
Species
Both, Dog, Horse
Dosage forms
Liquid
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
IsoFlo™ Isospire™ ATTANE™ Isoflurane, USP Isoflurane ANIRANE Aerrane® Fluriso Isospire IsoSol
Dosage forms
Liquid

Indications / Uses

For induction and maintenance of surgical anesthesia. For induction and maintenance of general anesthesia.

Warnings / Contraindications

Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Side Effects

Top reported reactions (openFDA): Vomiting, Death, Bradycardia, Lack of efficacy - NOS, Lethargy (see also Central nervous system depression in 'Neurological'), Cardiac arrest.

FAQ

Both, Dog, Horse, Not For Meat Production

Yes. Roxee shows this as prescription-only.

Liquid

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For induction and maintenance of general anesthesia.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Administer by inhalation
  • Not for use in horses sensitive to halogenated agents
  • Increasing depth of anesthesia may increase hypotension and respiratory depression
  • Use less than usual amounts of nondepolarizing relaxants
  • Use with vaporizers producing predictable percentage concentrations
  • Not for use in horses intended for food
  • Not for use in dogs sensitive to halogenated agents
  • wobbly/unsteady walking (1 reports)
  • Loss of appetite (1 reports)
  • Bladder distension (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Isoflurane; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case GBR-USFDACVM-2026-GB-000014
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 22 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case GBR-USFDACVM-2026-GB-000014
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case GBR-USFDACVM-2026-GB-000014
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Unsteady walking (ataxia) (1 reports), Loss of appetite (1 reports), Bladder distension (1 reports), Bilirubinuria (1 reports), Behavioral disorder (unspecified) (1 reports)

Body systems represented Signal grouping

Digestive (2), Skin & allergy (3), Neurologic (1), Behavior (2)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Dog (18 reports), Cat (14 reports)

Breed metadata in reports Metadata only

Domestic Shorthair (4), Ragdoll (1), Persian (1), Retriever - Labrador (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Isoflurane fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Administer by inhalation, Not for use in horses sensitive to halogenated agents, Increasing depth of anesthesia may increase hypotension and respiratory depression, Use less than usual amounts of nondepolarizing relaxants, Use with vaporizers producing predictable percentage concentrations

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Isoflurane brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case GBR-USFDACVM-2026-GB-000014 · adverse_reaction · adverse reactions
  2. Contraindication source · fda_animal_drugs · warnings contraindications
  3. FDA application profile · official_label · quick facts
  4. FDA application profile · official_label · quick facts
  5. Medication usage source · fda_animal_drugs · quick facts
  6. FOI · document · documents
  7. SPL · document · documents
  8. FOI · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 10:44 PM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Administer by inhalation
  • Not for use in horses sensitive to halogenated agents
  • Increasing depth of anesthesia may increase hypotension and respiratory depression
  • Use less than usual amounts of nondepolarizing relaxants
  • Use with vaporizers producing predictable percentage concentrations

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Loss of appetite (1 reports)
  • Bladder distension (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Dog, Horse
Indication / use
For induction and maintenance of general anesthesia.
Form / route / dose
Form: Liquid
Route: Inhalation
Confirm product label and patient-specific plan.
Warnings
  • High: Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may inc…
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Multiple FDA labelers
Form: Liquid
Identifiers:
ANADA: 200070 ANADA: 200129 ANADA: 200141 ANADA: 200237 ANADA: 200821 ANADA: 200822 NADA: 135773 NDC Package: 11695-6777-1 NDC Package: 11695-6777-2 NDC Package: 13985-528-40 NDC Package: 13985-528-60 NDC Package: 17033-091-25 NDC Package: 46066-115-03 NDC Package: 46066-115-04 NDC Package: 50989-150-12 NDC Package: 50989-150-15 NDC Package: 66794-013-10 NDC Package: 66794-013-25 NDC Package: 68504-010-01 NDC Product: 11695
Source metadata:

Warnings / Contraindications

Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
59
Matching reports
59
Active filters
0
Reset
Drill into common report signals
Lethargy (see also Central nervous system depression in Neurological) (10) Not eating (9) Death (8) Intentional misuse (8) Other (54) Neurologic (18) Digestive (14) Skin & allergy (10)
Showing up to 50 matching reports. Narrow filters to inspect the remaining reports.

USA-USFDACVM-2026-US-014107

Received 2026-03-24 · MSK · MSK

Non-serious
Species
Cat
Breed
Ragdoll
Size / weight
10-24 lb (5.498 Kilogram)
Age
8+ years (1 Year)
Sex
Male Neutered
Region
USA
Reactions
Head tilt - neurological disorder (see also Head tilt - ear disorder)Ataxia
Body systems
Neurologic
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-013840

Received 2026-03-20 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.89 Kilogram)
Age
4-7 years (6 Year)
Sex
Male Neutered
Region
USA
Reactions
Gastrointestinal foreign body NOS
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2026-US-013262

Received 2026-03-19 · MSK · MSK

Serious
Species
Cat
Breed
Persian
Size / weight
Under 10 lb (4.08 Kilogram)
Age
4-7 years (4 Year)
Sex
Male Neutered
Region
USA
Reactions
Laboured breathingAnorexia
Body systems
OtherDigestive
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-012958

