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Roxee Medication Guide

Ketamine

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Liquid (Solution) Multiple FDA sponsors Official label facts Owner quick guide first
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Data freshness

Reference facts
Reference refreshed
Aug 6, 2026, 7:47 p.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
Aug 6, 2026, 7:47 p.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
Aug 6, 2026, 7:49 p.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Illustration placeholder
Ketamine

Ketamine

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Both Liquid (Solution) Rx required 100% reference complete

Species: Both

Manufacturer: Multiple FDA sponsors

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Ketamine

It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation. It is used for restraint. It is used in cats as the sole anesthetic agent for ovariohysterectomy and general surgery. Species commonly shown: Both, Cat, Primates, Non-Human Primates.

Generic name
Ketamine
Brand names
Ketamine Hydrochloride Injection, Ketamine Hydrochloride Injection, USP, Ketamine HCL, KetaFlo™
Manufacturer
Multiple FDA sponsors
Species
Both, Cat, Primates
Dosage forms
Liquid (Solution)
Prescription
Prescription required
Completeness
100%
Validation
Needs review
Brand names
Ketamine Hydrochloride Injection Ketamine Hydrochloride Injection, USP Ketamine HCL KetaFlo™
Dosage forms
Liquid (Solution)

Indications / Uses

It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation. It is used for restraint. It is used in cats as the sole anesthetic agent for ovariohysterectomy and general surgery.

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Side Effects

Top reported reactions (openFDA): Vomiting, Death, Lack of efficacy - NOS, Death by euthanasia, Lethargy (see also Central nervous system depression in 'Neurological'), Bradycardia.

FAQ

Both, Cat, Primates, Non-Human Primates, Cat, Restricted During Pregnancy

Yes. Roxee shows this as prescription-only.

Liquid (Solution)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Store in a cool place
  • Protect from light
  • Do not use if precipitate appears
  • wobbly/unsteady walking (1 reports)
  • Loss of appetite (1 reports)
  • Cardiac arrest (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Ketamine; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case DEU-USFDACVM-2025-DE-000039
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 20 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case DEU-USFDACVM-2025-DE-000039
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case DEU-USFDACVM-2025-DE-000039
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Unsteady walking (ataxia) (1 reports), Loss of appetite (1 reports), Cardiac arrest (1 reports), Breathing difficulty (1 reports), Bradycardia (1 reports)

Body systems represented Signal grouping

Digestive (2), Skin & allergy (2), Neurologic (1), Behavior (4)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Cat (23 reports), Dog (9 reports)

Breed metadata in reports Metadata only

Domestic Shorthair (5), Spaniel - King Charles Cavalier (1), Domestic Longhair (1), Domestic Mediumhair (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Ketamine fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Store in a cool place, Protect from light, Do not use if precipitate appears, wobbly/unsteady walking, Loss of appetite

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Ketamine brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case DEU-USFDACVM-2025-DE-000039 · adverse_reaction · adverse reactions
  2. Contraindication source · fda_animal_drugs · warnings contraindications
  3. FDA application profile · official_label · quick facts
  4. FDA application profile · official_label · quick facts
  5. Medication usage source · fda_animal_drugs · quick facts
  6. FOI · document · documents
  7. SPL · document · documents
  8. FOI · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: April 15, 2026, 10:04 AM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Store in a cool place
  • Protect from light
  • Do not use if precipitate appears
  • wobbly/unsteady walking
  • Loss of appetite

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Loss of appetite (1 reports)
  • Cardiac arrest (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Cat, Primates
Indication / use
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Form / route / dose
Form: Liquid (Solution)
Route: Intramuscular
Confirm product label and patient-specific plan.
Warnings
  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect fr…
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Multiple FDA sponsors
Form: Liquid (Solution)
Identifiers:
ANADA: 200029 ANADA: 200042 ANADA: 200055 ANADA: 200073 ANADA: 200257 ANADA: 200279 NADA: 45290 NADA: 92116 NDC Package: 11695-0703-1 NDC Package: 11695-7039-1 NDC Package: 13985-584-10 NDC Package: 17033-101-10 NDC Package: 54771-2013-1 NDC Package: 69043-063-01 NDC Package: 86136-144-31 NDC Product: 11695 NDC Product: 13985 NDC Product: 17033 NDC Product: 54771 NDC Product: 69043
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
55
Matching reports
55
Active filters
0
Reset
Drill into common report signals
Behavioural disorder NOS (8) Hyperactivity (7) Intentional misuse (7) Not eating (7) Other (51) Neurologic (14) Behavior (11) Skin & allergy (10)
Showing up to 50 matching reports. Narrow filters to inspect the remaining reports.