Received 2026-03-18 · MSK · MSK

Serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (29.211 Kilogram)
Age
4-7 years (7 Year)
Sex
Female Unknown
Region
USA
Reactions
AtaxiaHind limb paresisProprioception deficitPain NOSPartial lack of efficacy
Body systems
NeurologicOtherEffectiveness
Outcomes
Ongoing

USA-USFDACVM-2026-US-014257

Received 2026-03-17 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (4.53 Kilogram)
Age
1-3 years (2 Year)
Sex
Female Neutered
Region
USA
Reactions
Limb amputationInjection site sarcomaBehavioural disorder NOSLethargy (see also Central nervous system depression in Neurological)Localised pain NOS (see other SOCs for specific pain)VocalisationLimpingInjection site mass NOS
Body systems
OtherBehaviorNeurologic
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-013808

Received 2026-03-17 · MSK · MSK

Serious
Species
Dog
Breed
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)
Size / weight
50-99 lb (26.26 Kilogram)
Age
8+ years (1 Year)
Sex
Male Neutered
Region
USA
Reactions
Emesis (multiple)Not eatingBloody stoolHaematemesisAnxietyLack of efficacy - NOSIntentional misuseLow thyroxine (T4)Elevated blood urea nitrogen (BUN)Elevated amylaseGastritis
Body systems
DigestiveOtherBehaviorEffectiveness
Outcomes
Ongoing

USA-USFDACVM-2026-US-012422

Received 2026-03-17 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.98 Kilogram)
Age
4-7 years (7.58 Year)
Sex
Male Neutered
Region
USA
Reactions
Application site hair loss
Body systems
Skin & allergy
Outcomes
Ongoing

USA-USFDACVM-2026-US-014092

Received 2026-03-16 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (4.354 Kilogram)
Age
4-7 years (7 Year)
Sex
Female Neutered
Region
USA
Reactions
DroolingReluctant to moveNot eatingDilated pupilsNot himself/herselfHypothermiaTachypnoeaIntentional misuseLeukopenia NOSHypoglycaemiaElevated symmetrical dimethylarginine (SDMA)AzotaemiaLow ionized calcium (Ca; Hypocalcaemia, ionized)ObtundedWeak pulseLateral recumbencyRegurgitationCardiac arrestDeath
Body systems
DigestiveOther
Outcomes
Died

USA-USFDACVM-2026-US-013382

Received 2026-03-16 · MSK · MSK

Non-serious
Species
Dog
Breed
['Retriever - Golden', 'Poodle (unspecified)']
Size / weight
25-49 lb (14.243 Kilogram)
Age
4-7 years (4 Year)
Sex
Female Unknown
Region
USA
Reactions
Respiratory depression
Body systems
Neurologic
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-013265

Received 2026-03-16 · MSK · MSK

Non-serious
Species
Dog
Breed
Corso Dog
Size / weight
50-99 lb (42.184 Kilogram)
Age
1-3 years (1 Year)
Sex
Female Neutered
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)Not eatingFeverInjection site lumpApplication site serous discharge
Body systems
NeurologicOther
Outcomes
Ongoing

USA-USFDACVM-2026-US-013125

Received 2026-03-16 · MSK · MSK

Non-serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (34.473 Kilogram)
Age
8+ years (9 Year)
Sex
Female Neutered
Region
USA
Reactions
DiarrhoeaBlood in faecesWatery diarrhoeaBloody diarrhoeaSoft stoolPantingTarry or black stool (see also haemorrhagic diarrhoea)
Body systems
DigestiveOther
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-013124

Received 2026-03-16 · MSK · MSK

Non-serious
Species
Dog
Breed
['Spaniel - Cocker American', 'Poodle - Miniature']
Size / weight
25-49 lb (12.106 Kilogram)
Age
8+ years (9 Year)
Sex
Male Neutered
Region
USA
Reactions
Inappropriate urination
Body systems
Other
Outcomes
Outcome Unknown

GBR-USFDACVM-2026-GB-000014

Received 2026-03-16 · MSK · MSK

Serious
Species
Dog
Breed
['Spaniel - Springer English', 'Spaniel - Cocker English']
Size / weight
25-49 lb (2 Kilogram)
Age
4-7 years (4 Year)
Sex
Male Neutered
Region
USA
Reactions
DiarrhoeaAnorexiaHaemorrhagic diarrhoeaQuietPale mucous membraneAbdominal discomfortHypotensionLeukopenia NOSElevated haematocritHypocalcaemic conditionLow alanine aminotransferase (ALT)Digestive tract hypomotilityRegurgitationWeak pulseHypothermiaJaundiceIcterusSepticaemiaNeutropeniaHypoalbuminaemiaThrombocytopeniaEcchymosisPetechiae NOSEpistaxis (bilateral)DeathCardiorespiratory arrestUnwellVomitingMalaiseDisseminated intravascular coagulation
Body systems
DigestiveOther
Outcomes
Died

GBR-USFDACVM-2026-GB-000012

Received 2026-03-16 · MSK · MSK

Non-serious
Species
Dog
Breed
Whippet
Size / weight
10-24 lb (9.8 Kilogram)
Age
8+ years (8 Year)
Sex
Female Neutered
Region
USA
Reactions
Bulging eyeLow blood pressure
Body systems
Other
Outcomes
Outcome Unknown

DNK-USFDACVM-2026-DK-000001

Received 2026-03-16 · MSK · MSK

Serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (32.6 Kilogram)
Age
4-7 years (6 Year)
Sex
Male Neutered
Region
USA
Reactions
DiarrhoeaUnwellVomitingAbdominal painTremorHigh pancreatic-specific lipaseElevated C-reactive proteinAcute pancreatitisDecreased appetiteLethargy (see also Central nervous system depression in Neurological)QuietDrinking a lotPolyuriaTachycardiaDehydrationHard stoolMelaenaDeathNecropsy performedDuodenal ulcerPeritoneal fluid, abnormal NOSEnlarged lymph node (localised)
Body systems
DigestiveOtherNeurologic
Outcomes
Died

DEU-USFDACVM-2026-DE-000006

Received 2026-03-16 · MSK · MSK

Serious
Species
Dog
Breed
Terrier - Tibetan
Size / weight
25-49 lb (16 Kilogram)
Age
8+ years (8 Year)
Sex
Male Neutered
Region
USA
Reactions
Recovery prolonged
Body systems
Other
Outcomes
Recovered/Normal

DEU-USFDACVM-2026-DE-000005

Received 2026-03-16 · MSK · MSK

Serious
Species
Dog
Breed
Terrier - Tibetan
Size / weight
25-49 lb (21 Kilogram)
Age
4-7 years (7.7 Year)
Sex
Male Neutered
Region
USA
Reactions
Tonic seizureHyperthermiaTense muscles
Body systems
NeurologicOther
Outcomes
Recovered/Normal

AUS-USFDACVM-2026-AU-000008

Received 2026-03-16 · MSK · MSK

Serious
Species
Dog
Breed
['Terrier - Bull - Staffordshire', 'Boxer (German Boxer)']
Age
8+ years (1 Year)
Sex
Female Unknown
Region
USA
Reactions
Hyperaemic mucous membraneSkin hyperaemiaSwelling around eye (see also Immune system disorders)TachycardiaHypothermiaStiffness NOSHypersensitivity reaction
Body systems
OtherSkin & allergy
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-014083

Received 2026-03-13 · MSK · MSK

Serious
Species
Dog
Breed
American Pit Bull Terrier
Size / weight
50-99 lb (26.4 Kilogram)
Age
4-7 years (4 Year)
Sex
Male Neutered
Region
USA
Reactions
Cardiac arrestDeath
Body systems
Other
Outcomes
Died

USA-USFDACVM-2026-US-014082

Received 2026-03-13 · MSK · MSK

Serious
Species
Dog
Breed
Shih Tzu
Size / weight
10-24 lb (6.4 Kilogram)
Age
1-3 years (3 Year)
Sex
Female Neutered
Region
USA
Reactions
Cardiac arrestDeath by euthanasiaNeurological symptoms NOS
Body systems
OtherNeurologic
Outcomes
Euthanized

USA-USFDACVM-2026-US-014081

Received 2026-03-13 · MSK · MSK

Serious
Species
Dog
Breed
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)
Size / weight
50-99 lb (23.2 Kilogram)
Age
4-7 years (5 Year)
Sex
Male Neutered
Region
USA
Reactions
Sudden death
Body systems
Other
Outcomes
Died

USA-USFDACVM-2026-US-010748

Received 2026-03-04 · MSK · MSK

Non-serious
Species
Dog
Breed
['Terrier - Bull - American Pit', 'Terrier - Bull - Staffordshire']
Size / weight
25-49 lb (21.22 Kilogram)
Age
Under 1 year (9 Month)
Sex
Female Neutered
Region
USA
Reactions
Skin lumpSurgical site disorderSkin inflammation NOSReddening of the skinIntentional misuseApplication site irritationApplication site reddeningApplication site inflammationContamination NOS
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2026-US-009973

Received 2026-02-27 · MSK · MSK

Serious
Species
Dog
Breed
Crossbred Canine/dog
Size / weight
50-99 lb (34.019 Kilogram)
Age
8+ years (10.5 Year)
Sex
Male Neutered
Region
USA
Reactions
Not eatingWalking difficultyPantingSeizure NOSDeathIntentional misuse
Body systems
OtherNeurologic
Outcomes
Died

USA-USFDACVM-2026-US-008768

Received 2026-02-25 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (4.536 Kilogram)
Age
8+ years (14.5 Year)
Sex
Female Unknown
Region
USA
Reactions
Open mouth breathingUnable to walkBalance impairedDilated pupilsAbnormal posture NOSArthritisTwitchingLethargy (see also Central nervous system depression in Neurological)Unresponsive to stimuli
Body systems
OtherSkin & allergyNeurologic
Outcomes
Ongoing

USA-USFDACVM-2026-US-010895

Received 2026-02-18 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.688 Kilogram)
Age
Under 1 year (8 Month)
Sex
Male Neutered
Region
USA
Reactions
Not sleepingHyperactivityBehavioural disorder NOS
Body systems
OtherBehavior
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-010894