USA-USFDACVM-2026-US-014624

Received 2026-03-26 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5 Kilogram)
Age
Under 1 year (1 Month)
Sex
Male Intact
Region
USA
Reactions
Seizure NOS
Body systems
Neurologic
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-014468

Received 2026-03-26 · MSK · MSK

Serious
Species
Dog
Breed
Spaniel - King Charles Cavalier
Size / weight
10-24 lb (9.48 Kilogram)
Age
4-7 years (7 Year)
Sex
Female Unknown
Region
USA
Reactions
CyanosisRespiratory arrestPremature ventricular contractionsDeath
Body systems
Other
Outcomes
Died

USA-USFDACVM-2026-US-013761

Received 2026-03-24 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Longhair
Size / weight
Under 10 lb (2.781 Kilogram)
Age
Under 1 year (5 Month)
Sex
Male Neutered
Region
USA
Reactions
Increased respiratory rateBreathing difficultyCrackles on auscultationAbnormal ultrasound findingPulmonary disorder NOSIntentional misuseDecreased pulse oxygenationPale mucous membrane
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2026-US-013871

Received 2026-03-23 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (2.72 Kilogram)
Age
Under 1 year (6 Month)
Sex
Female Intact
Region
USA
Reactions
Tongue ulceration
Body systems
Other
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-013856

Received 2026-03-23 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Mediumhair
Size / weight
Under 10 lb (2.95 Kilogram)
Age
Under 1 year (6 Month)
Sex
Female Intact
Region
USA
Reactions
Tongue ulceration
Body systems
Other
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-013840

Received 2026-03-20 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.89 Kilogram)
Age
4-7 years (6 Year)
Sex
Male Neutered
Region
USA
Reactions
Gastrointestinal foreign body NOS
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2026-US-013633

Received 2026-03-19 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.33 Kilogram)
Age
8+ years (11 Year)
Sex
Female Neutered
Region
USA
Reactions
DysphoriaBehavioural disorder NOSDilated pupilsAnorexiaSkin and tissue infection NOSLethargy (see also Central nervous system depression in Neurological)
Body systems
OtherBehaviorDigestiveNeurologic
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-014092

Received 2026-03-16 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (4.354 Kilogram)
Age
4-7 years (7 Year)
Sex
Female Neutered
Region
USA
Reactions
DroolingReluctant to moveNot eatingDilated pupilsNot himself/herselfHypothermiaTachypnoeaIntentional misuseLeukopenia NOSHypoglycaemiaElevated symmetrical dimethylarginine (SDMA)AzotaemiaLow ionized calcium (Ca; Hypocalcaemia, ionized)ObtundedWeak pulseLateral recumbencyRegurgitationCardiac arrestDeath
Body systems
DigestiveOther
Outcomes
Died

USA-USFDACVM-2026-US-014083

Received 2026-03-13 · MSK · MSK

Serious
Species
Dog
Breed
American Pit Bull Terrier
Size / weight
50-99 lb (26.4 Kilogram)
Age
4-7 years (4 Year)
Sex
Male Neutered
Region
USA
Reactions
Cardiac arrestDeath
Body systems
Other
Outcomes
Died

USA-USFDACVM-2026-US-014082

Received 2026-03-13 · MSK · MSK

Serious
Species
Dog
Breed
Shih Tzu
Size / weight
10-24 lb (6.4 Kilogram)
Age
1-3 years (3 Year)
Sex
Female Neutered
Region
USA
Reactions
Cardiac arrestDeath by euthanasiaNeurological symptoms NOS
Body systems
OtherNeurologic
Outcomes
Euthanized

USA-USFDACVM-2026-US-012217

Received 2026-03-13 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Longhair
Size / weight
Under 10 lb (1.992 Kilogram)
Age
Under 1 year (5 Month)
Sex
Female Intact
Region
USA
Reactions
Elevated temperatureDecreased body temperature
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2026-US-011585

Received 2026-03-13 · MSK · MSK

Serious
Species
Dog
Breed
Collie - Smooth-haired
Size / weight
50-99 lb (30.9 Kilogram)
Age
8+ years (11 Year)
Sex
Female Unknown
Region
USA
Reactions
Generalised itchingIncreased drinkingPolyuria
Body systems
Skin & allergyOther
Outcomes
Ongoing

USA-USFDACVM-2026-US-011394

Received 2026-03-12 · MSK · MSK

Non-serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (42.003 Kilogram)
Age
8+ years (1 Year)
Sex
Male Intact
Region
USA
Reactions
WeaknessMedication error NOS
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2026-US-012200

Received 2026-03-04 · MSK · MSK

Serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (33.566 Kilogram)
Age
4-7 years (4 Year)
Sex
Male Intact
Region
USA
Reactions
FeverPantingElevated temperature
Body systems
Other
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-010748

Received 2026-03-04 · MSK · MSK

Non-serious
Species
Dog
Breed
['Terrier - Bull - American Pit', 'Terrier - Bull - Staffordshire']
Size / weight
25-49 lb (21.22 Kilogram)
Age
Under 1 year (9 Month)
Sex
Female Neutered
Region
USA
Reactions
Skin lumpSurgical site disorderSkin inflammation NOSReddening of the skinIntentional misuseApplication site irritationApplication site reddeningApplication site inflammationContamination NOS
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2026-US-009881

Received 2026-03-03 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Longhair
Size / weight
Under 10 lb (3.175 Kilogram)
Age
1-3 years (2 Year)
Sex
Male Neutered
Region
USA
Reactions
HyperthermiaAnxiety
Body systems
OtherBehavior
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-009585

Received 2026-03-03 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (2.6 Kilogram)
Age
Under 1 year (0.51 Year)
Sex
Male Neutered
Region
USA
Reactions
Application site abscessApplication site scabInjection site abscessInjection site scabDefect Unknown/Not Specified
Body systems
Other
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-009573

Received 2026-03-03 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.123 Kilogram)
Age
4-7 years (6.92 Year)
Sex
Male Neutered
Region
USA
Reactions
Application site swellingApplication site scabApplication site bleedingInjection site scabInjection site swellingInjection site bleeding
Body systems
Skin & allergyOther
Outcomes
Ongoing

USA-USFDACVM-2026-US-009864

Received 2026-02-23 · MSK · MSK

Non-serious
Species
Cat
Breed
Cat (unknown)
Sex
Unknown Unknown
Region
USA
Reactions
NauseaDrooling
Body systems
Digestive
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-010895

Received 2026-02-18 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.688 Kilogram)
Age
Under 1 year (8 Month)
Sex
Male Neutered
Region
USA
Reactions
Not sleepingHyperactivityBehavioural disorder NOS
Body systems
OtherBehavior
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-010894

Received 2026-02-18 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (2.495 Kilogram)
Age
Under 1 year (7 Month)
Sex
Female Neutered
Region
USA
Reactions
RestlessnessAgitationDifficulty standingStumbling gaitNot sleepingBehavioural disorder NOS
Body systems
OtherBehavior
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-006579

Received 2026-02-13 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (2.495 Kilogram)
Age
Under 1 year (7 Month)
Sex
Female Neutered
Region
USA
Reactions
RestlessnessAgitationDifficulty standingStumbling gaitNot sleepingBehavioural disorder NOS
Body systems
OtherBehavior
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-006576

Received 2026-02-13 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.688 Kilogram)
Age
Under 1 year (8 Month)
Sex
Male Neutered
Region
USA
Reactions
Not sleepingHyperactivityBehavioural disorder NOS
Body systems
OtherBehavior
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-004923

Received 2026-02-04 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (4.33 Kilogram)
Age
Under 1 year (6 Month)
Sex
Male Neutered
Region
USA
Reactions
HallucinationHyperactivityFallingLocomotor disturbance
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2026-US-008917

Received 2026-01-29 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.53 Kilogram)
Age
1-3 years (1.33 Year)
Sex
Male Neutered
Region
USA
Reactions
PtyalismTremorSeizure NOSAggressionLeukocytosis NOSNeutrophiliaEosinopeniaHypernatraemiaElevated cholesterol (total)Eyes rolling backHyperactivityElevated haematocritDisorientationUrinary tract obstruction/blockageAnaemia NOSOther abnormal test result NOSMydriasisActing tenseMental confusionTwitchingBradycardiaDecreased heart rateBehavioural disorder NOSHaematuriaProteinuria
Body systems
OtherNeurologicBehaviorSkin & allergy
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-003352

Received 2026-01-27 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.992 Kilogram)
Age
8+ years (13 Year)
Sex
Female Neutered
Region
USA
Reactions
DiarrhoeaDecreased appetiteLethargy (see also Central nervous system depression in Neurological)Bloody diarrhoeaDry mucous membraneOpen mouth breathingUnresponsive to stimuliDecreased haematocritIncreased percentage reticulocytesRegenerative anaemiaIntentional misuseThrombocytopeniaHypersalivationHeart murmur
Body systems
DigestiveNeurologicOther
Outcomes
Ongoing

USA-USFDACVM-2026-US-002947

Received 2026-01-20 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.901 Kilogram)
Age
1-3 years (3 Year)
Sex
Male Neutered
Region
USA
Reactions
AnisocoriaTwitchingTachypnoeaHypothermia
Body systems
OtherSkin & allergy
Outcomes
Ongoing