Received 2026-02-18 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (2.495 Kilogram)
Age
Under 1 year (7 Month)
Sex
Female Neutered
Region
USA
Reactions
RestlessnessAgitationDifficulty standingStumbling gaitNot sleepingBehavioural disorder NOS
Body systems
OtherBehavior
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-006579

Received 2026-02-13 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (2.495 Kilogram)
Age
Under 1 year (7 Month)
Sex
Female Neutered
Region
USA
Reactions
RestlessnessAgitationDifficulty standingStumbling gaitNot sleepingBehavioural disorder NOS
Body systems
OtherBehavior
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-006576

Received 2026-02-13 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.688 Kilogram)
Age
Under 1 year (8 Month)
Sex
Male Neutered
Region
USA
Reactions
Not sleepingHyperactivityBehavioural disorder NOS
Body systems
OtherBehavior
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-005986

Received 2026-02-04 · MSK · MSK

Serious
Species
Dog
Breed
Terrier - Boston
Size / weight
25-49 lb (12.3 Kilogram)
Age
1-3 years (3.6 Year)
Sex
Female Neutered
Region
USA
Reactions
Hives (see also Skin)AngioedemaFacial swelling (see also Skin)
Body systems
Skin & allergyOther
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-003352

Received 2026-01-27 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.992 Kilogram)
Age
8+ years (13 Year)
Sex
Female Neutered
Region
USA
Reactions
DiarrhoeaDecreased appetiteLethargy (see also Central nervous system depression in Neurological)Bloody diarrhoeaDry mucous membraneOpen mouth breathingUnresponsive to stimuliDecreased haematocritIncreased percentage reticulocytesRegenerative anaemiaIntentional misuseThrombocytopeniaHypersalivationHeart murmur
Body systems
DigestiveNeurologicOther
Outcomes
Ongoing

USA-USFDACVM-2026-US-004595

Received 2026-01-26 · MSK · MSK

Serious
Species
Dog
Breed
Bulldog - American
Age
4-7 years (5.16 Year)
Sex
Female Neutered
Region
USA
Reactions
Other abnormal test result NOSTooth disorderBumps on skinCyst NOSAllergy NOSLoose stoolCrustLocal erythemaLickingDermal noduleOtitis NOSScratchingSneezingDermatitisBehavioural disorder NOSHair loss NOSNasal dischargeWeight gainSkin disorders NOSAlopecia generalAbnormal cytologyLocalised pain NOS (see other SOCs for specific pain)Salivary stainingAnxietySkin lumpMast cell tumourReddening of the skinSkin lesion NOSLack of efficacy (bacteria) - Ehrlichia
Body systems
OtherBehaviorSkin & allergyDigestiveEffectiveness
Outcomes
Ongoing

USA-USFDACVM-2026-US-003636

Received 2026-01-23 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.311 Kilogram)
Age
Under 1 year (25 Week)
Sex
Female Intact
Region
USA
Reactions
Not eatingNot sleepingDilated pupilsRestlessnessNot drinkingPacingHyperactivity
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2026-US-002947

Received 2026-01-20 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.901 Kilogram)
Age
1-3 years (3 Year)
Sex
Male Neutered
Region
USA
Reactions
AnisocoriaTwitchingTachypnoeaHypothermia
Body systems
OtherSkin & allergy
Outcomes
Ongoing

USA-USFDACVM-2026-US-003528

Received 2026-01-19 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (4 Kilogram)
Age
8+ years (13 Year)
Sex
Female Neutered
Region
USA
Reactions
Unresponsive to stimuliOpen mouth breathingAnorexiaLethargy (see also Central nervous system depression in Neurological)DiarrhoeaDry mucous membraneBloody diarrhoeaIncreased percentage reticulocytesDecreased haematocritRegenerative anaemiaThrombocytopeniaHypersalivationMurmur
Body systems
OtherDigestiveNeurologic
Outcomes
Ongoing

USA-USFDACVM-2025-US-075237

Received 2025-12-23 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.08 Kilogram)
Age
Under 1 year (7 Month)
Sex
Female Neutered
Region
USA
Reactions
FeverCough, productiveWeight lossBreathing difficultyAbnormal radiograph findingPulmonary disorder NOSLethargy (see also Central nervous system depression in Neurological)SedationKidney atrophyBilirubinuriaElevated mean corpuscular haemoglobin concentration (MCHC)Enlarged kidney(s)Elevated mean corpuscular volume (MCV)EosinopeniaLow serum alkaline phosphatase (ALP)NeutropeniaDiscoloured urineMonocytosisLymphopeniaElevated amylaseElevated alanine aminotransferase (ALT)Low creatinineHyponatremiaOther abnormal test result NOSElevated total bilirubinHyperglycaemiaLymphocytosisNeutrophiliaLeucocytosis NOSBasophilia
Body systems
OtherNeurologic
Outcomes
Recovered/Normal

USA-USFDACVM-2025-US-075113

Received 2025-12-22 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic (unspecified)
Size / weight
10-24 lb (5.9 Kilogram)
Age
1-3 years (3.67 Year)
Sex
Male Intact
Region
USA
Reactions
AgitationDecreased pulse oxygenationIncreased respiratory rateHyperthermiaHyperactivity
Body systems
Other
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-075112