USA-USFDACVM-2026-US-003528

Received 2026-01-19 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (4 Kilogram)
Age
8+ years (13 Year)
Sex
Female Neutered
Region
USA
Reactions
Unresponsive to stimuliOpen mouth breathingAnorexiaLethargy (see also Central nervous system depression in Neurological)DiarrhoeaDry mucous membraneBloody diarrhoeaIncreased percentage reticulocytesDecreased haematocritRegenerative anaemiaThrombocytopeniaHypersalivationMurmur
Body systems
OtherDigestiveNeurologic
Outcomes
Ongoing

USA-USFDACVM-2026-US-003253

Received 2026-01-16 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.53 Kilogram)
Age
1-3 years (1.33 Year)
Sex
Male Neutered
Region
USA
Reactions
PtyalismTremorSeizure NOSAggressionLeukocytosis NOSNeutrophiliaEosinopeniaHypernatraemiaElevated cholesterol (total)Eyes rolling backHyperactivityElevated haematocritDisorientationUrinary tract obstruction/blockageAnaemia NOSOther abnormal test result NOSMydriasisActing tenseMental confusionTwitchingBradycardiaDecreased heart rateBehavioural disorder NOSHaematuriaProteinuria
Body systems
OtherNeurologicBehaviorSkin & allergy
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-000100

Received 2026-01-05 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (4.26 Kilogram)
Age
4-7 years (6.5 Year)
Sex
Male Neutered
Region
USA
Reactions
AtaxiaBalance problemHead shake - behavioural disorderFallingNot eatingDifficulty chewingImpaired hearingDilated pupilsAbnormal pupil light reflexAbnormal movement NOSMuscle atrophy (see also Muscle wasting)Head tilt - neurological disorder (see also Head tilt - ear disorder)
Body systems
NeurologicOtherBehavior
Outcomes
Ongoing

USA-USFDACVM-2025-US-075461

Received 2025-12-29 · MSK · MSK

Serious
Species
Dog
Breed
Greyhound
Size / weight
50-99 lb (27.3 Kilogram)
Age
8+ years (9 Year)
Sex
Female Neutered
Region
USA
Reactions
Lack of efficacy - NOSUnrelated death
Body systems
EffectivenessOther
Outcomes
Euthanized

USA-USFDACVM-2025-US-075440

Received 2025-12-29 · MSK · MSK

Serious
Species
Dog
Breed
['Retriever - Golden', 'Poodle - Standard']
Size / weight
50-99 lb (25.5 Kilogram)
Age
4-7 years (5 Year)
Sex
Male Neutered
Region
USA
Reactions
Lack of efficacy - NOSUnrelated death
Body systems
EffectivenessOther
Outcomes
Euthanized

USA-USFDACVM-2025-US-075367

Received 2025-12-29 · MSK · MSK

Serious
Species
Dog
Breed
Crossbred Canine/dog
Size / weight
25-49 lb (17.7 Kilogram)
Age
8+ years (14 Year)
Sex
Male Neutered
Region
USA
Reactions
Lack of efficacy - NOSUnrelated death
Body systems
EffectivenessOther
Outcomes
Euthanized

USA-USFDACVM-2025-US-074179

Received 2025-12-18 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.084 Kilogram)
Age
Under 1 year (6 Month)
Sex
Female Intact
Region
USA
Reactions
Elevated temperatureBreathing difficultyQuiet
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2025-US-074533

Received 2025-12-17 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (2.5 Kilogram)
Age
Under 1 year (4 Month)
Sex
Female Neutered
Region
USA
Reactions
HypersalivationTachypnoeaAbnormal radiograph findingHypothermiaHyperactivityNot eatingLethargy (see also Central nervous system depression in Neurological)Hiding
Body systems
DigestiveOtherNeurologic
Outcomes
Ongoing

USA-USFDACVM-2025-US-074366

Received 2025-12-17 · MSK · MSK

Non-serious
Species
Dog
Breed
Coton de Tuléar
Size / weight
Under 10 lb (3.719 Kilogram)
Age
4-7 years (4 Year)
Sex
Female Unknown
Region
USA
Reactions
Lack of efficacy - NOSVomitingIntentional misuse
Body systems
EffectivenessDigestiveOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-073634

Received 2025-12-17 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.62 Kilogram)
Age
Under 1 year (5 Month)
Sex
Male Neutered
Region
USA
Reactions
Seizure NOSAgitation
Body systems
NeurologicOther
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-074431

Received 2025-12-16 · MSK · MSK

Serious
Species
Dog
Breed
['Retriever - Golden', 'Poodle - Standard']
Size / weight
50-99 lb (43.273 Kilogram)
Age
4-7 years (7 Year)
Sex
Male Neutered
Region
USA
Reactions
ThrombocytopeniaBlood loss NOSSkin petechiaeDeath
Body systems
Other
Outcomes
Died