Received 2025-12-22 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.2 Kilogram)
Age
Under 1 year (8 Month)
Sex
Female Unknown
Region
USA
Reactions
Cardiac arrestDeathFaint heart soundNecropsy performedCardiac enlargement
Body systems
Other
Outcomes
Died

USA-USFDACVM-2025-US-074782

Received 2025-12-22 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (2.4 Kilogram)
Age
Under 1 year (4 Month)
Sex
Female Neutered
Region
USA
Reactions
Head shake - behavioural disorderUnable to walkNot drinkingNot eatingAtaxiaCircling - behavioural disorder (see also Neurological disorders)Unsteady gait
Body systems
BehaviorOtherNeurologic
Outcomes
Ongoing

USA-USFDACVM-2025-US-074695

Received 2025-12-19 · MSK · MSK

Serious
Species
Cat
Breed
Cat (unknown)
Size / weight
Under 10 lb (3.49 Kilogram)
Sex
Unknown Unknown
Region
USA
Reactions
Pulmonary congestionDecreased body temperatureDrowsiness - systemic disorderDisorientationUnable to standDysphoria
Body systems
Other
Outcomes
Recovered/Normal

USA-USFDACVM-2025-US-074803

Received 2025-12-18 · MSK · MSK

Non-serious
Species
Cat
Breed
Persian
Size / weight
10-24 lb (4.67 Kilogram)
Age
8+ years (10.83 Year)
Sex
Male Neutered
Region
USA
Reactions
Application site alopeciaDefect Unknown/Not Specified
Body systems
Skin & allergyOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-074179

Received 2025-12-18 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.084 Kilogram)
Age
Under 1 year (6 Month)
Sex
Female Intact
Region
USA
Reactions
Elevated temperatureBreathing difficultyQuiet
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2025-US-074366

Received 2025-12-17 · MSK · MSK

Non-serious
Species
Dog
Breed
Coton de Tuléar
Size / weight
Under 10 lb (3.719 Kilogram)
Age
4-7 years (4 Year)
Sex
Female Unknown
Region
USA
Reactions
Lack of efficacy - NOSVomitingIntentional misuse
Body systems
EffectivenessDigestiveOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-074168

Received 2025-12-17 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Mediumhair
Size / weight
10-24 lb (5.27 Kilogram)
Age
8+ years (8.5 Year)
Sex
Male Neutered
Region
USA
Reactions
DysphoriaSleep disturbance NOSHallucinationThird eyelid prolapseDilated pupilsClosed eyelid
Body systems
Other
Outcomes
Recovered/Normal

USA-USFDACVM-2025-US-073604

Received 2025-12-16 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (2.5 Kilogram)
Age
Under 1 year (6 Month)
Sex
Male Neutered
Region
USA
Reactions
HyperthermiaWarm feeling to the touch
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2025-US-073827

Received 2025-12-15 · MSK · MSK

Serious
Species
Dog
Breed
Shepherd Dog - Australian
Size / weight
Under 10 lb (4.037 Kilogram)
Age
Under 1 year (7 Month)
Sex
Female Unknown
Region
USA
Reactions
DroolingAnorexiaDeathMuscle tremorTirednessIntestinal disorder NOS
Body systems
DigestiveOtherNeurologic
Outcomes
Died

FIN-USFDACVM-2025-FI-000004

Received 2025-12-15 · MSK · MSK

Non-serious
Species
Dog
Breed
Dachshund - Standard Long-haired
Size / weight
10-24 lb (5.1 Kilogram)
Age
8+ years (12 Year)
Sex
Female Intact
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)Erythema (for urticaria see Immune SOC)Low blood pressure
Body systems
NeurologicSkin & allergyOther
Outcomes
Recovered/Normal

AUS-USFDACVM-2025-AU-000020

Received 2025-12-15 · MSK · MSK

Serious
Species
Dog
Breed
Dog (other)
Size / weight
100+ lb (47 Kilogram)
Age
4-7 years (6 Year)
Sex
Female Neutered
Region
USA
Reactions
ShakingApnoeaTachycardiaArrhythmia
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2025-US-074118

Received 2025-12-11 · MSK · MSK

Serious
Species
Dog
Breed
['Retriever - Golden', 'Poodle (unspecified)']
Size / weight
25-49 lb (16.329 Kilogram)
Age
Under 1 year (7 Month)
Sex
Female Unknown
Region
USA
Reactions
Intestinal perforationPeritonitisFeverDiarrhoeaNot eating
Body systems
OtherDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-072426

Received 2025-12-10 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.81 Kilogram)
Age
8+ years (9 Year)
Sex
Male Neutered
Region
USA
Reactions
Application site alopecia
Body systems
Skin & allergy
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-072148

Received 2025-12-10 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.175 Kilogram)
Age
Under 1 year (8 Month)
Sex
Female Intact
Region
USA
Reactions
Faint heart soundCardiac arrestIntentional misuseDeath
Body systems
Other
Outcomes
Died

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
22
Species represented
2
Grouped by Body System
Digestive (2) · Loss of appetite, Bloody diarrhoea Skin & allergy (3) · Hair loss at application site, Application site hair loss, Alopecia general Neurologic (1) · Unsteady walking (ataxia) Behavior (2) · Behavioral disorder (unspecified), Anxiety Other (24) · Blood in faeces, Bladder distension, Bilirubinuria
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Dog 1
Digestive 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Behavior 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1