USA-USFDACVM-2025-US-073842

Received 2025-12-15 · MSK · MSK

Non-serious
Species
Cat
Breed
Maine Coon
Size / weight
10-24 lb (6.1 Kilogram)
Age
Under 1 year (7 Month)
Sex
Male Intact
Region
USA
Reactions
Not eatingNot sleepingStaringFalling
Body systems
Other
Outcomes
Recovered/Normal

USA-USFDACVM-2025-US-074903

Received 2025-12-12 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (4.354 Kilogram)
Age
1-3 years (12 Month)
Sex
Male Intact
Region
USA
Reactions
Local swelling (not application site)Death
Body systems
Skin & allergyOther
Outcomes
Died

USA-USFDACVM-2025-US-074118

Received 2025-12-11 · MSK · MSK

Serious
Species
Dog
Breed
['Retriever - Golden', 'Poodle (unspecified)']
Size / weight
25-49 lb (16.329 Kilogram)
Age
Under 1 year (7 Month)
Sex
Female Unknown
Region
USA
Reactions
Intestinal perforationPeritonitisFeverDiarrhoeaNot eating
Body systems
OtherDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-072426

Received 2025-12-10 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.81 Kilogram)
Age
8+ years (9 Year)
Sex
Male Neutered
Region
USA
Reactions
Application site alopecia
Body systems
Skin & allergy
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-072148

Received 2025-12-10 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.175 Kilogram)
Age
Under 1 year (8 Month)
Sex
Female Intact
Region
USA
Reactions
Faint heart soundCardiac arrestIntentional misuseDeath
Body systems
Other
Outcomes
Died

USA-USFDACVM-2025-US-074439

Received 2025-12-09 · MSK · MSK

Serious
Species
Dog
Breed
['Retriever - Golden', 'Poodle - Standard']
Size / weight
100+ lb (46 Kilogram)
Age
8+ years (8 Year)
Sex
Male Intact
Region
USA
Reactions
Seizure NOSRough recovery
Body systems
NeurologicOther
Outcomes
Recovered/Normal

USA-USFDACVM-2025-US-074438

Received 2025-12-09 · MSK · MSK

Serious
Species
Dog
Breed
['Siberian Husky', 'Dog (unknown)']
Size / weight
100+ lb (46 Kilogram)
Age
4-7 years (5 Year)
Sex
Male Neutered
Region
USA
Reactions
Seizure NOSRecovery prolonged
Body systems
NeurologicOther
Outcomes
Recovered/Normal

USA-USFDACVM-2025-US-073513

Received 2025-12-09 · MSK · MSK

Non-serious
Species
Dog
Breed
['Pointing Dog - Hungarian Short-haired (Vizsla)', 'Retriever - Labrador']
Size / weight
50-99 lb (40.415 Kilogram)
Age
8+ years (8 Year)
Sex
Male Neutered
Region
USA
Reactions
Application site scarInjection site alopeciaInjection site reaction NOSInjection site noduleMast cell tumourLack of efficacy (neoplasia, relapse)
Body systems
OtherSkin & allergyEffectiveness
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-073350

Received 2025-12-04 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic (unspecified)
Size / weight
10-24 lb (5.9 Kilogram)
Age
1-3 years (3.67 Year)
Sex
Male Intact
Region
USA
Reactions
AgitationDecreased pulse oxygenationIncreased respiratory rateHyperthermiaHyperactivity
Body systems
Other
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-072431

Received 2025-12-04 · MSK · MSK

Non-serious
Species
Cat
Breed
Cat (unknown)
Size / weight
Under 10 lb (1.81 Kilogram)
Age
4-7 years (4 Year)
Sex
Male Neutered
Region
USA
Reactions
DepressionBehavioural disorder NOSLow creatinineHypoproteinaemiaElevated blood urea nitrogen (BUN)HypoglycaemiaHypoalbuminaemiaReduced globulinsElevated alanine aminotransferase (ALT)Low serum alkaline phosphatase (ALP)Decreased body temperature
Body systems
NeurologicBehaviorOther
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-072415

Received 2025-12-04 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic (unspecified)
Size / weight
Under 10 lb (3.86 Kilogram)
Age
1-3 years (2 Year)
Sex
Female Intact
Region
USA
Reactions
DysphoriaElevated temperature
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2025-US-071193

Received 2025-12-04 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.65 Kilogram)
Age
8+ years (14 Year)
Sex
Female Neutered
Region
USA
Reactions
Application site alopeciaWobblinessNot eating
Body systems
Skin & allergyOther
Outcomes
Ongoing