Species coverage: Dog (18) Cat (14)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Dog Serious - 1
Digestive Cat Serious - 1
Skin & allergy Cat Non-serious - 1
Digestive Dog Non-serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Behavior Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Skin & allergy Cat Non-serious - 1
Other Dog Serious - 1
Behavior Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Skin & allergy Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Source metadata:

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

ANIRANE SPL · SPL Isoflurane SPL · SPL ATTANE™ SPL · SPL

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

14

FOI

6

ANIRANE

SPL · SPL

Open original
FDA Structured Product Label

ANIRANE

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Baxter Healthcare Corp.
ANADA
200-822
Status
RX
Form
Liquid
Route
Inhalation
Composition / specifications
Each mL contains 99.9% isoflurane

Horses

Indication

For induction and maintenance of general anesthesia.

Dosage

For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).

Dogs

Indication

For induction and maintenance of general anesthesia.

Dosage

For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).

Isoflurane

SPL · SPL

Open original
FDA Structured Product Label

Isoflurane

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Parnell Technologies Pty. Ltd.
ANADA
200-821
Status
RX
Form
Liquid
Route
Inhalation
Composition / specifications
Each mL contains 99.9% isoflurane

Horses

Indication

For induction and maintenance of general anesthesia.

Dosage

For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes, For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).

Dogs

Indication

For induction and maintenance of general anesthesia.

Dosage

For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).

ATTANE™

SPL · SPL

Open original
FDA Structured Product Label

ATTANE™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Piramal Pharma Ltd.
ANADA
200-141
Status
RX
Form
Liquid
Route
Inhalation
Species
Dog • Horse
Composition / specifications
The drug is a clear, colorless, stable liquid containing no additives or chemical stabilizers. It is nonflammable and non-explosive

Dogs

Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Horses

Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Isoflurane, USP

SPL · SPL

Open original
FDA Structured Product Label

Isoflurane, USP

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Piramal Pharma Ltd.
ANADA
200-237
Status
RX
Form
Liquid
Route
Inhalation
Species
Dog • Horse

Horses

Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Dogs

Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Isospire™

SPL · SPL

Open original
FDA Structured Product Label

Isospire™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Dechra Veterinary Products LLC
ANADA
200-129
Status
RX
Form
Liquid
Route
Inhalation
Species
Dog • Horse

Horses

Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Dogs

Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

IsoFlo™

SPL · SPL

Open original
FDA Structured Product Label

IsoFlo™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
ANADA
200-070
Status
RX
Form
Liquid
Route
Inhalation
Species
Dog • Horse
Composition / specifications
The drug is a clear, colorless, stable liquid containing no additives or chemical stabilizers. It is nonflammable and non-explosive.

Dogs

Indication
For induction and maintenance of general anesthesia.
Dosage
For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Horses

Indication
For induction and maintenance of general anesthesia.
Dosage
For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Aerrane®

SPL · SPL

Open original
FDA Structured Product Label

Aerrane®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Baxter Healthcare Corp.
NADA
135-773
Status
RX
Form
Liquid
Route
Inhalation
Species
Dog • Horse
Composition / specifications
The drug is a clear, colorless, stable liquid containing no additives or chemical stabilizers. It is nonflammable and non-explosive.

Horses

Indication
For induction and maintenance of surgical anesthesia.
Dosage
3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes, then 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Dogs

Indication
For induction and maintenance of surgical anesthesia.
Dosage
2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes, then 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Isoflurane SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Isoflurane. Use the source link for the full official labeling record.

IsoSol SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for IsoSol. Use the source link for the full official labeling record.

Isoflurane SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Isoflurane. Use the source link for the full official labeling record.

Isoflurane SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Isoflurane. Use the source link for the full official labeling record.

Isoflurane SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Isoflurane. Use the source link for the full official labeling record.

Isospire SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Isospire. Use the source link for the full official labeling record.

Fluriso SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Fluriso. Use the source link for the full official labeling record.