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
20
Species represented
2
Grouped by Body System
Digestive (2) · Loss of appetite, Bloody diarrhoea Skin & allergy (2) · Hair loss at application site, Application site swelling Neurologic (1) · Unsteady walking (ataxia) Behavior (4) · Biting -aggression, Behavioral disorder (unspecified), Anxiety Other (23) · Cardiac arrest, Breathing difficulty, Bradycardia
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Cat 1
Digestive 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Digestive 1 Cat 1
Other 1 Dog 1
Behavior 1 Dog 1

Species coverage: Cat (23) Dog (9)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Cat Serious - 1
Digestive Cat Serious - 1
Skin & allergy Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Digestive Cat Serious - 1
Other Dog Serious - 1
Behavior Dog Serious - 1
Behavior Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Skin & allergy Cat Non-serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Behavior Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Behavior Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Source metadata:

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

VetaKet® SPL · SPL Ketamine HCL SPL · SPL Ketamine Hydrochloride Injection SPL · SPL

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

6

FOI

6

VetaKet®

SPL · SPL

Open original
FDA Structured Product Label

Ketamine Hydrochloride Injection

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Cronus Pharma Specialities India Private Ltd.
ANADA
200-055
Status
RX
Form
Liquid (Solution)
Route
Intramuscular
Species
Primates • Cat
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.

Cats

Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

Subhuman primates

Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

Ketamine HCL

SPL · SPL

Open original
FDA Structured Product Label

Ketamine HCL

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Mylan Institutional LLC, a Viatris Company
ANADA
200-257
Status
RX
Form
Liquid (Solution)
Route
Intramuscular
Species
Primates • Cat
Composition / specifications
Each milliliter contains ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.

Subhuman primates

Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Cats

Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Ketamine Hydrochloride Injection

SPL · SPL

Open original
FDA Structured Product Label

Ketamine Hydrochloride Injection

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Cronus Pharma Specialities India Private Ltd.
ANADA
200-029
Status
RX
Form
Liquid (Solution)
Route
Intramuscular
Species
Cat
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.

Cats

Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

Ketamine Hydrochloride Injection, USP

SPL · SPL

Open original
FDA Structured Product Label

Ketamine Hydrochloride Injection, USP

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Elanco US Inc.
ANADA
200-042
Status
RX
Form
Liquid (Solution)
Route
Intramuscular
Species
Primates • Cat
Composition / specifications
Each milliliter contains ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.

Subhuman primates

Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Cats

Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Ketamine Hydrochloride Injection, USP

SPL · SPL

Open original
FDA Structured Product Label

Ketamine Hydrochloride Injection, USP

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Dechra Veterinary Products LLC
ANADA
200-073
Status
RX
Form
Liquid (Solution)
Route
Intramuscular
Species
Primates • Cat
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.

Cats

Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

Subhuman primates

Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

KetaFlo™

SPL · SPL

Open original
FDA Structured Product Label

KetaFlo™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Abbott Laboratories
ANADA
200-279
Status
RX
Form
Liquid (Solution)
Route
Intramuscular
Species
Primates • Cat
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.

Cats

Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Subhuman primates

Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

A200055_Orig_08_03_1998.pdf

FOI · FOI

Open original

ucm061682.pdf

FOI · FOI

Open original

A200029_Org_8_16_1995.pdf

FOI · FOI

Open original

A200042_Orig_06_30_1994.pdf

FOI · FOI

Open original

A200073_Org_7_21_1994.pdf

FOI · FOI

Open original

ucm061704.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat, Primates
Rx/OTC: RX
Form/route: Liquid (Solution) • Intramuscular
Applications: ANADA 200-055 • ANADA 200-257 • ANADA 200-029 • ANADA 200-042 • ANADA 200-073 • ANADA 200-279
Documents: 6 (FOI: 6) • SPL: 6 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 52 • Cat 123 • View
Case summaries: 55 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Unsteady walking (ataxia) (1) Loss of appetite (1) Cardiac arrest (1) Breathing difficulty (1) Bradycardia (1) Bloody diarrhoea (1) Blood loss NOS (1) Biting -aggression (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200029 ANADA: 200042 ANADA: 200055 ANADA: 200073 ANADA: 200257 ANADA: 200279 NADA: 45290 NADA: 92116 NDC Package: 11695-0703-1 NDC Package: 11695-7039-1 NDC Package: 13985-584-10 NDC Package: 17033-101-10 NDC Package: 54771-2013-1 NDC Package: 69043-063-01 NDC Package: 86136-144-31 NDC Product: 11695 NDC Product: 13985 NDC Product: 17033 NDC Product: 54771 NDC Product: 69043 NDC Product: 86136
Package NDC Product NDC Form / Route Status
11695-0703-1 11695 -
11695-7039-1 11695 -
13985-584-10 13985 -
17033-101-10 17033 -
54771-2013-1 54771 -
69043-063-01 69043 -
86136-144-31 86136 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 16 Clinical 9 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appe… (Clinical, 2026-04-15)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appe… (Clinical, 2026-04-15)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appe… (Clinical, 2026-04-11)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-15)
  • side_effects: Top reported reactions (openFDA): Vomiting, Death, Lack of efficacy - NOS, Death by euthanasia, Lethargy (see also Central nervous system depression in 'Neurol… (Clinical, 2026-04-11)
  • usage: It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation. It i… (Clinical, 2026-04-15)
  • usage: It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation. It i… (Clinical, 2026-04-15)
  • usage: It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation. It i… (Clinical, 2026-04-11)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appe… (Official, 2026-04-22)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appe… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Vomiting, Death, Lack of efficacy - NOS, Death by euthanasia, Lethargy (see also Central nervous system depression in 'Neurol… (Official, 2026-04-22)
  • side_effects: Top reported reactions (openFDA): Vomiting, Death, Lack of efficacy - NOS, Death by euthanasia, Lethargy (see also Central nervous system depression in 'Neurol… (Official, 2026-04-15)
  • side_effects: Top reported reactions (openFDA): Vomiting, Death, Lack of efficacy - NOS, Death by euthanasia, Lethargy (see also Central nervous system depression in 'Neurol… (Official, 2026-04-15)
  • side_effects: Top reported reactions (openFDA): Vomiting, Death, Lack of efficacy - NOS, Death by euthanasia, Lethargy (see also Central nervous system depression in 'Neurol… (Official, 2026-02-12)
  • usage: It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation. It i… (Official, 2026-04-22)
  • usage: Senvelgo (velagliflozin oral solution) is approved in cats for control of hyperglycemia associated with diabetes mellitus. (Official, 2026-04-16)
  • usage: Senvelgo (velagliflozin oral solution) is approved in cats for control of hyperglycemia associated with diabetes mellitus. (Official, 2026-04-15)
  • usage: It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation. It i… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-04-22 10:07 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-22 10:07 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-22 10:07 by etl_backfill • Backfilled from existing medication fields
  • monitoring updated 2026-04-16 13:28 by curated_loader • Clinical monitoring context for feline diabetes management.
  • usage updated 2026-04-16 13:28 by curated_loader • Usage statement from FDA warning letter and approved-product context.
  • drug_profile_type updated 2026-04-16 13:28 by curated_loader • FDA source confirms Senvelgo as a branded approved product.
  • manufacturer_name updated 2026-04-16 13:28 by curated_loader • FDA warning letter identifies the approved sponsor/manufacturer.
  • brand_names updated 2026-04-16 13:28 by curated_loader • FDA warning letter references Senvelgo as the approved animal drug.
  • approval_reference updated 2026-04-16 13:28 by curated_loader • Official FDA application reference for Senvelgo.
  • side_effects updated 2026-04-15 10:07 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-15 10:07 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-15 10:07 by etl_backfill • Backfilled from existing medication fields
  • monitoring updated 2026-04-15 10:07 by curated_loader • Clinical monitoring context for feline diabetes management.
  • usage updated 2026-04-15 10:07 by curated_loader • Usage statement from FDA warning letter and approved-product context.
  • drug_profile_type updated 2026-04-15 10:07 by curated_loader • FDA source confirms Senvelgo as a branded approved product.
  • manufacturer_name updated 2026-04-15 10:07 by curated_loader • FDA warning letter identifies the approved sponsor/manufacturer.
  • brand_names updated 2026-04-15 10:07 by curated_loader • FDA warning letter references Senvelgo as the approved animal drug.
  • approval_reference updated 2026-04-15 10:07 by curated_loader • Official FDA application reference for Senvelgo.
  • side_effects updated 2026-04-15 10:04 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-15 10:04 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Ketamine Hydrochloride Injection
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Cronus Pharma Specialities India Private Ltd. ANADA 200-055 Approved Jun 25, 2026
Ketamine HCL
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Mylan Institutional LLC, a Viatris Company ANADA 200-257 W Jan 21, 2025
Ketamine Hydrochloride Injection
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Cronus Pharma Specialities India Private Ltd. ANADA 200-029 Approved Feb 1, 2018
Ketamine Hydrochloride Injection, USP
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Elanco US Inc. ANADA 200-042 Approved Aug 4, 2017
Ketamine Hydrochloride Injection, USP
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Dechra Veterinary Products LLC ANADA 200-073 Approved May 19, 2017
KetaFlo™
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Abbott Laboratories ANADA 200-279 W Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Primates • Cat
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.
Subhuman primates
Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

FDA page: Open in Animal Drugs @ FDA

Species: Primates • Cat
Composition / specifications
Each milliliter contains ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Subhuman primates
Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Cat
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

FDA page: Open in Animal Drugs @ FDA

Species: Primates • Cat
Composition / specifications
Each milliliter contains ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Subhuman primates
Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Primates • Cat
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.
Subhuman primates
Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

FDA page: Open in Animal Drugs @ FDA

Species: Primates • Cat
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Subhuman primates
Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Usage

It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation. It is used for restraint. It is used in cats as the sole anesthetic agent for ovariohysterectomy and general surgery.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Cat Bloody diarrhoea (1) • Cat

Showing top 5 for Digestive.