FOI Summary oA 200-822 Approved February 23, 2026.pdf

FOI · FOI

Open original

FOI Summary oA 200-821 Approved August 28, 2025.pdf

FOI · FOI

Open original

A200141_Orig_07_26_1994.pdf

FOI · FOI

Open original

A200237_Orig_12_19_1997.pdf

FOI · FOI

Open original

A200129_Orig_06_29_1995.pdf

FOI · FOI

Open original

A200070_Org_3_11_1993.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Mar 3, 2026, 11:00 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Fluriso IsoSol Isoflurane Isospire
Manufacturer mapping: Multiple FDA labelers
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Dog, Horse
Rx/OTC: RX
Form/route: Liquid • Inhalation
Applications: ANADA 200-822 • ANADA 200-821 • ANADA 200-141 • ANADA 200-237 • ANADA 200-129 • ANADA 200-070 • NADA 135-773
NDC: Packages 11695-6777-1 11695-6777-2 13985-528-40 13985-528-60 17033-091-25 46066-115-03 • Products 11695 13985 17033 46066 50989 66794
Documents: 6 (FOI: 6) • SPL: 7 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 139 • Cat 129 • View
Case summaries: 59 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Unsteady walking (ataxia) (1) Loss of appetite (1) Bladder distension (1) Bilirubinuria (1) Behavioral disorder (unspecified) (1) Basophilia (1) Balance impaired (1) Azotaemia (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200070 ANADA: 200129 ANADA: 200141 ANADA: 200237 ANADA: 200821 ANADA: 200822 NADA: 135773 NDC Package: 11695-6777-1 NDC Package: 11695-6777-2 NDC Package: 13985-528-40 NDC Package: 13985-528-60 NDC Package: 17033-091-25 NDC Package: 46066-115-03 NDC Package: 46066-115-04 NDC Package: 50989-150-12 NDC Package: 50989-150-15 NDC Package: 66794-013-10 NDC Package: 66794-013-25 NDC Package: 68504-010-01 NDC Product: 11695 NDC Product: 13985 NDC Product: 17033 NDC Product: 46066 NDC Product: 50989
Package NDC Product NDC Form / Route Status
11695-6777-1 11695 -
11695-6777-2 11695 -
13985-528-40 13985 -
13985-528-60 13985 -
17033-091-25 17033 -
46066-115-03 46066 -
46066-115-04 46066 -
50989-150-12 50989 -
50989-150-15 50989 -
66794-013-10 66794 -
66794-013-25 66794 -
68504-010-01 68504 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • Isoflurane SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • IsoSol SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Isoflurane SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Isoflurane SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Isoflurane SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Isospire SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Fluriso SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • FOI Summary oA 200-822 Approved February 23, 2026.pdf • FOI summary • Official • March 2, 2026
    FDA FOI summary for application 200822
  • FOI Summary oA 200-821 Approved August 28, 2025.pdf • FOI summary • Official • Sept. 2, 2025
    FDA FOI summary for application 200821
  • A200237_Orig_12_19_1997.pdf • FOI summary • Official • March 14, 2024
    FDA FOI summary for application 200237
  • A200141_Orig_07_26_1994.pdf • FOI summary • Official • March 14, 2024
    FDA FOI summary for application 200141
  • A200129_Orig_06_29_1995.pdf • FOI summary • Official • Nov. 16, 2022
    FDA FOI summary for application 200129
  • A200070_Org_3_11_1993.pdf • FOI summary • Official • May 17, 2017
    FDA FOI summary for application 200070

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 132 Clinical 1 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Vomiting, Death, Bradycardia, Lack of efficacy - NOS, Lethargy (see also Central nervous system depression in 'Neurological')… (Clinical, 2026-04-11)
  • contraindications: Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depres… (Official, 2026-04-12)
  • contraindications: Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depres… (Official, 2026-04-11)
  • contraindications: Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depres… (Official, 2026-02-12)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-08-06)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-08-05)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-08-04)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-08-03)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-08-02)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-08-01)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-07-31)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-07-30)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-07-29)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-07-28)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-07-27)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-07-26)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-07-25)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-07-25)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-07-22)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-07-22)
Recent Revisions
  • side_effects updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
ANIRANE
RX
Isoflurane
Liquid • Inhalation
Label highlights
Official documents
Baxter Healthcare Corp. ANADA 200-822 Approved Mar 2, 2026
Isoflurane
RX
Isoflurane
Liquid • Inhalation
Label highlights
Official documents
Parnell Technologies Pty. Ltd. ANADA 200-821 Approved Sep 2, 2025
ATTANE™
RX
Isoflurane
Liquid • Inhalation
Label highlights
Official documents
Piramal Pharma Ltd. ANADA 200-141 Approved Mar 14, 2024
Isoflurane, USP
RX
Isoflurane
Liquid • Inhalation
Label highlights
Official documents
Piramal Pharma Ltd. ANADA 200-237 Approved Mar 14, 2024
Isospire™
RX
Isoflurane
Liquid • Inhalation
Label highlights
Official documents
Dechra Veterinary Products LLC ANADA 200-129 Approved Nov 16, 2022
IsoFlo™
RX
Isoflurane
Liquid • Inhalation
Label highlights
Official documents
Zoetis Inc. ANADA 200-070 Approved May 17, 2017
Aerrane®
RX
Isoflurane
Liquid • Inhalation
Label highlights
Official documents
Baxter Healthcare Corp. NADA 135-773 W Apr 4, 2017

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Composition / specifications
Each mL contains 99.9% isoflurane
Horses
Indication

For induction and maintenance of general anesthesia.

Dosage

For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).

Limitations
Dogs
Indication

For induction and maintenance of general anesthesia.

Dosage

For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications
Each mL contains 99.9% isoflurane
Horses
Indication

For induction and maintenance of general anesthesia.

Dosage

For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes, For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).

Limitations
Dogs
Indication

For induction and maintenance of general anesthesia.

Dosage

For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog • Horse
Composition / specifications
The drug is a clear, colorless, stable liquid containing no additives or chemical stabilizers. It is nonflammable and non-explosive
Dogs
Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Horses
Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog • Horse
Horses
Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog • Horse
Horses
Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
For induction and maintenance of surgical anesthesia.
Dosage
For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog • Horse
Composition / specifications
The drug is a clear, colorless, stable liquid containing no additives or chemical stabilizers. It is nonflammable and non-explosive.
Dogs
Indication
For induction and maintenance of general anesthesia.
Dosage
For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Horses
Indication
For induction and maintenance of general anesthesia.
Dosage
For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog • Horse
Composition / specifications
The drug is a clear, colorless, stable liquid containing no additives or chemical stabilizers. It is nonflammable and non-explosive.
Horses
Indication
For induction and maintenance of surgical anesthesia.
Dosage
3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes, then 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
For induction and maintenance of surgical anesthesia.
Dosage
2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes, then 1.5 to 1.8 percent isoflurane (with oxygen).
Limitations
Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Usage

For induction and maintenance of surgical anesthesia. For induction and maintenance of general anesthesia.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Cat Bloody diarrhoea (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Hair loss at application site (1) • Cat Application site hair loss (1) • Cat Alopecia general (1) • Dog

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Dog

Showing top 5 for Neurologic.

Behavior
Behavioral disorder (1) • Cat Anxiety (1) • Dog

Showing top 5 for Behavior.

Other
Blood in faeces (1) • Dog Bladder distension (1) • Cat Bilirubinuria (1) • Cat Basophilia (1) • Cat Balance impaired (1) • Cat
Show more (19)
Azotaemia (1) • Cat Arthritis (1) • Cat Arrhythmia (1) • Dog Application site serous discharge (1) • Dog Application site reddening (1) • Dog Application site irritation (1) • Dog Application site inflammation (1) • Dog Apnoea (1) • Dog Anisocoria (1) • Cat Angioedema (1) • Dog Allergy NOS (1) • Dog Agitation (1) • Cat Acute pancreatitis (1) • Dog Abnormal ultrasound finding (1) • Dog Abnormal radiograph finding (1) • Cat Abnormal posture NOS (1) • Cat Abnormal cytology (1) • Dog Abdominal pain (1) • Dog Abdominal discomfort (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Ragdoll, Male, 10 year, 5.498 kilogram • Drug: MSK, Unknown • Reactions: Head tilt - neurological disorder, Unsteady walking (ataxia) • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2026-US-014107
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 10.00 Year
  • Weight: 5.498 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Head tilt - neurological disorder Unsteady walking (ataxia)
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 6 year, 5.89 kilogram • Drug: MSK, Unknown • Reactions: Gastrointestinal foreign body NOS • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-013840
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 6.00 Year
  • Weight: 5.890 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Gastrointestinal foreign body NOS
Outcomes: Ongoing

Cat, Persian, Male, 4 year, 4.08 kilogram • Drug: MSK, Unknown • Reactions: Laboured breathing, Loss of appetite • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-013262
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 4.00 Year
  • Weight: 4.080 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Laboured breathing Loss of appetite
Outcomes: Recovered/Normal

Dog, Retriever - Labrador, Female, 7 year, 29.211 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Unsteady walking (ataxia), Hind limb paresis, Proprioception deficit, Pain NOS, Partial lack of efficacy • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-012958
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 29.211 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Unsteady walking (ataxia) Hind limb paresis Proprioception deficit Pain NOS Partial lack of efficacy
Outcomes: Ongoing

Cat, Domestic Shorthair, Female, 2 year, 4.53 kilogram • Drug: MSK, Unknown • Reactions: Limb amputation, Injection site sarcoma, Behavioral disorder (unspecified), Tiredness (lethargy), Localised pain NOS… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2026-US-014257
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 2.00 Year
  • Weight: 4.530 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Limb amputation Injection site sarcoma Behavioral disorder (unspecified) Tiredness (lethargy) Localised pain NOS Vocalisation Limping Injection site mass NOS
Outcomes: Outcome Unknown

Dog, Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog), Male, 10 year, 26.26 kilogram • Drug: MSK, Solution, Respiratory (Inhalation) • Reactions: Vomiting, Not eating, Bloody stool, Haematemesis, Anxiety… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-013808
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 10.00 Year
  • Weight: 26.260 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Respiratory (Inhalation)
  • Form: Solution
Reactions Reported:
Vomiting Not eating Bloody stool Haematemesis Anxiety Lack of efficacy - NOS Intentional misuse Low thyroxine Elevated blood urea nitrogen Elevated amylase Gastritis
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 7.58 year, 6.98 kilogram • Drug: MSK, Unknown • Reactions: Application site hair loss • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-012422
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 7.58 Year
  • Weight: 6.980 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Application site hair loss
Outcomes: Ongoing

Cat, Domestic Shorthair, Female, 7 year, 4.354 kilogram • Drug: MSK, Respiratory (Inhalation) • Reactions: Drooling, Reluctant to move, Not eating, Dilated pupils, Not himself/herself… • Outcome: Died

  • Report ID: USA-USFDACVM-2026-US-014092
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 4.354 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Respiratory (Inhalation)
Reactions Reported:
Drooling Reluctant to move Not eating Dilated pupils Not himself/herself Hypothermia Tachypnoea Intentional misuse Leukopenia NOS Hypoglycaemia Elevated symmetrical dimethylarginine Azotaemia Low ionized calcium Obtunded Weak pulse Lateral recumbency Regurgitation Cardiac arrest Death
Outcomes: Died

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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