Skin & allergy
Hair loss at application site (1) • Cat Application site swelling (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Cat

Showing top 5 for Neurologic.

Behavior
Biting -aggression (1) • Dog Behavioral disorder (1) • Cat Anxiety (1) • Cat Aggression (1) • Cat

Showing top 5 for Behavior.

Other
Cardiac arrest (1) • Cat Breathing difficulty (1) • Cat Bradycardia (1) • Cat Blood loss NOS (1) • Dog Balance problem (1) • Cat
Show more (18)
Azotaemia (1) • Cat Application site scar (1) • Dog Application site scab (1) • Cat Application site reddening (1) • Dog Application site irritation (1) • Dog Application site inflammation (1) • Dog Application site bleeding (1) • Cat Application site abscess (1) • Cat Anisocoria (1) • Cat Anaemia NOS (1) • Cat Agitation (1) • Cat Acting tense (1) • Cat Abnormal ultrasound finding (1) • Dog Abnormal radiograph finding (1) • Cat Abnormal pupil light reflex (1) • Cat Abnormal posture NOS (1) • Dog Abnormal movement NOS (1) • Cat Abdominal pain (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Shorthair, Male, 10 month, 5 kilogram • Drug: MSK, Unknown • Reactions: Seizure NOS • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-014624
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 10.00 Month
  • Weight: 5.000 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Seizure NOS
Outcomes: Recovered/Normal

Dog, Spaniel - King Charles Cavalier, Female, 7 year, 9.48 kilogram • Drug: MSK, Injection, solution, Unknown • Reactions: Cyanosis, Respiratory arrest, Premature ventricular contractions, Death • Outcome: Died

  • Report ID: USA-USFDACVM-2026-US-014468
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 9.480 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Injection, solution
Reactions Reported:
Cyanosis Respiratory arrest Premature ventricular contractions Death
Outcomes: Died

Cat, Domestic Longhair, Male, 5 month, 2.781 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Increased respiratory rate, Breathing difficulty, Crackles on auscultation, Abnormal ultrasound finding, Pulmonary disorder NOS… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-013761
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 5.00 Month
  • Weight: 2.781 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Increased respiratory rate Breathing difficulty Crackles on auscultation Abnormal ultrasound finding Pulmonary disorder NOS Intentional misuse Decreased pulse oxygenation Pale mucous membrane
Outcomes: Ongoing

Cat, Domestic Shorthair, Female, 6 month, 2.72 kilogram • Drug: MSK, Unknown • Reactions: Tongue ulceration • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-013871
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 6.00 Month
  • Weight: 2.720 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Tongue ulceration
Outcomes: Recovered/Normal

Cat, Domestic Mediumhair, Female, 6 month, 2.95 kilogram • Drug: MSK, Unknown • Reactions: Tongue ulceration • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-013856
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 6.00 Month
  • Weight: 2.950 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Tongue ulceration
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Male, 6 year, 5.89 kilogram • Drug: MSK, Unknown • Reactions: Gastrointestinal foreign body NOS • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-013840
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 6.00 Year
  • Weight: 5.890 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Gastrointestinal foreign body NOS
Outcomes: Ongoing

Cat, Domestic Shorthair, Female, 11 year, 5.33 kilogram • Drug: MSK, Unknown • Reactions: Dysphoria, Behavioral disorder (unspecified), Dilated pupils, Loss of appetite, Skin and tissue infection NOS… • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-013633
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 11.00 Year
  • Weight: 5.330 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Dysphoria Behavioral disorder (unspecified) Dilated pupils Loss of appetite Skin and tissue infection NOS Tiredness (lethargy)
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Female, 7 year, 4.354 kilogram • Drug: MSK, Intramuscular • Reactions: Drooling, Reluctant to move, Not eating, Dilated pupils, Not himself/herself… • Outcome: Died

  • Report ID: USA-USFDACVM-2026-US-014092
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 4.354 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
Reactions Reported:
Drooling Reluctant to move Not eating Dilated pupils Not himself/herself Hypothermia Tachypnoea Intentional misuse Leukopenia NOS Hypoglycaemia Elevated symmetrical dimethylarginine Azotaemia Low ionized calcium Obtunded Weak pulse Lateral recumbency Regurgitation Cardiac arrest Death
Outcomes: Died

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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